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Journal : Universa Medicina

Effect of astaxanthin supplementation on oxidative stress in adult women with polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials Pratiwi, Donna; Harimawan, Agustinus I Wayan; Weta, I Wayan; Sumartini, Ni Ketut; Awan, Syuma Adhy; Sutadarma, I Wayan Gede
Universa Medicina Vol. 45 No. 1 (2026)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2026.v45.125-134

Abstract

BackgroundPolycystic ovary syndrome (PCOS) can cause significant morbidity through fertility disorders and most often found in the productive age. Recent research suggests that oxidative stress plays an important role in the pathogenesis of PCOS. Astaxanthin (AST) has broad protective effects, particularly in the regulation of antioxidant and anti-inflammatory activity. The objective of this systematic review and meta-analysis was to evaluate the efficacy of AST supplementation on PCOS management. MethodsA systematic literature search was conducted in PubMed, Scopus, Science Direct, and Cochrane Library from January 2020 to March 2025. Randomized controlled trials (RCTs) assessing astaxanthin supplementation in adult women with PCOS were included. Outcomes of interest were malondialdehyde (MDA), superoxide dismutase (SOD), and total antioxidant capacity (TAC). Data were analyzed using Review Manager (RevMan) version 5.4.1. Pooled effects were calculated as mean differences (MDs) with 95% confidence intervals (CIs).  ResultsFour RCTs involving 194 participants were included. Astaxanthin supplementation significantly reduced MDA levels (MD −0.670; 95% CI −1.070 to −0.270; p = 0.001; I² = 93%) and significantly increased TAC levels (MD 0.030; 95% CI 0.000 to 0.060; p = 0.030; I² = 76%). No significant effect was observed on SOD levels (MD 0.025; 95% CI −0.850 to 1.350; p = 0.660; I² = 57%). The overall risk of bias across included studies was low. ConclusionThis systematic review shows that AST supplementation significantly reduced lipid peroxidation in women with PCOS. These findings suggest that AST may serve as potential adjuvant antioxidant therapy in PCOS management.
Co-Authors ., Ni Putu Ayu Laksmini A. A. D. Dalem Dwi Putra AAG Budhiarta Aagp Wiraguna Adhi, I Gusti Ayu Mirah Aditia Martanti Aditya Johan Romadhon Agung Nova Mahendra Agung Wiwiek Indrayani Agus Eka Darwinata Ali Imron Alvina, Made Kurnia Ana Yulia Anak Agung Gde Putra Wiraguna Anak Agung Gede Budhiarta Anggreini ** Aprilany Stella peng Astrid Amanda Pangalela Awan, Syuma Adhy Bagus Komang Satriyasa Christine Icasia Citra Anissa Ayu Cok Gde Prema Kurnia Baswara Desak Ketut Ernawati Desak Made Wihandani Dhumaranang, Hyangayu Dedari Dian Damayanti Dinda Anggita Meiwita Sari Donal Syafrianto Duarsa, iDyah Pradnyaparamita Dwi Halim Kevin Gautama Dyah Pradnyaparmita Duarsa Faradilla N Fendy Nugroho Fenni Liem Fibriany Chandra Florensa Krismawati Gde Ngurah Idraguna Pinatih Gusti Made Agung Mega Utama Gusti Ngurah Prana Jagannatha Harimawan, Agustinus I Wayan Heidy Dwi Nadia I A Md Dwi Purwitasari I Dewa Ayu Inten Dwi Primayanti I Gde Ardika Nuaba I Gede Marantika Yogananda Sutela I Gusti Made Aman I Ketut Suastika I Made Ady Wirawan I Made Dwi Ariyuda I Made Jawi I MADE MULIARTA . I Nengah Sandi I Nyoman Adi Putra I Nyoman Mangku Karmaya I P G. Adiatmika I Putu Adiartha Griadhi I Putu Agus Budi Sudarsana I Putu Eka Jaya I Wayan Gede Sutadarma I.A.A. Widhiartini Ida Ayu Mustika Suri Jayanti Ida Bagus Ngurah IN. Adiputra Indra Lesmana Indraguna Pinatih, Gde Ngurah Intan Lestari Putri Istiana Marfianti J. A. Pangkahila K Tangking Widarsa K. G. Budhi Riyanta Kadek Ayu Purwaningsih Kadek Tresna Adhi Ketut Adi Jaya Sutana Ketut Tirtayasa Komang Ayu Kartika Sari LMI. Sri Handari Adiputra Luh Putu Ayu Vitalistyawati Luh Putu Iin Indrayani Maker Luh Putu Ratna Sundari Luh Putu Wrasiati Luh Seri Ani Luh Wayan Ayu Rahaswanti Made Adinanta Purnawijaya, Made Adinanta Made Oka Negara Marfianti, Istiana Maria C Hindom Maria Marissa Maharani Marselli Widya Lestari Masrum Syam MB. Redy Utama Milhanah Milhanah Moh. Ali Imron, Moh. Muh. Ali Imron Muh. Ali Imron Muh. Ali Imron Muh. Irfan Muhammad Hafiz Bin Mohd Arifin Muhammad Irfan Munawwarah, Muthiah Muthiah Munawaroh Myranti Puspitaningtsya Junaedi Nadia Anastasia Ni Kadek Parswa Diah Pradnyandari Ni Luh Partiwi Wirasamadi Ni Luh Putu Suariyani Ni Made Sri Nopiyani Ni Made Suasti Wulanyani Ni Nyoman Ayu Dewi Ni Nyoman Ayu Dewi Ni Nyoman Ayu Dewi Ni Nyoman Ayu Dewi Ni Putu Idaryati NL Partiwi Wirasamadi, NL Partiwi Nurpratiwi, Resti NW. Tianing NYOMAN SEMADI ANTARA Pande Putu Yoga Kamayana Phebe Indriani Prabandari, A A S Mirah Pradnyaparamita, Dyah Pramartha, I Made Dwi Adi Pratiwi, Donna Putu Aryani Putu Ayu Sita Saraswati Putu Cintya Denny Yuliyatni Putu Diani Wirayanti, Putu Diani Ratha, I Putu Prayoga Rizky Wulandari S. Indra Lesmana S. Indra Lesmana S. Indra Lesmana Sari, Komang Ayu Kartika Saskara , I Dewa Gde Wira Sawitri, Anak Agung Sagung Siallagan, Rini Martha Sintia Sugiarta Rahmasari Sirait, Josephine Claudia Stefani Marietta Sugijanto - Sukawati, Cokorda Istri Mas Dalem Sumartini, Ni Ketut Susy Purnawati Sutana, Ketut Adi Jaya Sutanto, Grace Abigail Syahmirza Indra Lesmana Teja, Anjaya Artha Tince Sarlin Nalle Wahyuddin - Wahyuddin, Wahyuddin Wayan Citra Wulan Sucipta Putri Wibawa, Anak Agung Ngurah Alit Dwi Nanda Wijanadi, M. Candra Wimpie I Pangkahila Wirasamadi, Ni Luh Partiwi Yuliani, Eni