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All Journal International Journal of Public Health Science (IJPHS) Journal of Food and Pharmaceutical Science Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Disease Prevention and Public Health Journal Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Majalah Obat Tradisional JOURNAL OF HEALTHCARE TECHNOLOGY AND MEDICINE INDONESIAN JOURNAL OF PHARMACY Jurnal Farmasi Sains dan Komunitas Jurnal Teknologi Laboratorium Jurnal Fitofarmaka Indonesia Jurnal Penelitian Pendidikan IPA (JPPIPA) Syntax Literate: Jurnal Ilmiah Indonesia Jurnal Kesehatan Manarang Jurnal Pemberdayaan: Publikasi Hasil Pengabdian Kepada Masyarakat Jurnal Ilmu Kefarmasian Indonesia Lumbung Farmasi : Jurnal Ilmu Kefarmasian Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Farmasi Sains dan Praktis Jurnal Farmasi Klinik dan Sains Journal of Public Health and Pharmacy Journal of Food and Pharmaceutical Sciences Medical Sains : Jurnal Ilmiah Kefarmasian Tamilis Synex: Multidimensional Collaboration
Nanik Sulistyani
Fakultas Farmasi, Universitas Ahmad Dahlan
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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The Effectiveness of Herbal Supplements on Improving the Anthropometric Status of Stunted Children Hardia, Lukman; Akrom, Akrom; Sulistyani, Nanik
Jurnal Kesehatan Manarang Vol 11 No 3 (2025): December 2025
Publisher : Politeknik Kesehatan Kemenkes Mamuju

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33490/jkm.v11i3.1597

Abstract

Stunting has become a health issue that threatens the future generation of Indonesia, which is why the government has set a target prevalence of stunting at 14% by 2024. This has become a challenge because some areas, such as Sorong Regency, still have a higher prevalence of stunting compared to the national prevalence. One of the causes of stunting is malnutrition, so efforts are needed to address this issue by utilizing Indonesia's natural wealth, such as herbal honey, Curcuma xanthorrhiza, and black cumin, which are widely used by the community to tackle various health problems. The objective is to determine the effect of administering herbal honey made from temulawak and black cumin on changes in the anthropometric status of stunted children in Sorong Regency. This type of research is quantitative, using a quasi-experimental research design with a pre- and post-test with a control group design. The sampling technique used is purposive sampling, with a total sample of 60 children divided into 3 groups: the normal control group (20 children), the stunting control group (20 children), and the stunting intervention group (20 children). The data analysis techniques used in the research are paired-samples t-test and independent-samples t-test. The statistical test of the mean difference between the pre- and post-test between the intervention group and the control group showed a significant increase in body weight (average increase of 1.60 ± 0.66 kg, p < 0.001), height (1.49 ± 0.74 cm, p < 0.001), and z-score height-for-age (-0.42 ± 0.22 SD, p < 0.001). The administration of herbal honey, Curcuma xanthorrhiza, and black cumin can improve the anthropometric status of stunted children in Sorong Regency.
Phytochemical Constituents and Pharmacological Effects of Baeckea Frutescens: A Review Suleman, Abdul Wahid; Mahfudh, Nurkhasanah; Sulistyani, Nanik
Jurnal Penelitian Pendidikan IPA Vol 11 No 12 (2025): December
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i12.13476

Abstract

Baeckea frutescens is a medicinal species widely used in traditional practices and known for its rich phytochemical diversity, yet its pharmacological profile remains fragmented across multiple studies. This systematic review aims to integrate current evidence on the phytochemical constituents and pharmacological activities of B. frutescens, focusing on anti-inflammatory, antimicrobial, antioxidant, anticancer, wound-healing, and insecticidal effects. A literature evaluation was conducted using previously compiled research comprising 16 studies from China, Indonesia, Malaysia, and Southeast Asia, covering chemical isolation, essential oil analysis, in vitro assays, in vivo experiments, and computational approaches. The results indicate that B. frutescens contains meroterpenoids, phloroglucinol derivatives, flavonoids, phenolics, and terpenes that collectively contribute to significant modulation of NF-κB, MAPK, TLR4–MyD88, and COX-related pathways. Essential oils and polar extracts exhibit broad antimicrobial and antioxidant activities, while cytotoxic and wound-healing assays demonstrate promising therapeutic potential. Insecticidal studies further highlight ecological relevance through antifeedant and repellent properties. Overall, the review confirms B. frutescens as a pharmacologically versatile species with strong prospects for drug discovery and functional applications. However, further mechanistic and in vivo investigations are needed to strengthen its translational value.
Ethnopharmacology Analysis of Antidiabetic Medicinal Plants from Menoreh Hills: Linking Local Knowledge to Pharmacological Evidence Kintoko, Kintoko; Faisal Nur Arib; Nanik Sulistyani; Akrom
Journal of Food and Pharmaceutical Sciences Article In Press 2026
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.24603

Abstract

Abstract: The prevalence of type 2 diabetes mellitus (T2DM) has been increasing worldwide and in Indonesia. Documenting locally utilized antidiabetic plants may inform evidence-based phytotherapy. This study mapped antidiabetic medicinal plants in Samigaluh (Menoreh Hills) and prioritized candidates by linking community knowledge with pharmacological data. Semi-structured interviews and observation were conducted between July and August 2025, and involved ten informants selected through purposive and snowball sampling. Quantitative ethnobotanical indices (Use Value, Relative Frequency of Citation, Fidelity Level, Plant Part Value) were calculated, followed by a PubMed-based narrative review. The Zingiberaceae family was predominant (seven species); rhizomes were the most utilized (39.58%), followed by stems (25.00%) and leaves (22.92%). Vernonia amygdalina was prioritized for diabetes-specific consensus (Fidelity Level 100%, Relative Frequency of Citation 0.7), and Curcuma mangga for its high usage and popularity (Use Value 1.3, Relative Frequency of Citation 0.6). Pharmacological evidence indicates that V. amygdalina exhibits antidiabetic effects through the inhibition of α-amylase and α-glucosidase, enhancement of GLUT4, and suppression of gluconeogenesis, supported by its antioxidant and anti-inflammatory properties, while C. mangga demonstrates hypoglycemic activities and β-cell protection, along with anti-inflammatory, antioxidant, and immunostimulant activities as supportive mechanisms. Local knowledge thus aligns with mechanistic findings, supporting a complementary pairing of V. amygdalina and C. mangga for future antidiabetic combinations; further validation through in vitro and in vivo studies is recommended. Keywords: Curcuma mangga; indigenous knowledge; pharmacological evidence; phytotherapy; Vernonia amygdalina
THE TREND OF STUDIES RELATED TO MYASTHENIA GRAVIS AND GENETICS IN VARIOUS POPULATIONS AROUND THE WORLD Fitri, Dwiki; Irham, Lalu Muhammad; Sulistyani, Nanik; Adikusuma, Wirawan; Sianu, Rahman S; Ma’ruf, Muhammad
Jurnal Farmasi Klinik dan Sains Vol 5, No 2 (2025): Jurnal Farmasi Klinik dan Sains
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Universitas Muhammadiyah Gombong

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26753/jfks.v5i2.1944

Abstract

Myasthenia gravis (MG) is an autoimmune disease involving the neuromuscular junction, mainly influenced by antibodies to acetylcholine receptors. In addition, antibodies to Muscle-Specific Kinase (MUSK), Low-Density Lipoprotein Receptor-Related Protein 4 (LRP4). It is essential to determine publication trends regarding Myasthenia gravis because, currently, there are no studies that describe Myasthenia gravis publication trends related to genes in this field of study. Bibliometric analysis is used to see research trends, including frequently used keywords, most published journals, most cited publishers, author agencies, and collaboration between authors depicted in visualization using the VOSViewer application. Bibliometric analysis shows that the research trend is increasing from 1969 to 2023. The most frequently used keywords are myasthenia gravis, human, autoimmune disease, genetics, and article. The leading information related to the data is that the average annual publication is 5.89%, and the average citation for documents is 13.9%. Indonesia, as one of the countries experiencing Myasthenia gravis, has excellent potential to increase the number of research articles, which can be a means of exchanging knowledge, ideas, and technology and also has the potential for collaboration with other countries
Ethnopharmacology Analysis of Antidiabetic Medicinal Plants from Menoreh Hills: Linking Local Knowledge to Pharmacological Evidence Kintoko, Kintoko; Faisal Nur Arib; Nanik Sulistyani; Akrom
Journal of Food and Pharmaceutical Sciences Article In Press 2026
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.24603

Abstract

Abstract: The prevalence of type 2 diabetes mellitus (T2DM) has been increasing worldwide and in Indonesia. Documenting locally utilized antidiabetic plants may inform evidence-based phytotherapy. This study mapped antidiabetic medicinal plants in Samigaluh (Menoreh Hills) and prioritized candidates by linking community knowledge with pharmacological data. Semi-structured interviews and observation were conducted between July and August 2025, and involved ten informants selected through purposive and snowball sampling. Quantitative ethnobotanical indices (Use Value, Relative Frequency of Citation, Fidelity Level, Plant Part Value) were calculated, followed by a PubMed-based narrative review. The Zingiberaceae family was predominant (seven species); rhizomes were the most utilized (39.58%), followed by stems (25.00%) and leaves (22.92%). Vernonia amygdalina was prioritized for diabetes-specific consensus (Fidelity Level 100%, Relative Frequency of Citation 0.7), and Curcuma mangga for its high usage and popularity (Use Value 1.3, Relative Frequency of Citation 0.6). Pharmacological evidence indicates that V. amygdalina exhibits antidiabetic effects through the inhibition of α-amylase and α-glucosidase, enhancement of GLUT4, and suppression of gluconeogenesis, supported by its antioxidant and anti-inflammatory properties, while C. mangga demonstrates hypoglycemic activities and β-cell protection, along with anti-inflammatory, antioxidant, and immunostimulant activities as supportive mechanisms. Local knowledge thus aligns with mechanistic findings, supporting a complementary pairing of V. amygdalina and C. mangga for future antidiabetic combinations; further validation through in vitro and in vivo studies is recommended. Keywords: Curcuma mangga; indigenous knowledge; pharmacological evidence; phytotherapy; Vernonia amygdalina
Co-Authors . Mulyadi Abdi Wira Septama Abdul Rahman Wahid Abdul Wahid Suleman ACHMAD NURYADIN AKBAR Ade Irawan Ade Irawan Adnan, Adnan Akrom, Akrom Aldri Frinaldi Alfian Syarifuddin Alvionida, Fitra Andhika Septiawan Anisa Devi Kharisma Wibowo Anisaningrum Anisaningrum Anisaningrum, Anisaningrum Anisaningrum, Anisaningrum Aprilia Kusbandari Astryna, Syarifah Yanti Athifah Candra Dewi Ayu Lifia Nur Kartikasari Definingsih Yuliastuti Dhega Agung Wichaksono Dinda Anindya Sabillah Dyah Aryani Perwitasari Eka Kumalasari Eka Kumalasari Faisal Nur Arib Fauziyya, Riri Fitra Alvionida Fitri, Dwiki Ghina Adhila Henry Budiawan Prasetya Ibnatul Azizah Ichwan Ridwan Rais IIN NARWANTI Iin Narwanti Ken Zaim Arifin Kintoko Kintoko Kintoko, Kintoko La Malihi Laela Hayu Nurani Lalu Muhammad Irham Leswara, Dianita Febrina Lilies Kusuma Wardhani Lilies Kusuma Wardhani Lola Angelita Lukman Hardia Lukman Mahdi M. Kuswandi Mahdi, Lukman Maliza, Rita Ma’ruf, Muhammad Melati Aprilliana Ramadhani, Melati Aprilliana Meta Ayuni Mika Triza Misba Muhammad Fathurrachman Mantali Muhammad Syakbani Mulyadi, . Mulyadi, . Mutti, Annisa Aulia Nina Salamah Nining Sugihartini NUR HASANAH Nurhayati Nurhayati Nurkhasanah Mahfudh Nurkhasanah Mahfudh Nurkhasanah Mahfudh Nurkhasanah Nurkhasanah Nurkhasanah Nurkhasanah Nurkhasanah Nurkhasanah Nyoman Rudi Kusuma Panji Ratih Suci Rahma Dona Rahmat Dani Satria Riat El Khair Ricke Desyratnaputri Rizky H. Mawardi Rofidah Nur Umar Sabrina Wulandari Sianu, Rahman S Sismindari . Sudjadi . Sun, Suny Tegar Prasetya Budi Titiek Suhardi Haripurnomo Kushadiwijaya Hidayati Wardhani, Lilies Kusuma Warsi Warsi Wirawan Adikusuma Wulandari, Sabrina Wulandari, Sabrina Zainab Zainab Zainab Zainab Zainab, Zainab