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All Journal Jurnal Teknologi Dan Industri Pangan Jurnal Kimia (Journal of Chemistry) IPTEK The Journal for Technology and Science Alchemy : Journal of Chemistry Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Jurnal AgroBiogen Indonesian Journal of Cancer Chemoprevention MPI (Media Pharmaceutica Indonesiana) UNEJ e-Proceeding Journal of Islamic Pharmacy JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Penelitian Kesehatan Suara Forikes Jurnal Wiyata : Penelitian Sains dan Kesehatan Journal Of Vocational Health Studies SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Jurnal Kreativitas PKM Jurnal Pemberdayaan: Publikasi Hasil Pengabdian Kepada Masyarakat PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Pharmaceutical Journal of Indonesia Riayah: Jurnal Sosial dan Keagamaan Jurnal Al-Irsyad: Jurnal Bimbingan Konseling Islam Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang Journal Pharmasci (Journal of Pharmacy and Science) Berkala Penelitian Hayati Jurnal Kreativitas dan Inovasi (Jurnal Kreanova) Borneo Journal of Pharmacy Journal of Tropical Pharmacy and Chemistry Jurnal Sains dan Kesehatan International Journal of Sociology of Religion Ulul Albab: Journal Dak'wah and Social Religiousity
Sukardiman
Department Of Pharmaceutical Sciences, Faculty Of Pharmacy, UniversitasAirlangga, Surabaya
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Journal : JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA

 1 
Molecular Docking of Mangostin and Sinensetin Derivatives on SUR1-Pancreatic KATP Channel Target as Antidiabetic Intan Kris Prasetyanti; Sukardiman Sukardiman; Suharjono Suharjono
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 8 No. 3 (2021): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v8i32021.271-276

Abstract

Background: Diabetes Mellitus (DM) is a complex chronic disease characterized by increased blood glucose. The incidence of this disease is rising, especially type 2 diabetes which is caused by insulin resistance in the body. SUR1-Pancreatic KATP Channel is a receptor as an antidiabetic target because its inhibition process can increase insulin production so that it can reduce blood glucose in people with type 2 diabetes. Objective: This study aims to identify the in-silico activity of the SUR1-Pancreatic KATP Channel macromolecules. Methods: Identification of macromolecular binding sites using Protein Plus software, then carried out molecular docking using AutoDock software, where the formed molecular interactions are further identified using the BIOVIA Discovery Studio software. Results: After determining the macromolecular binding site, the RMSD value was 1.253, allowing for further molecular docking. Molecular docking showed that the Ligands of mangostin (α, β, γ-mangostin) and sinensetin derivatives had a good affinity, namely α-mangostin -6,31 kcal/mol; β-mangostin -5.78 kcal/mol; γ-mangostin -6.17 kcal/mol and sinensetin -4.75 kcal/mol. Conclusion: The affinity sequence in the docking process for the SUR1 KATP channel macromolecules is α-mangostin > γ-mangostin > β-mangostin > sinensetin. The highest affinity for the docking process on the macromolecule SUR1 KATP channel was α-mangostin with a value of ΔG -6.31 kcal/mol Ki 23.65 μM.
Standardization of Myristicin in Nutmeg (Myristica fragrans Houtt.) Fruit using TLC-Densitometric Method Engel, Daniella Elizabeth; Sudjarwo; Sukardiman
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 11 No. 1 (2024): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v11i12024.12-19

Abstract

Background: Myristica fragrans Houtt. (Myristicaceae family), with the main content of myristicin, has been immensely used in herbal medicine. Standardization is essential to ensure the safety of natural extracts and the quality of herbal medicines using various chemical analysis techniques. Method validation is necessary to ascertain the reliability and reproducibility of the method. Myristicin is a member of the phenylpropene group, a natural organic compound found in small amounts in nutmeg fruit, which has pharmacological effects. Objective: This study aims to determine the myristicin content in nutmeg fruit using TLC-Densitometry. Methods: Determination of myristicin in nutmeg fruit extract was performed using TLC-Densitometry with silica GF254 as stationary phase, mobile phase n-hexane: ethyl acetate (8:2 v/v), and spot visualized at 285 nm. In this study, the content of myristicin in nutmeg fruit was determined using compendial methods (AOAC), thus requiring method verification with parameters including selectivity, linearity, precision, LOD, and LOQ. Results: The validation of this method showed good linearity and selectivity with y = 0.0001x + 0.0226 (r = 0.9996) and 1.53 (>1.5), respectively. The LOD and LOQ results were low with values of 0.11 μg/spot and 0.33 μg/spot, respectively. The percentage coefficient of variation for precision was below the requirement value of not more than 4%. The average myristicin content in nutmeg fruit extract was approximately 0.0017 ± 0.0003% (w/w). Conclusion: The developed method was valid and sensitive for the quantification of myristicin content in nutmeg fruit.
Co-Authors A. Dinar Ambarwati Achmad Fuad Hafid Adam Hermawan Al ‘Amali, Mayla Khayra Aly, M. Ainun Najib Anak Agung Gede Sugianthara Annisa Farida Muti Arie Ika Susanty Ario Imandiri, Ario Aty Widyawaruyanti Awik Puji Dyah Nurhayati Bambang Prayogo Bambang Sugiharto Bambang Tri Purwanto Corry, Maylisa Natalia Dewi Hidayati Dini Retnowati Diyah, Nuzul Wahyuning Djoko Agus P. Djoko Agus Purwanto Dwi Ningsih Dwi Riani Oktavia Palupi Edhi, Narendrani Sasmitaning Edy Listanto Edy Meiyanto Edy Meiyanto Emma Rahmawati Emma Rahmawati Engel, Daniella Elizabeth Eny I. Riyanti Esti Hendradi Faisal Akhmal Muslikh Hadi Poerwono Handayani, Rosita Hardiyanti, Andi Sry Hasan, Muhammad Amir Hidayati, Agriana Rosmalina I.A.A. Widhiartini Idha Kusumawati Iis Wahyuningsih Ilmi, Hilkatul Isna Rahmayani Isnaeni Istiqamah, Farida Junaidi Khotib Juni Ekowati Kholis Amalia Nofianti Kusmana Kusmana Lahardo, Devanus Marcellino Rudyanto Maria Lucia Ardhani Dwi Lestari Melanny Ika Sulistyowaty Miatmoko, Andang Misgiati, Misgiati Munandar, Tristiana Erawati Noor Erma NS Nur Fadilla Achmad Nurhidayah - Nuri Nuri Oka Adi Parwata Prasetyanti, Intan Kris Pratama, Edo Purwitasari, Neny Putri, Anisa Yustikka Rahmawati, Emma Ramadhani, Firmansyah Ardian Rarastoeti Prastiwi Retno Sari Retno Widyowati Riesta Primaharinastiti, Riesta Rijal, Agus Syamsur Roihatul Mutiah Shigeru Sasaki Shigeru Sasaki Siti Maimunah Siti Zulaikah Suciati Suciati Sudjarwo Sudjarwo Sudjarwo Suharjono, Suharjono Sulistiyono, Ilham Robbynoor Sulistyowati, Melanny Ika SUZANA, SUZANA Taufikurrahman Taufikurrahman Taufikurrahman Toto Hadiarto Tri Dewanti W. Tri J. Santoso Tri Sundari Tri Widiandani Tutik Sri Wahyuni Tutuk Budiati Wicaksana, Firman Widiyaningsih, Arum Widyowati , Retno Widyowati, Rr. Retno Wijayanti Pujitono Win Darmanto Wiwied Ekasari Yurika Sastyarina Yurika Sastyarina Yurika Sastyarina Yusuf, Helmy