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Journal : Science and Technology Indonesia

Cholesterol-Lowering Effects of Turmeric Effervescent Dosage in Preventing Atherosclerosis Pomalango, Zulkifli B.; Paneo, Mohamad Aprianto; Pakaya, Nasrun; Aman, La Ode; Hutuba, Ariani H.
Science and Technology Indonesia Vol. 10 No. 2 (2025): April
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.2.482-492

Abstract

This study aims to evaluate the cholesterol-lowering effects of turmeric (Curcuma domestica) in an effervescent powder drink formulation to prevent atherosclerosis. The effervescent preparation was produced using standard effervescent techniques, with organoleptic tests revealing an orange color, the characteristic aroma of turmeric, and a slightly sweet taste. The formulation’s pH was approximately 5.9, with a flowability test result of 14 seconds, a powder angle of repose of 30°, and a dissolution time of  4 minutes and 20 seconds. Curcumin shows potential as an anticholesterol as a preventive measure of atherosclerosis disease  through molecular docking testing using autodock-vina. Qualitative test on turmeric effervescent with Sprektrofotometer UV-VIS, Scanning Electon Microscopy (SEM) and Fourier Transform Infrared Spectroscopy (FTIR). Cholesterol testing was conducted on mice induced with cholesterol using margarine over a one-week period, resulting in increased cholesterol levels of maximum 290 mg/dL. Following administration of the converted turmeric dosage, cholesterol levels significantly maximum decreased in the first week to  165 mg/dL. By the second week, further reductions were observed, with cholesterol levels maximum dropping to 143 mg/dL. These results suggest that turmeric effervescent formulation exhibits promising cholesterol-lowering properties and may contribute to the prevention of atherosclerosis
Co-Authors Abdi Dzul Ikram Hasanuddin Agung Dwi Laksono Agus Ishak Agustina A. Seran Andi Mursyidah Anggriani Eka Putri Nento Anita Dewi Prahastuti Sujoso Ariani H. Hutuba Arsyad, Ananda Putri Gusti Astrit Lamadi Aswad, Ahmad Ayu Thirta Lestari Cindy Puspita Sari Haji Jafar Dinastri Andari S. Atma Edy Dharma Putra Duhe Fajar Oktavian Hulukati Fatra Lapagulu Fazriah Nurul Hamzah Febriyanti Umar Gusti Pandi Liputo Hairun Nisya A.Mamente Hari Basuki Notobroto HARTONO HADJARATI Hiola, Dewi Suryaningsi Hunawa, Rachmawaty Dirham Hunawa, Rahmawati Husain, Filsa Ibrahim Sulemen Iin Pratiwi Adjami Ika Wulansari Ilyas Ibrahim Indra Irwan Irwan Ismail, Mirta Della Ita Sulistiani Jerawati Yunus Jerwati Yunus Jerwati Yunus Juna, Mersilan K Kusnanto La Ode Aman Langoni, Anggriyani Liputo, Gusti Pandi Maharani, Adinda Mahmud, Ismivanti Marasabessy, Nur Baharia Masruroh - Meiti Yolanda Mery Adriany Yunus Meyrin Hasan Mihrawaty Antu Mihrawaty S. Antu Mihrawaty Suleman Antu Moh. Nisyar Sy. Abd. Azis Mohamad Aprianto Paneo Mohamad, Rini Wahyuni Muhammad Rizaldi Kaharu Nikmatur Rohmah Nirwanto K. Rahim Nistain Kune Novita Angraeni Nur Alifta Manopo Nur Ayun R. Yusuf Nur Fitriah Jumatrin Nur Mawadah Djano Nur Syukriani Yusuf Nurdiana Djamaluddin Nurlatifah Zakaria Nurul Fitrah Akadji Oktia Woro Kasmini Handayani Pakaya, Midyan K. Pinoi, Ersavira S. Prameswari, Arawindah Rika Subarniati Triyoga Salawali, Siti Hajar Saskia Kumadji Sitti Fatimah Meylandari Arsad Sitti Fatimah Meylandri Arsad Stevani Mbuinga Suleman Ibrahim Sulistiani, Ita Sumiyati Moo Suryaningsih, Dewi Susan Monoarfa Widy Susanti Abdulkadir Wirda Y Dulahu Y Dulahu, Wirdha Yusuf, Muh. Nur Syukriani Yusuf, Nur Ayun R. Zainuddin Zainuddin Zainuddin, Zainuddin Zulkifli B. Pomalango