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Faktor neurotrofik yang diturunkan dari otak dalam darah meningkat sementara setelah sesi tunggal latihan intensitas sedang pada wanita gemuk Raharjo, Slamet; Harisman, Ahmad Syahru Mubarok; Andiana, Olivia; Pamungkas, Yualita Putri
Jurnal SPORTIF : Jurnal Penelitian Pembelajaran Vol 7 No 3 (2021): Jurnal SPORTIF: Jurnal Penelitian Pembelajaran
Publisher : Universitas Nusantara PGRI Kediri

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1713.391 KB) | DOI: 10.29407/js_unpgri.v7i3.16372

Abstract

This study aimed to analyze the increase in serum BDNF levels after moderate-intensity exercise in obese females. This study used the True-Experimental method with the Randomized Control Group Pre-test-Post-test design. A total of 14 obese female adolescents aged 19-24 years participated in this study and were divided into two groups, i.e., the control group (CG, n=7) and the moderate-intensity exercise group (MIEG, n=7). The exercise was performed with an intensity of 64 – 76 HRmax for 40 minutes using a Richter Treadmill (4.0 HP DC). Moderate-intensity exercise was carried out in one intervention. Blood sampling was carried out before and after moderate-intensity exercise on the cubital vein as much as 3 ml. Examination of serum BDNF levels using the ELISA method. The results of statistical analysis show that the mean pre-test serum BDNF levels were CG (258.66±27.11 pg/mL), MIEG (252.48±23.17 pg/mL), and (p=0.865). The mean post-test serum BDNF levels were CG (236.22±20.83 pg/mL), MIEG (497.73±59.55 pg/mL), and (p=0.001). The mean delta of serum BDNF levels on CG (-22.43±26.04), MIEG (245.25±61.57 pg/mL), and (p=0.002). Based on the study results, it is concluded that a single session of moderate-intensity exercise in the morning increases serum BDNF levels in obese females.
Model permainan lari dan lompat efektif dalam memperbaiki gangguan motorik fisik pada anak dengan keterbelakangan mental Raharjo, Slamet; Yunus, Mahmud; Subagio, Irmantara; Azidin, Raja Mohammed Firhad Raja
Jurnal SPORTIF : Jurnal Penelitian Pembelajaran Vol 10 No 2 (2024): Jurnal SPORTIF: Jurnal Penelitian Pembelajaran
Publisher : Universitas Nusantara PGRI Kediri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29407/js_unpgri.v10i2.23108

Abstract

This study aims to demonstrate the effect of a running and jumping game model in improving physical motor impairments in children with intellectual disabilities. A pre-experimental design method was used, involving 15 male children aged 11-12 years with intellectual disabilities, who were selected through purposive sampling. The running and jumping game model was conducted for 30 minutes per session, with moderate intensity (60-70% HRmax), three times a week for four weeks. Data collection involved measuring motor skill development, namely running speed and jump height, between pretest and posttest using a 40-meter run test and vertical jump test. Data analysis was conducted using a paired sample t-test with a 5% confidence level. The results showed a significant difference in running speed between pretest and posttest (8.98±0.07 vs. 7.66±0.09 seconds; p=0.001). Similarly, jump height analysis showed a significant difference between the pretest and posttest (21.57±0.98 vs. 31.43±1.72 cm; p=0.001). This proves that the running and jumping game model effectively improves motor skills impairments in children with intellectual disabilities.
Pengaruh Latihan Dribble Bola Basket Mini Terhadap Kemampuan Koordinasi Tangan Dan Mata Anak Tunagrahita Raharjo, Slamet; Subagio, Irmantara
Jurnal Sporta Saintika Vol 11 No 1 (2026): Jurnal Sporta Saintika Edisi Maret 2026
Publisher : Departemen Kesehatan Dan Rekreasi Fakultas Ilmu Keolahragaan Universitas Negeri Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/sporta.v11i1.470

Abstract

This study aims to determine the effect of mini-basketball dribbling training on eye-hand coordination in children with moderate intellectual disabilities in the SDLB Malang Regency. This study uses a one-group pretest-posttest design. The study sample consisted of students with moderate intellectual disabilities at the SDLB Widya Shantika Malang Regency. The sample selection in this study used purposive sampling, involving 6 children. Data collection techniques utilized a testing instrument, specifically a test measuring the distance a ball can be thrown by hand. Data were tested for normality using the Kolmogorov-Smirnov test and hypothesis testing using the paired sample t-test, assisted by the SPSS Statistics for Windows version 25 application. The data analysis technique used was the paired sample t-test with a significance level of α > 0.05. The results of this study indicate that mini basketball dribbling practice showed an improvement, but was not significant in terms of eye-hand coordination among children with moderate intellectual disabilities at the elementary school level at SLB Widya Shantika in Malang Regency. The statistical test results showed a significance value of 0.363. Since the significance value was > 0.05, the data was not significant. However, when comparing the average eye-hand coordination scores before the intervention (1.50) and after the intervention (1.83), the posttest average was higher than the pretest average, indicating an improvement in eye-hand coordination of 0.33.
Discovery of New Antibacterial Peptide from Trypsin Hydrolysate of Monocled Cobra (Naja kaouthia) Venom Protein using C18 SPE Column and LC-HRMS Erlista, Garnies Putri; Raharjo, Slamet; Raharjo, Tri Joko
Journal of Multidisciplinary Applied Natural Science Articles in Press
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.364

Abstract

Antimicrobial peptides (AMPs), as new antibiotic candidates, have the potential to treat infectious diseases. Peptides from N. kaouthia venom proteins can be used to produce AMP. The aim of this study was to identify the antibacterial potential of peptides derived from N. kaouthia venom protein purified by a reverse-phase solid-phase extraction column (SPE C18). N. kaouthia venom protein was isolated using Amicon® Ultra-15 with a 3000 Da centrifugal filter and then hydrolyzed using trypsin. The hydrolyzate was fractionated using reverse-phase (SPE C18), and the resulting fraction was tested for its antibacterial activity against S. aureus (Gram-positive) and E. coli (Gram-negative) bacteria. The most active fraction as an antibacterial was analyzed by high-resolution mass spectrometry (HRMS). The results showed that the 50% methanol fraction was active against E. coli bacteria, and the 100% methanol fraction was active against S. aureus. There are seven peptides identified, namely TVPVKR, TTMMNMLK, WWSDHR, SSLLVK, NSLLVK, LIPIASK, and GALMLK, which are responsible for the activity of the 50% methanol fraction. Meanwhile, there are two peptides, namely SSLLVK and NSLLVK, responsible for the activity of the 100% methanol fraction. LIPIASK and GALMLK peptides are predicted to show better potential as antimicrobial peptides.
Pengembangan flipbook sains materi metamorfosis hewan untuk meningkatkan motivasi belajar siswa kelas IV sekolah dasar Raharjo, Slamet
Tuladha : Jurnal Pendidikan Dasar Vol. 4 No. 2 (2025): December
Publisher : Universitas Sarjanawiyata Tamansiswa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30738/tuladha.v4i2.21944

Abstract

Motivasi belajar merupakan faktor penting yang memengaruhi keterlibatan dan keberhasilan siswa dalam proses pembelajaran, khususnya pada pembelajaran IPA di sekolah dasar. Namun, berbagai penelitian menunjukkan bahwa motivasi belajar siswa sekolah dasar cenderung mengalami penurunan akibat faktor internal maupun eksternal, seperti metode pembelajaran yang monoton dan keterbatasan media pembelajaran. Penelitian ini bertujuan untuk mengembangkan dan menguji efektivitas media Flipbook Sains dalam meningkatkan motivasi belajar siswa kelas IV sekolah dasar pada materi metamorfosis hewan. Penelitian ini menggunakan metode Research and Development (R&D) dengan model ADDIE, yang meliputi tahap analisis, desain, pengembangan, implementasi, dan evaluasi. Media Flipbook Sains dikembangkan menggunakan aplikasi Canva Heyzine dengan memuat materi pembelajaran, video, serta latihan soal interaktif. Hasil validasi ahli materi dan ahli media menunjukkan bahwa media Flipbook Sains berada pada kategori sangat layak untuk digunakan. Hasil uji coba lapangan menunjukkan adanya peningkatan motivasi belajar siswa secara signifikan setelah penggunaan media, yang ditunjukkan oleh peningkatan skor observasi motivasi dan nilai N-Gain yang berada pada kategori tinggi. Temuan ini menunjukkan bahwa Flipbook Sains efektif sebagai media pembelajaran interaktif untuk meningkatkan motivasi belajar siswa. Dengan demikian, media Flipbook Sains dapat dijadikan sebagai alternatif inovatif dalam pembelajaran IPA di sekolah dasar.Kata kunci: flipbook sains, motivasi belajar, pembelajaran IPA, sekolah dasar, media pembelajaran digital Learning motivation is an essential factor that influences students’ engagement and success in the learning process, particularly in science education at the elementary school level. However, various studies indicate that elementary school students’ learning motivation tends to decline due to both internal and external factors, such as monotonous teaching methods and limited learning media. This study aims to develop and examine the effectiveness of Science Flipbook media in improving the learning motivation of fourth-grade elementary school students on the topic of animal metamorphosis. The research employed a Research and Development (R&D) method using the ADDIE model, which consists of the analysis, design, development, implementation, and evaluation stages. The Science Flipbook media was developed using the Canva Heyzine application and included learning materials, videos, and interactive practice questions. The results of validation by material experts and media experts indicated that the Science Flipbook media was categorized as highly feasible for use in learning. Field trial results demonstrated a significant increase in students’ learning motivation after the implementation of the media, as evidenced by improved motivation observation scores and an N-Gain value in the high category. These findings indicate that the Science Flipbook is effective as an interactive learning medium to enhance students’ learning motivation. Therefore, Science Flipbook media can serve as an innovative alternative for science learning in elementary schools.
Pengembangan Buku Panduan Budaya Kerja Berbasis Religius di Sekolah Menengah Kejuruan Muhamadi, Arif; Dahlan, Bakhrun; Susatya, Edhy; Pamilih, Indra Jamal; Sunarso; Raharjo, Slamet; Hasanah, Noviatun
Indo-MathEdu Intellectuals Journal Vol. 7 No. 2 (2026): Indo-MathEdu Intellectuals Journal
Publisher : Lembaga Intelektual Muda (LIM) Maluku

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54373/imeij.v7i2.5303

Abstract

Abstract. SMK graduates face challenges in work culture alignment. 5R implementation at SMK Muhammadiyah 2 Jatinom is not yet internalized sustainably. This study aims to develop a religious-based 5R work culture guidebook. The method uses Research and Development (R&D) with the ADDIE model involving 85 teachers and employees, and validation by ten experts. Results show current 5R conditions are at the habituation stage but depend on external supervision. Strategic religious values like amanah and discipline are integrated into 5R elements. The product was declared feasible in the "Good" category (score 3.60) by experts. Field trials showed the product was practical (3.48), effective (3.48), and well-accepted (3.56) by 90.5% of users. Religious value integration changed 5R perception from administrative burden to worship, increasing intrinsic motivation. It is concluded that the guidebook is feasible for adoption as a permanent institutional guide to build sustainable work culture through balancing technical, pedagogical, and spiritual dimensions. Keywords: Work culture, 5R, Religious values, ADDIE, SMK Abstrak. Lulusan SMK menghadapi tantangan kesenjangan budaya kerja industri. Penerapan 5R di SMK Muhammadiyah 2 Jatinom belum terinternalisasi secara berkelanjutan. Penelitian ini bertujuan mengembangkan buku panduan budaya kerja 5R berbasis nilai religius. Metode menggunakan Research and Development (R&D) dengan model ADDIE melibatkan 85 guru dan karyawan, serta validasi sepuluh ahli. Hasil menunjukkan kondisi 5R saat ini berada pada tahap pembiasaan namun bergantung pada pengawasan eksternal. Nilai religius strategis seperti amanah dan disiplin diintegrasikan ke dalam elemen 5R. Produk dinyatakan layak kategori "Baik" (skor 3,60) oleh ahli. Uji lapangan menunjukkan produk praktis (3,48), efektif (3,48), dan diterima baik (3,56) oleh 90,5% pengguna. Integrasi nilai religius mengubah persepsi 5R dari beban administratif menjadi ibadah, meningkatkan motivasi intrinsik. Disimpulkan buku panduan layak diadopsi sebagai panduan institusional permanen untuk membangun budaya kerja berkelanjutan melalui keseimbangan dimensi teknis, pedagogis, dan spiritual. Kata Kunci: Budaya kerja, 5R, Nilai religius, ADDIE, SMK
Co-Authors - Afrizal A.A. Ketut Agung Cahyawan W Abd. Rasyid Syamsuri Adi, Hardian Pamungkas Agung Purniawan, Agung Ahmad Abdullah ahmad yani Ainul Yaqin Salam Airlangga Daulay, Dio Alif Akhrom, Afif Muhammad Akrom, Afif Muhammad Alfarisa Nururrozi, Alfarisa Alfitri Alfitri Aminuyati Andarini, Zahrah Prawita Andi Asmunandar Andini, Siska Ervi Aphrodita, Adiva Ardinal Ardinal Ardinal, Ardinal Assyaumin, Moch. Ian Brilian Aulia Azhar Ayubi, Novadri Azidin, Raja Mohammed Firhad Raja Badaruddin, Helda F. Chairil Syam Claude Mona Airin Daeng, Suharjo Dahlan, Bakhrun Dahlia, Karlina Puspa Dani Ramdani, Dani Darussalam, Ahmad Muttaqin Datrianto, Dwi S. Dean Eka Putri Delvi, Delvi Destri Muliastri Devita Anggraeni Dharma Wangsa Didik Setiyadi Dina Fathia Putri Edhy Susatya, Edhy Erlista, Garnies Putri Fadjar Goembira Fajar Raya Ferdinal Kusuma Bakti Fajar Sofyantoro Finta Amalinda Fitriana, Ida Galih Prasetyo Gewe, Rima Senditya Gosy Endra Vigriawan Govendan, Puveanthan Nagappan Guntari Titik Mulyani Hairuddin Haribowo, Nurman Haribowo, Nurman Harisman, Ahmad Syahru Mubarok Hariyati Purwaningsih Hary Purnamaningsih Hasanah, Noviatun Hastari Wuryastuty Helmi Helmi Heri Purnama Pribadi Heru Surianto Hery Widijanto I Sakan, Gerson Yohanes Ida Tjahajati Imam Yunianto Iman, Firdaus Nur Indriyani Rachman Irkham Widiyono Irmantara Subagio Iskandar R, Iskandar R Isra Wahid Jasin, Rocmat Jauharsah Krisdayanti P, Carinada Oki KURNIAWAN, LYNN KAAT LAURA Luh Putu Ratna Sundari Mahfud, Achmad - Mahmud Yunus Manik, Nengteng Manis, Siti Mariam Maryam, Annisa Masiti, Masiti Matsumoto, Toru Milla, Yunita Apriana Muarif, Samsul Muhamadi, Arif Mulyani, Prayitno Musytaqim Nasra Muttaqin, Akhsanul Nabila, Rahma Nofri Dodi Nuringtyas, Tri R. Olivia Andiana Pamilih, Indra Jamal Pamungkas, Yualita Putri Permana, Rief Ghulam Satria Pratama, Dedy Aulya Pribadi, David Rinekso Purwestri, Yekti A. Puti Sri Komala Putra, Rifqi Tantyo Putri, Salva Almayda Raharjo, Imannuel Samyo Rahayu Pramadya, Sugeng Rahayu, Ida Rahmat, Indra Chasugih Rahmi, Sri N. Ramadhani, Mungky Ema Rati Yuliarningsih Razkya, Adinda Refi Martha Retno Widyastuti, Retno Rias Gesang Kinanti Rima Senditya Gewe Rini Widayanti Rizki Aziz Rochman Rochiem Rusli, Sfandi Saichudin Saichudin, Saichudin Santuso, Edy Satriawan, Ahmad Ichsan Sentono, Diva N. Setyo Budhi Singgih Saptadi Sitarina Widyarini Sitompul, Yeremia Yobelanno Soedarmanto Indarjulianto Sri Hartati Sri Rahmiwati Yuned Suci Wulandari Sudirman Sudirman Sugiarto, Dinta Suhardiansyah, Agung Budi Sunarso Suradiradja, Kahfi Suradiradja, Kahfi Heryandi Surendra, Surendra Syafii . Taufiq Ihsan Tiara Wahyuni Tri Joko Raharjo Trini Susmiati Tulloh, Luthfi Hidayat Ummah, Riza Thoyibatul Uswatun Hasanah Utomo, Al Hadi Vera Surtia Bachtiar Viandry Tetriva Putri Wahyudi, Setyanto T. Wijaya, Rachel Yanuartono, Yanuartono Yanuartono, Yanuartono Yenni Ruslinda Yudha, Donan S. Yuniarto, Andryas Yuriadi Yuriadi, Yuriadi Zagita Andriani Ariska Zainal Abidin