Garuda - Garba Rujukan Digital

p-Index From 2020 - 2025

4.221

P-Index

This Author published in this journals

All Journal International Journal of Public Health Science (IJPHS) MEDIA MEDIKA INDONESIANA Jurnal Anestesi Perioperatif Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Medical Journal of Indonesia Indonesian Journal of Cancer Chemoprevention Pharmascience Majalah Kedokteran Sriwijaya Sari Pediatri Biomedical Journal of Indonesia Jurnal Kedokteran Gigi Universitas Padjadjaran Jurnal Kedokteran dan Kesehatan Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan Indonesian Journal of Obstetrics & Gynecology Science Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Jurnal Ilmu Kedokteran dan Kesehatan Oceana Biomedicina Journal SRIWIJAYA JOURNAL OF MEDICINE Majalah Anestesia dan Critical Care Bioscientia Medicina : Journal of Biomedicine and Translational Research Sriwijaya Journal of Surgery Jurnal Kesehatan dan Pembangunan Bioscientia Medicina : Journal of Biomedicine and Translational Research International Journal of Islamic and Complementary Medicine

Theodorus Theodorus

Bagian Farmakologi Fakultas Kedokteran Universitas Sriwijaya

Author-ID : 403007

Religion Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Physics Public Health

Published : 66 Documents Claim Missing Document

Claim Missing Document

Articles

2 3 4 5 6

RATIONALIZATION OF CALCIUM ANTAGONIST IN PREECLAMPSIA Novianty, Novianty; Tanzil, Sutomo; Theodorus, Theodorus
Biomedical Journal of Indonesia Vol 5, No 2 (2019)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v5i2.7984

Preeclampsia is a hypertension condition after the 20th week of pregnancy with proteinuria. Eclampsia is a preeclampsia with convulsion and or coma. In Indonesia preeclampsia and eclampsia still one of the main causes of maternal and perinatal mortality. The aim of this study was to know the pattern of utilization of calcium antagonists in hypertension in pregnancy in Mohammad Hoesin Hospital. Drug utilization study has been done at medical records ward in November until December 2013. The population is medical records of hypertension in pregnancy patients at The Medical Record Installation of Obstetrics and Gynecology Department of Mohammad Hoesin Hospital from July until December 2012. The sample is 63 medical records which fulfill the inclusion criteria. The result is tabulated in percentage and presented descriptively. There were 63 pregnant women with hypertension. Hypertension in pregnant women aged between 33 till 37 years old (40%). Hypertension in pregnant women was found in first pregnancy (11.3%). Hypertension in pregnant women was hypertension stage two (68.2%). Calcium antagonists that mainly used were nifedipine and amlodipine. Nifedipine was given orally in 10 mg dose three times daily (100%). Amlodipine was given orally in 10 mg dose once a day (100%). The most frequent drug that was given at the same time with hypertension drugs is magnesium sulphate (89%). The use of calcium antagonists in hypertension in pregnancy at Obstetrics and Gynecology Department of Mohammad Hoesin Hospital has been rational

ANTIBACTERIAL EFFECT PROPOLIS AGAINST ESCHERICHIA COLI AND SHIGELLA DYSENTERIAE IN VITRO Ferdi, Roni; Saleh, Irsan; Theodorus, Theodorus; Salni, Salni
Biomedical Journal of Indonesia Vol 5, No 2 (2019)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v5i2.7982

The bacteria that often cause infectious diarrhea are Escherichia coli and Shigella dysenteriae. Excessive and less rational use of antibiotics in diarrhea cases encourages the development of multi drug pathogen resistance. Propolis is one solution to overcome diarrheal infections. The purpose of this study was to determine the ability of the antibacterial effects of propolis extract on Escherichia coli and Shigella dysenteriae bacteria in in vitro testing with various concentrations. Research in laboratory experiments in vitro. The sample in this study was the bacteria Escherichia coli and Shigella dysenteriae with the stages of research starting from the extraction process carried out using a multilevel extraction method. The results showed that the smallest concentration of n-hexane fraction which still inhibited the growth of Escherichia coli and Shigella dysenteriae bacteria was 250 µg / ml and this concentration was expressed as KHM value. The equality test of 250 µg / ml n-hexane propolis fraction was equivalent to 4.0 µg / ml ciprofloxacin to Escherichia coli and equivalent to 4.6 µg / ml ciprofloxacin against Shigella dysenteriae, while the equality test concentration of 250 µg / ml ethyl acetate propolis equivalent to 5.2 µg / ml of ciprofloxacin against Escherichia coli and equivalent to 4.5 µg / ml of ciprofloxacin against Shigella dysenteriae. The conclusion of this study is that n-hexane extract and ethyl acetate propolis have antibacterial effectiveness against Escherichia coli and Shigella dysenteriae. The n-hexane and ethyl acetate propolis fractions have lower antibacterial activity compared to ciprofloxacin in inhibiting the growth of Escherichia coli and Shigella dysenteriae. Antibacterial compounds contained in the n-hexane fraction and ethyl acetate propolis are flavonoids and phenol

Efektivitas Pemberian Ekstrak Daun Jati Belanda (Guazuma Ulmifolia Lam) terhadap Kadar CRP pada Tikus Wistar Model Kontusio Pulmonum Nadhif, Aufa Muhammad; Kamaluddin, M. T.; Theodorus, Theodorus
Sriwijaya Journal of Medicine Vol. 3 No. 1 (2020): Sriwijaya Journal of Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar

Guazuma ulmifolia Lam is a plant with high flavonoid and phenol content. Both of these substances can provide antioxidant effects that are good for the treatment of pulmonary contusions. The aim of the study was to determine the efficacy of Guazuma ulmifolia Lam leaves extract on CRP levels in wistar rats in pulmonary contusion models. In vivo study, pre-post test only has been done in Animal House Faculty of Medicine Sriwijaya University in the period from November to December 2019. There were 25 male Wistar strain rats and divided into five groups, each group consisting of five mice. Mice are induced pulmonary contusions by dropping a load from a certain height. after that, rat blood was taken to be examined for pre-treatment CRP levels. Rats were treated according to the group for 48 hours, then their blood was taken to be examined for post-treatment CRP levels with ELISA. Data was analyzed using SPSS version 25. The rats weight and CRP levels are homogen. Guazuma ulmifolia Lam leaves extract showed significant results in reducing CRP levels in all groups compared with the control group.. The administration of the Guazuma ulmifolia Lam leaves extract (Guazuma ulmifolia Lamk) in rats with pulmonary contusions can reduce serum CRP levels.

The Effectiveness of Karamunting Leafâ€™s Fraction (Rhodomyrtus tomentosa (Aiton) Hassk) as Antimicrobials in Carbapenemase Resistant Klebsiella pneumonia Sabrina, Tia; Kamaluddin, MT; Theodorus, Theodorus; Salni, Salni
Sriwijaya Journal of Medicine Vol. 4 No. 1 (2021): Sriwijaya Journal of Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v4i1.225

In the world, the incidence of nosocomial infections in hospitals had increased. There had been an increase in the incidence of infections caused by Enterobacteriaceae, one of them is Klebsiella pneumonia, which resistant to carbapenem in the worldwide. The consequences of increased rates of resistance to many drugs pose a high need for the discovery of new types of antibiotic drugs. Rhodomyrtus tomentosa (aiton) hassk has an antibacterial effect that has long been used by Indonesians as a traditional drug. This study aims to find out the effectiveness of karamunting leaf fraction as an antimicrobial in carbapenemase resistant K.pneumonia bacteria and to find out the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of the active compound of karamunting leaves as antimicrobial in Carbapenemase resistant Klebsiella pneumonia (CRKP) bacterial isolates. This research was an experimental laboratory research in vitro that exploratory analytical. The results of the study obtained the value of MIC ethyl acetate fraction started at a concentration of 125 Î¼g/ml and n-hexan fraction at a concentration of 4000 Î¼g/ml. MBC value was 125 Î¼g/ml for ethyl acetat fraction and n-hexan fraction of karamunting leaves was 8000 Î¼g/ml. From the bacterial activity test obtained at a concentration 32000 Î¼g/ml of n-hexan fraction, the average diameter of the inhibitory zone 7.80 Â± 1.30 mm and ethyl acetate fraction at a concentration of 4000 Î¼g/ml can inhibit the growth of CRKP bacteria with an average of inhibition zone diameter was 9.40 Â± 1.67 mm. From the results of the analysis using the Independent T Test and mann whitney test obtained a probability value between all groups with positive control was <0.05. It can be concluded that the ethyl fraction of acetate and n-hexan leaves of karamunting leaves contains active compounds that can interfere with the integrity of CRKP bacterial cell walls or membranes so that the bacteria can die.

EFEKTIVITAS DEXMEDETOMIDINE TERHADAP KADAR KORTISOL PADA PASIEN YANG MENJALANI OPERASI GINEKOLOGI DALAM ANESTESI UMUM Yuliana Yuliana; Rose Mafiana; Agustina Br. Haloho; Theodorus Theodorus
Jurnal Anestesi Perioperatif Vol 7, No 3 (2019)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Respons stres adalah perubahan hormon dan metabolik yang terjadi setelah trauma seperti pembedahan, salah satunya terjadi peningkatan kadar kortisol. Dexmedetomidine dapat menurunkan respons stres dengan menghambat sintesis kortisol. Tujuan penelitian ini adalah mengetahui efek dexmedetomidine terhadap kadar kortisol pada pasien yang menjalani operasi ginekologi dalam anestesi umum yang dilakukan di RSUP dr. Mohammad Hoesin Palembang dari Januari–Maret 2018. Jumlah sampel 30 orang yang dibagi menjadi 2 kelompok, kelompok dexmedetomidine dan kelompok plasebo. Kelompok dexmedetomidine mendapatkan dosis dexmedetomidine awal 1 µg/kgBB selama 10 menit dilanjutkan 0,5 µg/kgBB/jam, 20 menit sebelum induksi. Pada kelompok plasebo menggunakan NaCl 0,9%. Induksi menggunakan propofol, fentanil 2 µg/kgBB, dan atrakurium 0,5 µg/kgBB serta pemeliharaan menggunakan sevofluran 3% dalam O2 dan N2O 50%:50%. Kemudian 1 jam pascaekstubasi diambil sampel darah kembali untuk pemeriksaan kadar kortisol. Hasil penelitian pada kedua kelompok terjadi peningkatan kadar kortisol saat 1 jam pascaekstubasi dibanding dengan awal (9,638±7,082 µg/dL menjadi 14,503±7,082 µg/dL pada kelompok dexmedetomidine dan 10,276±3,166 µg/dL menjadi 19,99±6,273 µg/dL pada kelompok placebo). Namun, kadar kortisol signifikan lebih tinggi pada kelompok plasebo. Simpulan, pada kedua kelompok terjadi peningkatan kadar kortisol dibanding dengan nilai awal, tetapi kadar lebih rendah pada kelompok dexmedetomidine. Effectiveness of Dexmedetomidine on Cortisol Level in Patients Undergoing Gynecologic Surgery under General AnesthesiaStress response is a term used to define the metabolic and hormonal changes following an injury or trauma, including as surgery. One of the responses is an increase in cortisol release. Dexmedetomidine may attenuate stress response by inhibiting cortisol synthesis. The aim of this study was to determine the effects of dexmedetomidine on cortisol level, compared to placebo, in patients undergoing major gynecological surgery under general anesthesia. A double-blind randomized clinical trial was performed at Mohammad Hoesin General Hospital from January to March 2018. There were thirty samples that were divided into two groups, dexmedetomidine group and placebo group. The dexmedetomidine group received an initial dexmedetomidine loading dose of 1 µg kg -1 over 10 min, followed by 0.5 µg kg-1h-1 20 minutes before induction. In the placebo group, 0.9% sodium chloride was administered. Anesthesia was induced with propofol, 2 µg/kgBW fentanyl, and 0.5 mg/kgBW atracurium and was maintained with 3% sevoflurane in O2 and N2O 50%:50%. After standard monitoring was established, blood samples were collected for cortisol plasma testing at baseline and 1 hour post-extubation. Hemodynamic data were recorded intraoperatively and postoperatively. Results in both groups presented a significant increase in cortisol level relative to the baseline at 1 hour post-extubation (9.638±7.082 µg/dL to 14.503±7.082 µg/dL in dexmedetomidine group and 10.276±3.166 µg/dL to 19.99±6.273 µg/dL in placebo group [P value<0.05]) with a significantly higher corticsol level in the placebo group when compared to the dexmedetomidine group (P value<0.05). In conclusion, the plasma cortisol level was found to increase significantly relative to baseline level in both groups. However, the increase was significantly lower in the dexmedetomidine group.

Prevalence of hypospadias patients with undescended testis Abrar Arbhiwa Tanguirsyaf Siregar; Shalita Dastamuar; Theodorus Theodorus; Marta Hendry
International Journal of Public Health Science (IJPHS) Vol 8, No 2: June 2019
Publisher : Intelektual Pustaka Media Utama

Hypospadias is an anomaly of meatus urethra externus on ventral penis. It caused by incomplete fusion of urethral folds. The purpose of this study was to investigate the prevalence of hypospadias with undescended testis in the Department of Surgery Mohammad Hoesin Hospital in Palembang Indonesia. A prevalence study was done in the Medical Records Department of Mohammad Hoesin Hospital from July 2018 to February of 2019. 103 patients met study inclusion criteria. Univariate analysis of the patients’ data was conducted using IBM SPSS Statistics 25. The study found that hypospadias was most common in the age group of 1 to 5 years old (49.5%) and the most common type of hypospadias was severe hypospadias (68.9%). Furthermore, 7 out of 103 patients (6.8%) were hypospadias patients with undescended testis and the most common types of undescended testis among them were bilateral undescended testis and left undescended testis with 3 patients each (42,85%). Prevalence of hypospadias with undescended testis were 7 people (6,8%).

The Prevalence of Alprazolam Uses in Geriatric Patients at Dr. Mohammad Hoesin Hospital Palembang Yohanes Febrianto; Sutomo Tanzil; Theodorus Parulian
International Journal of Public Health Science (IJPHS) Vol 5, No 2: June 2016
Publisher : Intelektual Pustaka Media Utama

One of the most frequently prescribed drugs in geriatric patients is a benzodiazepine, especially a short-acting such as alprazolam. Unfortunately, alprazolam is oftenly used inappropriately because this drug has a short acting effect. Geriatric patients are more sensitive to this drug that can lead to the dependence. However, there is still lack of data on the use of this drug in geriatric patients. The aim of this study was to determine the prevalence of the use of alprazolam. A drug utilization study has been done for 2 months through analysis of patient’s medical records in the internal medicine ward at RSMH Palembang from June 1st, 2012 to May 31st, 2013. There were 25 out of 1634 patients receiving alprazolam, but only 23 patients whose data were obtained from the available medical records. Prevalence of alprazolam use was 1.408%. Based on gender, the prevalence was 1.798% in female and 1.09% in male patients. Proportion by age group was 91.3%, 8.7% and 0% in age group 60-74 years, 75-90 years and over 90 years, respectively. Based on the job, the population study comprised of the housewive (52.1%), unemployment (39.1%), and entrepreneur and farmer (4.3% together). The indication of usage was atheroscerotic heart disease, diarrhoea and gastroenteritis of presumed infectious origin, unspecified gastritis, and thyrotoxic heart disease. In other words, it could be said that the usage of alprazolam was inappropriate.

PERBANDINGAN AKTIVITAS FISIK AEROBIK DAN ANAEROBIK TERHADAP KADAR LAKTAT DAN LAKTAT DEHIDROGENASE (LDH) admin; Sari Octarina Piko; Rostika Flora; Theodorus
Jurnal Kesehatan dan Pembangunan Vol 9 No 17 (2019): Jurnal Kesehatan dan Pembangunan
Publisher : LPPM STIKes Mitra Adiguna

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52047/jkp.v9i17.33

Aktivitas fisik atau olahraga adalah pergerakan tubuh yang dilakukan otot dengan terencana dan berulang yang menyebabkan peningkatan pemakaian energi dengan tujuan untuk memperbaiki kebugaran fisik. Ada dua jenis aktifitas fisik yaitu aktivtas fisik aerobik dan anaerobik. Kedua aktivitas ini berdampak pada pengeluaran kadar laktat dan LDH. Adapun tujuan penelitian ini untuk mengetahui pengaruh aktivitas fisik aerobik dan anaerobik terhadapa kadar laktat dan LDH. Metode penelitian ini uji klinik berpembanding dengan rancangan pre dan post test only desighn. Pelaksanaan aktivitas fisik aerobik dan anaerobik dilaksanakan di stadion Sriwijaya Sport Centre Jakabaring palembang. Sampel dalam penelitian ini sebanyak 34 responden yang dibagi menjadi 2 kelompok yaitu kelompok aerobik dan anaerobik. Dilakukan pengambilan darah di vena cubiti sebanyak 5cc untuk pemeriksaan kadar laktat dan LDH. Terdapat perbedaan bermakna kadar laktat sebelum dan sesudah aktivitas fisik pada kelompok aerobik dan anaerobik (p<0,05). Akan tetapi apabila kedua kelompok dibandingkan tidak terdapat perbedaan bermakna (p<0,05). Begitu juga pada kadar LDH, terdapat perbedaan bermakna kadar LDH sebelum dan sesudah aktivitas fisik aerobik dan anaerobik. Akan tetapi apabila kedua kelompok dibandingkan tidak terdapat perbedaan bermakna (p<0,05). Aktivitas fisik aerobik dan anaerobik berpengaruh terhadap pengeluaran kadar asam laktat dan LDH.

Phytoestrogen Genistein and Black Cohosh and Marker of BMD in Menopausal Women Rizani Amran; Adenan Abadi; Theodorus Theodorus; Elvi Widiastuti
MEDIA MEDIKA INDONESIANA 2012:MMI VOLUME 46 ISSUE 2 YEAR 2012
Publisher : MEDIA MEDIKA INDONESIANA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (235.624 KB)

Background: In Indonesia, phytoestrogens can be found in the market as supplement to resolve climacteric complaint and osteoporosis. This phytoestrogens has not been proven scientifically to have benefit in overcoming the climacteric complaints and osteoporosis in menopausal women. Therefore, it is important to have clinical test searching data for knowing the increase of bone mineral density (BMD).Methods: The design was comparison clinical test in the form of “add on” with double blind in Hospital of Mohammad Hoesin Palembang started in August 2010 until February 2011 putting subjects into fitoestrogen and placebo groups randomly. T-score of spine and femur were measured using done densitometry before and after 6 months supplementation.Results: In the beginning of study, it was found that the average of spine T-score in the group of phytoestrogens was -1.455±0.264 after 6 months it increased to -1.295±0.223 with change 0.160±0.153 (p=0.001).Whereas in placebo group the average of spine T-score at the beginning of the study was -1.295±0.223 becoming -1.560±0.414 with decrease of -0.100±0.273 (p=0.118). Femur T-score level, of phytoestrogens group at the beginning of the study was -1.415±0.215, after 6 months it became -1.270±0.141 with change of 0.145±0.170 (p=0.001). In placebo group, the average of femur T-score was -1.475±0.202 becoming -1.595±0.421 with of decrease -0.120±0.33 (p=0.124). The status of spine and femur T-score BMD both in, phytoestrogens and placebo group was osteopenia at the beginning of the study. After 6 months, spine T-score in phytoestrogens group did not change, and in placebo group, 2 subject showed osteoporosis with spine T-score and femur T-score -2.7 and -2.75(±0.212).Conclusions: The administration of phytoestrogens is able to maintain bone mineral density and prevent the occurrence of osteoporosis.Keywords: Phytoestrogens, BMD, T-score, menopauseABSTRAK Fitoestrogen genistein dan black cohosh dan penanda BMD pada perempuan menopauseLatar belakang: Di Indonesia, fitoestrogen beredar di pasaran sebagai suplemen untuk mengatasi keluhan klimakterik dan osteoporosis. Fitoestrogen ini belum terbukti secara ilmiah bermanfaat untuk mengatasi keluhan klimakterik maupun osteoporosis pada perempuan menopause. Oleh karena itu uji klinik ini dilakukan untuk mencari data guna mengetahui meningkatnya gambaran BMD.Metode: Desain adalah uji klinik berpembanding dalam bentuk add on, secara tersamar ganda di RS Dr. Mohammad Hoesin Palembang bulan Agustus 2010 sampai dengan Februari 2011 pada subyek yang dibagi dalam kelompok fitoestrogen dan placebo secara acak. Variabel yang diukur adalah skor T tulang vertebra dan femur menggunakan bone densitometer sebelum dan setelah 6 bulan mendapat suplemen.Hasil: Pada awal penelitian rerata T-skor tulang belakang kelompok fitoestrogen -1,455±0,264 setelah 6 bulan menjadi -1,295±0,223 dengan perubahan 0,160 ± 0,153 (p=0,001). Sedangkan kelompok plasebo rerata T-skor tulang belakang pada awal penelitian -1,295±0,223 menjadi -1,560±0,414 dengan penurunan -0,100±0,273 (p=0,118). Pada kadar T-skor femur, di awal penelitian kelompok fitoestrogen -1,415±0,215 setelah 6 bulan menjadi -1,270±0,141 dengan besaran perubahan 0,145±0,170 (p=0,001). Pada kelompok plasebo rerata T-skor femur pada awal penelitian -1,475±0,202 menjadi -1,595±0,421 dengan perubahan -0,120±0,33 (p=0,124). Status BMD T-skor tulang belakang dan femur di awal penelitian, kelompok fitoestrogen dan kelompok plasebo adalah osteopeni. Setelah 6 bulan kemudian, pada kelompok fitoestrogen tidak terdapat perubahan status BMD sedangkan pada kelompok plasebo terdapat 2 orang yang densitas mineral tulangnya mengalami perubahan menjadi osteoporosis dengan rerata T-skor tulang belakang -2,70 dan T-skor femur -2,750 ± 0,212.Simpulan: Pemberian fitoestrogen dapat mempertahankan densitas mineral tulang dan mencegah terjadinya osteoporosis.

HUBUNGAN TINGKAT EKSPRESI P15 TERHADAP NEVUS MELANOSITIK DAN MELANOMA MALIGNA Renny Apliza Nasution; Ika Kartika; Theodorus Theodorus
JURNAL KEDOKTERAN DAN KESEHATAN Vol 8, No 3 (2021)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/JKK.V8I3.12582

Lesi melanositik memiliki gambaran morfologi dan sitomorfologi yang luas mencakup lesi jinak yaitu nevus melanositik dan lesi ganas yaitu melanoma maligna. Beberapa gambaran nevus melanositik menyerupai melanoma. p15 merupakan gen penekan tumor dan biomarker yang kuat sehingga dapat digunakan untuk membedakan antara nevus dan melanoma. Tujuan penelitian ini adalah mengetahui hubungan tingkat ekspresi p15 pada nevus dan melanoma. Penelitian ini merupakan penelitian deskriptif observasional dengan desain serial kasus sejak 1 Januari 2015 sampai 30 Desember 2019. Sebanyak 60 sampel dilakukan pemeriksaan imunohistokimia menggunakan antibodi p15. Ekspresi p15 dinilai berdasarkan proporsi sel tumor yang terpulas dan intensitas pulasan. Analisis statistik menggunakan SPSS versi 23.0. Hasil penelitian menunjukkan bahwa nevus melanositik paling bnayk dijumpai pada perempuan (76,7%), pada kelompok usia <55 tahun (90%), lokasi tumor pada kepala dan leher (83,3) dan pada tipe histopatologi dermal naevus (53,3%). Melanoma maligna paling banyak ditemukan pada jenis kelamin laki-laki (53,6%), pada kelompok usia <55 tahun (57,1%), lokasi tumor pada kepala dan leher (35,7%) dan pada tipe histopatologi nodular melanoma (42,9%). Terdapat hubungan bermakna antara tingkat ekspresi p15 dengan lesi melanositik (nevus melanositik dan melanoma maligna) (r=0,9666; p=0,000). Ekspresi p15 tinggi dijumpai pada nevus melanositik dan rendah pada melanoma maligna. Terdapat hubungan bermakna antara tingkat ekspresi p15 dengan lesi melanositik (nevus melanositik dan melanoma maligna). Semakin rendah ekspresi p15 maka semakin besar kemungkinan terjadi melanoma maligna. Background. Melanocytic lesions have a broad morphological and cytomorphological picture including benign conditions or melanocytic naevus and malignant melanoma. Some features of a melanocytic nevus mimicking melanoma. p15 is a tumor suppressor gene and is a robust biomarker that can be used to differentiate between nevus and melanoma. This study aims to determine the correlation between p15 expression in melanocytic naevus and malignant melanoma. Methods. This research is an observational descriptive study with a case series design, conducted from January 1st, 2015 to December 30th 2019. A total of 60 samples were subjected to immunohistochemical examinations using antibody p15. The expression p15 is based on tumor cell proportion and intensity. Statistical analysis using SPSS version 23. Result. Melanocytic nevus was predominantly female (76.7%), age group <55 years (90%), location of tumors on the head and neck (83.3), histopathological type of dermal naevus (53.3%). Malignant melanoma was mostly found in men (15, 53.6%), age group <55 years (57.1%), the location of tumors on the head and neck (35.7%), type histopathology of nodular melanoma (42.9%). The correlation between p15 level expression and melanocytic lesions (melanocytic nevus and malignant melanoma) (r = 0.9666; p = 0.000). Conclusion. High expression of p15 was found in melanocytic nevus and low in malignant melanoma. There was correlation between p15 level expression and melanocytic lesions (melanocytic nevus and malignant melanoma). The lower the p15 expression, the more likely malignant melanoma will occur.

Co-Authors Abrar Arbhiwa Tanguirsyaf Siregar Abu Bakar Lutfi Adenan Abadi Adenan Abadi admin Adnan Abadi Asnawi Adnan Abadi, Adnan Afifa Ramadanti Agustina Br. Haloho Agustinus William Agustria Z. Saleh Amarel, Fahma Alfarizqy Amir Fauzi Amirah Novaliani Anak Agung Gede Sugianthara Anang Tribowo Andriani, R.A. Linda Andriansyah, Yulius Andrina, Hana Anugrah Onie Awan Nurtjahyo Awan Nurtjahyo Azhar Susanto Azhari Azhari Azhari Rozali B, Firmansyah Benedictus Wicaksono Widodo Bernolian, N Bernolian, N Billy Sujatmiko D Saputra, Akbar N D.Y. Riyanto, D.Y. Dahler Bahrun Daniatiek, Soneta Dastamuar, Shalita Debby Handayani Harahap Debby Handayati Harahap Devy Octarina Ditto Ruldifar Pribadi Doni Kurniawan Dwi Tantri Marylin Ellen Callista Angelica Elvi Widiastuti Elza Iskandar, Elza Evi Lusiana F, Amir Fahma Alfarizqy Amarel Fakhrudit, Emir Fatimah Syakirah Fauzit, Amir Fedriyansyah Fedriyansyah Ferdi, Roni Ferry Yusrizal Firmansyah Basir Fita Asfianti Forbes, Darlin Gita Dwi Prasasty H.M. Nazir H.M. Nazir Haidar Ali Hamzah Harahap, Debby Handayani Heriansyah, Jhon Hidayat, Syarief Taufik Hilmawan, Bagus HM Nazir Hz Ika Kartika Indira, Tissa Ismail Bastomi, Ismail Julius Anzar Kamaluddin Kamaluddin Kamaluddin, MT Kamaluddin, MT Khrismawan Khrismawan Kiagus Ahmad Imanuddin Kms Yusuf Effendi Kms Yusuf Effendy Kusuma Harimin Leni Wijaya, Leni Lestari, Mayang Indah Lorenza, Geofanny Lutfi, Abu Bakar M Kamaluddin M. T. Kamaluddin Mahacakri, Eke P Mahadika, Febrinata Manan, Heriyadi Marta Hendry, Marta Martadiansyah, Abarham Maulani, H Maulani, H Maulani, Henni Mgs. Irsan Saleh, Mgs. Irsan Mgs. M. Irsan Saleh Muhammad Despriansyah Romadhan Muhammad Hafidh Komar Muhammad Irsan Saleh Muhammad Totong Kamaluddin Mulawan Umar Muzakkie Muzakkie, Muzakkie Nadhif, Aufa Muhammad Nita Parisa Nopriansyah Darwin Novianesari, Putri H Novianty, Novianty Nugraha, M Daffa Nugroho, Achmadi S Nur Qodir Nurul Islamy Nuswil Bernolian Octarina, Bertha Oktariana, Desi Pangemanan, W T Pangemanan, W T Pangemanan, Wim T PATIYUS AGUSTIANSYAH, PATIYUS Puspita, Yusni Putri Mahirah Afladhanti Putri Mirani Raden Ayu Kusuma Andini Rafiyandi Rafiyandi Rahima Rahima Renny Apliza Nasution Resiana Resiana Riani Erna Rika Saputri Rini Purnamasari Risa Vera Rizal Sanif Rizani Amran Rogatianus Bagus Pratignyo Rose Mafiana Rostika Flora Rostika Flora Rusydi, Syakroni D Sabrina, Tia Safa Nabila Putri Sahab, Abdullah Saleh, Masagus Irsan Salni Sari Octarina Piko Sastradinata, Irawan Shaleh, Agustria Z Silvana, Rista Silvia Triratna Siti Rusdiana Puspa Dewi Sonlimar mangunsong Stevanny, Bella Sudarto Sudarto Sujatmiko, Billy Sulbahri, Robby P. Suriani Rosida Sutomo Tanzil Syarif Husin Syarif Husin Tahany, Hanifah Tanzil, Sutomo Tindar, Mirzah Tissa Indira Usman, Fatimah Veronita Veronita Veronita, Veronita Wahyu Pranata, Wahyu Pranata Yohanes Febrianto Yulia Iriani, Yulia Yuliana Yuliana Yundari, Yundari Yusuf, Kemas Zainal, Rizal Zanaria, Rima Zulkifli Zulkifli

Title

Found 66 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 66 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 66 Documents
Search