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Aris Santjaka
Jurusan Kesehatan Lingkungan Purwokerto Poltekkes Kemenkes Semarang
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Journal : MEDISAINS

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In vivo study of the antihypertensive effect of bidara leaf (Ziziphus spina-christi) during pregnancy Dilla, Tasya Nurlaila; Hadisaputro, Suharyo; Santjaka, Aris
MEDISAINS Vol 19, No 2 (2021)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v19i2.11431

Abstract

Background: Bidara is drought tolerant and very easy to grow in tropical climates such as Indonesia. Bidara contains a combination of calcium, potassium, and magnesium, and active flavonoid compounds, and antioxidant activity that play a role in inhibiting free radical damage, improving endothelial function so that it can potentially lower blood pressure. Previous studies explained that a dose variant of no more than 300mg/kg BW is beneficial while minimizing pathological changes. However, there has been no research related to the effect of bidara leaf in lowering blood pressure, so it is necessary to do related research.Objective: Analyze the effect of bidara leaf extract at a 200 mg/kg BW dose and 300 mg/kg BW on systolic and diastolic blood pressure.Methods: 24 pregnant female Wistar rats induced hypertension, aged 6-8 weeks with a weight of 130-230 grams. The rats were randomized so that they consisted of 2 control groups and two experimental groups, which were given various doses of bidara leaf for nine days. Blood pressure was measured using non-invasive CODA.Results: The blood pressure of rats in the bidara leaf extract group at doses of 200mg/kg BW and 300mg/kg BW decreased systolic and diastolic compared to the control group (p<0.05). The 200mg/kg BW dose group experienced a decrease in blood pressure of 12.3% for systolic and 16.32% for diastolic; the 300mg/kg BW dose group experienced a decrease in blood pressure of 19.99% for systolic and 27.73% for diastolic.Conclusion: Bidara leaf extract can reduce the blood pressure of pregnant rats with hypertension.
Accelerating perineal wound healing using binahong leaf extract sanitary pads Asmaidar, Asmaidar; Runjati, Runjati; Santjaka, Aris; Cicilia, Fitri
MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Early Release
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v0i0.24284

Abstract

Background: Sanitary pads are essential for postpartum mothers to accommodate lochia and prevent infection in perineal wounds. Binahong leaves (Anredera cordifolia) contain flavonoids with antiseptic, antioxidant, and analgesic properties that promote wound healing by inhibiting microbial growth and reducing inflammation. However, research on the use of sanitary pads infused with Binahong leaf extract for perineal wound healing remains limited.Objective: This study investigates the effectiveness of Binahong leaf extract sanitary pads in accelerating postpartum perineal wound healing. Methods: A quasi-experimental study with a post-test-only randomized control group design was conducted at the Poasia Health Center, Kendari City. The study included postpartum mothers meeting specific inclusion and exclusion criteria, with a total sample of 34 participants (17 intervention, 17 control). The intervention group used Binahong leaf extract sanitary pads four times daily, while the control group relied on standard dry wound care. The intervention lasted seven days, and wound healing was assessed using the REEDA scale on days three, five, and seven.Results: The findings demonstrated a significant effect of Binahong leaf extract sanitary pads on perineal wound healing. The intervention group (2.52 ± 0.87) experienced faster wound recovery than the control group (5.23 ± 1.67) (p< 0.001).Conclusion: Binahong leaf extract sanitary pads effectively accelerate perineal wound healing in postpartum mothers and may serve as an alternative wound care approach.
Co-Authors , SST., M.Si, Sugeng Abdullah Agista Delima Permadani Agus Subagyo Amaliah, Nurul Anak Agung Aris Diartama Andriana Andriana Andriana, Andriana - Anisah Maulida Anwar, M. Choerul Anwar, M. Choirul Aptiningsih Aptiningsih Ardi Soesilo Wibowo Ardi Soesilo Wibowo, Ardi Soesilo Arfiyan Sukmadi Arif Widyanto Arif Widyanto Arif Widyanto Arif Widyanto Arif Widyanto, Arif Army Mitasari Artathi Eka Suryandari Aryanti Puspitasari Asep Tata Gunawan, Asep Tata Asmaidar, Asmaidar Bedjo Santoso Kadri Budi Utomo Chandra Irawan Chatarina Umbul Wahyuni Cicilia, Fitri Dewi Dwi Haryani Dewi Nugraheni RM Dian Kusuma Yudiasti Diartama, Anak Agung Aris Dilla, Tasya Nurlaila Djamaluddin Ramlan, Djamaluddin Donny Kristanto Mulyantoro Donny Kristanto Mulyantoro Elsa Indiyani Elsye Rimimper Faisal Amri Faisal Amri Ferly Tiraningtyas Nusa Dewi Florentina Melani, Florentina Hapsari, Wanodya Hari Basuki Notobroto Hari Rudijanto Indro Wardono Hari Rudijanto IW Hari Rudjianto Indro Wardono Heni Pujiastuti Hermina Sukmaningtyas Hermina Sukmaningtyas Hidayat, Dita Nafira Hikmandari Hikmandari Husnul Yusmianti, Siti Nur I Nyoman Jirna I Wayan Sudiadnyana Ida Nilawati Ike Mayasari Iqbal Ardiansyah Isna Fadlilah Kartika Ayu Lestari Ketut Sudiantara Khomsatun Khuliyah Candraning Diyanah Komang Ayu Henny Achjar Kurnia Saraswati Lagiono Lalu Rian Setiawan Setiawan Leny Latifah Leny Latifah Lilis Sulistyorini Liyana Azizatul Muadibah M. Choerul Anwar M. Choiroel Anwar M.Pd S.T. S.Pd. I Gde Wawan Sudatha . Makruf, Fauzan Mardiyono Mardiyono, Mardiyono Maulana, Jaya Mayasari, Ike Mela Firdaust Melyana Nurul Widyawati Muadibah, Liyana Azizatul Nasichatus Shofa Noor Linda Vitria Sari Noviyanti, Aldila Nur Aini Nur Hilal Nur Lu’lu Fitriyani Nur Utomo Nurjazuli Nurjazuli Nurul Baiti Permadani, Agista Delima Priantoro, Win Priantoro, Win R. Azizah Rahmayanti Amini Ratih Kesuma Dewi Rini Indrati Rini Indrati, Rini Ririh Yudhastuti Ristiawati Rizky Aulia Salsabila RM, Dewi Nugraheni Rockmawati, Dliyau Rr Sri Endang Pujiastuti Rr. Vita Nurlatif Runjati Saifudin Saifudin Saifudin Septiani, Ainishfi Laili Serly Aprili Yani Siti Hidayatul Majidah Soedjajadi Sri Sumarni Sri Sumarni Subagiyo , Agus Sudiyono Sudiyono Sudiyono Sudiyono Sudiyono Sugeng Abdullah, Sugeng SUGIYANTO Sugiyanto - Sugiyanto Sugiyanto Suharto Suharto Suharyo Hadisaputro Suharyo Hadisaputro Sumarni . Sumiyati Sumiyati Sunaryo Sunaryo Suparmi Suparmi Supriyadi Supriyadi Suryati Kumorowulan Susy Suswaty Susy Suswaty Taadi Taadi Tata Gunawan, Asep Tauleka, Abdul Rohim Teguh Widiyanto Tiyara Safitri Tiyara Safitri Tri Cahyono Utomo, Nur Wachid Bambang Suharto, Abdul Wahyu Handayani Widayati, Rezeki Widyatun, Diah Win Priantoro Yohanes Didik Setiawan Yudastuti, Ririh Yulianto YUSVITA ARIANI RAHAYU Zaeni Budiono, Zaeni