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All Journal Jurnal Teknologi Dan Industri Pangan Jurnal Kimia (Journal of Chemistry) IPTEK The Journal for Technology and Science Alchemy : Journal of Chemistry Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Jurnal AgroBiogen Indonesian Journal of Cancer Chemoprevention MPI (Media Pharmaceutica Indonesiana) UNEJ e-Proceeding Journal of Islamic Pharmacy JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Penelitian Kesehatan Suara Forikes Jurnal Wiyata : Penelitian Sains dan Kesehatan Journal Of Vocational Health Studies Jurnal Kreativitas PKM Jurnal Pemberdayaan: Publikasi Hasil Pengabdian Kepada Masyarakat PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Pharmaceutical Journal of Indonesia Riayah: Jurnal Sosial dan Keagamaan Jurnal Al-Irsyad: Jurnal Bimbingan Konseling Islam Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang Journal Pharmasci (Journal of Pharmacy and Science) Berkala Penelitian Hayati Jurnal Kreativitas dan Inovasi (Jurnal Kreanova) Borneo Journal of Pharmacy Journal of Tropical Pharmacy and Chemistry Jurnal Sains dan Kesehatan International Journal of Sociology of Religion Jurnal Info Kesehatan Ulul Albab: Journal Dak'wah and Social Religiosity
Sukardiman
Department Of Pharmaceutical Sciences, Faculty Of Pharmacy, UniversitasAirlangga, Surabaya
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Journal : JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA

 1 
Molecular Docking of Mangostin and Sinensetin Derivatives on SUR1-Pancreatic KATP Channel Target as Antidiabetic Intan Kris Prasetyanti; Sukardiman Sukardiman; Suharjono Suharjono
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 8 No. 3 (2021): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v8i32021.271-276

Abstract

Background: Diabetes Mellitus (DM) is a complex chronic disease characterized by increased blood glucose. The incidence of this disease is rising, especially type 2 diabetes which is caused by insulin resistance in the body. SUR1-Pancreatic KATP Channel is a receptor as an antidiabetic target because its inhibition process can increase insulin production so that it can reduce blood glucose in people with type 2 diabetes. Objective: This study aims to identify the in-silico activity of the SUR1-Pancreatic KATP Channel macromolecules. Methods: Identification of macromolecular binding sites using Protein Plus software, then carried out molecular docking using AutoDock software, where the formed molecular interactions are further identified using the BIOVIA Discovery Studio software. Results: After determining the macromolecular binding site, the RMSD value was 1.253, allowing for further molecular docking. Molecular docking showed that the Ligands of mangostin (α, β, γ-mangostin) and sinensetin derivatives had a good affinity, namely α-mangostin -6,31 kcal/mol; β-mangostin -5.78 kcal/mol; γ-mangostin -6.17 kcal/mol and sinensetin -4.75 kcal/mol. Conclusion: The affinity sequence in the docking process for the SUR1 KATP channel macromolecules is α-mangostin > γ-mangostin > β-mangostin > sinensetin. The highest affinity for the docking process on the macromolecule SUR1 KATP channel was α-mangostin with a value of ΔG -6.31 kcal/mol Ki 23.65 μM.
Standardization of Myristicin in Nutmeg (Myristica fragrans Houtt.) Fruit using TLC-Densitometric Method Engel, Daniella Elizabeth; Sudjarwo; Sukardiman
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 11 No. 1 (2024): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v11i12024.12-19

Abstract

Background: Myristica fragrans Houtt. (Myristicaceae family), with the main content of myristicin, has been immensely used in herbal medicine. Standardization is essential to ensure the safety of natural extracts and the quality of herbal medicines using various chemical analysis techniques. Method validation is necessary to ascertain the reliability and reproducibility of the method. Myristicin is a member of the phenylpropene group, a natural organic compound found in small amounts in nutmeg fruit, which has pharmacological effects. Objective: This study aims to determine the myristicin content in nutmeg fruit using TLC-Densitometry. Methods: Determination of myristicin in nutmeg fruit extract was performed using TLC-Densitometry with silica GF254 as stationary phase, mobile phase n-hexane: ethyl acetate (8:2 v/v), and spot visualized at 285 nm. In this study, the content of myristicin in nutmeg fruit was determined using compendial methods (AOAC), thus requiring method verification with parameters including selectivity, linearity, precision, LOD, and LOQ. Results: The validation of this method showed good linearity and selectivity with y = 0.0001x + 0.0226 (r = 0.9996) and 1.53 (>1.5), respectively. The LOD and LOQ results were low with values of 0.11 μg/spot and 0.33 μg/spot, respectively. The percentage coefficient of variation for precision was below the requirement value of not more than 4%. The average myristicin content in nutmeg fruit extract was approximately 0.0017 ± 0.0003% (w/w). Conclusion: The developed method was valid and sensitive for the quantification of myristicin content in nutmeg fruit.
Optimization of Self-Nanoemulsifying Drug Delivery System Combining Red Ginger and Aromatic Ginger Extracts to Improve Solubilization and Stability Hindiana, Linda; Widyowati, Retno; Sukardiman
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 12 No. 3 (2025): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v12i32025.355-363

Abstract

Background: Red ginger (Zingiber officinale var. rubrum) and aromatic ginger (Kaempferia galanga L.) are traditional Indonesian medicinal plants with proven pharmacological activity, but their poor aqueous solubility requires formulation strategies to enhance solubilization and physical stability. Objective: This study aimed to optimize and evaluate a Self-Nanoemulsifying Drug Delivery System (SNEDDS) combining red ginger and aromatic ginger. Methods: The optimization was conducted by varying the oil-to-Smix ratio and extract concentration, while the internal Smix composition (Tween 80: PEG 400 = 1:2.8 w/w) remained constant to isolate the effect of oil–surfactant proportion. Virgin coconut oil (VCO), Tween 80, and PEG 400 were used as the oil phase, surfactant, and co-surfactant, respectively. Three formulas were prepared based on oil-to-Smix (w/w): Formula A (1:4.68, 500 mg extract), Formula B (1:10.6, 500 mg extract), and Formula C (1:10.6, 460 mg extract). Physical characterization included visual observation, centrifugation, particle size, polydispersity index (PDI), and transmittance before and after thermodynamic stability tests. Results: Formula A was unstable and exhibited precipitation. Before stability testing, Formula C showed improved dispersion, with a 41.5% reduction in droplet size and a 79.9% decrease in PDI relative to Formula B. After stability testing, Formula C demonstrated markedly better performance, including an 85.5% smaller droplet size, 81.4% lower PDI, and a 2.4% increase in transmittance compared with Formula B. These quantitative improvements indicated that Formula C exhibited more optimal solubilization capacity and physical stability. Conclusion: This study concludes that extract concentration and the oil-to-Smix ratio significantly influence SNEDDS characteristics, and Formula C represents the most favorable formulation for further development.
Formulation, Physical Characterization, and Stability Study of Nanoemulgel Containing Jatropha curcas Leaves Extract Aly, M. Ainun Najib; Pratama, Edo; Shobahah, Jauharotus; Munandar, Tristiana Erawati; Sukardiman
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 12 No. 3 (2025): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v12i32025.407-413

Abstract

Background: Jatropha curcas extract has been identified as a promising herbal remedy for various skin disorders. However, its application is limited by its low water solubility and poor skin permeability. Nanotechnology-based strategies provide a way to overcome these limitations. Objective: This study aimed to develop a new drug delivery system for J. curcas extract as a topical treatment for skin conditions. Methods: J. curcas extract was obtained through maceration. The system included a Carbopol 940-based gel and a J. curcas extract (JCE 10% w/w) nanoemulsion (NE) created using a high-energy method with an ultrasonic homogenizer. The appearance, pH, viscosity, spreadability, particle size, polydispersity index, and zeta potential of the nanoemulgel were assessed to verify its physical properties. Results: The optimal formulation produced a dark green nanoemulgel with a distinctive leafy smell and a semi-solid texture. Physical characterization of the JCE-NE-gel included a pH of 6.3, particle size of 142.67 nm, polydispersity index of 0.248, zeta potential of -23.23 mV, viscosity of 87.881 cP, and spreadability of 6.13 cm. Stability testing showed no significant differences after accelerated stability testing and thermal cycling. Conclusion: The study demonstrated that J. curcas extract (JCE-NE-gel) was successfully incorporated into a nanoemulgel formulation (F4), showing excellent physical properties and stability.
Co-Authors A. Dinar Ambarwati Achmad Fuad Hafid Adam Hermawan Al ‘Amali, Mayla Khayra Aly, M. Ainun Najib Anak Agung Gede Sugianthara Annisa Farida Muti Arie Ika Susanty Ario Imandiri, Ario Aty Widyawaruyanti Awik Puji Dyah Nurhayati Bambang Prayogo Bambang Sugiharto Bambang Tri Purwanto Dewi Hidayati Dini Retnowati Diyah, Nuzul Wahyuning Djoko Agus P. Dwi Ningsih Dwi Riani Oktavia Palupi Edy Listanto Edy Meiyanto Edy Meiyanto Emma Rahmawati Emma Rahmawati Engel, Daniella Elizabeth Eny I. Riyanti Esti Hendradi Faisal Akhmal Muslikh Hadi Poerwono Handayani, Rosita Hardiyanti, Andi Sry Hindiana, Linda I.A.A. Widhiartini Idha Kusumawati Iis Wahyuningsih Isna Rahmayani Isnaeni Istiqamah, Farida Junaidi Khotib Juni Ekowati Kholis Amalia Nofianti Kusmana Kusmana Marcellino Rudyanto Maria Lucia Ardhani Dwi Lestari Melanny Ika Sulistyowaty Miatmoko, Andang Misgiati, Misgiati Munandar, Tristiana Erawati Noor Erma NS Nur Fadilla Achmad Nurhidayah - Nuri Nuri Oka Adi Parwata Prasetyanti, Intan Kris Pratama, Edo Purwitasari, Neny Putri, Anisa Yustikka Rahmawati, Emma Ramadhani, Firmansyah Ardian Rarastoeti Prastiwi Retno Sari Retno Widyowati Rijal, Agus Syamsur Roihatul Mutiah Samudra, Rizka Putra Shigeru Sasaki Shigeru Sasaki Shobahah, Jauharotus Siti Maimunah Siti Zulaikah Sudjarwo Sudjarwo Sudjarwo Suharjono, Suharjono Sulistiyono, Ilham Robbynoor Sulistyowati, Melanny Ika SUZANA, SUZANA Taufikurrahman Taufikurrahman Taufikurrahman Toto Hadiarto Tri Dewanti W. Tri J. Santoso Tri Sundari Tutik Sri Wahyuni Tutuk Budiati Widiyaningsih, Arum Widyowati , Retno Widyowati, Rr. Retno Wijayanti Pujitono Win Darmanto Wiwied Ekasari Yurika Sastyarina Yurika Sastyarina Yurika Sastyarina Yusuf, Helmy