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Tiwuk Susantiningsih
Universitas Pembangunan Nasional Veteran Jakarta
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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THE UTILIZATION OF ETHANOL EXTRACT OF THE SOURSOP LEAVES (Annona muricata L.) AS BREAST CANCER CHEMOPREVENTIVE Karimah Ihda Husnayain; Asep Sukohar; Tiwuk Susantiningsih
Jurnal Agromedicine Unila: Jurnal Kesehatan dan Agromedicine Vol. 1 No. 1 (2014): Jurnal Agromedicine
Publisher : Fakultas Kedokteran Universitas Lampung

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Abstract

The breast cancer is the highest incidence and causes of women mortality in the world. It is estimated every year that 12 million people suffering from the cancer and 7,6 million of them died. Cancer treatment includes surgery, radiotherapy and chemotherapy have more side effects. The preventions is needed to reduce the incidence of breast cancer. Then, a natural materials anticancer is needed as an alternative chemopreventive such as soursop (Annona muricata L.) which contains anticancer. The active substance in the soursop which is capable of acting as an anticancer is annonaceous acetogenins. Acetogenins in soursop leaves could selectively attack cancer cell growth. Acetogenins consist of active compounds that has cytotoxic activity which works by inhibiting the transport of adenosine triphosphate (ATP) in the mitochondria of breast cancer cells. The soursop leaf extract contains acetogenins as an anticancer agents that can prevent the growth of cancer cells that can not be controlled by the body's defense mechanism, so it can be concluded that the leaf extract of soursop can be used as an alternative chemopreventive against breast cancer. [J Agromed Unila 2014; 1(1):72-6] Keywords: acetogenins, breast cancer, soursop (Annona muricata L.)
Pengaruh Perlakuan Treadmill terhadap Jumlah dan Motilitas Sperma Mencit (Mus musculus L.) Obesitas Tiwuk Susantiningsih; Lana Asfaradilla
Jurnal Agromedicine Unila: Jurnal Kesehatan dan Agromedicine Vol. 2 No. 3 (2015): JURNAL AGROMEDICINE
Publisher : Fakultas Kedokteran Universitas Lampung

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Abstract

Saat ini masih banyak masalah gizi yang dapat memengaruhi kualitas kesehatan salah satunya yaitu masalah kegemukan. Pencegahan epidemi kegemukan merupakan salah satu tantangan besar gizi dan kesehatan masyarakat baik di negara maju maupun negara berkembang. Terjadinya obesitas lebih ditentukan oleh terlalu banyaknya makan, terlalu sedikitnyaaktivitas atau latihan fisik, maupun keduanya. Latihan Treadmill selain meningkatkan kekuatan otot dan memperbaiki metabolisme tubuh, juga dapat meningkatkan penyerapan oksigen pada darah serta melatih otot jantung dan paru-paru). Penelitian tentang pelatihan fisik yang berlebihan (stres fisik) dengan penurunan kualitas spermatozoa menunjukkan bahwaterjadi peningkatan Reactive Oxygen Species (ROS) dalam seminal plasma dan penurunan perlindungan oleh antioksidan. Pelatihan fisik memulai respon fisiologis dan biokimia yang kompleks. Setiap gerakan otot yang cepat dimulai dengan metabolisme anaerobik. Tenaganya berasal dari pemecahan Adenosin Triphosphate (ATP) dengan hasil Adenosin Diphosphate (ADP) dan berlangsung di mitokondria. Jumlah sperma atau konsentrasi sperma dari spesies uji dapat ditentukan dari sampel ejakulat, epididimis, atau testis. Penentuan jumlah sperma epididimis biasanya hanya menggunakan sperma dari bagian kauda. [J Agromed Unila 2015; 2(3):343-346]Kata kunci: jumlah sperma, motilitas sperma, obesitas, treadmill
Anti-inflammatory and hepatoprotective effects of Moringa oleifera fruit in obesity-induced liver injury Susantiningsih, Tiwuk; Thadeus, Maria Selvester; Citrawati, Mila; Setyaningsih, Yuni
MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Vol. 24 No. 1 (2026)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v24i1.30081

Abstract

Background: Hepatic metabolic disorders are closely associated with obesity and are characterized by systemic inflammation and liver injury. Moringa oleifera fruit contains various bioactive compounds with potential anti-inflammatory and hepatoprotective properties. However, evidence regarding its effects on obesity-induced liver injury remains limited..   Objective: This study aimed to evaluate the anti-inflammatory and hepatoprotective effects of Moringa oleifera fruit extract in an obesity-induced rat model..   Methods: This experimental study used 30 male Sprague-Dawley rats divided into five groups: normal control (N), obese control (O), obese rats treated with Moringa oleifera fruit extract at 500 mg/kg body weight once daily (OEMO1), twice daily (OEMO2), and obese rats treated with vitamin C (OC). Systemic inflammation was assessed by measuring serum C-reactive protein (CRP) levels using ELISA, while hepatic changes were evaluated through biochemical markers and histopathological analysis. Data were analyzed using one-way ANOVA followed by post hoc testing.   Results: Obese rats exhibited significantly elevated serum CRP levels and marked hepatic alterations compared to normal controls (p < 0.05). Administration of Moringa oleifera fruit extract significantly reduced CRP levels and improved hepatic histoarchitecture in obese rats, with the greatest effect observed in the twice-daily treatment group (OEMO2) (p < 0.05). The effects were comparable to or greater than those observed with vitamin C. Conclusions: Moringa oleifera fruit extract demonstrates significant anti-inflammatory and hepatoprotective effects in an obesity-induced rat model, suggesting its potential as a natural therapeutic agent for obesity-related liver injury.
Pelatihan Pembuatan Teh Daun Kelor Kayu Manis pada Ibu-ibu PKK Desa Pangkalan Jati Depok Setyaningsih, Yuni; Tiwuk Susantiningsih; Maria Selvester Thadeus; Mila Citrawati; Hikmah Muktamiroh; Melly kristanti
BERNAS: Jurnal Pengabdian Kepada Masyarakat Vol. 7 No. 2 (2026)
Publisher : Universitas Majalengka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31949/jb.v7i2.16121

Abstract

Kelor memiliki berbagai manfaat bagi kesehatan seperti sebagai antibakteri, antiinflamasi, antioksidan dan lain-lain. Kelor dapat dikonsumsi sebagai sayuran, bubuk, jus atau teh. Kayu manis merupakan rempah yang memiliki manfaat sebagai antioksidan dan antidiabetes. Pemanfaatan daun kelor kayu manis belum pernah dilakukan di Desa Pangkalan Jati, Cinere, Depok, yang merupakan daerah perbatasan dengan ibu kota. Tujuan pengabdian kepada masyarakat ini adalah untuk meningkatkan pengetahuan dan keterampilan kader PKK dalam membuat teh daun kelor kayu manis. Metode yang dilakukan dengan melakukan penyuluhan tentang manfaat daun kelor bagi kesehatan dan pelatihan pembuatan teh daun kelor kayu manis dari seduhan langsung dan merebus daun kelor. Hasil pengabdian ini menunjukkan terdapat peningkatan pengetahuan yang bermakna tentang manfaat daun kelor dengan uji Wilcoxon p 0,001. Kader PKK juga dapat melakukan pembuatan teh daun kelor kayu manis dengan baik. Pengabdian yang dilakukan berhasil meningkatkan pengetahuan kader tentang manfaat daun kelor dan meningkatkan keterampilan membuat teh daun kelor kayu manis. Diharapkan kader dapat mengaplikasikan pengetahuan yang sudah didapatkan dalam kehidupan sehari-hari dan memberikan informasi pengetahuan ini kepada masyarakat sehingga dapat meningkatkan kesehatan masyarakat.
The Effect of Moringa oleifera Fruits Extract in Lowering Triglycerides Levels in Obesity Abdul Halim Arif; Tiwuk Susantiningsih; Sri Wahyuningsih; Melly Kristanti; Fajriati Zulfa
Biology, Medicine, & Natural Product Chemistry Vol 15, No 1 (2026)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2026.151.623-629

Abstract

Obesity is a global health problem that is often accompanied by hypertriglyceridemia as a manifestation of lipid metabolism disorders. Moringa fruit contains bioactive compounds that have the potential to be a natural hypolipidemic agent. Objective: This study aims to determine the effect of moringa fruit extract administration on triglyceride levels in obese model mice. An experimental study used 30 male Sprague Dawley mice divided into five groups: normal control, obesity negative control, positive control with vitamin C 15 mg/kgBB, moringa fruit extract treatment 500 mg/kgBB once daily, and moringa fruit extract treatment 500 mg/kgBB twice daily. Obesity was induced with a high-fat, high-protein feed for 49 days, followed by treatment for 14 days. Triglyceride levels were measured using the ELISA method and analyzed by the One-Way ANOVA test. The obese group showed the highest triglyceride levels (265.767 mg/dL) compared to the normal control (191.639 mg/dL). The administration of moringa fruit extract lowered the triglyceride level to 230,054 mg/dL for a once-daily dose and 212,463 mg/dL for a twice-daily dose. Statistical tests showed a significant difference (p<0.05) between the twice-daily treatment group and the obesity group. Moringa fruit extract was effective in lowering triglyceride levels in obese rats, with administration twice daily showing more optimal results.
Pendidikan Remaja dalam Pencegahan Stunting melalui Pencegahan Pernikahan Dini di Pangkalan Jati, Cinere, Depok Maria Selvester Thadeus; Mila Citrawati; Tiwuk Susantiningsih; Yuni Setyaningsih
Jurnal Penyuluhan dan Pemberdayaan Masyarakat Vol. 5 No. 2 (2026): Jurnal Penyuluhan dan Pemberdayaan Masyarakat
Publisher : CV. Era Digital Nusantara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59066/jppm.v5i2.2298

Abstract

Pernikahan dini masih marak terjadi di Indonesia, yang menimbulkan berbagai tantangan kesehatan dan sosial. Kedewasaan yang dibutuhkan untuk menikah tidak hanya mencakup kesiapan biologis, tetapi juga kesiapan psikologis, sosial, mental, dan spiritual. Pernikahan dini memiliki dampak negatif bagi kaum muda dan generasi mendatang. Mengingat kaitannya yang erat dengan tradisi budaya setempat, pencegahan pernikahan dini memerlukan kerja sama yang sinergis antara pemerintah, tokoh agama, tokoh adat, dan masyarakat. Program pengabdian masyarakat ini bertujuan untuk memberikan pemahaman yang lebih mendalam kepada remaja mengenai bahaya pernikahan dini dan kesehatan reproduksi, serta mengedukasi mengenai hubungan antara pernikahan dini dan stunting pada remaja Masjid Al Muhajirin, Pangkalan Jati Cinere Depok. Kegiatan ini dilaksanakan sebagai upaya pencegahan terhadap pernikahan dini dan sebagai strategi konvergensi untuk pencegahan stunting pada remaja. Program ini terdiri dari tiga tahap yaitu pengumpulan data, konseling/sosialisasi, dan evaluasi. Penilaian pengetahuan dilakukan melalui pre-test dan postest untuk mengukur pemahaman peserta mengenai risiko pernikahan dini dan pencegahan stunting. Hasil pengabdian menunjukkan peningkatan pengetahuan dan kesadaran remaja mengenai risiko pernikahan dini serta hubungannya dengan stunting. Kegiatan ini menunjukkan bahwa pendidikan berbasis masyarakat di kalangan kelompok remaja dapat menjadi strategi yang efektif untuk mencegah pernikahan dini dan mengurangi prevalensi stunting dalam jangka panjang.
Implementation of contextual and experimental learning through training on yogurt production for chemistry teachers in the MGMP Jakarta Selatan 2 Irma Kartika; Fera Kurniadewi; Muktiningsih Nurjayadi; Amarisa Nur Affifah; Ikhsandy Alfindo; Wandira Danil Ramadhan; Konita Adhani; Bella Pricilya Nababan; Azzahra Cahya Maulida; Tiwuk Susantiningsih
Transformasi: Jurnal Pengabdian Masyarakat Vol. 21 No. 2 (2025): Transformasi Desember
Publisher : LP2M Universitas Islam Negeri Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20414/transformasi.v21i2.13237

Abstract

[Bahasa]: Kimia sebagai mata pelajaran yang bersifat abstrak dan konseptual seringkali dianggap kurang menarik oleh siswa karena didominasi metode hafalan dan minim penerapan kontekstual. Hasil wawancara dengan siswa SMA menunjukkan bahwa pembelajaran berbasis eksperimen lebih efektif dalam meningkatkan pemahaman, namun implementasinya terkendala oleh keterbatasan fasilitas laboratorium, sehingga menurunkan relevansi materi dan motivasi belajar siswa. Kondisi ini mendorong pengembangan kompetensi guru dalam praktikum berbasis Contextual Teaching and Learning (CTL) melalui pembuatan yoghurt yang mengintegrasikan berbagai konsep Kimia serta isu lingkungan dan kesehatan berkelanjutan.  Menanggapi kebutuhan tersebut, Tim Pengabdian kepada Masyarakat (PkM) UNJ telah menyelenggarakan pelatihan pembuatan yoghurt bagi 40 guru Kimia di lingkungan MGMP Kimia Jakarta Selatan 2. Kegiatan laboratorium awal telah dilakukan pada Mei–Juni 2024 di Laboratorium Biokimia FMIPA UNJ dan kegiatan inti PkM (meliputi pendahuluan, perencanaan dan persiapan, pelaksanaan, dan evaluasi) telah terlaksana pada Agustus 2024 di SMAN 70 Jakarta. Kegiatan ini berhasil meningkatkan keterampilan dan kreativitas guru dalam merancang pembelajaran Kimia yang kontekstual dan aplikatif, sesuai dengan prinsip Kurikulum Merdeka, serta mendukung pencapaian Tujuan Pembangunan Berkelanjutan (SDGs) poin ke-4 tentang pendidikan berkualitas. Para peserta juga merekomendasikan keberlanjutan program melalui pendampingan intensif dan penyusunan modul praktikum berbasis CTL yang terstandar. Kata Kunci: Contextual Teaching and Learning, eksperimen, kimia, Kurikulum Merdeka Belajar, yoghurt [English]: The abstract and conceptual characteristics of chemistry often lead students to perceive the subject as less appealing, particularly when instruction relies heavily on rote memorization and lacks contextual relevance. Interviews with senior high school students indicate that experiment-based learning is more effective at enhancing understanding; however, its implementation is constrained by limited laboratory facilities, which reduces the relevance of the material and students’ motivation to learn. This condition encourages the development of teachers’ competencies in Contextual Teaching and Learning (CTL)–based laboratory activities through yogurt production, which integrates diverse chemistry concepts with environmental and sustainable health issues. To address this need, the UNJ Community Service (PkM) team conducted a yogurt production training program for 40 chemistry teachers from MGMP Jakarta Selatan 2. The preliminary laboratory activities were conducted from May to June 2024 at the Biochemistry Laboratory, Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Jakarta, while the main Community Service (PkM) activities—including introduction, planning and preparation, implementation, and evaluation—were carried out in August 2024 at SMAN 70 Jakarta. The program successfully improved teachers’ skills and creativity in designing contextual and applied chemistry learning in accordance with the principles of the Merdeka Belajar Curriculum, while also supporting the achievement of Sustainable Development Goal (SDG) 4 on quality education. The participants further recommended continuing the program through intensive mentoring and the development of standardized CTL-based laboratory modules. Keywords: Contextual Teaching and Learning, experiment, chemistry, Merdeka Belajar curriculum, yogurt
Peningkatan Ketrampilan Membuat Minuman Jasule Untuk Imunitas Dimasa Pandemi Covid-19 Di Pangkalan Jati Cinere Depok Tiwuk Susantiningsih; Yuni Setyaningsih; Agneta Irmarahayu; Fajriati Zulfa
Jurnal Pemberdayaan Masyarakat Vol 6 No 1 (2021): Mei
Publisher : Direktorat Penelitian dan Pengabdian kepada Masyarakat (DPPM)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21067/jpm.v6i1.5056

Abstract

During the Covid-19 pandemic, good immunity was needed to avoid the corona virus infection. One of the efforts to prevent corona virus infection was to increase the body's immune status. High body immunity can be obtained from eating healthy foods, getting adequate rest and avoiding stress / mental stress. One local wisdom of the people in Indonesia to increasing immunity level was the habit of consuming herbal drinks which were believed to increase immunity level because there were several very useful ingredients. One of the herbal drinks made from ginger and lemon was JASULE (Jahe Susu Lemon), which was a ginger milk drink with lemon added. In this training, the participants were given material about the importance of the herbal drink JASULE (Jahe Susu Lemon). The importance of growing ginger and lemon as a medicinal plant in the yard. Also given training in making JASULE drink until all participants can make it themselves. The training activities for making herbal drinks JASULE to increase body immunity level during the Covid-19 Pandemic were held in Pangkalan Jati Cinere, Depok. This activity was well received by all participants with enthusiasm and the questions asked. Participants gained additional knowledge and skills in making herbal drinks JASULE, which can be seen from the increasing in post test scores after counseling and training in making herbal drink JASULE to increasing body immunity level during the Covid-19 Pandemic in Pangkalan Jati Cinere, Depok was 42.4% ie from 47.9% to 90.3%.
Prevention of Anemia in Adolescent Girls in Pangkalan Jati Village, Cinere, Depok Mila Citrawati; Maria Selvester Thadeus; Tiwuk Susantiningsih; Yuni Setyaningsih
Abdimas Indonesian Journal Vol. 6 No. 1 (2026)
Publisher : Civiliza Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59525/aij.1518

Abstract

Stunting remains a major public health issue that must be addressed today. Stunting represents a significant nutritional problem that affects social and economic life both within and across communities. There is clear evidence that stunted individuals have higher mortality rates and greater disease incidence. Contributing factors to stunting include inadequate nutritional intake during pregnancy, which leads to fetal growth restriction, marking the beginning of stunting. Stunting prevention education is essentially an activity or effort to convey messages to communities, groups, or individuals with the expectation that they will gain knowledge that can influence their attitudes and behaviors. The youth of the Al Muhajirin Mosque in Pangkalan Jati, Cinere, Depok, have limited knowledge regarding the dangers of anemia among adolescent girls and its link to stunting. The objective of this community service activity was to educate the youth members of Al Muhajirin Mosque about the dangers of anemia and the importance of iron supplementation to reduce the risk of stunting in children. Our finding that this activity can increase adolescents’ understanding of anemia and stunting, thereby contributing to the reduction of anemia and stunting rates in Pangkalan Jati, Cinere, Depok.
Education on Making Chicken Porridge and Moringa Oleifera Leaves to Prevent Stunting in Mothers PKK Cadres in Pangkalan Jati Cinere Depok Tiwuk Susantiningsih; Sri Wahyuningsih; Pritha Maya Savitri; Agneta Irmarahayu; Dwi Arwandi Yogi Saputra; Yuni Setyaningsih
Abdimas Indonesian Journal Vol. 6 No. 1 (2026)
Publisher : Civiliza Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59525/aij.1519

Abstract

Moringa leaves contain bioactive compounds such as flavonoids and polyphenols which have antioxidant and anti-inflammatory properties. The benefits of adding Moringa leaves to chicken porridge as infant formula is that it can enhance the nutritional quality of the porridge, making it a more balanced and complete meal. The protein content from the chicken combined with the vitamins, minerals, and antioxidants from Moringa leaves creates a good synergy for infant growth.  Adding Moringa leaves to chicken porridge as infant formula is a smart step to enhance the nutritional value of infant food. The benefits of making Moringa leaf chicken porridge are not yet widely known by the public, so its use for daily consumption is still rare. Therefore, we conducted an educational activity on making moringa leaf chicken porridge for PKK mothers and Posyandu cadres in Pangkalan Jati, Cinere, Depok. This community service initiative involved educating PKK cadres about the benefits of adding Moringa leaves to chicken porridge by providing training on how to make chicken porridge with Moringa leaves, so it can be applied by families and the surrounding community to improve public health and serve as complementary food to enhance breast milk production.
Co-Authors Abd. Rasyid Syamsuri Abdul Halim Arif Agneta Irmarahayu Amarisa Nur Affifah Andri Pramesyanti Pramono Ani R. Prijanti Ani Retno Prijanti Arfiyanti, Arfiyanti Asep Sukohar Audrey Alvura Digna Azzahra Cahya Maulida Baehaqi Basuki Supartono Bella Pricilya Nababan Boenga Nurcita Chantika Zahra Adisaputra Desi Purwaningsih Dian Ayu Paramitha Dwi Arwandi Yogi Saputra Evi Kurniawaty Fachruddin Perdana Fadilah Fajriati Zulfa Fajriati Zulfa Fera Kurniadewi HANS-JOACHIM FREISLEBEN Hardyanti, Putri Heryani, Monalisa Hikmah Muktamiroh Hikmah Muktamiroh Huzaimah Huzaimah Ikhsandy Alfindo Irma Kartika Juliana, Dara Karimah Ihda Husnayain Karimatul Himmah Khairun Nisa Konita Adhani Kristina Simanjuntak Kristina Simanjuntak Kristina Simanjuntak Kristina Simanjuntak Kristina Simanjuntak, Kristina Simanjuntak Kurniawaty, Evi Lana Asfaradilla Makkiyah, Feda Anisah Maria Selvester Thadeus Melly Kristanti Mila Citrawati Mohamad Sadikin Monalisa Heryani Mufidatur Rosyidah, Mufidatur Muhammad Alif Farhan Muhammad Kevin Auliansyah Akbar Muktamiroh Hikmah Muktiningsih Nurjayadi Muttia Amalia Muttia Amalia Ni Luh Aurial Widjayanti Novi Silvia Hardiany Nunuk Nugrohowati Pritha Maya Savitri Putri Elok Septiana Dewi Rahajeng, Herera Rahmah, Nida Nabila Rahman, Ihsan Febrianto Rahmawati Ridwan Reinhart Fikram Imam Akbar Retno Yulianti Retno Yuliyanti Ria Maria Theresa Roro Rukmi Windi Perdani, Roro Rukmi Rukman Abdullah Setiya Purbasari Setyaningsih, Yuni Setyaprawira, Fallery Simanjuntak, Kristina Soraya Rahmanisa Soroy Lardo Sri Wahyuningsih Sri Wahyuningsih Sri Wahyuningsih Sukmara, Uta Provinsiana Syazili Mustofa Tasya Nooramadhani Thadeus, Maria Selevster Wandira Danil Ramadhan Wendi Corlia Cahyaninglatri Yanto Sandy Tjang Yuliyanti, Retno Yuni Setyaningsih Yuni Setyaningsih Zihono, Yudivaniel