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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Psikoislamika : Jurnal Psikologi dan Psikologi Islam Nexus Kedokteran Klinik Jurnal Edukasi dan Penelitian Informatika (JEPIN) The Indonesian Biomedical Journal Universa Medicina Jurnal Kedokteran Anatomica (Anatomica Medical Journal) Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Majalah Kesehatan Pharmamedika Bali Medika Jurnal JOSSAE (Journal of Sport Science and Education) BIMIKI (Berkala Ilmiah Mahasiswa Ilmu Keperawatan Indonesia) Jurnal Kebidanan Indonesia JOURNAL LA MEDIHEALTICO Narra J Cermin Dunia Kedokteran International Journal of Islamic and Complementary Medicine Plexus Medical Journal Jurnal Kesehatan Masyarakat National Journal of Occupational Health and Safety Folia Medica Indonesiana
Nanang Wiyono
Fakultas Kedokteran, Universitas Sebelas Maret
Religion Arts Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary Other

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Journal : the indonesian biomedical journal

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Vitamin D and Magnesium Combination Lowers High-Sensitivity C-Reactive Protein, Interleukin-12, Renin, and Carotid Vessel in Diabetic Rats Rahayu, Rachmi Fauziah; Zahrah, Fathimah Afifah; Anugrah, Tessa Septian; Yudhani, Ratih Dewi; Yueniwati, Yuyun; Irawan, Amelia Tjandra; Kusumaningrum, Sulistyani; Fauzi, Adam; Wasita, Brian; Wiyono, Nanang; Muthaminah, Muthaminah; Sholikah, Tri Agusti; Wardhani, Lusi Oka; Suyatmi, Suyatmi; Yarso, Kristanto Yuli; Pesik, Riza Novierta; Siswanto, Febby Gunawan
The Indonesian Biomedical Journal Vol 18, No 2 (2026)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v18i2.4061

Abstract

BACKGROUND: Diabetes mellitus induces oxidative stress, inflammation, and endothelial dysfunction, accelerating atherosclerosis development marked by elevated high-sensitivity C-reactive protein (hs-CRP) and interleukin-12 (IL-12). Diabetes often causes significant vascular changes, which can be represented by carotid tunica intima thickening and elevated renin level. Metformin, which remains as the standard therapy, has limited vascular effects. Vitamin D and magnesium exhibit vasoprotective and anti-inflammatory properties; however, their combined effects on diabetic vascular injury remain unclear. This study evaluated the effects of vitamin D and magnesium combination on serum hs-CRP, IL-12, renin, and carotid tunica intima thickness in diabetic rats.METHODS: Wistar rats were diabetic-induced by 45 mg/kg streptozotocin and 110 mg/kg nicotinamide. Following the induction, the rats were subsequently assigned to receive no treatment, metformin, or a combination of vitamin D and magnesium. Healthy rats were also included as control. Blood sample was collected after 21 days of treatment. Serum hs-CRP, IL-12, and renin were measured using enzyme-linked immunosorbent assay (ELISA), while the carotid tunica intima thickness was assessed by Doppler ultrasound.RESULTS: Diabetic rats showed significant increases hs-CRP, IL-12, renin level, and intima thickness (p<0.001) compared to control. Both metformin and combination of Vitamin D and magnesium reduced these parameters, with combination of Vitamin D and magnesium showing the greatest improvement. Carotid intima thickness in the combination of Vitamin D and magnesium group was comparable to normal controls, indicating marked vascular protection.CONCLUSION: Vitamin D and magnesium combination provided superior glycemic, anti-inflammatory, and vascular protective effects compared to metformin alone. This adjunctive strategy might have potential in preventing vascular complications in diabetes.KEYWORDS: diabetes mellitus, oxidative stress, endothelial dysfunction, hs-CRP, IL-12, atherosclerosis
Co-Authors -, Muthmainah Adam Fauzi Agus Supinganto Amaliah, Lili Amru, Khaeriah Annang Giri Moelyo Anugrah, Tessa Septian Aripa, Lusyana Aryoseto, Lukman Baharuddin Baharuddin Bakti, Alfonsus Aryo Sunu Baskoro, Reza Setyo Brian Wasita Budiastuti, Veronika Ika Budiono, Enrico Ananda Bukhari, Agussalim Bulan Kakanita Hermasari Devinta, Salzha Dhoni Akbar Ghozali Diah Kurnia Mirawati Dian Fikri Rachmawan Dorce Sisfiani Sarimin Duwi Handayani, Juleha Dwi Cahyani Ratna Sari Endang Sri Wahyuni Evy Aryanti Ferdian, Hanum Ferianasari, Ineke Winda Firnadi, Jossefa Ginus Partadiredja Hanifa, Shafira N. Hastami, Yunia Herawati, Fitriana Hilmy, Farhan Ilyas, Muhana F. Ilyas, Muhana Fawwazy Ina Kusrini Irawan, Amelia Tjandra Kusumadewi, Isnindri Annisa Kusumaningrum, Sulistyani Lukas, Graciella A. Lutfatul Jannah, Safella maryatun maryatun Mashudi, Sugeng Mashuri, Yusuf Ari Muchtar Hanafi Muthaminah, Muthaminah Muthmainah Muthmainah Nandyantami, Farah Fauziah Nunqaf, Anjani Maulaya Nurdin, Nugi Nurhadi, Asty A. Nurhani, Ahmad Isnaini Shidqi Nurul Mahmudah, Irvina Nurwijayanti Nuryani Nuryani Paramasari Dirgahayu Pesik, Riza N. Rachmi Fauziah Rahayu Rahayu, Rachmi F. Rahma, Annisa A. Rahma, Annisa Aghnia Rahmadany, Muhammad Fa'iz Rahmadany, Muhammad Faiz Rahmani, Muhammad Z. Rahmatillah, Arif Ratih Dewi Yudhani Ridhallah, Muhammad Syauqi Riyanto, Agus Sugeng Riza Novierta Pesik Selfi Handayani Shabrina, Syania Sholikah, Tri Agusti Siswanto, Febby Gunawan Siti Munawaroh Suyatmi Suyatmi Tamaulina Br Sembiring Tedja Danudjo Oepomo Triniputri, Winastari Y. Ufqi, Ana Tsalitsal Futiya Roisal Wardhani, Lusi O. Wardhani, Lusi Oka Wijayanto, Matthew A. Yarsa, Kristanto Y. Yarso, Kristanto Yuli Yenni Zulhamidah, Yenni Yudhani, Ratih D. Yuridian Purwoko, Reza Yuyun Yueniwati Zahrah, Fathimah Afifah Zaki, Shifa Nurzahra