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All Journal International Journal of Public Health Science (IJPHS) Journal of Food and Pharmaceutical Science Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Disease Prevention and Public Health Journal Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Majalah Obat Tradisional JOURNAL OF HEALTHCARE TECHNOLOGY AND MEDICINE INDONESIAN JOURNAL OF PHARMACY Jurnal Farmasi Sains dan Komunitas Jurnal Teknologi Laboratorium Jurnal Fitofarmaka Indonesia Jurnal Penelitian Pendidikan IPA (JPPIPA) Syntax Literate: Jurnal Ilmiah Indonesia Jurnal Kesehatan Manarang Jurnal Pemberdayaan: Publikasi Hasil Pengabdian Kepada Masyarakat Jurnal Ilmu Kefarmasian Indonesia Lumbung Farmasi : Jurnal Ilmu Kefarmasian Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Farmasi Sains dan Praktis Jurnal Farmasi Klinik dan Sains Journal of Pharmaceutical and Sciences. Journal of Food and Pharmaceutical Sciences Borneo Journal of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian
Nanik Sulistyani
Fakultas Farmasi, Universitas Ahmad Dahlan
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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THE TREND OF STUDIES RELATED TO MYASTHENIA GRAVIS AND GENETICS IN VARIOUS POPULATIONS AROUND THE WORLD Fitri, Dwiki; Irham, Lalu Muhammad; Sulistyani, Nanik; Adikusuma, Wirawan; Sianu, Rahman S; Ma’ruf, Muhammad
Jurnal Farmasi Klinik dan Sains Vol 5, No 2 (2025): Jurnal Farmasi Klinik dan Sains
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Universitas Muhammadiyah Gombong

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26753/jfks.v5i2.1944

Abstract

Myasthenia gravis (MG) is an autoimmune disease involving the neuromuscular junction, mainly influenced by antibodies to acetylcholine receptors. In addition, antibodies to Muscle-Specific Kinase (MUSK), Low-Density Lipoprotein Receptor-Related Protein 4 (LRP4). It is essential to determine publication trends regarding Myasthenia gravis because, currently, there are no studies that describe Myasthenia gravis publication trends related to genes in this field of study. Bibliometric analysis is used to see research trends, including frequently used keywords, most published journals, most cited publishers, author agencies, and collaboration between authors depicted in visualization using the VOSViewer application. Bibliometric analysis shows that the research trend is increasing from 1969 to 2023. The most frequently used keywords are myasthenia gravis, human, autoimmune disease, genetics, and article. The leading information related to the data is that the average annual publication is 5.89%, and the average citation for documents is 13.9%. Indonesia, as one of the countries experiencing Myasthenia gravis, has excellent potential to increase the number of research articles, which can be a means of exchanging knowledge, ideas, and technology and also has the potential for collaboration with other countries
Ethnopharmacology Analysis of Antidiabetic Medicinal Plants from Menoreh Hills: Linking Local Knowledge to Pharmacological Evidence Kintoko, Kintoko; Faisal Nur Arib; Nanik Sulistyani; Akrom
Journal of Food and Pharmaceutical Sciences Article In Press 2026
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.24603

Abstract

Abstract: The prevalence of type 2 diabetes mellitus (T2DM) has been increasing worldwide and in Indonesia. Documenting locally utilized antidiabetic plants may inform evidence-based phytotherapy. This study mapped antidiabetic medicinal plants in Samigaluh (Menoreh Hills) and prioritized candidates by linking community knowledge with pharmacological data. Semi-structured interviews and observation were conducted between July and August 2025, and involved ten informants selected through purposive and snowball sampling. Quantitative ethnobotanical indices (Use Value, Relative Frequency of Citation, Fidelity Level, Plant Part Value) were calculated, followed by a PubMed-based narrative review. The Zingiberaceae family was predominant (seven species); rhizomes were the most utilized (39.58%), followed by stems (25.00%) and leaves (22.92%). Vernonia amygdalina was prioritized for diabetes-specific consensus (Fidelity Level 100%, Relative Frequency of Citation 0.7), and Curcuma mangga for its high usage and popularity (Use Value 1.3, Relative Frequency of Citation 0.6). Pharmacological evidence indicates that V. amygdalina exhibits antidiabetic effects through the inhibition of α-amylase and α-glucosidase, enhancement of GLUT4, and suppression of gluconeogenesis, supported by its antioxidant and anti-inflammatory properties, while C. mangga demonstrates hypoglycemic activities and β-cell protection, along with anti-inflammatory, antioxidant, and immunostimulant activities as supportive mechanisms. Local knowledge thus aligns with mechanistic findings, supporting a complementary pairing of V. amygdalina and C. mangga for future antidiabetic combinations; further validation through in vitro and in vivo studies is recommended. Keywords: Curcuma mangga; indigenous knowledge; pharmacological evidence; phytotherapy; Vernonia amygdalina
Phytochemical Constituents and Pharmacological Effects of Baeckea Frutescens: A Review Abdul Wahid Suleman; Nurkhasanah Mahfudh; Nanik Sulistyani
Jurnal Penelitian Pendidikan IPA Vol 11 No 12 (2025): December
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i12.13476

Abstract

Baeckea frutescens is a medicinal species widely used in traditional practices and known for its rich phytochemical diversity, yet its pharmacological profile remains fragmented across multiple studies. This systematic review aims to integrate current evidence on the phytochemical constituents and pharmacological activities of B. frutescens, focusing on anti-inflammatory, antimicrobial, antioxidant, anticancer, wound-healing, and insecticidal effects. A literature evaluation was conducted using previously compiled research comprising 16 studies from China, Indonesia, Malaysia, and Southeast Asia, covering chemical isolation, essential oil analysis, in vitro assays, in vivo experiments, and computational approaches. The results indicate that B. frutescens contains meroterpenoids, phloroglucinol derivatives, flavonoids, phenolics, and terpenes that collectively contribute to significant modulation of NF-κB, MAPK, TLR4–MyD88, and COX-related pathways. Essential oils and polar extracts exhibit broad antimicrobial and antioxidant activities, while cytotoxic and wound-healing assays demonstrate promising therapeutic potential. Insecticidal studies further highlight ecological relevance through antifeedant and repellent properties. Overall, the review confirms B. frutescens as a pharmacologically versatile species with strong prospects for drug discovery and functional applications. However, further mechanistic and in vivo investigations are needed to strengthen its translational value.
Mekanisme Molekuler Efek Hipolipidemik Senyawa Bioaktif dari Ekstrak Kulit Buah Alpukat (Persea americana Mill.) : Sebuah Kajian Literatur Suwahyuni Mus; Nanik Sulistyani; Sapto Yuliani
Jurnal Penelitian Pendidikan IPA Vol 12 No 1 (2026)
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v12i1.13733

Abstract

Avocado peel (Persea americana L.) contains a number of bioactive compounds that have the potential to act as antihyperlipidemic agents. These compounds include polyphenols, flavonoids, triterpenoids, phytosterols, and phenolic acids, which are known to affect lipid metabolism through various molecular pathways. This review aims to identify the molecular mechanisms underlying the antihyperlipidemic effects of avocado peel extract. Relevant literature was obtained through searches in the PubMed, Scopus, and Web of Science databases using relevant keywords. Selected studies were analyzed based on the PICO (Population, Intervention, Comparison, Outcome) framework and summarized using the PRISMA methodology. The results of the review indicate that avocado peel extract has the potential to activate the AMPK pathway, regulate PPAR-α/γ, inhibit HMG-CoA reductase, and increase bile acid excretion. However, most of the evidence is limited to animal models and in vitro studies, and further research in humans is needed to confirm the efficacy and to elucidate more in-depth molecular mechanisms.
Ethnopharmacology Analysis of Antidiabetic Medicinal Plants from Menoreh Hills: Linking Local Knowledge to Pharmacological Evidence Nur Arib, Faisal; Kintoko, Kintoko; Sulistyani, Nanik; Akrom, Akrom
Journal of Food and Pharmaceutical Sciences Vol 14, No 1 (2026): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.24603

Abstract

Abstract: The prevalence of type 2 diabetes mellitus (T2DM) has been increasing worldwide and in Indonesia. Documenting locally utilized antidiabetic plants may inform evidence-based phytotherapy. This study mapped antidiabetic medicinal plants in Samigaluh (Menoreh Hills) and prioritized candidates by linking community knowledge with pharmacological data. Semi-structured interviews and observation were conducted between July and August 2025, and involved ten informants selected through purposive and snowball sampling. Quantitative ethnobotanical indices (Use Value, Relative Frequency of Citation, Fidelity Level, Plant Part Value) were calculated, followed by a PubMed-based narrative review. The Zingiberaceae family was predominant (seven species); rhizomes were the most utilized (39.58%), followed by stems (25.00%) and leaves (22.92%). Vernonia amygdalina was prioritized for diabetes-specific consensus (Fidelity Level 100%, Relative Frequency of Citation 0.7), and Curcuma mangga for its high usage and popularity (Use Value 1.3, Relative Frequency of Citation 0.6). Pharmacological evidence indicates that V. amygdalina exhibits antidiabetic effects through the inhibition of α-amylase and α-glucosidase, enhancement of GLUT4, and suppression of gluconeogenesis, supported by its antioxidant and anti-inflammatory properties, while C. mangga demonstrates hypoglycemic activities and β-cell protection, along with anti-inflammatory, antioxidant, and immunostimulant activities as supportive mechanisms. Local knowledge thus aligns with mechanistic findings, supporting a complementary pairing of V. amygdalina and C. mangga for future antidiabetic combinations; further validation through in vitro and in vivo studies is recommended.
Uji Iritasi Kulit Sediaan Sunscreen Spray yang Mengandung Ekstrak Bunga Telang (Clitoria ternatea) dengan Metode Patch Test Nyoman Rudi Kusuma; Nanik Sulistyani; Nining Sugihartini
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1281

Abstract

Background: Butterfly pea flower (Clitoria ternatea) contains high levels of anthocyanins with potent antioxidant activity, making it a promising natural ingredient for sunscreen formulations. However, the skin safety of sunscreen spray containing this extract must be evaluated before cosmetic application. Objective: This study aimed to evaluate the skin irritation potential of sunscreen spray formulations containing butterfly pea flower extract using the patch test method. Methods: A patch test was conducted on 15 male Wistar rats. The test materials included sunscreen spray formulations with butterfly pea flower extract at concentrations of 1% (F1), 2% (F2), and 3% (F3). A base formulation without extract (F0) served as a negative control, and sodium lauryl sulfate served as a positive control. Erythema and edema scores were observed at 24, 48, and 72 hours after application. Results: The mean erythema and edema scores for formulations F1, F2, and F3 were 0.0 ± 0, indicating no signs of skin irritation in all tested groups. The positive control group showed slight erythema (score 2.33 ± 0.5), confirming the validity of the test method. Conclusion: Sunscreen spray formulations containing butterfly pea flower extract at concentrations of 1%, 2%, and 3% did not induce skin irritation in male Wistar rats under the patch test conditions. These findings support the potential of butterfly pea flower extract as a safe natural ingredient for sunscreen products.
Identification of Gene Variations Associated with Diabetic Neuropathy Using Bioinformatics Approach Siti Fatimah Sultan; Adisti Putri Novriyanti; Siti Rohmah; Lalu Muhammad Irham; Nanik Sulistyani; Muhammad Ma'ruf
Borneo Journal of Pharmacy Vol. 9 No. 1 (2026): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v9i1.7148

Abstract

Diabetic neuropathy is the most common complication of diabetes, experienced by almost 90% of diabetic patients. Pain is one of the most common symptoms of diabetic neuropathy, but the pathophysiologic mechanism of pain is not clearly known. The hypothesis of hyperglycemia toxicity to the development of pain complications has been widely accepted worldwide, but there are still other hypotheses proposed. The basic concept in the management of painful diabetic neuropathy is to exclude other causes of peripheral neuropathic pain, improve glycemic control for prophylactic therapy, and use drugs to reduce pain. Variation data for diabetic neuropathy can be obtained from the Ensembl Genome Browser. Here, genes associated with 26 variants were selected according to Haploreg version 4.2. In addition, protein expression of missense gene variants was examined using the GTEx portal to determine two variants: rs55703767, which encodes the COL4A3 gene, and rs141560952, which encodes the DIS3L2 gene. According to data obtained from the Ensembl Genome Browser, the two most prevalent populations for SNP rs55703767, which is linked to the COL4A3 gene, are in Africa, while SNP rs141560952, which is linked to the DIS3L2 gene, is most prevalent in Africa, the Americas, East Asia, Europe, and South Asia.
Co-Authors . Mulyadi Abdi Wira Septama Abdul Rahman Wahid Abdul Wahid Suleman ACHMAD NURYADIN AKBAR Ade Irawan Ade Irawan Adisti Putri Novriyanti Adnan, Adnan Aldri Frinaldi Alfian Syarifuddin Alvionida, Fitra Andhika Septiawan Anisa Devi Kharisma Wibowo Anisaningrum Anisaningrum Anisaningrum, Anisaningrum Anisaningrum, Anisaningrum Aprilia Kusbandari Athifah Candra Dewi Ayu Lifia Nur Kartikasari Definingsih Yuliastuti Dhega Agung Wichaksono Dinda Anindya Sabillah Dyah Aryani Perwitasari Eka Kumalasari Eka Kumalasari Faisal Nur Arib Fauziyya, Riri Fitra Alvionida Fitri, Dwiki Ghina Adhila Henry Budiawan Prasetya Ibnatul Azizah Ichwan Ridwan Rais Iin Narwanti Ken Zaim Arifin Kintoko Kintoko Kintoko, Kintoko La Malihi Laela Hayu Nurani Lalu Muhammad Irham Lalu Muhammad Irham Leswara, Dianita Febrina Lilies Kusuma Wardhani Lilies Kusuma Wardhani Lola Angelita Lukman Hardia Lukman Mahdi M. Kuswandi Mahdi, Lukman Maliza, Rita Melati Aprilliana Ramadhani, Melati Aprilliana Meta Ayuni Mika Triza Misba Muhammad Fathurrachman Mantali Muhammad Ma'ruf Muhammad Ma'ruf Muhammad Syakbani Mulyadi, . Mulyadi, . Mutti, Annisa Aulia Nina Salamah Nining Sugihartini Nining Sugihartini Nur Arib, Faisal NUR HASANAH Nurhayati Nurhayati Nurkhasanah Mahfudh Nurkhasanah Mahfudh Nurkhasanah Nurkhasanah Nurkhasanah Nurkhasanah Nurkhasanah Nurkhasanah Nyoman Rudi Kusuma Nyoman Rudi Kusuma Panji Ratih Suci Rahma Dona Rahmat Dani Satria Riat El Khair Ricke Desyratnaputri Rizky H. Mawardi Rofidah Nur Umar Sabrina Wulandari Sapto Yuliani Sianu, Rahman S Sismindari . Siti Fatimah Sultan Siti Rohmah Sudjadi . Sun, Suny Suwahyuni Mus Syarifah Yanti Astryna Tegar Prasetya Budi Titiek Suhardi Haripurnomo Kushadiwijaya Hidayati Wardhani, Lilies Kusuma Warsi Warsi Wirawan Adikusuma Wulandari, Sabrina Wulandari, Sabrina Zainab Zainab Zainab Zainab Zainab, Zainab