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All Journal Proceedings of Annual International Conference Syiah Kuala University - Life Sciences & Engineering Chapter Jurnal Kedokteran Brawijaya Jurnal Ilmiah Kursor Indonesian Journal of Urology Berkala Ilmu Kesehatan Kulit dan Kelamin Folia Medica Indonesiana Indonesian Journal of Tropical and Infectious Disease Indonesian Journal of Cancer Majalah Obstetri dan Ginekologi Medical Laboratory Technology Journal Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Jurnal Manajemen Kesehatan Yayasan RS.Dr. Soetomo Majalah Patologi Indonesia Prosiding Seminar Nasional Multidisiplin Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Majalah Biomorfologi (Biomorphology Journal) Indian Journal of Forensic Medicine & Toxicology INDONESIAN MIDWIFERY HEALTH AND SCIENCES JOURNAL Indonesia Journal of Physical Medicine and Rehabilitation Indonesia Journal Physical Medicine and Rehabilitation Cermin Dunia Kedokteran Indonesian Journal of Cancer Jurnal Pengabdian Masyarakat Bhinneka The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal Pengabdian Masyarakat Bangsa Enrichment: Journal of Multidisciplinary Research and Development Jurnal Widya Medika
Willy Sandhika
Departemen/ SMF Patologi Anatomi , Fakultas Kedokteran Universitas Airlangga/ RSU Dr. Soetomo, Surabaya, Indonesia
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Journal : Medical Laboratory Technology Journal

 1 
Role of CD44 and CD8 in Colorectal Adenocarcinoma metastatic Baiq Ratna Kumaladewi; Willy Sandhika; Heryawati Heryawati
Medical Laboratory Technology Journal Vol. 6 No. 2 (2020): December
Publisher : Poltekkes Kemenkes Banjarmasin Jurusan Analis Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (383.637 KB) | DOI: 10.31964/mltj.v6i2.314

Abstract

Colorectal adenocarcinoma is one of the most prevalent malignancies worldwide. The presence of regional lymph node metastases is an important prognostic indicator in colorectal adenocarcinoma. CD44 is a transmembrane protein and a cancer stem cell biomarker that plays a role in tumor proliferation, metastasis, and recurrence. The tumor microenvironment has a vital role in the stage of tumor development. CD8 is one of microenvironment's component which kills the tumor cells. This study aimed to analyze the expression of CD44 and CD8 and investigated their association with colorectal adenocarcinoma metastatic. This study's benefit is that the resulting study can be used as a prognostic factor in colorectal adenocarcinoma. This study included 56 paraffin blocks of patients diagnosed as colorectal adenocarcinoma during January 2017-December 2018 in Anatomic Pathology Laboratory Dr. Soetomo Hospital Surabaya. The paraffin blocks were sliced and stained with immunohistochemistry for CD44 and CD8. The parameters were a positive percentage of tumor cell and lymphocyte immunoreactivity against CD44 and CD8 antibodies. The percentage of CD44 is higher in the metastatic group, and the percentage of CD8 is higher in the non-metastatic group. There was a significant negative correlation between CD44 and CD8 expression in regional lymph nodes metastatic. These results indicated that CD44 and CD8 have a vital role in the incidence of metastasis.
The Cytotoxic Activity of Annona muricata Linn Leaves Ethanolic Extract (AMEE) on T47D Breast Cancer Cell Line Soilia Fertilita; Willy Sandhika; Desak Gede Agung Suprabawati
Medical Laboratory Technology Journal Vol. 6 No. 1 (2020): June
Publisher : Poltekkes Kemenkes Banjarmasin Jurusan Analis Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1113.168 KB) | DOI: 10.31964/mltj.v6i1.291

Abstract

Breast cancer is the most common cancer in women throughout the world, with new cases and deaths which continue to increase. Soursop leaves (Annona muricata L) have been used extensively in traditional medicine, including cancer. Acetogenin, alkaloids, and phenols contained in soursop leaves are known to have anti-cancer effects. Among them, acetogenin has the most dominant role and reported to have a cytotoxic effect on various cancer cell lines. This study aims to determine the cytotoxic activity of soursop leaf ethanol extract on T47D breast cancer cell line. Measurement of cytotoxic activity was carried out by the MTT method, and the viability percentage of T47D cells was calculated based on the absorbance values in the treatment, cell control, and media control groups of each replicate. The correlation between extract concentration and viability percentage of the T47D cell line was outlined in the regression equation to obtain the IC50 value. IC50 values of 109.91 ± 3.04 with R values 0.975 and R2 0.9508 obtained. R values close to 1 indicated a strong correlation between extract concentration and the percentage of living T47D cells. Meanwhile, the amount of R2 suggested that the level of AMEE had a 95.08% influence on the rate of cell viability, and the other 4.92% influenced by factors other than the AMEE dose. These results indicated that the ethanol extract of soursop leaves has a cytotoxic effect and has the potential to inhibit T47D cell proliferation in vitro.
Co-Authors A.A. Ketut Agung Cahyawan W Afif Nurul Hidayati, Afif Nurul Agung Dwi Wahyu Widodo Agustin Nurliani Aisha Grayli Cahyani Alief Yudo Astuti Alphania Rahniayu Anny Setijo Rahaju, Anny Setijo Ariani, Grace Aries Sasongko Astindari Astindari Astindari Astindari, Astindari Ayu Tyasmara Bagus Haryo Kusumaputra, Bagus Haryo Baiq Ratna Kumaladewi Bernadetta Jonan Betty Agustina Tambunan Brama Rachmantyo Budiono Budipramana, Vicky Sumarki Cita Rosita Sigit Prakoeswa Densy Violina Harnanti Dian Eskaningrum Djoni Susanto Dwi Murtiastutik DYAH FAUZIAH, DYAH Endi Prilansa Mahadi Erlina Erlina Faizah, Zakiyatul Fanny Gunawan Fertilita, Soilia Firda Azizah Gatut Hardianto, Gatut Gilda Hartecia Gondo Mastutik Grace Ariani Hartanto, Felix Hartecia, Gilda Heny Arwati Heriyawati, Heriyawati Heryawati Heryawati I Wayan Yudiana Ibrahim, Azarya Ida Septika Wulansari Ilmiah, Khafidhotul Imam Susilo INDROPO AGUSNI Irene Lingkan Parengkuan Irmadita Citrashanty, Irmadita Isnin Anang Marhana Iswinarno Doso Saputro iwan Syarif Jimmy Hadi Widjaja Jonan, Bernadetta Junita Jeanne Paliman Kartika Arum Wardani Kholida Nur Aini Kiki Apnita Sari Kintan Putri KUSUMASTUTI, ETTY HARY LaleMaulin Prihatina Linda Astari, Linda M. Yulianto Listiawan Mappamasing, Hasnikmah Marina Rimadhani Marina Rimadhani Martha Kurnia Kusumawardani Maylita Sari Maylita Sari, Maylita Meita Ardini Pratamasari, Meita Ardini Muhammad Miftahussurur Nanda Amalia Ramadhanti Navisa, Claudia Clary Nidya Ulfana Tsania Nila Kurniasari Novia Indriyani Adisty Nurina Hasanatuludhhiyah Nurul Wiqoyah, Nurul Poernomo, Adinda Sandya PUNGKY MULAWARDHANA, PUNGKY Purwati Purwati Purwati Puteri, Agnes Ilene Suprapto Qonitatillah, Ana R. Heru Prasetyo R.A. Astrid Putri Wandhita Rahel Yuana Sadikim Ratna Darjanti Haryadi Regina Martina Cilik Ridholia, Ridholia Rizaldi, Fikri Rulisiana Widodo Rusdamayanti Rusdamayanti Rwahita Satyawati Dharmanta Ryski Meilia Novarina Ryski Meilia Novarina, Ryski Meilia S.Pd. M Kes I Ketut Sudiana . Sabilal Alif Sari, Aditya Sita Sari, Festi Artika savitri, Lisa Sawitri Sawitri Sawitri Sawitri Sawitri Sjahjenny Mustokoweni, Sjahjenny Soilia Fertilita Sunarso Suyoso Sunaryo Hardjowijoto Suprabawati, Desak Gede Agung Tessy Badriyah, Tessy Theresia Fifi Judikristiani Tri Hartini Yuliawati Trisniartami Setyaningrum Tyasmara, Ayu Umi Choviva, Farida Ummi Maimunah Vinna Chrisdianti Widati Fatmaningrum Wilda Fitria Rachmadina Windya Tri Hapsari Winona May Hendrata Wiratama, Priangga Adi yasmin, dzakiyah Yusfita Evi Rosdiana