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All Journal Jurnal Kedokteran Brawijaya Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Indonesian Journal of Human Nutrition Indonesian Journal of Tropical and Infectious Disease Berkala Kedokteran MNJ (Malang Neurology Journal) Majalah Kesehatan FKUB MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan Jurnal Respirologi Indonesia Oto Rhino Laryngologica Indonesiana Jurnal Respirasi (JR) Medica Hospitalia Journal of Issues in Midwifery Abdi Dosen : Jurnal Pengabdian Pada Masyarakat Babali Nursing Research Caring : Jurnal Pengabdian Masyarakat Indonesian Journal of Cancer Journal of Global Pharma Technology Journal of Community Health and Preventive Medicine (JOCHAPM) Jurnal Ilmu Kedokteran Keluarga JMMR (Jurnal Medicoeticolegal dan Manajemen Rumah Sakit) Cermin Dunia Kedokteran
Nanik Setijowati
Department Of Family Medicine, Faculty Of Medicine, Brawijaya University.
Religion Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences

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The Influence of Nigella sativa on the Increase of IFN-γ and Quality of Life in Lung Cancer Patients Undergoing Chemotherapy Mahendra, Reza Aditya; Pratiwi, Suryanti Dwi; Sartono, Teguh Rahayu; Rakhma, Sastia; Setijowati, Nanik
Jurnal Respirasi Vol. 11 No. 1 (2025): January 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.1.2025.31-38

Abstract

Introduction: In vitro and animal model studies have shown that Nigella sativa reduces cancer cell proliferation and improves chemotherapy effectiveness. Cellular activation triggers the production of IFN-γ by natural killer (NK) cells. This study examined the effect of Nigella sativa supplementation on IFN-γ levels and quality of life in lung cancer patients before and after interferon therapy. Methods: This study used a non-equivalent control experimental design involving 21 lung cancer patients undergoing initial chemotherapy at Dr. Saiful Anwar General Hospital, Malang, in 2023. The patients were divided into two groups: one group received standard chemotherapy, and another group received a combination of chemotherapy and Nigella sativa supplementation at a dose of 2x500 mg for nine weeks. The effects of this intervention were assessed by measuring IFN-γ levels using an enzyme-linked immunosorbent assay (ELISA) kit and evaluating quality of life using the European Organization for Research and Treatment of Cancer (EORTC) Core Quality of Life (QLQ-C30) questionnaire before and after the fourth cycle of chemotherapy. Results: The results showed a significant increase in IFN-γ levels in the combination group undergoing chemotherapy and receiving Nigella sativa supplementation (6140.44±2233.89) compared to the standard chemotherapy group (3827.08±1722.79), with a p-value of 0.015. Quality of life improved in both groups, with scores of 53.70±6.05 before and 65.74±14.70 after chemotherapy (p=0.000). Conclusion: This study found that Nigella sativa supplementation can enhance IFN-γ levels and quality of life in lung cancer patients after four chemotherapy treatment cycles. These findings indicated that Nigella sativa could be a beneficial supplement for lung cancer patients.
Correlation of LMP-1 expression with KRAS and IL-8 expression in NPC WHO type III Soehartono, Soehartono; Marini, Marini; Surjotomo, Hendradi; Fadli, Muhammad Luqman; Setijowati, Nanik
Oto Rhino Laryngologica Indonesiana Vol. 54 No. 2 (2024): VOLUME 54, NO. 2 JULY - DECEMBER 2024
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v54i2.530

Abstract

Background: Nasopharyngeal carcinoma (NPC) is a squamous cell carcinoma originating from mucosal epithelium of the nasopharynx with complex disease progression. About 95% are caused by Epstein-Barr virus (EBV) infection which is characterized by the detection of viral gene product protein of Latent Membrane Protein-1 (LMP-1). Tumor growth and metastasis depend on the mechanism of angiogenesis. Interleukin-8 (IL-8) is a potent angiogenic factor and involved in the angiogenesis mechanism. Kirsten Rat Sarcoma (KRAS) is one of the proto-oncogenes that has an increased expression of more than 60% in NPC. The KRAS activation played a role in the modulation of IL-8 expression by triggering several important signaling pathways, which triggered neovascularization in the process of angiogenesis. Purpose: To determine the correlation between expression of LMP-1 with KRAS and IL-8, in mechanism of angiogenesis in NPC WHO type III. Method: Analytical observational study with a cross-sectional approach involving 30 paraffin blocks of biopsy tissue from NPC patients who had not received radiotherapy or chemotherapy. Expressions of LMP-1, KRAS, and IL-8 were examined with immunohistochemistry (IHC) staining method, and calculated using manual counting by Anatomic Pathologists. Result: Statistical analysis of LMP-1 expression with KRAS showed an insignificant positive correlation (p=0.546), with a correlation coefficient (ρ=0.115). The KRAS expression with IL-8 showed an insignificant positive correlation (p=0.851), with a correlation coefficient (ρ=0.036). The LMP-1 expression with IL-8 showed a significant positive correlation (p=0.042), with a correlation coefficient (ρ=0.321). Conclusion: The increase in the expression of LMP-1 was followed with the increase in the IL-8 expression. Keywords: NPC, LMP-1, KRAS, IL-8, angiogenesis   ABSTRAK Latar belakang: Karsinoma nasofaring (KNF) adalah karsinoma sel skuamosa yang berasal dari epitel mukosa nasofaring. Perkembangannya melibatkan hubungan yang kompleks. Sekitar 95% disebabkan oleh infeksi virus Epstein-Barr (VEB) yang ditandai dengan terdeteksinya protein produk gen virus, salah satunya yaitu Latent Membrane Protein-1 (LMP-1). Pertumbuhan dan metastasis tumor tergantung pada mekanisme angiogenesis. Interleukin-8 (IL-8) adalah faktor angiogenik yang kuat, dan terlibat dalam mekanisme angiogenesis. Kirsten Rat Sarcoma (KRAS) merupakan salah satu proto- onkogen yang mengalami peningkatan ekspresi lebih dari 60% pada KNF. Aktivasi KRAS memainkan peran dalam modulasi ekspresi IL-8 dengan memicu beberapa jalur sinyal penting, dan hal ini dapat memicu neovaskularisasi pada proses angiogenesis. Tujuan: Mengetahui korelasi antara ekspresi LMP-1 dengan ekspresi KRAS dan IL-8 dalam mekanisme angiogenesis KNF WHO tipe III. Metode: Penelitian observasional analitik dengan pendekatan potong lintang yang melibatkan 30 blok parafin jaringan biopsi penderita KNF yang belum mendapat pengobatan radioterapi maupun kemoterapi. Pemeriksaan ekspresi LMP-1, KRAS, dan IL-8 menggunakan pewarnaan imunohistokimia, dan hasilnya dihitung secara manual oleh ahli Patologi Anatomi. Hasil: Analisis statistik ekspresi LMP-1 dengan KRAS menunjukkan korelasi positif yang tidak signifikan (p =0,546), dengan koefisien korelasi ρ=0,115. Ekspresi KRAS dengan IL-8 menunjukkan korelasi positif yang tidak signifikan (p=0,851), dengan koefisien korelasi ρ=0,036. Ekspresi LMP-1 dengan IL-8 menunjukkan korelasi positif yang signifikan (p=0,042), dengan koefisien korelasi ρ=0,321. Kesimpulan: Semakin tinggi ekspresi LMP-1, maka diikuti oleh tingginya ekspresi IL-8. Kata kunci: KNF, LMP-1, KRAS, IL-8, angiogenesis
Paraaortic Lymph Node Involvement among Indonesian Women with Cervical Cancer Pradana, Wisniardhy Suarnata; Aslam, Achmad Bayhaqi Nasir; Nugroho, Rafiq Sulistyo; Setijowati, Nanik; Siswidiyati, Siswidiyati
Indonesian Journal of Cancer Vol 19, No 4 (2025): December
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v19i4.1350

Abstract

Background: Incorporating para-aortic irradiation alongside standard pelvic irradiation has shown potential benefits for treating cervical cancer. However, its efficacy remains debatable due to insufficient information about paraaortic lymph node (PALN) involvement among Indonesian women. This study aims to determine the incidence of PALN and assess potential influencing factors, such as age, characteristics of the cervical mass (size and surrounding tissue involvement), and histopathology.Method: This study was a retrospective analytic observational study with a cross-sectional design, examining PALN involvement and localization in patients’ computed tomography (CT) scans before radiotherapy in 2023. The inclusion criteria are cervical cancer patients who were confirmed through a histopathological examination and underwent an abdominal CT scan before radiotherapy from January to December 2023. The exclusion criteria are cervical cancer patients accompanied by other primary tumors and patients who have undergone hysterectomy. The CT scans were conducted using a 16-slice Canon Aquilion from T12 to the proximal third with a 3 mm slice thickness. Factors influencing the risk of PALN involvement were analyzed using chi-square tests.Results: Eighty-seven eligible patients were analyzed. The median age was 52.26 years, with 72.4% at stage IIIB, 77% diagnosed with squamous cell carcinoma, and 89.7% with a mass size of over 4 cm. Almost all patients exhibited surrounding tissue involvement. 32.2% of patients had paraaortic lymph node involvement, with the majority (70.7%) located in the left para-aortic region and ≤ 5 mm from the aorta. There was no significant relationship between PALN involvement and age, characteristics of the cervical mass, or histopathology type.Conclusion: In a population of locally advanced cervical cancer, almost one-third of patients showed PALN involvement. Implementing PALN radiation in this population could potentially enhance outcomes, irrespective of the patient’s age, characteristics of the cervical mass, or histopathology results.
Co-Authors Aisyah Aisyah Amalia Pradanti Widarso, Amalia Pradanti Anjelin, Isabella Kusuma Arinto Yudi Ponco Wardoyo Aslam, Achmad Bayhaqi Nasir Asmika Asmika Badrul Munir Bimo Mubyarto Catur Ari Setianto Chozin, Iin Noor Damayanti, Gita Retno DAMAYANTI, ZUHRIA PUSPITA Dasa Novita, Khuznita Dessika Rahmawati Deuina Grishelda, Irma Dewi Santosaningsih Dhelya Widasmara Dhiar Widianingtyas, Dhiar Dian Kusumaningtyas, Dian Djajalaksana, Susanthy Dwi Rahayu, Indriati Eddy, Mochammad Istiadjid Eko Arisetijono Erlangga, Eggi Eviana Norahmawati Fadli, Muhammad Luqman Fitria, Ruman Freddy, Antonius Hanggara, Dian Sukma Hatimul Asmy Hendradi Surjotomo, Hendradi Himawan, Asavita Rhena Holipah, Holipah I Wayan Agung Indrawan Ida Sri Maduretno, Ida Sri Imelda Ritunga Imowanto, Yuddy Indradmojo, Christyaji Indriati Dwi Rahayu irsan , Istan Irmansyah Irsan, Istan Irmansyah Jasin, Jessica Lingga Jemima Lewi Santoso Johan, Willy Johannes, Jeffrey Kartika Rini Kartikasari, Ulfah Kuntadi, Muhammad Lilik Zuhriyah Listuhayu, Kararawi Listyoko, Aditya Sri Maelo, Clara Angraini Mahendra, Reza Aditya Mahulette, Aisyah Nurulhisa Marini . Marini, Gita Mellyanawati Mellyanawati Michaela, Cleine Minarni Wartiningsih Muhammad, Athaya Rahmanardi Natasha Halim, Angie Nazila Tanasya Nia Novita Wirawan, Nia Novita Normawati Normawati, Normawati Novita, Khuznita Dasa Nugroho, Rafiq Sulistyo Nugroho, Soeryanto Eko Agung Nurul Laili Oktaviana, Ratih Panjaitan, Damaris Gabrielle Valentine Pardosi, Delima Silvani Paskadita, Nafiri Eldya Pradana, Wisniardhy Suarnata Prasetyadjati, Ari Pratiwi, Suryanti Dwi Pratiwi, Suryanti Dwi Prihatiningsih, Riska Dwi Putra, Ngakan Putu Parsama Putu, Ngakan rahmah, shofi nur Rahmawati Aminingrum Rakhma, Sastia Rakhmani, Alidha Nur Rusnianah, Farida Santosa, Andrew Sartono, Teguh Rahayu Siswidiyati, Siswidiyati Sitompul, Boyke Soehartono Soehartono Soplantila, Chelsy Gravia Sri Andarini Sugiri, Yani Jane Suparno Adi Santika, Suparno Adi Syahrul Chilmi, Syahrul Tantular, Rezki Tita Hariyanti Titin Andri Wihastuti Tri Wahju Astuti, Tri Wahju Triyuliarto, Dwiwardoyo Wahyudi, Mgs Ahmad Widowati, Yenny Wilmida, Anggun Diah Yoga Sedana, I Ketut Yusdianto, Adrian Yuyun Yueniwati Zaiyanah, Munsifah Zamroni Afif Zarithsyafiqah, Siti Zhakia, Jelita Zhufatul