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All Journal International Journal of Public Health Science (IJPHS) MEDIA MEDIKA INDONESIANA Jurnal Anestesi Perioperatif Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Medical Journal of Indonesia Indonesian Journal of Cancer Chemoprevention Pharmascience Majalah Kedokteran Sriwijaya Sari Pediatri Biomedical Journal of Indonesia Jurnal Kedokteran Gigi Universitas Padjadjaran Jurnal Kedokteran dan Kesehatan Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan Indonesian Journal of Obstetrics & Gynecology Science Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Jurnal Ilmu Kedokteran dan Kesehatan Oceana Biomedicina Journal SRIWIJAYA JOURNAL OF MEDICINE Majalah Anestesia dan Critical Care Bioscientia Medicina : Journal of Biomedicine and Translational Research Sriwijaya Journal of Surgery Jurnal Kesehatan dan Pembangunan Bioscientia Medicina : Journal of Biomedicine and Translational Research International Journal of Islamic and Complementary Medicine

Theodorus Theodorus

Bagian Farmakologi Fakultas Kedokteran Universitas Sriwijaya

Author-ID : 403007

Religion Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Physics Public Health

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Relationship between Knowledge, Attitude and Behavior of Postnatal Woman Toward Participation in Permanent Contraception Heriansyah, Jhon; Azhari, Azhari; Basir, Firmansyah; Theodorus, Theodorus
Indonesian Journal of Obstetrics and Gynecology Volume 6. No. 1. January 2018
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To investigate the association between knowledge,attitude, and behavior towards participation in permanentcontraception and describe factors that could affectparticipation of permanent contraception in women inRSMH Palembang.Methods: This case control study was conducted at the Departmentof Obstetrics and Gynecology, Dr. Mohammad Hoesin Hospital/Faculty of Medicine, Universitas Sriwijaya, Palembang, during theperiod of June 2016 to December 2016. Sample of the cases groupwas woman who agreed to use permanent contraception whilecontrol sample was women who refuse to use permanent contraception.Data were collected using a questionnaire. Statisticalanalysis was performed using SPSS.Results: There was a significant association between attitude,behavior, husband support, and disease complications withparticipation of permanent contraception. Factors that influencedparticipation of permanent contraception in woman in RSMHPalembang include husband support and behavior.Conclusion: Factors that influence the participation of women inRSMH safe contraception Palembang include support for herhusband and behavior.[Indones J Obstet Gynecol 2018; 6-1: 39-44]Keywords: family planning, participation, permanent contraception

Oral versus Vaginal Misoprostol for Labour Induction : A Comparative Study Mahacakri, Eke P; Bernolian, Nuswil; Pangemanan, Wim T; Theodorus, Theodorus
Indonesian Journal of Obstetrics and Gynecology Volume 6. No. 2 April 2018
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To compare the efficacy and safety of hourly titrated oralmisoprostol in solution (OMS) with vaginal misoprostol (PV) forlabor induction.Methods: Randomized Controlled Trial (RCT), double blind-add onthe study was conducted from January-November 2016 in deliveryward of Moh. Hoesin general hospital. Women 30 weeks of gestationwith an unfavorable cervix (Bishop score 6) and an indicationfor labor induction were randomly assigned to receive titrated oralor vaginal misoprostol. The OMS group received a basal unit of20 ml misoprostol solution (1 g/ml) every 1 hour for four dosesand then were titrated against individual uterine response. In theabsence of regular uterine contractions, the dose was increased to40 ml hourly for four doses and then 60 ml for four doses. Thevaginal group received 25 g every 4 hours until attaining a morefavorable cervix for three doses. All the subjects received amylumplacebo. In labor within 12 hours was the primary outcome.Results: A total of 30 women were enrolled in this study. One subjectin the OMS group was dropped out due to eclamptic seizure. Theaverage interval from induction until in labour in OMS group was5.753.14 hour and 6.604.46 hour in PV group (p = 0.56). In labourstage was achieved within 12 hours in 14 women (100%) in OMSgroup and 14 women (93.3%) in PV group (p = 1.00). Vaginaldelivery was achieved within 24 hours in 13 women (92.9%) inOMS group and 15 women (100%) in PV group. The incidence ofuterine hyperstimulation/ tachysystolic was 7.1% in OMS groupcompared with 13.3% in PV group. Fetal distress was found only 1case (7.1%) in OMS group. There was no difference in the maternaland neonatal outcome of labor in both the groups.Conclusion: Oral titrated in solution, and vaginal route ofadministration of misoprostol for induction of labour areequally effective and safe.[Indones J Obstet Gynecol 2018; 6-2: 89-97]Keywords: hourly titrated oral misoprostol in solution, oral misoprostol,randomized controlled trial, vaginal misoprostol

Different Doses of Intraumbilical Oxytocin on the Third Stage of Labor Islamy, Nurul; Bernolian, Nuswil; BasiR, Firmansyah; Theodorus, Theodorus
Indonesian Journal of Obstetrics and Gynecology Volume 6 No. 3 July 2018
Publisher : Indonesian Socety of Obstetrics and Gynecology

  Objective: To compare the dose of oxytocin injected intraumbilicalltowards the duration of the third stage, blood loss volume, hemoglobinand hematocrit.   Methods: This study is a prospective randomised study with acontrol. The control group was given an intramuscular injection of10 IU oxytocin. The intervention of the three groups intraumbilicaloxytocin treatment dose of 10 IU, 20 IU and 30 IU diluted in 50 ml ofnormal saline solution and administered intraumbilically. Thesample selection by purposive sampling and the distribution groupbased on systematic random sampling (10 samples each). Data weretaken from the period April 2016-January 2017 with the inclusionand exclusion criteria. Data were analysed using Chi-square, T-test,ANOVA and Post hoc tests.   Results: Characteristics study for variables of age, occupation,parity, education, episiotomy and neonates weight showed homogeneouscharacteristics. The mean duration of the third stage forall groups was between 366.7  159.0 seconds and 440.1  244.99seconds. While the average number of postpartum haemorrhage forall group 61.894  226.3ml and 309.5  110.26 ml. There were nodifferences in the dose of oxytocin on the duration of the thirdstage (p> 0.05) and the amount of bleeding (p> 0.005). There was adifference of haemoglobin between intervention group of oxytocindose of 10 IU and 30 IU intraumbilical (p = 0.031). There was nodifference between the mean hematocrit levels between the groups(p> 0.005).   Conclusion: There were no differences in the dose of oxytocinintraumbilical towards the duration of the third stage, the amountof bleeding and hematocrit levels. The decrease of haemoglobingreater in 30 IU intraumbilical significantly. Keywords: duration of the third stage, haemoglobin and hematocrit,oxytocin intraumbilical, the amount of bleeding

Comparison between Leukocyte Esterase Activity (LEA) and Histopathology Examination in Identifying Chorioamnionitis Cases Novianesari, Putri H; Bernolian, Nuswil; Maulani, Henni; Ramadanti, Afifa; Theodorus, Theodorus
Indonesian Journal of Obstetrics and Gynecology Volume 7, No. 1 January 2019
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To compare sensitivity and specificity of LEA to histopathology examination in diagnosing chorioamnionitis. Methods: We compared diagnostic tests in dr. Mohammad Hoesin hospital, Palembang, from September 2015 to April 2016. Ninety-one pregnant women were included. LEA and histopathology examination were carried out with neonatal sepsis as main outcome. Data were analysed by SPSS version 21.0 and Med-calc statistic. Results: Chorioamnionitis was detected in 54 (77.1%) patients with gestational period ≥37 weeks and in 16 (22.9%) patients with gestational period <37 weeks. Duration of membrane rupture was significantly associated with chorioamnionitis (p = 0.001 and p = 0.011). Neonatal sepsis was also significantly associated with chorioamnionitis in both groups (p = 0.014 and p = 0.036). LEA value with cut-off point >0.5 was able to significantly predict chorioamnionitis with 98.6% sensitivity and 95.2% specificity, providing better accuracy in diagnosing chorioamnionitis in preterm pregnancy group. Conclusion: LEA had a very good predictive value for chorioamnionitis with better accuracy in diagnosing chorioamnionitis in preterm pregnancy. Keywords: Chorioamnionitis, Histopathology, Leukocyte esterase activity, Neonatal sepsis, Salafia criteria       Tujuan: Membandingkan sensitifitas dan spesifisitas diagnosis korioamnionitis antara pemeriksaan Leukocyte esterase activity (LEA) terhadap histopatologi. Metode: Penelitian uji diagnostik dilakukan di RSUP dr. Mohammad Hoesin Palembang selama periode September 2015 – April 2016,  91 wanita hamil yang memenuhi kriteria inklusi selanjutnya dilakukan pemeriksaan LEA, Histopatologi dan luaran sepsis neonatorum. Data kemudian dianalisis dengan menggunakan software SPSS versi 21.0 dan Med-calc statistic. Hasil: Korioamnionitis terdeteksi pada 54 (77,1%) pasien dengan usia gestasi ≥37 minggu dan 16 (22,9%) pada usia gestasi <37 minggu. Durasi lamanya pecah ketuban akan berpengaruh secara signifikan terhadap kejadian korioamnionitis (p = 0,001 dan p = 0,011), Sepsis neonatorum juga secara signifikan berhubungan dengan kejadian korioamnionitis pada kedua kelompok (p = 0,014 dan p = 0,036). Kadar LEA dengan cut off point >0,5 secara signifikan mampu memprediksi kejadian korioamnionitis dengan sensitivitas 98,6%, spesifisitas 95,2% dan nilai akurasi yang lebih baik ditemukan dalam penegakan diagnosis korioamnionitis pada kelompok kehamilan preterm. Kesimpulan: Pemeriksaan LEA memiliki kekuatan prediksi yang sangat baik terhadap kejadian korioamnionitis dengan akurasi yang lebih baik dalam mendiagnosis korioamnionitis pada kehamilan preterm. Kata kunci: Korioamnionitis, Histopatologi, Leukocyte Esterase Activity,Sepsis Neonatorum, Kriteria Salafia

Relationship of the Role of Counselor, Knowledge, Trust, Values, and Social Relationship in Contraception Acceptors’ Decision of Using Intrauterine Device (IUD) Sulbahri, Robby P.; Azhari, Azhari; Basir, Firmansyah; Theodorus, Theodorus
Indonesian Journal of Obstetrics and Gynecology Volume 7, No. 1 January 2019
Publisher : Indonesian Socety of Obstetrics and Gynecology

Abstract Objective: to assess the relationship of the role of counselor, knowledge, trust, values, and social relationship regarding acceptors’ decision in using intrauterine device at Dr. Mohammad Hoesin Hospital Palembang. Method: An observational analytical cross-sectional research carried out on June 2017 until September 2017 in the Department of Obstetrics and Gynecology Dr. Mohammad Hoesin General Hospital. 40 subjects were included. The frequency and distribution data were described in table form, bivariate analysis was performed to assess the relationship between independent and dependent variables statistically using Chi-square/Fisher Exact test. Multivariate analysis using logistic regression test was performed to assess which independent variable affects acceptors’ decision the most. Data analysis was performed using SPSS 18.0 version.  Results: There were no statistically differences in age, duration of marriage, parity, number of children born alive, abortion, education, and jobs between the two groups (p<0.05). There was statistically significant relationship between knowledge, social relationship, and the role of counselor with contraception acceptors’ decision (p<0.005), but there was no significant relationship between trust and values with contraception acceptors’ decision (p>0.05). Meanwhile, the logistic regression analysis showed that the role of counselor significantly affects contraception acceptors’ decision (PR=108.989, p value=0.002). Concluson: The role of counselor is a factor that affects contraception acceptors’ decision in using IUD. Keywords: IUD, role of counselor, social relationship, trust, values, knowledge   Abstrak Tujuan: untuk mengetahui hubungan faktor peran konselor, pengetahuan, kepercayaan, nilai, dan kekerabatan terhadap keputusan akseptor KB untuk menggunakan alat kontrasepsi IUD di Rumah Sakit Mohammad Hoesin Palembang. Metode: Penelitian analitik observasional rancangan cross sectional ini dilakukan di Departemen Obstetri dan Ginekologi Rumah Sakit Dr. Mohammad Hoesin/Fakultas Kedokteran Universitas Sriwijaya Palembang sejak bulan Juni sampai September 2017. Didapatkan sampel sebanyak 40 wanita melahirkan memenuhi kriteria inklusi. Frekuensi dan distribusi data dijelaskan dalam bentuk tabel, analisa bivariat untuk mengetahui ada tidaknya hubungan secara statistik antara variabel bebas dan dengan variabel terikat menggunakan uji Chi Square/Fisher Exact dan analisis multivariat untuk mengetahui variabel independen mana yang paling besar pengaruhnya terhadap keputusan akseptor KB untuk menggunakan alat kontrasepsi IUD menggunakan uji Regresi Logistik. Analisa data menggunakan SPSS versi 18.0. Hasil: Tidak terdapat perbedaan karakteristik pasien baik usia, lama pernikahan, paritas, jumlah anak hidup, abortus, pendidikan dan pekerjaan antara kedua kelompok (p<0,05). Terdapat hubungan yang signifikan antara pengetahuan, kekerabatan, dan peran konselor dengan keputusan akspetor KB IUD (p<0,05), namun tidak terdapat hubungan yang signifikan antara kepercayaan dan nilai dengan keputusan akspetor KB IUD (p  > 0,05).  Pada analisis regresi logistik didapatkan hasil peran konselor berpengaruh secara signifikan terhadap keputusan akseptor KB IUD (PR = 108,989, p value = 0,002). Keimpulan: Peran konselor merupakan faktor yang mempengaruhi keputusan akseptor KB untuk menggunakan alat kontrasepsi IUD. Kata Kunci: IUD, Peran Konselor, Kekerabatan, Kepercayaan Nilai, Pengetahuan.

Effectiveness of Oral Misoprostol to Prevent Postcesarean Section Urinary Retention Mahadika, Febrinata; Fauzi, Amir; Mirani, Putri; Theodorus, Theodorus
Indonesian Journal of Obstetrics and Gynecology Volume 6 No. 4 October 2018
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: to determine the effect of misoprostol on the incidence of urinary retention in post cesarean section patients by measuring maternal residual urine volume 6 hours after catheter removal. Methods: This was a single-blind randomized controlled trial, at Department of Obstetrics and Gynecology Mohammad Hoesin Palembang Hospital from October 2016 to February 2017. Samples were patients who underwent cesarean section, either elective or emergencies treated at Department of Obstetrics and Gynecology Hospital, Mohammad Hoesin Palembang. Subjects were allocated into two groups: treatment group (receiving misoprostol) and placebo group. Urinary retention is diagnosed if post-voiding residual urine volume after Foley catheter removal was > 200 ml. Statistical analysis was performed using SPSS 17.0 Results: There were no differences in mean time between of urination between control group (placebo) and 600μg oral misoprostol group. The average of urine volume, and residual urine volume between control group (placebo) and 600μg oral misoprostol group was significantly different. 600μg misoprostol orally can increase the amount of urine and reduce the volume of urinary residue after cesarean section. Conclusion: 600μg oral misoprostol can increase urine volume and reduce volume of residual urine post cesarean section Keywords: Misoprostol, urinary retention, cesarean section   Tujuan: untuk mengetahui pengaruh misoprostol terhadap kejadian retensi urin pada pasien operasi seksio sesaria dengan mengukur volume residu urin maternal 6 jam setelah kateter dilepaskan. Metode: Penelitian uji klinik acak berpembanding (Randomized Controlled Trial) secara single blind (tersamar tunggal) ini dilakukan di Departemen Obstetri dan Ginekologi RSUP Mohammad Hoesin Palembang mulai bulan Oktober 2016 sampai dengan Februari 2017. Sampel penelitian adalah semua pasien seksio sesaria, baik elektif maupun emergensi yang dirawat di Departemen Obstetri dan Ginekologi RSUP Mohammad Hoesin Palembang. Subjek dialokasikan menjadi 2 kelompok yaitu kelompok penanganan yang menerima misoprostol dan kelompok placebo. Retensio urin didiagnosis jika volume residu urin pasca berkemih setelah kateter Foley dilepaskan >200 ml. Analisis statistik dilakukan dengan menggunakan SPSS 17.0 Hasil:Tidak terdapat perbedaan rerata waktu urinasi antara kelompok kontrol (plasebo) dengan misoprostol peroral 600µg.Terdapat perbedaan rerata jumlah urine, dan volume residu urine antara kelompok kontrol (plasebo) dengan misoprostol peroral 600µg. Misoprostol per oral 600µg dapat meningkatkan jumlah urin dan mengurangi volume residu urin pasca persalian seksio sesaria. Kesimpulan:. Misoprostol per oral 600µg dapat meningkatkan jumlah urin dan mengurangi volume residu urin pasca persalian seksio sesaria Kata kunci: Misoprostol, retensio urin, seksio sesaria

Efektivitas Kitosan Terhadap Kadar Feritin Darah Dan Kadar Besi Hati Tikus Putih Wistar Jantan Iron Overload Model Daniatiek, Soneta; Kamaluddin, MT; Theodorus, Theodorus
Biomedical Journal of Indonesia: Jurnal Biomedik Fakultas Kedokteran Universitas Sriwijaya Vol 3, No 2 (2017)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

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ABSTRAKPenelitian terdahulu telah membuktikan penggunaan kitosan sebagai absorben logam berat seperti Zn, Mg, Cd, Cr, Fe dan Cu. Kitosan Hasil penelitian dari Seo et al. (1) menggunakan kitosan yang larut dalam air (kitosan dengan BM lebih rendah) untuk menyerap berbagai ion logam. Peneliti tertarik untuk mengetahui pengaruh kitosan sebagai chelating agent dalam menurunkan kadar feritin serum dan kadar besi hati pada tikus wistar model iron overload dengan membandingkan kelompok perlakuan dengan kelompok pemberian deferiprone. Penelitian ini eksperimental laboratorik in vivo. Sampel yang digunakan dalam penelitian ini adalah 30 ekor tikus putih jantan (Rattus norvegicus) galur wistar yang dibagi menjadi enam kelompok. Kelompok normal (N) yang tidak mendapat perlakuan, kelompok kontrol negatif (K-), yaitu kelompok yang mendapatkan induksi berupa iron sucrose 75 mg/kgBB selama lima minggu (tiga kali seminggu), kelompok perlakuan (P1, P2 dan P3) yang telah mendapatkan induksi iron sukrose dan diberikan kitosan dengan dosis 16 mg/kgBB, 32 mg/kgBB dan 64 mg/kgBB dan kelompok kontrol positif (K+) yang mendapatkan induksi iron sukrose dan obat deferiprone (DFP) 75 mg/kgBB. Berdasarkan hasil penelitian dan analisis data, dapat disimpulkan terdapat peningkatan kadar feritin serum dan kadar besi hati kelompok induksi dengan iron sukrose 75 mg/kgBB selama lima minggu dibandingkan dengan kelompok normal. Secara klinis, pemberian kitosan dosis 16 mg/kgBB lebih efektif menurunkan kadar feritin serum dibandingkan dengan pemberian kitosan dosis 32 mg/kgBB dan 64 mg/kgBB. Sedangkan kitosan dosis 64 mg/kgBB lebih efektif menurunkan kadar besi hati dibandingkan dengan pemberian kitosan dosis 16 mg/kgBB dan 32 mg/kgBB. Pemberian kitosan 16 mg/kgBB setara dengan pemberian deferiprone 75 mg/kgBB dalam menurunkan kadar feritin serum dan kitosan 64 mg/kgBB setara dengan deferiprone 75 mg/kgBB dalam menurunkan kadar besi hati.

Efektivitas Ekstrak Etanol Daun Salam (Eugenia polyantha) terhadap GLUT 4 di Jaringan Adiposa dan Kadar Gula Darah Puasa pada Tikus Putih Jantan Zanaria, Rima; Kamaluddin, MT; Theodorus, Theodorus
Biomedical Journal of Indonesia: Jurnal Biomedik Fakultas Kedokteran Universitas Sriwijaya Vol 3, No 3 (2017)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

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Diabetes Mellitus merupakan penyakit epidemik global, cenderung meningkat dengan berbagai kondisi patologis yang menyertainya, sehingga membutuhkan preparat baru yang poten,tidak toksik, efektif dalam pemberian dan harga terjangkau untuk mengevaluasi efektivitas ekstrak etanol dalam daun salam (Eugenia polyantha) terhadap GLUT 4 di jaringan adiposa dan kadar gula darah puasa tikus putih jantan galur wistar (Rattus norvegicus) yang diinduksi diet tinggi lemak (HFD-dexamethasone. Desain penelitian ini adalah ekperimental, rancangan pre dan post test dengan kelompok kontrol dilakukan di Animal house Fakultas Kedokteran Universitas Sriwijaya. Tiga puluh enam ekor tikus dengan berat antara 150 - 200 gram secara acak dibagi menjadi 6 kelompok. Setelah di aklimatisasi selama 7 hari dan diinduksi dengan high fat diet 5 ml per oral serta dexamethasone 250 µg/kgbb intraperitoneal selama 35 hari. Kelompok kontrol (-) diberi larutan aquades sebanyak 2 ml, kelompok pertama diberi ekstrak ethanol daun salam dosis 62,5 per kilogram berat badan, kelompok kedua diberi ekstrak ethanol daun salam dosis 125 mg per kilogram berat badan, kelompok ketiga diberi ekstrak etanol daun salam dosis 250 mg per kilogram berat badan, kontrol (+) diberi Pioglithazone dosis 0,02 gram per kilogram berat badan. Semua perlakuan diberikan selama 14 hari. Data diperoleh dengan analisis ANOVA dan post hoct test spss versi 18. Induksi HFD /dexamethasone pada tikus selama 35 hari menujukan peningkatan kadar glukosa darah secara signifikan lalu tikus dieutanasia dengan ketamin 70 mg/kgbb intraperitoneal lalu dilakukan autopsi dan diambil jaringan adiposa. Intervensi ekstrak ethanol daun salam selama 14 hari pada tikus diabetes mellitus efektif meningkatkan kadar GLUT 4 di jaringan adiposa (p<0,05) dibanding kontrol negatif dan Pioglitazone, Ekstrak etanol daun salam dosis 125 mg per kilogram berat badan tikus merupakan dosis paling efektif dalam meningkatkan GLUT 4 dijaringan adiposa, sedangkan dalam menurunkan kadar gula darah puasa dosis 62,5 mg/kgbb tikus, 125 mg/kgbb tikus,250 mg/kgbb tikus sama efektifnya dengan kontrol positif obat pioglithazone. Ekstrak etanol daun salam (Eugenia polyantha) berpotensi meningkatkan kadar GLUT 4 di jaringan adiposa tikus dan menurunkan kadar gula darah puasa pada tikus putih jantan (Rattus norvegicus) galur wistar yang diinduksi HFD/dexametasone. Kata kunci : Ektrak Etanol daun salam, HFD/Dexamethasone, GLUT 4 di jaringan adiposa, in Vivo

Placental Factors Affecting Birth Weight of Late Onset Severe Preeclampsia Martadiansyah, A; Pangemanan, W T; Bernolian, N; Maulani, H; Theodorus, Theodorus
Sriwijaya Journal of Medicine Vol. 1 No. 3 (2018): Sriwijaya Journal of Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

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Objective of the study is to determine the correlation of placenta and birth weight in late onset preeclampsia. A case-control study,analysis prevalence was conducted in Moh Hoesin Hospital Palembang from August 2015 to August 2016. Samples were women who giving birth in Moh Hoesin Hospital Palembang. They were devided into two groups, severe preeclampsia as case group and normotension as control. Data were analyzed by X2, Exact Fisherâ€™s and logistic regression test using SPSS 16.0. There were 180 subjects (90 cases and 90 controls). There was a positive correlation between placental macroscopic and late onset preeclampsia (p=0.009; OR=6.9), in contrast there was only one different placental microvascularisation of 16, between late onset preeclampsia and normotension, the mural or occlusive fibrin thrombi chorion (p=0.005; OR=9.9). Birth weight in late onset preeclampsia tended to be small but still in normal range and it was not statistictly significant (p=0.112; OR=10.4). There was a positive correlation between placental macroscopic and SGA baby on late onset preeclampsia (p=0.026; OR=16.6), but it wasnot proven microscopically. Placenta remains contributed to the pathogenesis of the late onset preeclampsia, but not as dominant as the early one.

EFFECTIVENESS OF GARLIC WATER EXTRACT GEL (ALLIUM SATIVUM. L) AGAINST NECROTIC FACTOR ALFA TUMORS AND MOUTH ULCER DIAMETER IN WISTAR WHITE MALE RATS Anggraeni, Dian; Kamaluddin, Kamaluddin; Theodorus, Theodorus
Biomedical Journal of Indonesia Vol 6, No 1 (2020)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v6i1.7970

Oral ulcers are pathological conditions that are characterized by loss of epithelial tissue, causing inflammation. During inflammation, the inflammatory mediator is TNF will increase. Therefore, drugs are needed to suppress TNF-levels to suppress inflammation. One of the herbal ingredients that can suppress inflammation is garlic. In vivo laboratory experimental research with pre-post systems. The samples used were 36 male Wistar white rats divided into 6 groups (6 individuals / groups), namely the group without drug treatment (as pre-treatment data), negative control group namely HPMC gel base, positive control given benzydamin, group treatment I was given a garlic water extract gel 20%, treatment group II was given a garlic water extract gel 40%, treatment group III were given a garlic water extract gel 80%. The drug is given topically 2 times a day for 4 days. Making oral ulcers is done by placing filter paper that has been soaked in a 50% acetic acid solution in the labial area of the mandibular gingival tissue. Measurement of oral ulcers was performed on the 1st day after the manufacture of oral ulcers and the 5th day. On the 5th day all the mice were sacrificed to be taken gingival tissue and TNF-levels were measured. using ELISA. Data analysis using SPSS version 24 and One Way Anova test with 5% specification followed by Post Hoc Test using LSD test and Games Howell. Analysis using One Way Anova showed that there were significant differences in TNF-levels and the diameter of the oral ulcer (p <0.05) between groups which indicated that the garlic water extract gel applied in the area of the oral ulcer affected TNF levels. and the diameter of the oral ulcer. LSD test results showed that 80% effective garlic water extract gel significantly reduced TNF levels. (p <0.05). Games Howell test results showed that 20%, 40% and 80% garlic water extract gel had the same effectiveness as benzydamin in decreasing the diameter of oral ulcer. Garlic water extract gel (Allium sativum. L) concentration was 80% more effective than benzydamin for decreasing TNF levels Garlic water extract gel (Allium sativum. L) concentrations of 20%, 40% and 80% are as effective as benzydamin in reducing the diameter of oral ulcers in male wistar strain rats.

Co-Authors Abrar Arbhiwa Tanguirsyaf Siregar Abu Bakar Lutfi Adenan Abadi Adenan Abadi admin Adnan Abadi Asnawi Adnan Abadi, Adnan Afifa Ramadanti Agustina Br. Haloho Agustinus William Agustria Z. Saleh Amarel, Fahma Alfarizqy Amir Fauzi Amirah Novaliani Anak Agung Gede Sugianthara Anang Tribowo Andriani, R.A. Linda Andriansyah, Yulius Andrina, Hana Anugrah Onie Awan Nurtjahyo Awan Nurtjahyo Azhar Susanto Azhari Azhari Azhari Rozali B, Firmansyah Benedictus Wicaksono Widodo Bernolian, N Bernolian, N Billy Sujatmiko D Saputra, Akbar N D.Y. Riyanto, D.Y. Dahler Bahrun Daniatiek, Soneta Dastamuar, Shalita Debby Handayani Harahap Debby Handayati Harahap Devy Octarina Ditto Ruldifar Pribadi Doni Kurniawan Dwi Tantri Marylin Ellen Callista Angelica Elvi Widiastuti Elza Iskandar, Elza Evi Lusiana F, Amir Fahma Alfarizqy Amarel Fakhrudit, Emir Fatimah Syakirah Fauzit, Amir Fedriyansyah Fedriyansyah Ferdi, Roni Ferry Yusrizal Firmansyah Basir Fita Asfianti Forbes, Darlin Gita Dwi Prasasty H.M. Nazir H.M. Nazir Haidar Ali Hamzah Harahap, Debby Handayani Heriansyah, Jhon Hidayat, Syarief Taufik Hilmawan, Bagus HM Nazir Hz Ika Kartika Indira, Tissa Ismail Bastomi, Ismail Julius Anzar Kamaluddin Kamaluddin Kamaluddin, MT Kamaluddin, MT Khrismawan Khrismawan Kiagus Ahmad Imanuddin Kms Yusuf Effendi Kms Yusuf Effendy Kusuma Harimin Leni Wijaya, Leni Lestari, Mayang Indah Lorenza, Geofanny Lutfi, Abu Bakar M Kamaluddin M. T. Kamaluddin Mahacakri, Eke P Mahadika, Febrinata Manan, Heriyadi Marta Hendry, Marta Martadiansyah, Abarham Maulani, H Maulani, H Maulani, Henni Mgs. Irsan Saleh, Mgs. Irsan Mgs. M. Irsan Saleh Muhammad Despriansyah Romadhan Muhammad Hafidh Komar Muhammad Irsan Saleh Muhammad Totong Kamaluddin Mulawan Umar Muzakkie Muzakkie, Muzakkie Nadhif, Aufa Muhammad Nita Parisa Nopriansyah Darwin Novianesari, Putri H Novianty, Novianty Nugraha, M Daffa Nugroho, Achmadi S Nur Qodir Nurul Islamy Nuswil Bernolian Octarina, Bertha Oktariana, Desi Pangemanan, W T Pangemanan, W T Pangemanan, Wim T PATIYUS AGUSTIANSYAH, PATIYUS Puspita, Yusni Putri Mahirah Afladhanti Putri Mirani Raden Ayu Kusuma Andini Rafiyandi Rafiyandi Rahima Rahima Renny Apliza Nasution Resiana Resiana Riani Erna Rika Saputri Rini Purnamasari Risa Vera Rizal Sanif Rizani Amran Rogatianus Bagus Pratignyo Rose Mafiana Rostika Flora Rostika Flora Rusydi, Syakroni D Sabrina, Tia Safa Nabila Putri Sahab, Abdullah Saleh, Masagus Irsan Salni Sari Octarina Piko Sastradinata, Irawan Shaleh, Agustria Z Silvana, Rista Silvia Triratna Siti Rusdiana Puspa Dewi Sonlimar mangunsong Stevanny, Bella Sudarto Sudarto Sujatmiko, Billy Sulbahri, Robby P. Suriani Rosida Sutomo Tanzil Syarif Husin Syarif Husin Tahany, Hanifah Tanzil, Sutomo Tindar, Mirzah Tissa Indira Usman, Fatimah Veronita Veronita Veronita, Veronita Wahyu Pranata, Wahyu Pranata Yohanes Febrianto Yulia Iriani, Yulia Yuliana Yuliana Yundari, Yundari Yusuf, Kemas Zainal, Rizal Zanaria, Rima Zulkifli Zulkifli

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