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All Journal Pharmaciana: Jurnal Kefarmasian JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA JSFK (Jurnal Sains Farmasi & Klinis) Logista: Jurnal Ilmiah Pengabdian Kepada Masyarakat JURNAL MEDIA KESEHATAN Jurnal Ilmiah Farmasi Farmasyifa Jurnal Pengabdian Masyarakat Bumi Raflesia Dharma Raflesia : Jurnal Ilmiah Pengembangan dan Penerapan IPTEKS Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Pharmacopoeia Indonesian Journal of Community Empowerment and Service Journal of Pharmaceutical and Sciences. BATOBO: Jurnal Pengabdian Kepada Masyarakat Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan Bencoolen Journal of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan Jurnal Abdimas Bencoolen
Dominica, Dwi
Program Studi S1 Farmasi, Fakultas Matematika Dan Ilmu Pengetahuan Alam, Universitas Bengkulu, Kota Bengkulu, Indonesia.
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Assessment of the subchronic toxicity of ethanol extract of Merdeka-leaves (Chromolaena odorata L.) on SGOT, SGPT, and histological alterations in the kidneys and liver of male rats Pertiwi, Reza; Azhar, Afra Wafiqah; Dominica, Dwi; Yudha, Salprima; Rahmawati, Reza; Putri, Yona Harianti
Pharmaciana Vol. 15 No. 3 (2025): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v15i3.30278

Abstract

The Merdeka plant (Chromolaena odorata L.) is known for its various pharmacological benefits, including gastroprotection, antibacterial, antihyperglycemic effects, and wound healing promotion. To ensure safe use in the community, it is important to evaluate its potential toxicity. This study examined the effects of ethanol extract of Merdeka leaf (C. odorata) on liver function by measuring the levels of serum glutamic-oxaloacetic transaminase (SGOT) and serum glutamic-pyruvate transaminase (SGPT) in male rats (Rattus norvegicus). Twenty-five male Wistar rats were split into five groups: three treatment groups that received ethanol extract at doses of 150 mg/kg BW, 300 mg/kg BW, and 600 mg/kg BW, a negative control group that received 0.5% Na CMC, and a normal control group that received no treatment. For 28 days, the extract was taken orally every day. Following surgery, liver and kidney tissues were removed for histology on day 29, and blood samples were obtained via the aorta. The findings demonstrated that rats administered 600 mg/kg BW of ethanol extract had significantly greater SGOT and SGPT levels than controls (p < 0.05), suggesting that high dose of Merdeka leaf extract may have an impact on kidney and liver functions.
GERAKAN BANQUE D’ORDURES (BANK SAMPAH) DEMI MASYARAKAT MAJU DAN DONASI PEMBAGIAN MASKER DAN HANDSANITIZER SEBAGAI UPAYA PENCEGAHAN TERHADAP COVID-19 DI DESA RINDU HATI BENGKULU TENGAH Dominica, Dwi; Samudra, Agung Giri; Handayani, Dian; Maulina, Tya Chalifatul
Jurnal Pengabdian Masyarakat Bumi Rafflesia Vol. 5 No. 2 (2022): Jurnal Pengabdian Kepada Masyarakat Bumi Raflesia
Publisher : Universitas Muhammadiyah Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Dalam menjaga dan melestarikan lingkungan yang bersih dan sehat serta tetap mematuhi protocol kesehatan dalam suasana pandemic Covid-19 dilingkungan wisata salah satunya dengan penggunaa masker dan hansanitizer serta menyiapkan tempat pengolahan sampah yang bisa dimanfaatkan dan memiliki nilai ekonomi bagi masyarakat. Tujuan kegiatan pengabdian pada masyarakat ini kami buat untuk meningkatkan kesadaran masyarakat akan pentingnya kebersihan dan membangun  kreatifitas masyarakat untuk mencari pekerjaan dan mendapatkan kehidupan yang layak demi masyarakat maju. Serta bertujuan memutuskan mata rantai penyebaran virus covid-19 di tempat wisata khususnya di Desa Rindu Hati salah satunya meningkatkan kepatuhan masyarakat dengan tetap menggunakan masker dan selalu cuci tangan atau menggunakan handsanitizer di tempat umum. Metode dan Proses pelaksanaan kegiatan pengabdian melalui beberapa tahap yang digunakan pada kegiatan ini adalah:, yaitu: Sosialisasi, Pemberian bank sampah dan masker serta handsanitizer, Tahap Aplikasi. Indikator keberhasilan dari tahap ini adalah berkurangnya sampah yang berserakan dan adanya bank sampah pada beberapa titik tempat wisata, dan berkurangnya penyebaran covid-19 terutama ditempat wisata Desa Rindu Hati Kabupaten Bengkulu Tengah. Kata Kunci:  Banque D’ordures, Masker, Handsanitizer, pengabdian masyarakat
Co-Authors Agung Giri Samudra Agus Martono Hadi Putranto Aina Fatkhil Haque, Aina Fatkhil Amanda Gusti Fatika Anggi Triphosa Simanjuntak Anggraini, Dewi Febrina Anisah, Saskia Anjeliani, Cindy Choirina Azhar, Afra Wafiqah Buistu Arbaa Nuyuh Putri Danuartha, Dhimas Dea Eka Rina Deddi Prima Putra Delia Komala Sari, Delia Komala Delia Komalasari Denty Safitri Dhea Ananda Dian Handayani Dian Handayani Dian Handayani Dian Handayani Dinah Khairunisah Dinda Zulkarnain Dinda Zulkarnain Dionni Ditya Perdana Dwi Kurnia Putri Dwita Oktiarni Elsya Agustina Etriyanto Arman Fadilla, Alena Fahma Shufyani Fahma Shufyani Feby R.A Putri Firza, Bunga Al I Ketut Suada Ikhsan Ikhsan Khairani, Marah Kurnia Hafidzah Lathifa Olivia Adeshi M. Rifqi Efendi Maharini, Indri Maulina, Tya Chalifatul Mayang Sari Muhamad Arifin Muhammad Andry Mutia Annisa Putri Pin Saadin Nanda, Yogie Andika Tri Ningrum, Karina Primatyas Okta, Fauzia Noprima Oktarini, Rizki Oktoviani Pratiwi, Reza Puspa Dwi Pratiwi Putri , Yona Harianti Putri, Fadilla Aliyah Putri, Yona Harianti Rahmatullah, Febri Rahmawati, Reza Reza Pertiwi Reza Rahmawati Riana Versita Rizki Hadi Wibowo Ruri Ayu Agrace SALPRIMA YUDHA S Sani K, Fathnur SEPTI WULANDARI Shufyani , Fahma Shufyani, Fahma Susan Jaya Mutiara M Nur Syati Manaharawan Siregar Teja Dwi Sutanto Tiara Feni Lestari Triawan, Deni Agus Tya Chalifatul Versita , Riana Versita, Riana Wibowo, Risky Hadi Yesika, Relin Yolanda, Sefty Yona Harianti Putri Yulihasri Yustisia, Nova