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All Journal International Journal of Public Health Science (IJPHS) MEDIA MEDIKA INDONESIANA Jurnal Anestesi Perioperatif Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Indonesian Journal of Cancer Chemoprevention Majalah Kedokteran Sriwijaya Sari Pediatri Biomedical Journal of Indonesia Jurnal Kedokteran Gigi Universitas Padjadjaran Jurnal Kedokteran dan Kesehatan Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan Indonesian Journal of Obstetrics & Gynecology Science Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Jurnal Ilmu Kedokteran dan Kesehatan Oceana Biomedicina Journal SRIWIJAYA JOURNAL OF MEDICINE Majalah Anestesia dan Critical Care Bioscientia Medicina : Journal of Biomedicine and Translational Research Sriwijaya Journal of Surgery Jurnal Kesehatan dan Pembangunan INTELEKTIUM Bioscientia Medicina : Journal of Biomedicine and Translational Research International Journal of Islamic and Complementary Medicine Journal of Pharmascience
Theodorus Theodorus
Bagian Farmakologi Fakultas Kedokteran Universitas Sriwijaya
Religion Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Other

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Correlation between Elevated Nerve Growth Factor mRNA Expression with Pain Intensity or Disease Severity in Endometriosis Octarina, Bertha; Abadi, Adnan; Hidayat, Syarief Taufik; Usman, Fatimah; Saleh, Masagus Irsan; Theodorus, Theodorus; Stevanny, Bella
Indonesian Journal of Obstetrics & Gynecology Science Volume 8 Nomor 2 July 2025
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v8i2.908

Abstract

Objective: analyzed the relationship between NGF mRNA expression and pain levels and severity of endometriosis.Methods: This research involved 30 endometriosis patients undergoing surgery from November 2024 to April 2025. NGF mRNA expression was measured in blood plasma and ectopic tissue. Pain history was assessed retrospectively, and disease stage determined intraoperatively.Results: No significant relationship was found between NGF mRNA expression and pain levels or severity of endometriosis in either plasma or lesion tissue. Based on the Livak method analysis, the average value of relative expression of NGF gene mRNA increased 6.943-fold in blood plasma and 17.319-fold in endometriosis lesions of women with endometriosis. In the Mann Whitney test, there was a significant difference in the level of NGF gene mRNA expression between blood plasma and with p < 0.0001. NGF expression may not always correlate with disease severity because it is influenced by many factors.Conclusion: No significant correlation was found between NGF mRNA expression and endometriosis severity or pain intensity, but expression levels differed significantly between plasma and lesion tissue.
Etlingera elatior Compounds as Anticancer Agents of Breast Cancer Through Inhibition of Progesterone Receptor: An In Silico Study Afladhanti, Putri Mahirah; Hamzah, Haidar Ali; Romadhan, Muhammad Despriansyah; Putri, Safa Nabila; Angelica, Ellen Callista; Theodorus, Theodorus
Indonesian Journal of Cancer Chemoprevention Vol 14, No 2 (2023)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev14iss2pp94-104

Abstract

Breast cancer is the leading cause of cancer-related death in women globally. Progesterone receptor (PR) is known as the prime example of receptors amenable to targeted breast cancer drug therapy. Etlingera elatior is an herbal plant that has been renowned to have anticancer effect. This study aimed to identify the potential compounds derived from Etlingera elatior as anticancer agents of PR in breast cancer using molecular docking method. This study used fifteen compounds from Etlingera elatior along with lonaprisan as the comparative drug. The PR was downloaded from RCSB, whereas compounds and lonaprisan were from Pubchem. The drug-likeness test based on Lipinski’s rule of five was conducted using SwissADME. Toxicity analysis using admetSAR 2.0 was used to predict toxicological profile of the compounds. Compounds and lonaprisan were docked on PR using AutoDock tools 1.5.6 and AutoDock Vina 1.1.2. Molecular interactions were visualized by Discovery Studio v16. A total of nine compounds met the criteria as drugs based on drug-likeness and toxicity tests. All nine compounds except caffeic acid and vanillic acid had higher binding affinities on PR compared with lonaprisan. Ergosterol peroxide exhibited the highest binding affinity on PR with values of -9.8 kcal/mol. Moreover, ergosterol peroxide-PR interaction had thirteen hydrophobic bonds and a hydrogen bond with amino acid residues were found in the active site of PR. Most of the compounds found in Etlingera elatior have the potential to be anticancer agents of PR in breast cancer with ergosterol peroxide being the most potential compound. Further in vitro and in vivo research are needed.Keywords: breast cancer, ergosterol peroxide, Etlingera elatior, progesterone receptor, in silico.
Spiritualitas Seorang Pemimpin Kristen (Implikasi Kitab Nemia) Esterani, Esterani; Theodorus, Theodorus; Resti, Resti; Weldy, Weldy; Dandi, Dandi
INTELEKTIUM Vol 5 No 2 (2024): INTELEKTIUM
Publisher : Neolectura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37010/int.v5i2.1678

Abstract

Leadership is a familiar topic of discussion. In this era of globalization, leadership has increasingly become a subject of human attention. Numerous pieces of literature on leadership can be found, and seminars, workshops, and meetings discussing leadership are held everywhere. This shows that today, people place significant emphasis on leadership. Leadership is a determining factor in the success or failure of achieving goals in any community. The church, as a community, also recognizes the importance of leadership in achieving its objectives. The accomplishment of goals is closely tied to the role of a leader. Therefore, specific qualifications are needed for a Christian leader. One essential qualification for a Christian leader is spiritual qualification. This journal discusses the spiritual qualifications of a Christian leader, drawing implications from the Book of Nehemiah. One of the key factors contributing to Nehemiah's success in leadership was his spirituality.
Peran Optimasi Media TI dalam Pembelajaran Pendidikan Agama Kristen di SMP N 1 Ledo Esterani, Esterani; Theodorus, Theodorus; Resti, Resti; Weldy, Weldy; Dandi, Dandi
INTELEKTIUM Vol 5 No 2 (2024): INTELEKTIUM
Publisher : Neolectura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37010/int.v5i2.1679

Abstract

The use of IT-based media in education systems has continuously risen, and the digital era has provided a great opportunity to integrate any media in the process of learning. This research will present an assessment of the role of optimized IT media in CRE at SMP N 1 Ledo. A qualitative approach with the case study method is used to gain depth into how IT media influences the learning process in this particular context. The findings of the case study reveal that IT media implementation increased both student activity and enhanced learning achievements of students in the subject of CRE. Furthermore, IT-based media make learning more interactive and fun for students; in this way, students can manage to retain concentration and sustain motivation throughout the entire learning process. Secondly, it has been indicated that IT media has to be duly developed and maintained if it is ever going to serve its full purpose in the classroom. If no support is given from time to time and technical developments are not made, the effectiveness of IT media might be rendered gradually useless. It also confirms that teachers need sufficient training and support so that they would feel confident in their contribution to students via the integration of technology into teaching. Capability of easily combining traditional approaches with the aid of digital tools generally increases the level of learning. The results of this research then demonstrate that IT media is capable of enhancing the effectiveness of Christian Religious Education, especially in making learning more interactive and fun for students. They also indicate the necessity for continuous professional development of teachers themselves so that teachers are able to keep up with the times and make use of these facilities appropriately in teaching
CENTELLA ASIATICA EXTRACT EFFECT ON POSTOPERATIVE WOUND HEALING Iskandar, Elza; Theodorus, Theodorus; Tribowo, Anang; Erna, Riani; Syakirah, Fatimah
International Journal of Islamic and Complementary Medicine Vol. 2 No. 2 (2021): International Journal Islamic Medicine
Publisher : International Islamic Medicine Forum

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (444.052 KB) | DOI: 10.55116/IJIM.V1I1.28

Abstract

Wound healing is a complex process that is divided into four phases, namely the hemostasis, inflammation, proliferation, and tissue remodeling phase. Centella asiatica is a widely used and very popular traditional plant in the field of health for a long time. Various in vitro and in vivo studies have proven the efficacy of Centella asiatica extract in the wound healing process. This literature review uses literature search methods from Pubmed, Science Direct, and Cochrane Library with keywords Centella asiatica, wound healing, surgery. This study aims to study the effects of Centella asiatica extract on postoperative wound healing.
Single Nucleotide Polymorphism rs1800497 in Risperidone and Aripiprazole Therapy for Schizophrenia Patients Benedictus Wicaksono Widodo; Mgs. M. Irsan Saleh; Theodorus Theodorus
Journal of Pharmascience Vol. 8 No. 2 (2021): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v8i2.10514

Abstract

Schizophrenia is a variable of psychopathologic syndrome involving cognition, emotion, perception, and other behavioral aspects. Therapies on schizophrenia is solely based on history of mental illnesses and mental status. Schizophrenia affecting 1.1 million persons globally in 2017; 70.8% of them happened in 25-55 years old. This study was conducted in mental hospital in Palembang, Indonesia. Blood samples was taken from clinically diagnosed schizophrenia patients (20 patients taking aripiprazole and 60 patients taking risperidone) under therapy. DNA was extracted using Chelex 100 method and digested using Taq1 enzyme. DNA was electrophoresized and visualized. CC allele was found in 10% of patients taking aripiprazole and 11.67% patients taking risperidone. CT allele was found in 70% patients taking aripiprazole and 76.67% patients taking risperidone. TT allele was found in 20% patients taking aripiprazole and 11.67% patients taking risperidone. ANKK1 Taq1A polymorphism in schizophrenia patients shows different therapeutic response with worse therapeutic response compared to patients with normal allele.
Diagnostic Accuracy of the Modified ABSI Versus the Revised Baux Score for In-Hospital Mortality Prediction in Adult Burn Patients at a Tertiary Indonesian Burn Centre Ilham Taufan Ikramiawan; Abda Arif; Theodorus
Sriwijaya Journal of Surgery Vol. 9 No. 1 (2026): Sriwijaya Journal of Surgery
Publisher : Surgery Department, Faculty of Medicine Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/sjs.v9i1.148

Abstract

Introduction: Rapid bedside risk stratification of burn-injured patients informs intensive-care admission, fluid-resuscitation intensity, and timing of early surgical excision and grafting. The Modified Abbreviated Burn Severity Index (mABSI) and the Revised Baux (R-Baux) score are widely cited but have not previously been compared head-to-head in a Sumatran tertiary burn unit. Methods: STARD-aligned retrospective diagnostic-accuracy study of consecutive thermal-burn patients admitted to the Burn Unit, Dr. Mohammad Hoesin General Hospital Palembang (January–December 2025). Patients with concurrent major trauma or incomplete records were excluded. Both scores were calculated from medical records by an investigator blinded to the outcome. In-hospital mortality was the reference standard. Receiver-operating-characteristic, Wilson-CI sensitivity/specificity, DeLong AUC comparison, McNemar paired test, and Cohen's κ analyses were performed in SPSS v25 (α = 0.05). Results: Of 45 included patients (mean age 40.8 years; 77.8% male; 64.4% fire burns), 20 (44.4%) died. Optimal cutoffs were mABSI ≥ 5 (AUC 0.811, 95% CI 0.688–0.934; sensitivity 72.0%, specificity 75.0%, Youden 0.47) and R-Baux > 60 (AUC 0.808, 95% CI 0.678–0.938; sensitivity 52.0%, specificity 82.0%, Youden 0.34). Inter-test agreement was substantial (κ = 0.69, 95% CI 0.48–0.90; p < 0.001), with overall accuracy of 84.4% when R-Baux was treated as the comparator. Conclusion: Both scores discriminated burn mortality well; the Modified ABSI offered higher sensitivity and Youden index, supporting its evaluation as a primary triage tool in similar Indonesian tertiary burn units, while the Revised Baux retained complementary specificity for confirmatory risk classification.
Marshall CT Classification as an Early Radiological Predictor of In-Hospital Mortality in Adult Surgical Traumatic Brain Injury: A Tertiary Indonesian Cohort Study Vandy Ikra; Trijoso Permono; Theodorus
Sriwijaya Journal of Surgery Vol. 9 No. 1 (2026): Sriwijaya Journal of Surgery
Publisher : Surgery Department, Faculty of Medicine Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/sjs.v9i1.150

Abstract

Introduction: Computed tomography (CT) classification anchors surgical triage in traumatic brain injury (TBI), but contemporary Indonesian data on the prognostic performance of the Marshall CT score in surgically managed patients are scarce. Methods: An observational retrospective cohort study was conducted at Dr. Mohammad Hoesin Central General Hospital, Palembang. Consecutive adult surgical TBI patients operated on between January 2023 and December 2025 were enrolled. Marshall CT categories were assigned from non-contrast head CT scans by two independent raters (κ = 0.87). The primary outcome was in-hospital mortality. We quantified the association between Marshall score and in-hospital mortality using Spearman rank correlation, point-biserial correlation, penalised L2 logistic regression, and ROC analysis. Results: Thirty-six patients met the inclusion criteria (75.0% male; median age 25 years). In-hospital mortality was 19.4% (7/36; 95% CI 9.8–35.0%). Spearman correlation between Marshall score and mortality was ρ = 0.532 (95% CI 0.245–0.731, p = 0.001). Marshall category was an independent predictor in penalised logistic regression (adjusted OR 3.12, 95% CI 1.63–4.41; p = 0.013). ROC AUC was 0.852 (95% CI 0.724–0.960), numerically superior to admission GCS AUC of 0.778 (DeLong p = 0.298). Conclusion: Marshall CT classification is an independent, point-of-CT predictor of in-hospital mortality after surgery for TBI in an Indonesian tertiary cohort. Integration into structured operative triage may enhance early risk stratification.
Serum Calcium as a Preoperative Surrogate of Tumour Burden in Stage III Breast Carcinoma: A Cross-Sectional Surgical-Oncology Study Feizal Faturahman; Mulawan Umar; Theodorus
Sriwijaya Journal of Surgery Vol. 9 No. 1 (2026): Sriwijaya Journal of Surgery
Publisher : Surgery Department, Faculty of Medicine Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/sjs.v9i1.153

Abstract

Introduction: Stage III breast carcinoma dominates surgical-oncology practice in Indonesian referral hospitals. Tumour-secreted PTHrP and dysregulated calcium signalling link tumour mass to systemic calcium, yet routinely available serum calcium is rarely quantified as a preoperative surrogate of tumour burden. Methods: In this cross-sectional study, 35 women with Stage III breast carcinoma at Dr. Mohammad Hoesin General Hospital Palembang underwent preoperative serum calcium measurement. Tumour size was dichotomised (≤5 cm vs >5 cm). Associations were tested by Spearman correlation and the Mann–Whitney U test; serum calcium was assessed as a classifier of large tumours by ROC analysis, with multivariable logistic regression, effect sizes and 95% confidence intervals (CI). Results: Mean serum calcium was 9.34 ± 0.82 mg/dL, and 27 patients (77.1%) had tumours >5 cm. Calcium was higher in tumours >5 cm (9.58 ± 0.76 mg/dL; 95% CI 9.28–9.88) than ≤5 cm (8.54 ± 0.37 mg/dL; 95% CI 8.23–8.85), a difference of 1.04 mg/dL (95% CI 0.66–1.43; Cohen d = 1.50; Mann–Whitney U = 0.000; p < 0.001; r = 0.72). Calcium correlated with size (Spearman rho = 0.731; p < 0.001) and discriminated tumours >5 cm (area under the curve 1.000; cut-off 8.95 mg/dL; sensitivity and specificity 100%). Immunohistochemical subtype was the only independent predictor (adjusted odds ratio 71.37; 95% CI 2.95–1728; p = 0.009). Conclusion: Preoperative serum calcium rose in proportion to tumour size in Stage III breast carcinoma, acting as a low-cost surrogate of tumour burden that may aid risk stratification in resource-limited centres, pending validation.
Co-Authors Abda Arif Abrar Arbhiwa Tanguirsyaf Siregar Abu Bakar Lutfi Adenan Abadi Adenan Abadi admin Adnan Abadi Asnawi Adnan Abadi, Adnan Afifa Ramadanti Afladhanti, Putri Mahirah Agustina Br. Haloho Agustinus William Agustria Z. Saleh Amarel, Fahma Alfarizqy Amir Fauzi Amirah Novaliani Anak Agung Gede Sugianthara Andriani, R.A. Linda Andriansyah, Yulius Andrina, Hana Angelica, Ellen Callista Anugrah Onie Awan Nurtjahyo Awan Nurtjahyo Azhar Susanto Azhari Azhari Azhari Rozali B, Firmansyah Benedictus Wicaksono Widodo Bernolian, N Bernolian, N Billy Sujatmiko D Saputra, Akbar N D.Y. Riyanto, D.Y. Dahler Bahrun Dandi, Dandi Daniatiek, Soneta Dastamuar, Shalita Debby Handayani Harahap Debby Handayati Harahap Devy Octarina Ditto Ruldifar Pribadi Doni Kurniawan Dwi Tantri Marylin Elvi Widiastuti Elza Iskandar, Elza Esterani, Esterani Evi Lusiana F, Amir Fahma Alfarizqy Amarel Fakhrudit, Emir Fauzit, Amir Fedriyansyah Fedriyansyah Feizal Faturahman Ferdi, Roni Ferry Yusrizal Firmansyah Basir Fita Asfianti Forbes, Darlin Gita Dwi Prasasty H.M. Nazir H.M. Nazir Hamzah, Haidar Ali Harahap, Debby Handayani Heriansyah, Jhon Hidayat, Syarief Taufik Hilmawan, Bagus HM Nazir Hz Ika Kartika Ilham Taufan Ikramiawan Indira, Tissa Ismail Bastomi, Ismail Julius Anzar Kamaluddin Kamaluddin Kamaluddin, MT Kamaluddin, MT Khrismawan Khrismawan Kms Yusuf Effendi Kms Yusuf Effendy Kusuma Harimin Leni Wijaya, Leni Lestari, Mayang Indah Lorenza, Geofanny Lutfi, Abu Bakar M Kamaluddin M. T. Kamaluddin Mahacakri, Eke P Mahadika, Febrinata Manan, Heriyadi Marta Hendry, Marta Martadiansyah, Abarham Maulani, H Maulani, H Maulani, Henni Mgs. Irsan Saleh, Mgs. Irsan Mgs. M. Irsan Saleh Muhammad Irsan Saleh Muhammad Totong Kamaluddin Mulawan Umar Mulawan Umar Muzakkie Muzakkie, Muzakkie Nadhif, Aufa Muhammad Nita Parisa Nopriansyah Darwin Novianesari, Putri H Novianty, Novianty Nugraha, M Daffa Nugroho, Achmadi S Nur Qodir Nurul Islamy Nuswil Bernolian Octarina, Bertha Oktariana, Desi Pangemanan, W T Pangemanan, W T Pangemanan, Wim T PATIYUS AGUSTIANSYAH, PATIYUS Puspita, Yusni Putri Mirani Putri, Safa Nabila Raden Ayu Kusuma Andini Rafiyandi Rafiyandi Rahima Rahima Renny Apliza Nasution Resiana Resiana Resti Resti Riani Erna, Riani Rika Saputri Rini Purnamasari Risa Vera Rizal Sanif Rizani Amran Rogatianus Bagus Pratignyo Romadhan, Muhammad Despriansyah Rose Mafiana Rostika Flora Rostika Flora Rusydi, Syakroni D Sabrina, Tia Sahab, Abdullah Saleh, Masagus Irsan Salni Sari Octarina Piko Sastradinata, Irawan Shaleh, Agustria Z Silvana, Rista Silvia Triratna Siti Rusdiana Puspa Dewi Sonlimar mangunsong Stevanny, Bella Sudarto Sudarto Sujatmiko, Billy Sulbahri, Robby P. Suriani Rosida Sutomo Tanzil Syakirah, Fatimah Syarif Husin Syarif Husin Tahany, Hanifah Tanzil, Sutomo Tindar, Mirzah Tissa Indira Tribowo, Anang Trijoso Permono Usman, Fatimah Vandy Ikra Veronita Veronita Veronita, Veronita Wahyu Pranata, Wahyu Pranata Weldy, Weldy Yohanes Febrianto Yulia Iriani, Yulia Yuliana Yuliana Yundari, Yundari Yusuf, Kemas Zainal, Rizal Zanaria, Rima Zulkifli Zulkifli