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All Journal Journal of Food and Pharmaceutical Science Jurnal Sain Veteriner Jurnal Pendidikan Indonesia Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Jurnal Sains dan Teknologi Farmasi JURNAL ILMIAH PENDIDIKAN FISIKA AL BIRUNI Pharmacon Majalah Obat Tradisional JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Acta Pharmaciae Indonesia : Acta Pharm Indo Farmasains : Jurnal Ilmiah Ilmu Kefarmasian WIDYA LAKSANA PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) FITOFARMAKA: Jurnal Ilmiah Farmasi JURNAL FARMASIMED (JFM) Jurnal Komunikasi Pendidikan Optika : Jurnal Pendidikan Fisika Lumbung Farmasi : Jurnal Ilmu Kefarmasian Jurnal Insan Farmasi Indonesia Journal of Research in Instructional AL-KHAZINI: JURNAL PENDIDIKAN FISIKA Jurnal Pengabdian Kolaborasi dan Inovasi IPTEKS Indonesian Journal of Pharmacy and Natural Product Journal of Food and Pharmaceutical Sciences Borneo Journal of Pharmacy
Wahyu Widyaningsih
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Physics Public Health Social Sciences Veterinary Other

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Journal : JURNAL FARMASIMED (JFM)

 1 
Combination of Essential Oils of Ylang-Ylang (Cananga Odorata), Jasmine (Jasminum Sambac), and Mint Leaves (Mentha Piperita) TestingAphrodisiac on Male Mice Formulated in Candle Forms marpaung, Tio Widia A.; Kintoko; Wahyu Widyaningsih; Moch Saiful Bachri; Amelia Regina Arsyad
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/7q01y176

Abstract

This study explored the potential of Jasminum sambac (jasmine) and Mentha piperita (peppermint) as natural sexual stimulants (aphrodisiacs) to enhance sexual activity in males and females through the use of essential oils. The main objective was to identify the most effective combination of essential oil formulations, which were evaluated through several biological and physiological parameters, including sexual behavior in mice, sperm quality, testicular histopathology, and wax-based formulations as the delivery medium. Three formulations were tested: P1 (3:1:1), P2 (1:3:1), and P3 (1:1:3), administered to mice using a humidifier via inhalation. Sexual behavior was assessed through mounting latency and mounting frequency as indicators of libido. Sperm quality parameters included morphology, motility, viability, and sperm count. Testicular histopathology was examined to evaluate tissue structure and spermatogenesis activity. The results demonstrated that the P1 formulation was the most effective, showing the highest aphrodisiac activity. In the sexual behavior test, P1 recorded an activity value of 21±6.2, indicating enhanced libido. Sperm quality testing also confirmed the superiority of P1, with the lowest sperm abnormalities (5.3±1.53), highest motility (82±7.5), highest viability (85.6±4.58), and the greatest sperm count (53,300±16,653.3). Although testicular histopathology revealed a slight reduction in spermatogenic cells across all treatment groups, the change was not significant in the P1 group compared to the control. Overall, the P1 formulation improved libido and sperm quality more effectively than P3 and the control group, indicating its potential to be developed as an aphrodisiac preparation based on natural essential oils.
Formulation of Emollient Preparation from Rose Essential Oil (Rosa Damascena) Combined with Vanilla Essential Oil (Vanilla Planifolia)in Increasing Body Weight in Baby Rats (Rattus Norvegicus) arsyad, regina; Kintoko; Wahyu Widyaningsih; Tio Widia Astuti Marpaung
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/80n03c83

Abstract

Rose and vanilla essential oils have potential as natural active ingredients in emollient formulations due to their moisturizing and aromatherapeutic relaxation effects. This study aimed to formulate an aromatherapy emollient with four variations in the composition of rose and vanilla essential oils: F1 (0.1 mL:0.4 mL), F2 (0.2 mL:0.3 mL), F3 (0.3 mL:0.2 mL), and F4 (0.4 mL:0.1 mL). Each formula contained a total of 0.5 mL essential oil dissolved in 100 mL sunflower seed oil as the base. Organoleptic evaluation showed that all formulas had a yellowish-white color and liquid texture. The resulting aromas differed among formulas: F1 produced a woody scent, F2 and F3 had an oriental woody fragrance, while F4 exhibited a dominant rose aroma. The pH values ranged from 5.12 to 6.00, which is within the normal skin range. Viscosity values were between 4.92–5.30 cPs, specific gravity ranged from 1.0181–1.0682, and refractive indices were 1.470–1.471, indicating good physical stability. Hedonic testing revealed that Formula F2 was the most preferred by panelists in terms of aroma, texture, and after-feel on the skin. Skin irritation tests on rabbits showed no negative reactions, confirming the formulation’s safety for topical use. Biological activity tests on infant mice demonstrated significant increases in body weight and length compared to the control group. Based on overall results, Formula F2 (0.2 mL rose oil and 0.3 mL vanilla oil) was determined to be the best formulation, offering a balanced aroma, good physical stability, and optimal emollient and relaxation effects.
Co-Authors Aditya Prabowo Aditya Prabowo Ainiyah, Nadia Putri Aldri Frinaldi Amelia Regina Arsyad Anasyua, Fairuz Khairunnisa arsyad, regina Astutik, Novita Santi Ayu Wulandari Azis Ikhsanudin Bachri, Mochammad Saiful Br. Sebayang, Sri Rosepda Cahya, Sella Nur Danang Prasetyaning Amukti Dara Pranidya Tilarso Daru Estiningsih Dedi Kuswandi Desi Eko Wulansari Desi Iswahyuni Desyandri Desyandri Dini Rahmawati Dwi Fitriani Dwi Retno Nengtyas Dwi Utami Erliyana, Mila Eti Nurwening Sholikhah Fadilah, Ilham Fadilah, Nur Aini fatima, fatma Fauzi, Muh Fajar Fauziyyah, Khusna Fitriyati, Laeli Galang Pergiawan Ramadhan Gustinanda, Rizky Hanifah, Azka Khansa Hari Susanti Iin Narwanti Iin Narwanti Iis Wahyuningsih Indra Primardiana, Indra Irfan Yusuf Iriwi L.S Sinon, Iriwi L.S Iriwi L.S. Sinon, Iriwi L.S. Istyarini Istyarini, Istyarini Jumina Jumina Jumina Jumina Kaffah, Silmi Kintoko Kintoko Kintoko Kusuma, Rio Jati Laela Hayu Nurani Laela Hayu Nurani Lalu Muhammad Irham M. Paden, Thereziana marpaung, Tio Widia A. Meki Pranata Moch Saiful Bachri Moch Saiful Bachri Moch. Saiful Bachri Moch. Saiful Bachri Muhammad Ma'ruf Muhammad Ma'ruf Muhammad Yusron Maulana El-Yunusi Mujasam Mujasam Nina Salamah Nisa Isneni Hanifa Nur Asih, Nur Nurliawaty, Lilis Pramono, Suwidjiyo Primardiana, Indra Puteriragil Atma Pertiwi, Puteriragil Atma Putri Dwi Lestari Radjab Sutrisno, Radjab Ramadhan, Muhammad Marwan Rerung, Nensy Rezza Wahyudi Rifka Salsabila Riska Riska Riza Sativa, Riza Rumansara, Tamariska Herlindo Ryan Syahputra Sapto Yuliani Sapto Yuliani Sativa, Riza Septianingsih, Ulfah Shary, Aprilya Kumala Silmi Kaffah Siswanti Siswanti Sitarina Widyarini Siti Fatmawati Fatimah, Siti Fatmawati Sri Rosepda Sebayang, Sri Rosepda Suci Kurniati Sugiyanto - Sugiyanto, Sugiyanto Sumiasih Sumiasih Sundari, Trias Kania Suwidjiyo Pramono Tajudin, Tatang Tio Widia Astuti Marpaung Tirza Pangkali, Tirza Ulfah Septianingsih Vivi Sofia Vivi Sofia Wiki Yuli Anita Wiki Yuli Anita Wulandari, Silviana Wulandari, Silviana Wulansari, Widyanari Febriyana Wumu, Dea Anggrainy Y.T. Allo, Alberto Yenusi, Kaleb Amaghi Yoga Yuniadi Yulianto, Asep Nurrahman