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Journal : Medula

Usia Ibu Sebagai Faktor Risiko Terjadinya Plasenta Previa Salma Khairunnisa Hero; Rodiani; Giska Tri Putri
Medula Vol 13 No 1 (2023): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v13i1.554

Abstract

Placenta previa is complete or partial closure of the inner cervical ostium by the placenta. Placenta previa is one of the causes of postpartum hemorrhage and is a condition that can cause morbidity and mortality for both mother and baby. Placenta previa has the potential to become an emergency. Placenta previa is located in the lower uterine segment and causes obstruction of the cervix. This can make the vaginal birth process more difficult and risky, even leading to death from bleeding. There are several factors that can be risk factors for placenta previa, namely parity, history of curettage, cesarean section, previous history of placenta previa, multiple pregnancies, tumors, and age. At the age of <20 years the reproductive system is still immature. The endometrium in the immature uterine fundus causes the placenta to attach and grow in the lower uterine segment. At the age of> 35 years, the reproductive system has decreased, one of which is a decrease in blood flow to the uterus. So that the placenta will implant in the part that has more blood flow.
PERBEDAAN KONTAMINASI TELUR SOIL TRANSMITTED HELMINTH PADA TANAH DI DAERAH PEDESAAN DAN PERKOTAAN Alvan Muhammad Hibatullah Santoso; Hanna Mutiara; Giska Tri Putri; Jhons Fatriyadi Suwandi
Medula Vol 13 No 6 (2023): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v13i6.479

Abstract

Soil Transmitted Helminth is an infection that causes malnutrition, anemia, growth retardation. Transmission is through contact with eggs or larvae in the soil. Cases of STH infection in Indonesia are high in areas of poor sanitation, poor hygiene and lack of understanding of clean and healthy lifestyles. Therefore, this study aims to determine the contamination of STH eggs on soil in rural and urban areas. This research is a cross-sectional study with purposive sampling. The number of samples is 90 soil sample points in rural and urban areas and then the univariate and bivariate analysis tests are carried out using the pearson chi-square Test. The number of STH contamination in rural areas was 29 out of 90 samples with 26 samples of Ascaris lumbricoides, 2 samples of Hookworm, and 1 sample of Trichuris trichiura. STH egg contamination in urban areas was 22 out of 90 samples with details of 17 samples of Ascaris lumbricoides, 3 samples of Hookworm, and 2 samples of Trichuris trichiura. Based on the results of the pearson chi-square Test analysis, a p-value of 0.467 was obtained. There is no difference in contamination of STH eggs on soil in rural and urban areas.
Potensi Senyawa Alami dalam Polifenol dengan Mekanismenya untuk Melawan Kanker Mesensy, Natasya; Putri, Giska Tri
Medula Vol 14 No 2 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i2.933

Abstract

Globally, cancer is the leading cause of death because its pathophysiology includes multifactorial components. In general, various things mediate its development, such as genetic mutations, toxin intake, radiation exposure, unhealthy food, and work pressure. To increase the chance of cure from cancer and the possibility of survival, early detection, and appropriate treatment are needed. In the last decade, the high content of bioactive compounds contained in nutraceutical components has been considered as a complement in food, food supplements, and medicines. The medicines here include appropriate treatment to fight cancer without worrying about anticancer side effects that can cause adverse responses. Compounds in nutraceuticals are natural bioactive ingredients that have anticancer properties, which can kill cells that have metastasized or have become cancerous without being toxic to surrounding normal cells. This effect is proven when these natural bioactive compounds are contained in conventional medicine and show that nutraceutical supplementation contributes to the success of cancer treatment as an anticancer. This review examines the current knowledge from various literature regarding several natural bioactive extracts that contain certain polyphenolic compounds. The activity of this compound can be seen from the inhibition of cell proliferation, anti-inflammatory action, and antioxidant activity. Therefore, nutraceutical supplementation can be recommended along with conventional treatment to obtain a better therapeutic response in cancer patients.
Hubungan Determinan Sosial Kesehatan dengan Infeksi Toksoplasma gondii Jasmine, Almaina Puteri; Mutiara, Hanna; Suwandi, Jhons Fatriyadi; Putri, Giska Tri
Medula Vol 14 No 1 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i1.938

Abstract

Toxoplasma gondii is an obligate intracellular protozoan that causes toxoplasmosis. The high rate of toxoplasmosis infection in the Lampung region reaches 88.23%. Typically, toxoplasmosis presents no symptoms but can pose serious problems for individuals with compromised immune systems or pregnant women. The purpose of this study is to identify the relationship between social health determinant factors such as age, gender, educational level, occupation, and residence address with the incidence of T. gondii infection among patients at Dr. H. Abdul Moeloek Hospital. The aim is to identify individuals at risk of toxoplasmosis infection early so prevention can be done immediately. This study is an analitic quantitative research with a cross-sectional design. The study population consists of patients at Dr. H. Abdul Moeloek Hospital who have been screened for toxoplasmosis from 2017 to 2023, with a sample size of 93 samples. A total of 67 samples were tested positive for toxoplasmosis, while 26 samples tested negative with the sampling technique using total sampling. Data were collected from patients medical records and were analyzed by univariate and bivariate analysis using Chi-square method. The results indicate a relationship between age (p 0.002), gender (p <0.001), and educational level (p <0.001) with the incidence of Toxoplasma gondii infection among patients at Dr. H. Abdul Moeloek Hospital from 2017 to 2023.
Hubungan Antara Kadar D-Dimer dengan Angka Mortalitas pada Pasien Dewasa Terkonfirmasi Coronavirus Disease 19 di RSUD Abdul Moeloek Bandar Lampung Periode Tahun 2020 – 2021.docx Attila Firjatullah, Muhammad Daffa; Tjiptaningrum, Agustyas; Putri, Giska Tri
Medula Vol 14 No 4 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i4.1055

Abstract

Lampung is one of the regions with the highest Case Fatality Rate (CFR) in Indonesia, which was 7.7% on September 16, 2021. Several studies have shown that D-Dimer levels influenced the mortality of confirmed Covid-19 patients. This study aimed to analyze the correlation between D-Dimer levels and the mortality rate of confirmed Covid-19 adult patients. This research was an observational analytic study using a cross-sectional approach. The population of this study was all confirmed covid-19 adult patients who fulfilled the inclusion and exclusion criteria in Abdul Moeloek Hospital Medical Record Installation from 2020 to 2021. The samples were taken using simple random technique. Data collected were D-Dimer level, mortality rate, and patient’s personal information. Data were analyzed by Chi-Square using statistical data processing program. There were 94 subjects admitted in our study, divided into groups of survivors and non-survivors. From the non-survivors’ group, 43 (91%) subjects had a high D-Dimer level. The Chi-Square analysis showed a correlation between D-Dimer levels and the mortality rate of Covid-19 patients (p-value = 0,001). Statistically, there was a significant correlation between D-Dimer levels and the mortality rate of confirmed Covid-19 patients.
A Tinjauan Pustaka: Diagnosis Dan Tatalaksana Katarak Kongenital Adha Nurhaniefah, Azmi; Putri, Giska Tri
Medula Vol 14 No 5 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i5.1095

Abstract

Congenital cataract is a disorder of the loss of transparency of the lens, sometimes causing a change in its refractive index that occurs during the first year or childhood of life. Congenital cataract is a rare eye disease, with a variable prevalence of 0.6-9.3/10,000 live births. However, this disease remains one of the main causes of visual loss in children. This disease is considered a preventable cause of blindness. However, late diagnosis and treatment will also have an adverse impact and can cause severe permanent blindness. Congenital cataracts have a significant impact on affected patients due to the low age of the target population and the deprivation amblyopia that can occur as a complication of this disorder. The method used in compiling this literature review is through searching literature from various sources using online searches with Google Scholar, Pubmed, and NCBI instruments within the last 5 years and using the keywords congenital cataract, diagnosis, management, management, treatment data that have been collected were analyzed scientifically and systematically. The data analysis technique used is descriptive and argumentative. The results of this study indicate that the diagnosis of congenital cataracts can be made through anamnesis, physical examination, and supporting examinations. The main treatment with good visual results is through early intervention with surgical procedures. The surgical techniques used include anterior Capsulotomy, Lens Aspiration & Vitrectomy anterior/Lansectomy, and IOL Implantation.
RISK FACTORS FOR PULMONARY TUBERCULOSIS COINFECTION IN HIV/AIDS PATIENTS Ildha Rosendy Kurnianda; Apriliana, Ety; Putri, Giska Tri; Wardani, Dyah Wulan Sumekar Rengganis
Medula Vol 15 No 1 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i1.1318

Abstract

Tuberculosis and HIV co-infection is a major public health problem in many parts of the world. In Indonesia, tuberculosis (TB) is an opportunistic infection that most often occurs in people living with HIV/AIDS (PLWHA). HIV infection increases susceptibility to Mycobacterium tuberculosis, thereby increasing the risk of developing TB. The World Health Organization (WHO) estimates that TB causes 13% of deaths in AIDS sufferers. Tuberculosis (TB) and HIV co-infection occurs when a person is infected with Mycobacterium tuberculosis and HIV at the same time. People with HIV have a 30 times greater risk of suffering from TB than people who are not infected with HIV. There is a significant relationship between these two infections, where each infection accelerates the development of the other infection. HIV infection can trigger reactivation of latent TB into active TB, while TB infection can worsen the clinical condition of patients who have been infected with HIV. The aim of this study was to determine various risk factors for pulmonary tuberculosis co-infection in HIV/AIDS patients. The method used is qualitative with literature study as a data collection technique. The results obtained were alcohol consumption and extra-pulmonary TB, education level, monthly income, occupation, family history of PTB, lack of appetite, balanced diet, maintaining healthy nutrition, smoking, and stopping taking medication if you felt the condition was under control and the incidence of PTB were factors associated with an increase in pulmonary tuberculosis co-infection..
Fotokimia dan Farmakologi Daun Alpukat (Persea americana mill.) pada Aktivitas Antihipertensi Husnandari, Aqila; Carolia, Novita; Putri, Giska Tri; Rahmanisa, Soraya
Medula Vol 15 No 1 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i1.1246

Abstract

Hypertension is the number one generative disease in the world that has blood pressure of more than 140/90 mmHg. Hypertension without therapy will become chronic and complicated. Therapy carried out for a long period of time causes a fairly high risk factor so that herbal therapy becomes an alternative. This literature review aims to determine the photochemistry and pharmacology of avocado leaves (Persea americana mill.) On antihypertensive activity. Photochemistry contained in avocado leaves can lower blood pressure in the form of flavonoids, saponins, tannins, alkaloids, steroids, and terpenoids. The method used is to review journal articles that have been published in Google Scholar and Pubmed. Using keywords such as "photochemistry, pharmacology, avocado leaves, and antihypertensive activity" 231 scientific articles and journals were obtained. This review article uses 10 selected scientific articles and journals. Experimental studies show that there are pharmacological functions that fight hypertension, which means that they can lower blood pressure.
Skrining Fitokimia Kualitatif Ekstrak Etanol 96% dan H-Heksana Kulit Batang Bakau Lindur (Bruguiera gymnorrhiza) Ismunanto, Aziza Regina Kinasih; Kurniawati, Evi; Putri, Giska Tri; Susianti, Susianti
Medula Vol 15 No 1 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i1.1253

Abstract

Lindur mangrove plants (Bruguiera gymnorrhiza) are known to contain secondary metabolite compounds which function as antibacterials. These secondary metabolite compounds include alkaloids, flavonoids, tannins, phenols, saponins, terpenoids and steroids. The design of this research was experimental, carried out to determine and compare the phytochemical components contained in 96% ethanol extract and n-hexane of Bruguiera gymnorrhiza mangrove bark. Bruguiera gymnorrhiza mangrove bark was taken at KPH Gunung Balak, East Lampung, then 4.5 kg of wet mangrove bark was obtained and dried for 7 days, then the extract was made using the maceration method for 3x24 hours using 2 types of solvents, namely 96% ethanol and n-hexane with a ratio of 1:10 between simplicia and solvent. Thick extracts were obtained from the two types of solvents which were then carried out qualitative phytochemical tests.  The results of this study showed that 96% ethanol extract and n-hexane of Bruguiera gymnorrhiza mangrove bark positively contained secondary metabolite compounds. The 96% ethanol extract of Bruguiera gymnorrhiza mangrove bark contains all types of secondary metabolite compounds, namely alkaloids, flavonoids, tannins, phenols, saponins, terpenoids and steroids, while the n-hexane extract contains secondary metabolite compounds, namely alkaloids, flavonoids, tannins, phenols, terpenoids, steroid but does not contain saponins. The conclusion of this research is that the 96% ethanol extract of Bruguiera gymnorrhiza mangrove bark contains more secondary metabolite compounds than the n-hexane extract of Bruguiera gymnorrhiza mangrove bark.
Analysis of Malathion Insecticide Resistance in Aedes aegypti Mosquitoes Using the CDC Bottle Bioassay Method Kirche, Agnes Angelina; Kurniawan, Betta; Putri, Giska Tri; Mutiara, Hanna
Medula Vol 15 No 1 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i1.1376

Abstract

Dengue is an infectious disease transmitted by the Aedes aegypti mosquito, which breeds rapidly in Indonesia's tropical environment, increasing the risk of spreading this disease. Vector control using malathion insecticide can be effective, but repeated use and inappropriate dosage can cause resistance in mosquitoes which ultimately increases the risk of dengue infection. CDC Bottle Bioassay is a test method for evaluating mosquito resistance to insecticides with a standardized procedure and is carried out using bottles containing insecticides with different diagnostic doses. Research using this method shows that Aedes aegypti mosquitoes in various locations show resistance to malathion at certain doses and tolerance at other doses. Several studies have also shown that mosquitoes exposed to malathion show categories of resistance or tolerance based on the mortality rate recorded during the test. Malathion, which is a class of organophosphorus insecticides, works by irreversibly binding to acetylcholinesterase and effectively kills mosquitoes, but repeated use can trigger resistance. Factors influencing resistance include biological factors such as migration, operational factors such as insecticide dosage and application, as well as genetic factors associated with the resistant allele. If mosquitoes carrying resistant alleles move or interbreed, this can increase the resistance status in an area, which is seen in Aedes aegypti populations in several regions of the world.