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All Journal Althea Medical Journal Sari Pediatri Paediatrica Indonesiana Jurnal Plastik Rekonstruksi World Nutrition Journal Indonesian Journal of Global Health research Jurnal Psikiatri Surabaya (Surabaya Psychiatry Journal) Narra J Proceedings of the International Conference on Nursing and Health Sciences eJournal Kedokteran Indonesia Makara Human Behavior Studies in Asia Jurnal Muara Medika dan Psikologi Klinis
Tjhin Wiguna
Departemen Ilmu Kedokteran Jiwa, Fakultas Kedokteran, Universitas Indonesia
Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health Other

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The narrative review of recent studies in understanding the relationship between gut (microbiota)-brain axis, nutrition and cognitive function Taufiq Fredrik Pasiak; Tjhin Wiguna; Rini Sekartini; Juwalita Surapsari; Tonny Sundjaya; Erika Wasito; Ray Wagiu Basrowi; Melissa Stephanie Kartjito
World Nutrition Journal Vol. 6 No. S2 (2023): Special Issue : expert perspectives on the interconnections between immunity,
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V06.S2.0004

Abstract

The concept of the gut (microbiota)-brain axis, which influences the development and function of the gastrointestinal, immune, neuroendocrine, and metabolic systems, is gaining popularity. Recent animal studies have demonstrated that the gut (microbiota)-brain axis also plays a role in establishing cognitive function. It is known that a disruption in the environment's microbiota balance can increase disease susceptibility in children. Historically, it has been hypothesized that neurodevelopmental disorders are the results of a disruption in children’s health. However, it is becoming clear that the gut microbiota and the central nervous system communicate in both directions, which could explain how microbiota affects cognitive function. Dietary factors also play important role in the central nervous system via the gut (microbiota)-brain axis, demonstrating the importance of nutrition in optimizing cognitive function. This narrative review of recently published studies and current knowledge aims to elucidate the relationship between the gut (microbiota)-brain axis and cognitive function, as well as the variables that may influence it.
Exploring key cognitive indicators for practical use by parents in community setting Tjhin Wiguna; Rini Sekartini; Taufiq Fredrik Pasiak; Ray Wagiu Basrowi; Melissa Stephanie Kartjito
World Nutrition Journal Vol. 6 No. S2 (2023): Special Issue : expert perspectives on the interconnections between immunity,
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V06.S2.0005

Abstract

The identification of child development milestones, specifically cognitive abilities, requires parental/caregiver awareness and knowledge. With the existence of multiple cognitive abilities such as attention and focus, memory, language, psychomotor skills, logic, reasoning, decision-making, problem-solving, social/emotional, there are multiple indicators to measure children's cognitive abilities. Pediatricians are the most knowledgeable and trusted authority to routinely screen and monitor the development of healthy children. Therefore, it is crucial that parents understand their children's developmental milestones so if they encounter anomalies, they can immediately consult with the professionals. This review compiles recently published research and current knowledge to examine potential key indicators of cognitive development in infants and children that can be utilized by parents and communities in an easily understood manner.
Validitas dan Reliabilitas Patient Health Questionnaire-4 (PHQ-4) Versi Bahasa Indonesia sebagai Kuesioner Deteksi Dini Gejala Cemas dan Depresi pada Anak dan Remaja Tjhin Wiguna; Kusuma Minayati; Osi Kusuma Sari; Yunita Arihandayani; Imran Pambudi; Wafa Sofia Fitri
Sari Pediatri Vol 28, No 1 (2026)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp28.1.2026.8-18

Abstract

Latar belakang. Gangguan kecemasan dan depresi pada anak dan remaja dilaporkan meningkat terutama dalam beberapa tahun terakhir ini, sementara instrumen deteksi dini yang singkat dan tervalidasi dalam Bahasa Indonesia masih terbatas. PHQ-4 merupakan suatu kuesioner deteksi dini singkat sehingga berpotensi untuk digunakan luas di masyarakat.Tujuan. Mengevaluasi validitas dan reliabilitas PHQ-4 versi Bahasa Indonesia pada anak dan remaja usia 7–18 tahun.Metode. Studi potong lintang ini melibatkan 1846 anak dan remaja di Jakarta, Tangerang Selatan, dan Serang; yang terdiri dari 440 anak usia 7–10 tahun dan 1406 remaja usia 11–18 tahun. Validitas konten dinilai dengan CVI, reliabilitas dengan Cronbach’s alpha, construct validity dengan Exploratory Factor Analysis (EFA), dan validitas kriteria dengan ROC menggunakan The Mini International Neuropsychiatric Interview for Children and Adolescents (MINI-KID). Semua analisis dilakukan dengan menggunakan program SPSS versi 29.Hasil. Seluruh butir PHQ-4 versi Bahasa Indonesia untuk anak usia 7 – 10 tahun menunjukkan I-CVI ?0,83 setelah dilakukan modifikasi menjadi kalimat tanya, dan I-CVI=1,00 untuk PHQ-4 bagi anak usia 11–18 tahun. Reliabilitas PHQ-4 untuk anak usia 7–10 tahun adalah Cronbach’s ?=0,644, sedangkan untuk anak usia 11–18 tahun Cronbach’s ?=0,693. Analisis EFA untuk PHQ-4 untuk anak usia 7–10 tahun maupun 11–18 tahun menunjukkan KMO 0,712 dan 0,664, dengan loading factor seluruh butir >0,5 dan varians dijelaskan 52,3% dan 51,4%. Analisis ROC menunjukkan AUC untuk anak usia 7–10 tahun 54% dengan nilai ambang abatas adalah 5. Untuk anak usia 11–18 tahun, AUC ditemukan 69.9% nilai ambang batas 6. Kesimpulan. PHQ-4 versi Bahasa Indonesia adalah kuesioner unidimensiaonal yang valid dan reliabel sebagai kuesioner deteksi dini gejala cemas dan depresi pada populasi anak dan remaja, meskipun studi selanjutnya masih diperlukan.
Co-Authors A.A.A.A Kusumawardhani Ade Rachmat Yudianto Aditya Wardhana Agung Kusumawardhani Agung Muhammad Rheza Alida R. Harahap Amin Soebandrio Anak Agung Ayu Agung Kusumawardhani Anastasia Maureen Andika Widianti Andy Darma Anggono, Rendi F. Anindya, Isti Ardani, Yanuar Aria Kekalih Basrowi, Ray Wagiu Batubara, Jose Bernie Endyarni Medise Bonny Tjongjono Budi Sampurna Christa Pamela Christian, Hans Christy Venada Citra Fitri Agustina Dharma Asih, Ni Ketut Susila Dian R. Sawitri, Dian R. Dina Muktiarti, Dina E. Mudjaddid A. Siswanto Deddy N.W.Achadiono Hamzah Shatri Em Yunir, Em Erika Wasito Eva Suryani Evi Evi Evi Evi Firdaus, Karina Fransiscus D. Suyatna Fransiska Kaligis H.F. Wulandari Hartono Gunardi Heri Wibowo Ibnu Agus Ariyanto Ika Widyawati Imran Pambudi Inne Yuliawati Irawan Mangunatmadja Irene Yuniar, Irene Irmia Kusumadewi Ismail, Raden Ismail, Raden Irawati Jubilate Edward Iruanto Tambun Julianti Julianti, Julianti Juwalita Surapsari Kartjito, Melissa Stephanie Katarina, Matilda Kristiana Siste Kurniasanti, Kristiana Kurniasanti, Kristiana Siste Kusuma Minayati Levina Chandra Khoe Listya Tresnanti Mirtha Luh Nyoman Alit Aryani Mahaputra Mahaputra, Mahaputra Malik, Khamelia Martina Wiwie Setiawan Nasrun Martina Wiwiek Nasrun Masyur, Muhtaruddin Melissa Stephanie Kartjito Munar Lubis Munasir, Zakiudin Muzal Kadim Myron L. Belfer Naela Fadhila Noorhana Setyawati WR Nurmiati Amir Nurmiati Amir Oktarina, Molly Dumakuri Osi Kusuma Sari Pasiak, Taufiq Fredrik Paul Samuel Kris Manengkei Petrin Redayani Lukman Pratiwi Assandi Pustika Amalia Wahidiyat Putra, Anggi A. Raharjanti, Natalia Widiasih Ray Wagiu Basrowi Ricardo, William Rini Sekartini Rininta Mardiani Rismala Dewi Rivo Mario Warouw Lintuuran Rosalina Dewi Roeslani, Rosalina Dewi Sabarinah Prasetyo Sabrina Tan Safira A Tjandrasari Sari, Novika Purnama Sarwono, Sugeng J. Sasanto Wibisono Sekarpramita Darmaputri Soedjatmiko Subekti, Imam Sudigdo Sastroasmoro Sudung O Pardede, Sudung O Sukamto Koesnoe Sulaiman Yusuf Surapsari, Juwalita Sylvia D Elvira Taufiq Fredrik Pasiak Tonny Sundjaya Tribowo Tuahta Ginting Wafa Sofia Fitri Wahyu Damayanti Waldi Nurhamzah Wasito, Erika Widura Imam Mustopo Winanda, Rizki Aniza Windy Atika Hapsari Wira Febrisandi Irsan Wiwie, Martina Yudith Setiati Ermaya Yunita Arihandayani Yusri Dianne Jurnalis