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All Journal Jambura Journal of Chemistry Jurnal Ilmiah Manusia dan Kesehatan PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Penelitian Farmasi dan Herbal Jurnal Kesehatan Tambusai Sasambo Journal of Pharmacy JIFI (Jurnal Ilmiah Farmasi Imelda) International Journal of Health and Pharmaceutical (IJHP) FARMASAINKES PCJN Pharmaceutical and Clinical Journal of Nusantara Journal of Pharmaceutical and Sciences. Social Engagement: Jurnal Pengabdian Kepada Masyarakat Indonesian Journal of Science and Pharmacy Jurnal Bakti Nusantara Analit: Analytical And Environmental Chemistry
Fithri Pulungan, Ainil
Program Studi Farmasi, Fakultas Farmasi, Universitas Muslim Nusantara Al-Washliyah, Medan, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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Toxicity Test Of Ethanol Extract Of Pletekan Leaves (Ruellia tuberosa L) Using The Brine Shrimp Lethality Test (BSLT) Method Fajri, Fajrilda Aqilah; ridwanto, ridwanto; Pulungan, Ainil Fithri; Rani, Zulmai
Indonesian Journal of Science and Pharmacy Vol. 2 No. 1 (2024): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/ijsp.v2i1.71

Abstract

The pletekan plant (Ruellia tuberosa L.) is a family of Acanthaceae Ruellia tuberosa L.) one of the plants used as a medicinal plant, especially the leaves, have been used empirically for therapy as a diuretic, antidiabetic, antihypertensive. Also used in the treatment of syphilis, kidney stones, cancer, heart disease, colds, hypertension and digestive problems. The purpose of this study was to determine the toxicity by determining the LC50 in the ethanol extract of pletekan leaves (Ruellia tuberosa L). The analysis carried out was a toxicity test on the ethanol extract of pletekan leaves against Artemia Salina Leach shrimp larvae using the BSLT method with various concentrations, namely 10, 15, 20, 25, 30, 35, and 40 ppm and determining the LC50 value with probit analysis. Based on the results of the toxicity test, the LC50 value was 96.4595 µg/Ml. These results show that the ethanol extract of pletekan leaves (Ruellia tuberosa L) has a toxic effect on Artemia Salina Leach shrimp larvae.
Edukasi Bahaya Konsumsi Makanan dan Minuman Berpengawet di SD 101812 Namo Tualang Deli Serdang Pulungan, Ainil Fithri; Dalimunthe, Gabena Indrayani; Rani, Zulmai; Hermanto, Bambang; Miswanda, Dikki
Jurnal Bakti Nusantara Vol. 2 No. 1 (2024): Jurnal Bakti Nusantara
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/jbn.v2i1.58

Abstract

Perkembangan industri makanan dan minuman yang meningkat dalam beberapa dekade terakhir memunculkan problematika baru dalam kesehatan. Penambahan zat aditif pada makanan kemasan seperti pengawet makanan dan minuman yang tidak sesuai aturan, diduga menjadi penyebab berbagai penyakit degeneratif pada anak-anak. Pengabdian kepada masyarakat ini bertujuan memberikan edukasi kepada murid-murid SD 101812 Namo Tualang Kecamatan Biru-biru Kabupaten Deli Serdang yang pada umumnya mengkonsumsi makanan dan minuma kemasan yang tersedia di kantin sekolah. Edukasi dilakukan dengan metode ceramah, diskusi dan tanya jawab. Penilaian tingkat pengetahuan peserta dilakukan dengan menggunakan kuesioner. Hasil kuisioner menunjukkan ketertarikan peserta akan kegiatan sebesar 80,6%, pengetahuan peserta terhadap makanan berpengawet sebesar 70,3%, dan kewaspadaan terhadap pengawet makanan sintesis sebesar 89,7%. Kegiatan eduksai ini menunjukkan adanya peningkatan pengetahuan dan pemahaman murid mengenai bahaya konsumsi makanan dan minuman kemasan berpengawet.
ANALISIS KADAR VITAMIN C HASIL PERASAN BUAH NANAS DAN KERIPIK NANAS DARI BEBERAPA DAERAH SECARA SPEKTROFOTOMETRI UV-Vis Mardhatillah, Wulan; Pulungan, Ainil Fithri; Ridwanto; Daulay, Anny Sartika
FARMASAINKES: JURNAL FARMASI, SAINS, dan KESEHATAN Vol. 4 No. 2 (2025): FARMASAINKES: JURNAL FARMASI, SAINS dan KESEHATAN
Publisher : Fakultas Farmasi Universitas Muslim Nusantara Al Washliyah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32696/farmasainkes.v4i2.4166

Abstract

Buah nanas merupakan salah satu buah yang digemari dan dikonsumsi oleh masyarakat. Salah satu kandungan yang terdapat pada buah nanas adalah vitamin C. Vitamin C dapat berperan sebagai antioksidan dan efektif dalam menanggulangi radikal bebas yang dapat merusak sel-sel tubuh. Akan tetapi, kandungan vitamin C dapat dipengaruhi oleh beberapa faktor seperti lingkungan tempat tumbuh dan proses pengolahan. Penelitian ini bertujuan untuk mengetahui kandungan metabolit sekunder, kadar vitamin C pada buah nanas dan keripik nanas. Tahapan penelitian ini meliputi pengolahan sampel, skrining fitokimia, pemeriksaan analisis kualitatif, penentuan kadar vitamin C. Hasil penelitian yang diperoleh yaitu kadar vitamin C sari nanas A sebesar 25.85000 ± 0.28250, sari nanas B sebesar 33.7500 ± 0.28250, sari nanas C sebesar 21.52500 ± 0.10076, sari nanas D sebesar 21.45000 ± 0.08899, keripik nanas A sebesar 15.11666 ± 0.11785, keripik nanas B sebesar 20.08333 ± 0.12382, keripik nanas C sebesar 12.0000 ± 0 dan keripik nanas D sebesar 11.93333 ± 0.12382.
PENETAPAN KADAR NATRIUM BENZOAT PADA MINUMAN RINGAN YANG BEREDAR DI KOTA MEDAN DENGAN METODE KROMATOGRAFI CAIR KINERJA TINGGI (KCKT) Lestari, Yunda; Pulungan, Ainil Fithri
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 9 No. 1 (2025): APRIL 2025
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v9i1.41005

Abstract

Minuman ringan merupakan salah satu minuman yang disukai sebagai pelepas dahaga yang memiliki rasa nikmat dan segar. Minuman ringan dapat disimpan dalam jangka waktu tertentu dengan memberikan bahan pengawet agar kualitas dari minuman tersebut dapat terjaga, adapun salah satu pengawet yang sering digunakan untuk minuman ringan yaitu natrium benzoat. Menurut Peraturan BPOM No. 11 Tahun 2019 batas maksimal penggunaan pengawet Natrium Benzoat pada minuman ringan yaitu 600 mg/kg. Pengkonsumsian natrium benzoat secara berlebihan dapat menyebabkan keram perut, rasa kebas dimulut bagi orang yang lelah. Penelitian ini bertujuan untuk menetapkan kadar natrium benzoat pada minuman ringan dengan metode kromatografi cair kinerja tinggi (KCKT) apakah sudah sesuai dengan Peraturan BPOM No. 11 Tahun 2019. Pada penelitian ini dilakukan pengujian secara kualitatif untuk mengetahui waktu tambat. Pengujian secara kuantitatif untuk mengetahui linieritas dan kadar sampel serta pengujian validasi untuk mengetahui nilai LOD dan LOQ dengan konsentrasi baku pembanding natrium benzoat 5 µg/mL, 10 µg/mL, 15 µg/mL, 20 µg/mL dan 25 µg/mL dengan kecepatan alir  1 mL/menit.Hasil pengujian kualitatif diperoleh waktu tambat sekitar 2,0 menit. Pada pengujian kuantitatif didapatkan persa maan regresi y = 71,7344 x + 267,958 dengan R2 = 0,9989 dengan Kadar sampel X = 8,8096 mg/kg, sampel Y  = 10,8379 mg/kg dan sampel Z = 8,4169 mg/kg dan hasil pengujian validasi didapatkan Nilai LOD = 0,3331 µg/mL dan nilai LOQ = 1,1102  µg/mL.  Dari hasil analisis yang telah dilakukan kadar Natrium Benzoat yang terdapat pada minuman ringan yang beredar di Kota Medan memenuhi syarat sesuai dengan Peraturan BPOM No. 11 Tahun 2019 yaitu 600 mg/kg.  
Characterization and Screening Phytochemicals Orange Purut Leaves (Citrus hystrix) Extract from Kampar, Riau Wijiyaningsih, Dinda; Ridwanto, Ridwanto; Yuniarti, Rafita; Pulungan, Ainil Fithri
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 3 No. 01 (2025): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : CV. Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58549/pcjn.v3i01.83

Abstract

Orange purut leaves (Citrus hystrix) are one of the shrubs that have high economic value because they contain vitamin C and are often used as a food flavoring. The aim of this research is to determine whether orange purut leaf extract contains phytochemicals and to characterize the properties of orange purut leaf extract. Phytochemical screening of orange purut leaf extract (Citrus hystrix) included the examination of flavonoids, tannins, saponins, steroids/triterpenoids, alkaloids, and glycosides. Phytochemical screening was conducted on both simplicia powder and simplicia extract, and characterization of the simplicia was carried out. The water content of orange purut leaves was found to be 8%, the water-soluble juice content was 37.9%, the ethanol-soluble juice content was 19%, the total ash content was 7.6%, and the acid-insoluble ash content was 0.6%. Orange purut leaf extract positively contains alkaloids, flavonoids, saponins, tannins, steroids/triterpenoids, and glycosides.
Penetapan Kadar Rhodamin B Pada Bumbu Tabur Dengan Metode KLT Dan KCKT Munthe, Ariska; Daulay, Anny Sartika; Ridwanto, Ridwanto; Pulungan , Ainil Fithri
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.845

Abstract

Rhodamine B is a colouring substance in the form of green or reddish-purple crystals, which are odourless and in the form of a bright red solution (fluorescent). Rhodamin B is a colouring substance that can only be used in the textile, paint, paper, or clothing industries, so it cannot be added to food. Rhodamine B is often used as a coloring agent in paper and textiles. This substance is the most dangerous; if consumed, it can cause problems with liver function and liver cancer. The stages of this research include a sample solution, making Rhodamin B standard stock solution, and making a mobile phase. Examination of qualitative analysis using thin layer chromatography and determination of Rhodamine B levels in seasoning performance liquid chromatography method. The results of the research showed that in the qualitative examination, there were two samples containing Rhodamin B. Rhodamin B levels were determined by determining the retention time and calculating Rhodamin B levels using the high-performance liquid chromatography method. The result of deciding Rhodamine B levels in the two samples containing Rhodamin B was sample A; 2,8915 mcg/g  ,sampel B ; 19,6702 mcg/g  Mcg/g. Then, the highest levels of Rhodamin B are found in sample B.
Pengaruh Metode Ekstraksi Daun Jarak Cina (Jatropha multifida L.) Secara Maserasi dan Microwave-Assisted Extraction (MAE) Terhadap Aktivitas Antijamur Pada Candida albicans Aryunda, Divia; Nasution, Muhammad Amin; Nasution, Haris Munandar; Pulungan , Ainil Fithri
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.868

Abstract

Introduction: Indonesia possesses high biodiversity, including the Jatropha multifida L. plant, which contains secondary metabolites with potential antimicrobial properties. Traditionally, the leaves of Jatropha multifida have been used as herbal medicine, particularly for inhibiting the growth of microorganisms. Objective: This study aims to determine the total flavonoid content in the ethanol extract of Jatropha multifida leaves and to compare the effectiveness of two extraction methods, maceration and Microwave-Assisted Extraction (MAE), in inhibiting the growth of Candida albicans. Methods: The research stages included the characterization of the powdered simplicia, extraction of Jatropha multifida leaves using 96% ethanol by maceration and MAE methods, and phytochemical screening. The total flavonoid content was determined using UV-Vis spectrophotometry at a wavelength of 431 nm. Antifungal activity against Candida albicans was tested for each extract at specific concentrations. Results: The ethanol extract obtained through maceration showed a total flavonoid content of 34.7089 ± 0.1206 mg QE/g, while the MAE method yielded 32.1923 ± 0.1113 mg QE/g. The highest antifungal activity was observed in the MAE extract at a 75% concentration, producing an inhibition zone of 24.7 mm. The maceration extract at the same concentration produced an inhibition zone of 23.7 mm. As a positive control, 2% ketoconazole resulted in an inhibition zone of 31.4 mm. Conclusion: Although the maceration method produced a higher total flavonoid content, the extract obtained through the MAE method demonstrated more potent antifungal activity against Candida albicans at the same concentration.
Kandungan Vitamin C dan Uji Aktivitas Antioksidan Teh Herbal Kombucha Daun Bidara (Ziziphus mauritiana Lam) Siagian , Anggi Yani; Yuniarti, Rafita; Daulay, Anny Sartika; Pulungan , Ainil Fithri
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.880

Abstract

Background: Bidara leaves (Ziziphus mauritiana Lam.) have long been used in traditional medicine due to their bioactive compounds, such as flavonoids, tannins, and vitamin C. Fermenting bidara leaves into kombucha has the potential to enhance antioxidant activity through bioconversion processes carried out by starter microbes (Acetobacter xylinum and Saccharomyces cerevisiae). However, scientific data regarding the vitamin C profile and antioxidant activity of bidara leaf kombucha remain limited. Objective: This study aims to analyze the vitamin C content and antioxidant activity of bidara leaf herbal kombucha, as well as to characterize the quality of the simplisia based on the Indonesian National Standard (SNI) 4324:2014. Methods: This descriptive study involved: (1) preparation of bidara leaf simplisia, (2) 12-day kombucha fermentation, (3) phytochemical screening, (4) determination of vitamin C content using UV-Vis spectrophotometry (λ = 266 nm), and (5) antioxidant activity assay using the DPPH method (λ = 517 nm). Results: The bidara leaf simplisia met the SNI quality standards, with a moisture content of 5.33% and a total ash content of 6.73%. Phytochemical screening identified the presence of flavonoids, saponins, tannins, glycosides, steroids/triterpenoids, and alkaloids. The vitamin C content of the kombucha was 0.009 mg/g, while the IC₅₀ value for antioxidant activity was 621.2158 µg/mL, which falls into the weak category. Conclusion: Bidara leaf kombucha contains bioactive compounds and vitamin C, with weak antioxidant activity. Fermentation increases antioxidant activity compared to non-fermented bidara tea infusion (IC₅₀ = 1129.0069 µg/mL), although it remains lower than that of pure vitamin C (IC₅₀ = 3.0710 µg/mL).
Skrining Fitokimia dan Uji Aktivitas Antibakteri Ekstrak Etanol Dedak Padi (Oryza sativa L.) terhadap Kebocoran Membran Bakteri Staphylococcus aureus Auza , Maharani; Nasution , Haris Munandar; Pulungan , Ainil Fithri; Rani , Zulmai
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.907

Abstract

Background: Rice bran is commonly utilized only as animal feed and is often regarded as a byproduct of rice milling. However, rice bran contains flavonoid compounds that exhibit antibacterial activity. This study aims to explore the potential of rice bran as an antibacterial agent, specifically against Staphylococcus aureus, through antibacterial activity testing and analysis of cell membrane leakage mechanisms. Objective: This research aims to utilize rice bran by evaluating its antibacterial activity and its mechanism of bacterial membrane leakage against Staphylococcus aureus. Methods: This experimental study involved the collection of rice bran samples, plant determination, simplicia characterization, and extraction using maceration with 96% ethanol. Phytochemical screening was conducted to identify active compounds, while antibacterial activity was tested using the disk diffusion method (Kirby-Bauer) at concentrations of 10%, 12.5%, 25%, 50%, 70%, and 80%. The membrane leakage mechanism was assessed by measuring nucleic acid and protein leakage (UV-Vis spectrophotometry) as well as Ca²⁺ and K⁺ ion release (atomic absorption spectrophotometry, AAS). Data were statistically analyzed using SPSS. Results: The ethanolic extract of rice bran yielded a 26.38% extraction yield and contained secondary metabolites, including alkaloids, flavonoids, tannins, saponins, triterpenoids/steroids, and glycosides. The antibacterial assay revealed inhibition zones classified as strong activity. Furthermore, rice bran extract induced membrane leakage in S. aureus, evidenced by increased mean absorbance values and standard deviations for DNA, protein (UV-Vis spectrophotometry), and Ca²⁺ and K⁺ ions (atomic absorption spectrophotometry) with rising extract concentrations. Conclusion: Rice bran exhibits potential as an antibacterial agent against Staphylococcus aureus through a membrane leakage mechanism. These findings support the utilization of rice bran not only as animal feed but also as a source of bioactive antimicrobial compounds.
Pelapisan (Edible Coating) Kitosan Cangkang Bekicot terhadap Mutu Fisikokimia Terung Belanda (Solanum betaceum) Humairah, Dwina Angelina; Ridwanto, Ridwanto; Dalimunthe, Gabena Indrayani; Pulungan, Ainil Fithri
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.908

Abstract

Background: Chitosan, a natural polysaccharide derived from chitin deacetylation, shows potential as a natural edible coating to extend the shelf life of perishable fruits. Utilizing giant African snail (Achatina fulica) shells as a chitosan source offers a sustainable solution to reduce biological waste while replacing synthetic chemicals in food preservation. Objective: This study aimed to analyze the effectiveness of snail shell chitosan as an edible coating in maintaining the physicochemical quality of tamarillo (Solanum betaceum) during storage. Methods: Chitosan was isolated from snail shells and applied at concentrations of 10%, 20%, and 30%. Antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa was tested using the disc diffusion method. Physicochemical parameters including weight loss, moisture loss, color, pH, total acidity, vitamin C content, and total soluble solids (TSS) were measured over 7 days of storage. Results: Chitosan demonstrated strong to very strong antibacterial activity, with the largest inhibition zones at 30% concentration (29 mm for S. aureus; 33.8 mm for P. aeruginosa). The 30% chitosan treatment yielded optimal results: lowest weight loss (3.15%), moisture loss (5.75%), pH (7.72), total acidity (16.44%), and TSS (1.350). Vitamin C retention was significantly higher in the 30% chitosan group (551.47 mg/100g) compared to control (416.53 mg/100g), confirming its effectiveness in inhibiting oxidation. Conclusion: 30% snail shell chitosan proved effective as an edible coating for maintaining tamarillo's physicochemical quality, while providing a natural and sustainable solution for the food industry.
Co-Authors Akbar, Windi Hari Amelia Amelia Amelia, Listri Ananda , Nadia Anny Sartika Daulay Anny Sartika Daulay Apriyana, Nana Aryunda, Divia Auza , Maharani Azhar, Gustika Bambang Hermanto Barutu, Liza Anisa Shevia Daulay , Anny Sartika Debi Dinha Octora Sitepu Devi Mariana Sinaga Dikki Miswanda Embun Fajri, Fajrilda Aqilah Fitria Gabena Indrayani Dalimunthe Harahap, Sumiyarni Harahap, Syafrin Ananda Haris Munandar Nasution Hasibuan, Yanuar Rizki Humairah, Dwina Angelina Lubis, Aulia Chairani Lubis, Minda Sari Maghfirah , Dini Mambang, D Elysa Putri Mardhatillah, Wulan Muhammad Amin Nasution Munthe, Ariska Nafisah, Zawahir Nia Novranda Pertiwi Nurmala, Syandoval Triska Ananda Panjaitan, Mawaddah Mairina Pitaloka, Syifa Amilia Rahayu , Yayuk Putri Rahma Dona Ricky Andi Syahputra Ridwanto Ridwanto Ridwanto Robiatun Rambe Rohmah, Roihanah Rosaldi, Hikmah Sagala , Vipi Zetiara Santasa, Zhazha Sari, Gusti Nawang Siagian , Anggi Yani Sirait, Warhamni Anatasya Sri Wahyuni Sunita, Della Supiyani, Supiyani Tamara Army Wijiyaningsih, Dinda Yayuk Putri Rahayu Yunda Lestari, Yunda Yuniarti , Rafita Yuniarti, Rafita Zulmai Rani