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Journal : MEDIA MEDIKA INDONESIANA

Asupan Lemak dan Ekspresi Gen eNOS3 Alel Glu298Asp pada Penderita Hipertensi Etnik Minangkabau Delmi Sulastri; Lipoeto NI; Nasrul Zubir; Jamsari Jamsari
MEDIA MEDIKA INDONESIANA 2011:MMI Volume 45 Issue 1 Year 2011
Publisher : MEDIA MEDIKA INDONESIANA

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Abstract

ABSTRACTIntake of fat and Gen eNOS3 Alel Glu298Asp expression in hypertensive Minangkabau personsBackground: eNOS 3 gene is one of the important genes which is related to the high prevalence of hypertension essensial. This gene expresses the nitric oxide synthase (NOS) enzyme which regulates the synthesis of nitric oxide (NO) in human body.Methods: A research has been done on hypertensive and normotensive patients aged 30-65 years old. The main purpose of this research was to evaluate the association of fat intake on eNOS3 gene Glu298Asp allel expression in hypertension subjects in Minangkabau ethnicity. One hundred thirty subjects had been interview about their eating habits, and measured their omega-3, eNOS3 gene and NO plasma level. The data were analysed with t-tes and chi-square.Results: The hypertensive’s plasma NO concentration was 26.91±15.40 μM/L and normotensive’s was 25.79±15.04 μM/L. 52.5% of the hypertensive subjects and 47.5% of the normotensive has eNOS3 gene heterozygotes GT allele. Mean rates for total fat, SFA, MUFA and PUFA consumption of hypertensive subjects are 28.05±6.57%, 12.31±4.21%, 4.21±1.79%, 3.77±1.97% and normotensive are 30.14±13.98%, 12.58±4.22%, 4.40±2.22%, 4.00±1.96%. Mean rate for plasma omega-3 concentration of hypertensive subjects is 14.45±0.10μg/dL and normotensive is 14.49±1.00 μg/dL. There is significant relationship between omega-3 with NO plasma level on hypertension with GT heterozygote alleles.Conclusion: In hypertensive patients with GT heterozygote alleles, only omega-3 plasma is associated with NO2 plasma.Keywords: Essensial hipertension, eNOS3 gene, NO plasma levelABSTRAKLatar belakang: Gen eNOS3 alel Glu298Asp merupakan salah satu gen yang berhubungan dengan kejadian hipertensi esensial. Kemampuan Gen eNOS3 alel ini untuk mensintesis enzim nitric oxide synthase (NOS) berkurang sehingga sintesis nitric oxide (NO) menurun.Metode: Penelitian pada subyek hipertensi dan normotensi berusia 30-65 tahun bertujuan untuk melihat hubungan asupan lemak dengan ekspresi gen eNOS3 alel Glu298Asp. Seratus tiga puluh subyek, diwawancara pola makannya lalu dilakukan pemeriksaan kadar omega-3 dan omega-6 plasma, gen eNOS3, serta kadar NO plasma. Data yang diperoleh dianalisis menggunakan uji T dan chi-square.Hasil: Kadar NO plasma subyek hipertensi adalah 26,91±15,40 μM/L dan normotensi 25,79±15,04 μM/L. 52,5% subyek hipertensi dan 47,5% normotensi mempunyai polimorfisme gen eNOS3 alel heterozigot GT. Rerata persentase asupan lemak total, ALJ, ALTJT, ALTJG pada subyek hipertensi adalah 28,05±6,57%, 12,31±4,21%, 4,21±1,79%, 3,77±1,97% dan pada subyek normotensi adalah 30,14±13,98%, 12,58±4,22%, 4,40±2,22%, 4,00±1,96%. Rerata kadar omega-3 plasma subyek hipertensi adalah 14,45±0,10 μg/dL dan normotensi 14,49±1,00 μg/dL. Terdapat hubungan kadar omega-3 dengan NO plasma pada penderita hipertensi dengan alel heterozigot GT.Simpulan: Pada penderita hipertensi dengan alel heterozigot GT, hanya omega-3 plasma yang berhubungan dengan kadar NO2 plasma.
Co-Authors Abdiana Adang Bachtiar Afdhal, Fitrah Afriani, Nita Afriwardi Afriwardi Afrizal Afrizal Alfin Rahma Fadhilah Amara Azka Shafrina Amel Yanis Amir, Aprima Yona Andani Eka Putra Ariadi, Ariadi Ariani, Peny Arni Amir Azrimaidaliza Basyir, Vaulinne Defrin Defrin Defrin, Defrin Desmawati Desmawati Desmawati Desmawati Dessy Arisany Dian Isti Angraini Dian Isti Angraini Dolly Irfandy Eldi Sauma Endrinaldi Erasta, Junira Eva Chundrayetti Eva Chundrayetti Evynatra Evynatra Evynatra, Evynatra Fadillah Ulva Faisaelia, Rezka Nanda Fannya, Puteri Fasrini, Ulya U Firdawati, Firdawati Fitrah Afdhal Fivi Melva Diana, Fivi Melva Friska Eka Fitria Hafizth, Hendi Hafni Bachtiar Hardisman Hasmiwati Hema Malini, Hema Heriawita Heriawita, Heriawita Hermawan, Nur Sefa Arief Hudila Rifa Karmia Huvaid, Sevilla Ukhtil Ida Rahmah Burhan Ida Rahmah Burhan Ika Nur Saputri Ilmiawati Indah Gemala Inke Malahayati Iqbal Muhammad Helmi Izmi Fadhilah Nasution Jamsari Jamsari Joaninha Cavalho de Jesus Linosefa Linosefa Lipoeto NI Masrul Mayetti Mayetti Mizawati, Afrina Mudjiran Mudjiran Mudjiran Nasrul Zubir Neherta, Meri Nesva, Intan Silvia Novita Sari Nur Indrawaty Lipoeto Nur Indrawaty Lipoeto Nursyirwan Effendi, Nursyirwan Nurul Ramadhini Nur’afifah, Fauziah Nuzulia Irawati Oktarina, Mika Putra, Abdi Setia Putri Aisyah Mirza Putri, Miftahul NS Rauza Sukma Rita Rizanda Machmud Rizanda Mahmud` Rosfita Rasyid Roslaili Rasyid Roza Mulyana Rozi Sastra Purna Sari, Nur Mala Sari, Vivi Sary, Annisa Novita Sesmeri Haryani silvia thamrin Sri Mulyanti Susi Susanti Susi Susanti Thamrin, Silvia Ulya Uti Fasrini Utama, Bobby Indra Wahyuni, Yosha Putri Yulistini, Yulistini Yuniar Lestari Yusrawati Yusrawati Yusti Siana