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All Journal Jurnal Ilmu Pertanian Indonesia ACTA VETERINARIA INDONESIANA Jurnal Pengolahan Hasil Perikanan Indonesia Buletin Kimia VALENSI Jurnal Veteriner Jurnal Natur Indonesia JURNAL SAINS DAN TEKNOLOGI INDONESIA JURNAL TEKNOLOGI LINGKUNGAN Jurnal Penelitian Hasil Hutan The Journal of Pure and Applied Chemistry Research EduChemia: Jurnal Kimia dan Pendidikan Indonesian Journal of Chemistry Marinade Chemistry Indonesian Journal of Chemical Research EKOLOGIA : Jurnal Ilmiah Ilmu Dasar dan Lingkungan Hidup Molekul: Jurnal Ilmiah Kimia Jurnal Jamu Indonesia Asian Journal of Aquatic Sciences Jurnal Penelitian Hasil Hutan Makara Journal of Science Jurnal Kedokteran Hewan Indonesian Journal of Jamu
Purwantiningsih Sugita
Departemen Kimia, Fakultas MIPA, IPB University
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Veterinary Other

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DISOLUSI MIKROENKAPSULASI KURKUMIN TERSALUT GEL KITOSAN-ALGINAT-GLUTARALDEHIDA Herdini, Herdini; Darusman, Latifah K; Sugita, Purwantiningsih
Makara Journal of Science Vol. 14, No. 1
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Dissolution of Curcumin Microencapsulation Coated by Chitosan-Alginate-Glutaraldehide. In vitro dissolution of curcumin coated by chitosan-alginate gel in its optimum condition was studied. The maceration process using 17.08% ethanol yields and the content of the curcumin in the extract detected by visible spectrophotometry λ 430 nm is found to be 10.30 %. Its optimum condition was obtained using response surface method at concentrations ratio of alginate 0.62% (b/v) and glutaraldehide 4.63% (v/v) , respectively, where the chitosan concentration was fixed (1.75% [b/v]). The dissolution assay was done at 37 o C, at 100 rpm of stirring rate in 8 hours. Aliquots were taken at 15, 30, 45, 60, 90, 120, 150, 180, 240, 300, 360, 420, 480 minutes. Absorbance of the Aliquots was measured at λ 430 nm. The curcumin released has the best linear correlation to the first order reaction with released constant, k = 2.24 10-3 minute-1 while it’s half live is t1/2 = 5.16 hours. Release curcumin was determined mainly by diffusion mechanism. Compared to the result based on Fick model, the one of Higuchi model is better in agreement in reproducing the released data.
Antioxidant Activity, Cytotoxicity, and Identification of Secondary Metabolites of Kigelia africana from Waterpark Platinum Riau Fitri, Iis Yusma; Kurniawanti, Kurniawanti; Syahbirin, Gustini; Sugita, Purwantiningsih
Indonesian Journal of Chemical Research Vol 11 No 2 (2023): Edition for September 2023
Publisher : Jurusan Kimia, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598//ijcr.2023.11-iis

Abstract

Antioxidants can prevent reactive oxygen-associated diseases, which trigger carcinogenesis, cardiovascular disease, and premature aging. India and Africa have mostly practiced sausage trees (Kigelia africana) as traditional medicine, whereas Indonesia is still limited. The research aims to determine the phytochemistry and bioactivity of the n-hexane fractions from crude methanol extract of the leaves and bark of the sausage tree as antioxidants and their toxicity. The sausage tree is derived from Waterpark Platinum Riau. The sausage trees were macerated with methanol and fractionated by n-hexane and ethyl acetate. All samples were tested for their antioxidant to 1,1-diphenyl-2-picrylhydrazyl (DPPH) and cytotoxicity to Artemia salina Leach larvae. Phytochemical results of methanol crude extract, n-hexane, and ethyl acetate fractions of leaves and sausage bark showed the presence of all secondary metabolites except alkaloids in the n-hexane fraction. Antioxidant and cytotoxic activity of stem and leaf bark ethyl acetate fraction was stronger than crude methanol extract and n-hexane fraction. Based on LC-MS/MS data, the secondary metabolite components that have contributed strongly antioxidant activity of this study are flavonoid compounds such as kaempferol and the derivatives, lignans (cubebin), and steroids (pregnant).
Synthesis of Green Diesel from Palm Oil Using Nickel-based Catalyst: A Review Aziz, Isalmi; Sugita, Purwantiningsih; Darmawan, Noviyan; Dwiatmoko, Adid Adep
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 9, No. 1, May 2023
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v9i1.26488

Abstract

Petroleum is the primary energy that is generally used throughout the world. Its non-renewable nature and exhaust gas emissions that can damage the environment are a concern for developing environmentally friendly renewable energy. Green diesel is an alternative energy to replace diesel fuel (diesel) from petroleum which has the potential to be developed. The raw material in palm oil has great potential for development due to its relatively high production. Green diesel synthesis can be carried out using the catalytic deoxygenation method. The type of raw material, catalyst, and process conditions influences this method. The catalyst is the most influential factor in catalytic deoxygenation. Transition metal catalysts like nickel are inexpensive and have good catalytic activity like precious metals. Catalytic activity can be increased by modifying the catalyst components and optimizing the process. Modification of the catalyst can increase the surface area, Lewis and Bronsted sites, and crystal size so that the resulting green diesel can be maximized, such as Ni-Co, Ni-Zn, and Ni-Mo bimetallic catalysts.
ACUTE TOXICITY WATER EXTRACT OF Meretrix meretrix Linnaeus IN VIVO ON SPRAGUE DAWLEY RATS Apriandi, Azwin; Tarman, Kustiariyah; Sugita, Purwantiningsih
Asian Journal of Aquatic Sciences Vol. 4 No. 3 (2021): December
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31258/

Abstract

Meretrix meretrix empirically has been widely believed by the public to a wide variety of health benefits. It is necessary to do an analysis of the level of toxicity of Meretrix meretrix extract. The experiment was carried out extraction sample with water (1;4) (w/v), analysis of acute toxicity Meretrix meretrix extract with the OECD method 403:2009. Based on the results of water extract of Meretrix meretrix no effect on physical observations of test animals with LD50> 15 g/kg BW. Histopathological observation on the liver and kidneys, there is necrosis of the liver cells and some cell degeneration in the kidneys, but on the whole network under normal conditions appropriate control group.
Modified Natural Rubber Based on the Sulphur Curing System as Rubber Compound Formulation on Basic Design of Seismic Bearing Cifriadi, Adi; Sugita, Purwantiningsih; Kemala, Tetty; Nikmatin, Siti; Puspitasari, Santi; Falaah, Asron Ferdian; Wijaya, Usman
Jurnal Kimia Valensi Jurnal Kimia VALENSI, Volume 10, No. 2, November 2024
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v10i2.39963

Abstract

Indonesia is highly susceptible to earthquakes, with the southern and western coasts of Java and Sumatra being the most vulnerable regions. Due to this vulnerability, it is necessary to establish a culture of disaster mitigation in the most fertile and heavily populated islands to reduce the number of fatalities and economic losses caused by earthquakes. One of the promising real-world seismic base isolation methods is using a rubber seismic bearing constructed of rubber and metal layers. This study aimed to examine the typical behavior of natural rubber compounds subjected to various sulfur-curing processes as basic designs in the manufacture of rubber seismic bearings. The experiment was carried out by arranging the sulfur curing system into three categories, namely an efficient which applied N-cyclohexyl-2-benzothiazole sulfonamide (CBS)/Sulfur (S) ratio as 1.4/0.15 and 1.4/0.25, semi-efficient with CBS/S ratio of 1.4/1.4 and 1.4/1.7, and conventional with CBS/S ratio of 1.4/3.0 and 1.4/3.5. The results showed that the ideal modification condition for NR macromolecule chain found in seismic-bearing rubber compound was a semi-efficient sulfur curing system with a CBS/S ratio of 1.4/1.4. It suggested that a semi-efficient sulfur curing system was appropriate for developing rubber compound formulation for seismic rubber bearings, mainly for low-damping types.
Aktivitas Antioksidan, Antibakteri, dan Toksisitas Ekstrak Kulit Batang Pohon Kesambi (Schleichera oleosa (Lour) Oken) Puspita Sari; Purwantiningsih Sugita; Adi Santoso
Jurnal Jamu Indonesia Vol. 4 No. 3 (2019): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v4i3.163

Abstract

Penelitian ini bertujuan untuk membandingkan aktivitas antioksidan, antibakteri, dan uji toksisitas dari berbagai jenis ekstrak kulit batang pohon kesambi (Schleichera oleosa (Lour)Oken). Tahapan penelitian meliputi proses esktraksi kulit batang kesambi dari kecamatan Mancak Serang dengan teknik maserasi bertingkat menggunakan 3 pelarut : Metanol, n-heksan, dan etil asetat. Ekstrak tersebut kemudian diuji aktivitas antioksidan, antibakteri, dan toksisitasnya. Hasil pengujian antioksidan dengan metode DPPH, antibakteri dengan metode difusi agar, dan uji toksisitas dengan metode BSLT didapat hasil penelitian menunjukkan bahwa ekstrak etil asetat memiliki aktivitas antioksidan (IC50 7,723 ppm) yang lebih baik dibandingkan dengan ekstrak metanol (IC50 7,801 ppm), dan ekstrak n-heksan (IC50 8,568 ppm). Aktivitas antibakteri menunjukkan adanya kemampuan untuk menghambat pertumbuhan bakteri Streptococcus aureus dibandingkan bakteri Escherichia coli pada konsentrasi 10000 ppm, dan hasil uji toksisitas menunjukkan bahwa ekstrak etil asetat memiliki aktivitas yang lebih baik (LC50 305,17 ppm) dibandingkan ekstrak n-heksan (LC50 374,96 ppm) dan ekstrak metanol (LC50 431,26 ppm).
Gelatin Extraction and Characterization from Femur Bones of Bovine and Porcine with Acid Process Purwantiningsih Sugita; Muhamad Rifai; Laksmi Ambarsari; Dyah Utami Cahyaning Rahayu; Hanhan Dianhar
Jurnal Jamu Indonesia Vol. 6 No. 1 (2021): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v6i1.188

Abstract

Gelatin has been widely used as an additive in food industry pharmaceutical, and cosmetic. The similar physical appearance between bovine and porcine gelatin causes an issue for some communities like a Muslim due to awareness of halal food. This study aims to produce gelatin from femur bones of bovines with acid hydrolysis and their characteristics compared to standard gelatin of bovine and porcine. Bovine and porcine bones were soaked in 5% HCl for 10 days and every 2 days a HCl solution was replaced to get ossein. Ossein is hydrolyzed by gradual heating at 65, 75, and 85oC. Gelatin confirmed by the physico-chemical characters, FT-IR and analysis amino acid with HPLC.The results showed that the yield of bovine gelatin was 4.33%. The physico-chemical characters of bovine gelatin resulting from isolation and bovine gelatin standards are in conformity with porcine gelatin standards and meet the requirements of SNI 06-3735-1995 and GMIA. Therefore, bovine gelatin is specifically capable of substituting porcine gelatin for application in the pharmaceutical field. The FTIR spectrum of bovine gelatin shows the presence of amide A, amide I, amide II and amide III groups. The amino acid characters of gelatin were identified as glycine (13.57%) and proline (1.62%) for bovine gelatin and glycine (0.51%) and proline (0.09%) for porcine gelatin.
Screening Emodin Derivatives as DPP-4 Inhibitor Candidates: In Silico and In Vitro Assessment Azkiyah, Dina; Syahbirin, Gustini; Firdayani, Firdayani; Sugita, Purwantiningsih
Indonesian Journal of Chemical Research Vol 13 No 1 (2025): Edition for May 2025
Publisher : Jurusan Kimia, Fakultas Sains dan Teknologi, Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/ijcr.2025.13-din

Abstract

Diabetes mellitus (DM) is a chronic metabolic disease distinguished by disrupted glucose metabolism, causing elevated blood sugar levels. One of the latest therapeutic strategies involves inhibiting dipeptidyl peptidase-4 (DPP-4) to regulate glucose metabolism. Emodin, a bioactive compound, has shown potential as a DPP-4 inhibitor, but its efficacy requires further research. This study aims to identify and assess emodin and its derivatives as potential DPP-4 inhibitors through a comprehensive in silico and in vitro analysis. Molecular docking analysis revealed that 3-ρ-toluoyl emodin (ρTE) had the lowest binding energy (-111.4 kcal/mol) among the tested compounds. Furthermore, in vitro testing showed consistent results in silico, indicating that ρTE had significant inhibitory activity with an IC50 value of 1.37 μM. Pharmacokinetic and physicochemical evaluations confirmed ρTE’s potential as a safe antidiabetic drug candidate. The research findings indicate that ρTE holds potential as a promising drug candidate for further development.
Co-Authors Achmad Sjachriza Achmad Sjahriza Ade Heri Mulyati Adi Cifriadi, Adi Adi Santoso ADI SANTOSO Akhiruddin Maddu Apriandi, Azwin Asep Hidayat Asep Hidayat Asep Saefurohman Asron Ferdian Falaah, Asron Ferdian Auliya Ilmiawati Azkiyah, Dina Bambang Srijanto Bambang Srijanto Bambang Srijanto Budi Arifin Cece Sumantri Dedi Duryadi Solihin Dian Susanthy Diana Widiastuti Dita Ariyanti dwi wahyono Dwiatmoko, Adid Adep Dyah Iswantini Ellin Vina Setyowati Epi Taufik Ermin Katrin Winarno Ermin Katrin Winarno Fifia Zulti Firdayani, Firdayani fithri amelia Fitri, Iis Yusma Ghozali, Ali Aulia Gustini Syahbirin H Herdini Hanhan Dianhar Harjono - Harjono Harjono Hefni Effendi Henny Purwaningsih Herdini . Ida Ayu Putu Sri Widnyani Irmanida Batubara Isalmi Aziz Jaya Hardi Kiagus Dahlan Kiagus Dahlan Kurniawan, Yehezkiel Steven Kurniawanti, Kurniawanti Kustiariyah Tarman LAKSMI AMBARSARI latifah K Darusman Latifah K. Darusman Lia Anriani Luthfan Irfana mahdi mubarok Mas’ud, Zainal Alim Mela Faradika Mersi Kurniati Muhamad Rifai Muhammad Fathurrahman Napthaleni , Napthaleni, Napthaleni Novik Nurhidayat Noviyan Darmawan Nur Qadri Rasyid Okti Rachmawati Okti Rachmawati Pujiyati Pujiyati Pujiyati, Puspita Sari Rahayu, Dyah Utami Cahyaning Rahmani, Nabiila Rarah Ratih Adjie Maheswari Rasyid, Nur Qadri Rini Siswati Asnel Santi Puspitasari Siti Nikmatin Siti Warnasih Suminar S Achmadi SUMINAR SETIATI ACHMADI Taher, Dharmawaty M. Tetty Kemala Tiltje Andretha Ransaleleh Tuti Wukirsari Tuti Wukirsari Tuti Wukirsari Umi Cahyaningsih Uswatun Hasanah Wasmen Manalu Yuyu Yundhana Zainal Alim Mas’ud Zulti, Fifia Zuniar Subastian Zuraida Hanum Zuraida Hanum