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All Journal Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Jurnal Biologi Udayana ASPIRATOR Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Nutri-Sains: Jurnal Gizi, Pangan dan Aplikasinya BERDIKARI : Jurnal Inovasi dan Penerapan Ipteks Pharmasipha 2-TRIK: TUNAS-TUNAS RISET KESEHATAN JFM (Jurnal Farmasi Malahayati) Jurnal Pengabdian Masyarakat Bumi Raflesia Community Development Journal: Jurnal Pengabdian Masyarakat Janaka : Jurnal Pengabdian Masyarakat Indonesian Journal of Applied Research (IJAR) JOURNAL LA MEDIHEALTICO Al-I'jaz: Jurnal Studi Al-Qur'an, Falsafah, dan Keislaman International Journal of Islamic and Complementary Medicine LEBAH Prosiding Seminar Nasional Teknik Sipil UMS Journal of Halal Science and Research Jurnal Ilmiah Global Farmasi Jurnal Abdimas Kesehatan Berkala Ilmiah Kedokteran dan Kesehatan Masyarakat ASPIRATOR - Journal of Vector-Borne Diseases Studies APMa Jurnal Pengabdian Masyarakat

Marfu'ah, Nurul

Universitas Darussalam Gontor

Author-ID : 3468025

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FORMULASI SEDIAAN SABUN CAIR EKSTRAK DAUN SIRIH HIJAU (Piper battle folium L.) DAN EKSTRAK BAWANG PUTIH (Allium sativum L.) SEBAGAI ANTIJAMUR Candida albicans Nurul Marfuah, Rohmah Madya Ayu Fitriana, Solikah Ana Estikomah,
Pharmaceutical Journal of Islamic Pharmacy Vol 2, No 2 (2018)
Publisher : Universitas Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v2i2.2632

Islam is a religion that likes cleanliness, in case of body hygiene, clothing, and environment. One of the diseases that arise because it does not keep the body clean is white discharge. Piper bettle folium and Alium sativum are some of the natural ingredients that has the potential as an antifungal. This research aims to see the effect of antifungal Candida albicans extract of Piper bettle folium and Alium sativum after formulated as a liquid soap preparation. Liquid soaps are made by hot process methods with 3 formulations of combination of Piper bettle folium and Alium sativum extract with a ratio of 1) 25%: 75% 2) 50%: 50% 3) 75%: 25%. The evaluation of liquid soap include organoleptic examination, pH, high foam, moisture content, homogeneity, and antifungal power test against Candida albicans fungus. The results of the testing of liquid soap quality of green betel leaf extract and garlic have met the standards SNI (Indonesiaâs National Standards) set for the manufacture of liquid soap.The results showed that liquid soap extract of green betel leaf and garlic have antifungal activity against Candida albicans. The result of formulation with the highest inhibition zone is formulation 3 and formulation with the lowest inhibition zone is the formulation 1. The test of this liquid soap activity is higher than fluconazole as the positive control and liquid soap of female area spread in the market.

PENGARUH PUASA TERHADAP JUMLAH DAN MORFOLOGI SPERMATOZOA MENCIT (Mus musculus) Surya Amal, Nurul Marfuah,
Pharmaceutical Journal of Islamic Pharmacy Vol 2, No 2 (2018)
Publisher : Universitas Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v2i2.2630

One of the benefits of fasting is being able to control testosterone levels in the blood so as not to exceed normal. Normal testosterone levels will produce good quality (morphology, viability, motility) and good quantity (number) of spermatozoa. Therefore, thisÂ study was conducted to understand the effect of fasting on the number and morphology of spermatozoa in mice. This study is an experimental study with a completely randomized design trial (CRD) using5 treatments and 3 replications. The type of treatment given is not fasting (control); middle fasting month of Hijriah for 3 days (13th, 14th and 15th); Monday and Thursday fasting; fasting Daud (a day of fasting a day is not); and fasting every day for 36 days. Male mice used in this study were Balb C strains with an initial weight of 23-26 grams and in the age range of 8-10 weeks. Calculation of the number of epididymal spermatozoa carried out according to WHO procedures in Syamrizal (1995) and morphological observations of spermatozoa carried out included normal and abnormal. Data analysis used is one-way ANOVA with a significance level of 5%. The statistical program used for the analysis was the SPSS 20 program. The results showed that fasting could increase the number and percentage of normal spermatozoa in Balb C strain mice eventhough statistically the increase was not significantly different (sig.> 0.05). Based on the type of fasting that was done, fasting on Thursday Thursday had the highest effect on the increase in the number and percentage of normal spermatozoa. Then followed by fasting every day and fasting of Daud. While the mid-fasting month of Hijriah actually decreases the number and percentage of normal spermatozoa compared to controls.

PENGARUH PUASA TERHADAP JUMLAH DAN MORFOLOGI SPERMATOZOA MENCIT (Mus musculus) Surya Amal, Nurul Marfu'ah,
Pharmaceutical Journal of Islamic Pharmacy Vol 2, No 2 (2018)
Publisher : Universitas Darussalam Gontor

One of the benefits of fasting is being able to control testosterone levels in the blood so as not to exceed normal. Normal testosterone levels will produce good quality (morphology, viability, motility) and good quantity (number) of spermatozoa. Therefore, this study was conducted to understand the effect of fasting on the number and morphology of spermatozoa in mice. This study is an experimental study with a completely randomized design trial (CRD) using5 treatments and 3 replications. The type of treatment given is not fasting (control); middle fasting month of Hijriah for 3 days (13th, 14th and 15th); Monday and Thursday fasting; fasting Daud (a day of fasting a day is not); and fasting every day for 36 days. Male mice used in this study were Balb C strains with an initial weight of 23-26 grams and in the age range of 8-10 weeks. Calculation of the number of epididymal spermatozoa carried out according to WHO procedures in Syamrizal (1995) and morphological observations of spermatozoa carried out included normal and abnormal. Data analysis used is one-way ANOVA with a significance level of 5%. The statistical program used for the analysis was the SPSS 20 program. The results showed that fasting could increase the number and percentage of normal spermatozoa in Balb C strain mice eventhough statistically the increase was not significantly different (sig.> 0.05). Based on the type of fasting that was done, fasting on Thursday Thursday had the highest effect on the increase in the number and percentage of normal spermatozoa. Then followed by fasting every day and fasting of Daud. While the mid-fasting month of Hijriah actually decreases the number and percentage of normal spermatozoa compared to controls.

Aktivitas Antibakteri Kayu Siwak (Salvadora persica) Fraksi Eter terhadap Bakteri Staphylococcus aureus Secara In Vitro Riza Amalia; Nurul Marfu'ah; Surya Amal
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 2, No 1 (2018): Maret
Publisher : University Of Darussalam Gontor

Using miswak is one of sunnah performed by Prophet Muhammad SAW and it contains a variety of compounds including these terpenoids, alkaloids, tannins and flavonoids which function as an antibacterial on the periodontal disease. Therefore, extraction and fractionation process were done to get the active compounds in miswak wood that has antibacterial activity against Staphylococcus aureus. This study is an experimental research with Complete Random Design methods. Ethanol extract separated using miswak from solvent of ether. Screening phytochemicals on thin Layer Chromatography (TLC) and test tube, the antibacterial activity was done using diffusion method with a concentration of 50% v/v, 25% v/v, 12.5% v/v and 6.25% v/v, metronidazole as a positive control and a DMSO as the negative control. The data obtained were then analyzed using One Way ANOVA test. Wood of miswak from ether fraction provide inhibition of 14.6-20.8 mm included strong category. The use of metronidazole as positive controls provide significant inhibitory against Staphylococcus aureus and the solvent DMSO as a negative control did not provide any inhibitory area. As for the description of the zone of inhibition against Staphylococcus aureus bacteria. Miswak wood from ether has antibacterial activity against Staphylococcus aureus with fraction of ether concentration of 12.5% v/v and smallest zone amounting 14.6 mm. Whereas at the greatest concentration found in the inhibition of 50% v/v with the average diameter of the zone of drag of 20.8 mm, with secondary metabolites contained in miswak fraction of ether is these terpenoids, alkaloids and tannins

Pengaruh Steroid Anabolik Methandienone terhadap Kualitas Spermatozoa Tikus Putih (Rattus norvegicus) Nurul Marfu'ah
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 1, No 1 (2017): September
Publisher : University Of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v1i1.1120

Anabolic steroids are chemical derivative of the testosterone hormone that are commonly used in medical field, but in development it is abused by its users. Methandienone is one type of anabolic steroid that widely used in the world. The anabolic effects can develop muscle formation, but the androgenic effect can suppress testosterone synthesis. Low testosterone will disrupt spermatogenesis and ultimately decrease the quality of spermatozoa production. This study aim to determine effect of anabolic steroid methandienone to quality of spermatozoa in albino rats (Rattus norvegicus). Examination of the quality of spermatozoa was performed on cauda epididymal include speed, motility, viability, and morphology of spermatozoa. The results of this study showed that the average quality of spermatozoa between the control group and the treatment group statistically was not significantly different (P > 0.05). However, average quality of spermatozoa (speed of spermatozoa, percentage of motile spermatozoa, percentage of alive spermatozoa, percentage of normal spermatozoa) also showed a declining trend. Speed of spermatozoa was normal because it is able to move in 1-4 mm/min. Motility and morphology of spermatozoa was normal because the percentage of motile spermatozoa and normal spermatozoa showed more than 50%. Viability of spermatozoa in the treatment group was abnormal because the percentage of alive spermatozoa showed less than 25%.

Uji Efektivitas Ekstrak Etanol Daun Bidara (Ziziphus spina- christi L.) terhadap Pertumbuhan Propionibacterium acne Nurul Marfu’ah; Chelsea Aulia Ramadhani; Aural Miftahul Hasanah
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 3, No 1 (2019): Maret
Publisher : University Of Darussalam Gontor

Traditional medicinal plants can prove the importance of natural ingredients for various processes of human medicine. In recent years, there has been an increase in researchers' interest in the use of natural materials as natural biological compounds in the manufacture of drugs. One of the plants used as medicine by the community is bidara plants. Plant bidara contains phenolics and flavonoids which are rich in antibacterial properties. One of the bacteria that causes acne is Propionibacterium acnes. Untrated pimples will cause serious illness. Therefore, this study was conducted to determine the antibacterial activity of the ethanol extract of bidara against Propionibacterium acnes. This is an experimental study with 3 concentrations of bidara leaf extract namely concentrations of 70%, 80%, 90% and using negative controls (aquadest) and positive control (clindamisin). Extract of bidara leaves is done by maceration using 70% ethanol solution. While the antibacterial test uses the agar diffusion method using a well. Data obtained in the form of inhibitory zone measurements were analyzed using Analysis of variants (ANOVA). The results of this study indicate that the ethanol extract of Bidara leaves with a concentration of 70%, 80%, and 90% is not effective in inhibiting the growth of Propionibacterium acnes bacteria.

PENGARUH EKSTRAK METANOL BIJI OKRA (Abelmoschus esculantus L.) TERHADAP PENURUNAN KADAR KOLESTEROL TOTAL DARAH MENCIT HIPERKOLESTEROLEMIA Cisilliya Tandraini; Rahmat A Hi Wahid; Nurul Marfu’ah
Pharmasipha: Pharmaceutical Journal of Islamic Pharmacy Vol 4, No 1 (2020): Maret
Publisher : University Of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v4i1.3951

Pola hidup dan pola makan yang buruk mengakibatkan tingginya prevalensi penyakit hiperkolesterol di Indonesia. Senyawa dalam biji okra yang berpotensi menurunkan kolesterol adalah senyawa alkaloid, flavonoid, fenol, protein, terpenoid, tannin, dan sterol (Kumar, 2014). Penelitian ini dilakukan dengan tujuan untuk mengetahui pengaruh ekstrak metanol biji okra terhadap penurunan kadar kolesterol total darah mencit hiperkolesterolemia. Penelitian ini merupakan eksperimen dengan menggunakan hewan coba mencit jantan, berat badan awal 27 – 30 gram dan usia 2 – 3 bulan. Perlakuan yang diberikan meliputi P1 (kontrol negatif menggunakan aquades), P2 (Kontrol positif menggunakan simvastatin), P3 (ekstrak metanol biji okra 500 mg/kgBB), P4 (ekstrak metanol biji okra 1000 mg/kgBB) dan P5 (ekstrak metanol biji okra 2000 mg/kgBB). Perlakuan dilaksanakan selama 14 hari, kemudian kadar kolesterol total darah mencit diukur sebanyak dua kali yaitu setelah pemberian MDTL (Makanan Diet Tinggi Lemak menggunakan lemak sapi dan minyak jelantah) pada hari ke-14 dan setelah pemberian ekstrak metanol biji okra pada hari ke-28. Kadar kolesterol total darah mencit diukur menggunakan strip kolesterol Easy Touch GCU 3 in 1. Data dianalisis menggunakan uji One Way ANOVA dengan taraf kepercayaan 5% dan dilanjutkan dengan uji Post Hoc menggunakan Least Signifficant Different (LSD). Hasil penelitian menunjukkan rata-rata kadar kolesterol total pada P1 yaitu -53,75 mg/dL, rata-rata kadar kolesterol total pada P2 yaitu 49 mg/dL, rata-rata kadar kolesterol total pada P3 yaitu 20,5 mg/dL, rata-rata kadar kolesterol total pada P4 yaitu 18 mg/dL dan rata-rata kadar kolesterol total pada P5 yaitu 24,5 mg/dL. Berdasarkan hasil penelitian, dapat disimpulkan bahwa ektrak metanol biji okra berpengaruh terhadap penurunan kadar kolesterol total darah mencit hiperkolesterolemia. Konsentrasi ekstrak metanol biji okra yang paling berpengaruh terhadap penurunan kadar kolesterol total darah mencit hiperkolesterolemia yaitu 2000 mg/kg BB.

UJI DAYA HAMBAT EKTRAK ETANOL DAUN SIRIH HIJAU (Piper betle L.) TERHADAP PERTUMBUHAN BAKTERI Staphylococcus aureus Nurul Marfu'ah; Sha’sha’ Luthfiana; Ichwanuddin Ichwanuddin
Pharmasipha: Pharmaceutical Journal of Islamic Pharmacy Vol 5, No 2 (2021): September
Publisher : University Of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v5i2.6650

Bakteri Staphylococcus aureus dapat menyebabkan beberapa gangguan pada kulit. Salah satu tanaman yang memiliki kemampuan antibakteri yaitu sirih hijau yang mengandung senyawa fenol dan turunannya. Tujuan dari penelitian ini yaitu untuk mengetahui potensi antibakteri Staphylococcus aureus dari ekstrak etanol daun sirih hijau (Piper betle L.). Jenis penelitian ini adalah eksperimen dengan 6 perlakuan yaitu K- (CMC-Na 0,5%), K+ (kloramfenikol 50 µg/50 ml), serta ekstrak daun sirih hijau konsentrasi 10%, 20%, 30%, dan 40%. Proses ekstraksi daun sirih hijau dengan metode maserasi dan di uji antibakteri dengan paper disk dan metode difusi. Uji parametrik One Way ANOVA digunakan untuk menganalisis data berupa diameter zona hambat. Hasil penelitian menunjukkan bahwa ekstrak etanol daun sirih hijau memiliki potensi sebagai antibakteri Staphylococcus aureus (P<0,05). Kemampuan antibakteri terhadap Staphylococcus aureus paling optimal dimiliki oleh ekstrak etanol daun sirih konsentrasi 40%, dengan rata-rata zona hambat sebesar 3,01 mm (daya hambat lemah).

Uji Toksisitas Sub Akut Iunfusa Daun Afrika (Vernonina amygdalina Del.) terhadap Histopatologi Ginjal Mencit Galur Balb/C Nida Faradisa; Nurul Marfu'ah; Surya Amal
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 2, No 1 (2018): Maret
Publisher : University Of Darussalam Gontor

Alloh created everything in this universe to take benefit from it, including African Leaf plant. One of the benefits of this leaf is to treat diabetes mellitus, malaria and dysentery. African leaf contains saponin type compounds, flavonoids and steroid glycosides. Drugs that enter the body will go through the phase of metabolism in the liver and excretion in the kidneys. Kidney that serves to dispose of metabolic waste and body toxins in the form of urine. The purpose of this research is to know the effect of African Leaf infusion on histopathology of mice kidney BALB/c. Samples in the form of BALB / c male strain of mice were 12 samples were divided into 4 treatment types with 3 replications. Treatment of control (aquades), African leaf infusion 10% b/v, 20% b/v and 30% b/v infused orally for 28 days. The data obtained were analyzed by Kruskall Wallis test and the data shows congestion value 0.241 > p 0.05 and hemorragic value 0.070 > p 0.05 which means there is no significant difference between treatment types. Therefore, it can be concluded that African leaf infusion has no effect on histopathology of renal mice BALB/c. However, the trend of results in this study indicates that the increased dose given to mice can reduce congestion and hemorrhage in the kidneys

AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL TEH HIJAU (Camellia sinensis) TERHADAP PERTUMBUHAN Staphylococcus epidermidis Alifya Nur Azizah; Ichwanuddin Ichwanuddin; Nurul Marfu’ah
Pharmasipha: Pharmaceutical Journal of Islamic Pharmacy Vol 4, No 2 (2020): September
Publisher : University Of Darussalam Gontor

Staphylococcus epidermidis merupakan mikrobiota kulit yang bersifat non patogen namun terkadang dapat menimbulkan penyakit seperti infeksi oportunistik. Infeksi dapat diobati dengan menggunakan antibiotik, namun saat ini beberapa bakteri mulai resisten terhadap antibiotik dikarenakan penggunaannya yang berlebihan. Sebagai pengobatan alternatif, digunakan tanaman yang memiliki khasiat sebagai antibakteri misalnya teh hijau yang memiliki senyawa tanin, flavonoid, dan katekin yang merupakan golongan senyawa fenol serta alkaloid. Etanol merupakan pelarut yang paling umum digunakan untuk mengekstraksi senyawa-senyawa dalam tumbuhan. Tujuan penelitian ini adalah untuk mengetahui aktivitas antibakteri pada ekstrak etanol teh hijau terhadap pertumbuhan bakteri Staphylococcus epidermidis. Penelitian ini merupakan eksperimen 6 perlakuan yaitu kontrol negatif (aquades steril), kontrol positif (kloramfenikol 30 µg), teh hijau yang diekstraksi dengan pelarut etanol 60%, 70%, 80% dan 90%. Ekstraksi menggunakan metode maserasi selama 6 x 24 jam dan uji aktivitas antibakteri menggunakan metode difusi cakram (KirbyBauer). Data yang diperoleh dianalisis menggunakan one way ANOVA dengan nilai signifikansi yang dihasilkan p = 0,00 atau p < 0,05. Hasil penelitian menunjukkan bahwa ekstrak etanol teh hijau memiliki aktivitas antibakteri terhadap pertumbuhan Staphylococcus epidermidis. Ekstrak etanol 60%, 70%, 80% dan 90% teh hijau memiliki rata-rata diameter zona hambat dan standar deviasi masing-masing secara urut yaitu sebesar 18,45 mm ± 0,81; 19,86 mm ± 0,63; 16,68 mm ± 1,14 dan 13,58 mm ± 0,72 sedangkan untuk kontrol positif memiliki rata-rata diameter zona hambat dan standar deviasi sebesar 27,25 mm ± 0,71. Konsentrasi ekstrak etanol teh hijau yang memiliki aktivitas antibakteri paling optimal yaitu ekstrak etanol 70% dengan diameter zona hambat sebesar 19,86 mm

Co-Authors Al Hasanah, Fauziyyah Alifya Nur Azizah Amal Fadholah Amala, Nur Amilia Yuni Damayanti Ananda, Mutiara Andi Sri Suriati Amal Andri Karin, Elsy Juni Anjani, Hanifa Dyanti Anugerah Suciati Astuti, Eti Aural Miftahul Hasanah Ava Zaujah Awaluddin, Rizki Ayu, Gustin Swastika Azzahra, Isma Chelsea Aulia Ramadhani Cisilliya Tandraini Damayanti, Widya Dewi Ratnasari Diah Ayu Mutmaina Dianti Desita Sari Diwana, Nida Khofiya Puspa Eva Nor Diana Lestari Fajri, Mathla’il Fardyatullail, Haila Farhana, Siti Awalisanah Hani Fauziatunnisa, Elok Fazriah D., Gita Fitrian, Ahyana Frida SA, Yuna Hafifah, Cut Ajma Fitira Hamzah Gita Sari Hartinah Yulianto, Siti Haryanto, Qurrah A'yuniyyah I Wayan Kasa Ichwanuddin Ichwanuddin Indah Tri Lestari Indahtul Mufidah Khodijah, Alisya Khomarul Kuniyati Kurniawan Kurniawan Kurniawan Kurniawan, Kurniawan Kusumasary, Dhiyah Ayu KW, Faradhita Lestari, Eva Nor Diana Lia, Melda Lija Oktya Artanti Lija Oktya Artanti Lutfi Shantia Luthfiya, Lulu' Luthfiya, Lulu’ Mafazatien Nailiyah Isna Mahirotun NS, Anggun Mahmudah, Amalia Nurul Mahmudah, Hilma Radhia Mathlail Fajri Maulia Isnaini MIFTAKHUL JANNAH Mira Dian Naufalina Mira Dian Naufalina Muhammad El Riza NA, Eldyamarta Nadia Iha Fatihah Nadia Mira Kusumaningtyas Nadia Saptarina Nadia Saptarina Nida Faradisa Fauziyah Nisrina, Salma Nur Hazlia, Syarifah Pertamana, Ropia Pibriyanti, Kartika Pratiwi, Arika Putri Putri, Kayla Radina Dwi Qurrah A'yuniyyah Haryanto Rabbaniyah, Muthi’ah Rahmat A Hi Wahid Rahmat A.H. Wahid Rauf, Ichsan Riyani, Retno Indra Riza Amalia Riza, Muhammad El Rizka Safira Rizki Awaluddin Rizki Awaluddin Rizky Dila Khairunnisa Rohmah Madya Ayu Fitriana Sagun Chandra Yowani Salma, Rahimia Nuzula Sari, Dianti Desita Sari, Nandita Aprilia Satwika Budi Sawitri Sawitri, Satwika Budi Sha’sha’ Luthfiana Shifa Syururin, Wakhidatus Sholihatin, Binti Siska Fatkhul Hidayati Siska, Awenda Siti Awalisanah Hani Farhana Sitti Hijraini Nur Solikah Ana Estikomah Sujiat Zubaidi Sulikhah, Novia Anggreani Surya Amal Susi Nurohmi Tri Harianto Wafa Aufia Wahid, Rahmat A Hi Wahid, Rahmat A Hi Widayanti, Erna Desi Widyaratna, Indriyanti Winati, Dian Eska Yulia Dwi Andarini Yuwono, Ratna Rahajeng Putri Zulianita Zulianita Zulvia Faridatul Munawaroh

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