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All Journal Pharmascience Jambura Journal of Chemistry Jurnal Ilmiah Manusia dan Kesehatan PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Penelitian Farmasi dan Herbal Jurnal Kesehatan Tambusai Sasambo Journal of Pharmacy JIFI (Jurnal Ilmiah Farmasi Imelda) Jurnal Farmanesia International Journal of Health and Pharmaceutical (IJHP) SENTRI: Jurnal Riset Ilmiah FARMASAINKES PCJN Pharmaceutical and Clinical Journal of Nusantara Journal of Pharmaceutical and Sciences. Social Engagement: Jurnal Pengabdian Kepada Masyarakat Indonesian Journal of Science and Pharmacy Jurnal Bakti Nusantara Analit: Analytical And Environmental Chemistry
Fithri Pulungan, Ainil
Program Studi Farmasi, Fakultas Farmasi, Universitas Muslim Nusantara Al-Washliyah, Medan, Indonesia
Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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Merangkai Kreativitas, Membangun Karakter, dan Menjaga Kesehatan: Melalui Program Kuliah Kerja Nyata di SD Negeri 101812 Desa Namo Tualang Sirait, Warhamni Anatasya; Wahyuni, Sri; Lubis, Aulia Chairani; Apriyana, Nana; Sari, Gusti Nawang; Harahap, Syafrin Ananda; Pulungan, Ainil Fithri
Social Engagement: Jurnal Pengabdian Kepada Masyarakat Vol. 2 No. 4 (2024): September 2024
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat Universitas Internasional Batam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37253/se.v2i4.9853

Abstract

Kuliah Kerja Nyata (KKN) yang berlangsung selama 21 hari yaitu mulai dari tanggal 15 Juli sampai 03 Agustus, Adapun terdapat beberapa program kerja yang dilakukan mahasiswa Universitas Muslim Nusantara Al-Washliyah di SD Negeri 101812 Desa Namo Tualang diantaranya penyuluhan dan edukasi vit c, sosialisasi anti bullying, kegiatan P5, dan meningkatkan kreativitas pada anak melalui pembuatan kolase dari biji bijian pada siswa yg kurang memiliki minat belajar guna melatih motorik anak serta membantu wawasan anak dengan belajar sambil bermain. Kegiatan pengabdian mahasiswa bertujuan membantu menyelesaikan permasalahan, berkontribusi dan juga bersosialisasi dengan masyarakat. Program program ini berhasil meningkatkan pengetahuan, kesadaran, dan keterampilan siswa di berbagai aspek
Analysis of Sodium Benzoate Content in the Market Soft Beverages Using Uv-Vis Spectrophotometry Method Akbar, Windi Hari; Pulungan, Ainil Fithri; Ridwanto, Ridwanto; Daulay, Anny Sartika
Indonesian Journal of Science and Pharmacy Vol. 1 No. 1 (2023): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/ijsp.v1i1.15

Abstract

Sodium benzoate is one of the preservatives that are permitted to be used in food and beverages. Research has been carried out with the aim of knowing that carbonated drinks contain the preservative sodium benzoate, knowing the amount of sodium benzoate in soft drinks and to find out the levels of sodium benzoate in soft drinks fulfilling the maximum usage requirements according to BPOM RI Head Regulation No. 36 of 2013. This study used the uv-vis spectrophotometry method. To determine the preservative content of sodium benzoate, a qualitative test was first carried out on the sample using the color reaction method and esterification test. To determine the levels using a UV-Vis spectrophotometer at a wavelength of 269 nm with ethanol p.a as a solvent. The results of the qualitative test using the color reaction method showed that the three samples of soft drinks positively contained the preservative sodium benzoate. To validate this, an esterification test was carried out on the three samples and they produced the smell of Ambon bananas which proved that the three samples positively contained sodium benzoate. For the quantitative test using the Uv-Vis spectrophotometry method at a wavelength of 269 nm using ethanol p.a as a solvent. The results of the analysis showed that the preservative content of sodium benzoate which was calculated for each sample was for a soft drink sample a: 244.93 ± 19.9349 mg/kg. Soft drinks b: 65.3 ± 0 mg/kg, soft drinks. Soft drinks c: 78.6 ± 13.1291 mg/kg. Based on these results, it can be concluded that the levels of sodium benzoate in samples A, B, and C met the standard requirements for maximum usage limits, namely not more than 600 mg/kg.
Simultaneous Solubility Analysis of Paracetamol, Propyphenazone, and Caffeine Using Principal Component and Absorbance Ratio Regression Methods Rosaldi, Hikmah; Pulungan, Ainil Fithri; Ridwanto, Ridwanto; Daulay, Anny Sartika
Indonesian Journal of Science and Pharmacy Vol. 1 No. 2 (2023): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/ijsp.v1i2.39

Abstract

Medicines can cause changes in the physiology or psychology of an organism when consumed. In general, medicines consist of several mixtures of active ingredients such as paracetamol (PCT), propifenazone (PRO), and caffeine (KAF), which are often found in several types of branded medicines that are claimed to be able to cure or treat. This research aims to obtain a type of solvent that has the smallest photometric error value and can completely dissolve the active ingredient mixture of PCT, PRO, and KAF. In general, organic solvents such as ethanol and methanol are very often used to dissolve compounds that mix with each other, but these solvents cannot always dissolve other active substances. Therefore, researchers carried out an analysis of several types of solvents that could dissolve the three active ingredients. Solvents that can dissolve perfectly without any specification stage must go through a solvent optimization process. The types of solvents that will be tested are methanol, HCl 0.1N, phosphate buffer pH 7.2, and the ratio of phosphate buffer: methanol (DM) (DM 9:1 pH 7.4), (DM 7:3 pH 7.8), (DM 5:5 pH 8.3), (DM 3:7 pH 8.9), and (DM 1:9 pH 9.6). The results of this research show that the solvent that has the smallest photometric error value and can completely dissolve the three active substances is the DM 7:3 pH 7.8 solvent with a total percentage of 0.0846%, which is the smallest value compared to other solvents that have been optimized.
Sosialisasi Pemanfaatan Tanaman Herbal Kunyit Sebagai Alternatif Pencegahan Penyakit Dan Peningkat Daya Imun Tubuh di MTs Ar-Ridha Pulungan, Ainil Fithri; Nasution, Haris Munandar; Rani, Zulmai; Supiyani, Supiyani
Jurnal Bakti Nusantara Vol. 1 No. 1 (2023): Jurnal Bakti Nusantara
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/jbn.v1i1.1

Abstract

Kunyit merupakan salah satu jenis tanaman herbal yang memiliki prospek unuk dikembangkan, namun permasalahan dalam pemanfaatan dan pengolahan kunyit masih terbatas terutama pada kalangan muda. Untuk mengatasi masalah ini perlu dilakukan kegiatan sosialisasi untuk memberikan informasi terkait manfaat tanaman herbal kunyit dan pengolahannya. Kegiatan ini dilakukan di Yayasan Pendidikan Ar-Ridha tepatnya di MTs Ar-Ridha Desa Sidomulyo Kecamatan Biru-biru. Tujuan kegiatan ini adalah untuk melakukan sosialisasi agar generasi muda memiliki pengetahuan tentang manfaat dari tanaman herbal seperti kunyit yang biasa di gunakan sebagai bumbu penyedap masakan, bahwasanya selain menjadi bumbu masakan, kunyit juga dapat dimanfaatkan sebagai penangkal radikal bebas dan dapat meningkatkan daya imun tubuh ketika diolah menjadi minuma herbal (jamu). Metode yang dilakukan pada kegiatan ini adalah sosialisasi. Hasil kegiatan yang sudah dilakukan bahwa sekitar 80% siswa/i MTs Ar-ridha memiliki tanaman herbal dengan jenis yang berbeda-beda pada pekarangan rumah. Dan tanaman kunyit memiliki tingkat persentasi kedua yang diminati setelah tanaman sereh.
Konsentrasi Hambat Minimum dan Konsentrasi Bunuh Minimum Ekstrak dan Nanopartikel Ekstrak Etanol Daun Pepaya (Carica papaya L.) Terhadap Candida albicans Nurmala, Syandoval Triska Ananda; Rahayu , Yayuk Putri; Pulungan, Ainil Fithri; Miswanda, Dikki
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.999

Abstract

Background: Fungal infections, particularly those caused by Candida albicans, are a significant health problem in tropical countries such as Indonesia. Humid environmental conditions, inadequate sanitation, high population density, and low socioeconomic levels contribute to the high prevalence of fungal infections. Papaya leaves (Carica papaya L.) are known to contain bioactive compounds with antifungal potential; however, their effectiveness can be enhanced through nanoparticle formulation. Objective: This study aimed to formulate nanoparticles of ethanol extract from papaya leaves and evaluate their antifungal activity against Candida albicans by comparing the Minimum Inhibitory Concentration (MIC) and Minimum Fungicidal Concentration (MFC) values between the conventional extract and the nanoparticle extract. Methods: This experimental study utilized ethanol extract of papaya leaves and its nanoparticle formulation at varying concentrations. Particle size was characterized using a Particle Size Analyzer (PSA). Antifungal activity was tested against Candida albicans ATCC 10231 using broth and agar dilution methods as well as the disk diffusion method. Data were statistically analyzed using one-way ANOVA. Results: The nanoparticle extract exhibited a smaller particle size (330.27 nm) compared to the conventional extract (2203.45 nm). The MIC of the nanoparticle extract (1.25%) was lower than that of the conventional extract (12.5%), while the MFC of the nanoparticle extract (5%) was equivalent to that of the conventional extract (50%). The disk diffusion test showed that the 5% nanoparticle extract had an inhibition zone of 21.6 mm, classified as sensitive and comparable to the 50% conventional extract. Conclusion: The nanoparticle formulation of papaya leaf extract enhanced antifungal efficacy, enabling a tenfold dose reduction compared to the conventional extract. These findings highlight the potential of nanoparticles as a more efficient alternative therapy for fungal infections.
Penetapan Kadar Flavonoid Total dari Fraksi Etil Asetat Daun Sirsak (Annona muricata L.) Dengan Metode Spektrofotometri Uv-Vis Ananda , Nadia; Pulungan, Ainil Fithri; Nasution , Haris Munandar; Daulay , Anny Sartika
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.1023

Abstract

Background: The use of plants as traditional medicine is supported by their bioactive compounds, particularly secondary metabolites such as flavonoids. Soursop leaves (Annona muricata L.) are known to be rich in these compounds; however, quantitative data, especially in specific fractions, remain limited. Determining the total flavonoid content is essential for the standardization of herbal raw materials. Objective: This study aimed to identify the classes of chemical compounds present in the ethanol extract and ethyl acetate fraction of soursop leaves and to determine the total flavonoid content of both samples. Methods: Soursop leaf simplicia was extracted using 70% ethanol by the maceration method. The resulting ethanol extract was then fractionated with ethyl acetate. Phytochemical screening was conducted to identify compound classes, while the determination of total flavonoid content was quantitatively analyzed using the UV-Vis spectrophotometry method with quercetin as the standard. Results: Phytochemical screening revealed that both the ethanol extract and the ethyl acetate fraction tested positive for alkaloids, flavonoids, tannins, and steroids/triterpenoids. The total flavonoid content obtained in the ethanol extract was 31.524 ± 0.1524 mg QE/g, while the ethyl acetate fraction showed a significantly higher content of 41.425 ± 0.1363 mg QE/g. Conclusion: Fractionation with ethyl acetate effectively concentrated flavonoid compounds from the crude soursop leaf extract, as indicated by the higher total flavonoid content in the ethyl acetate fraction. These findings support the potential of the ethyl acetate fraction of soursop leaves as a source of flavonoids for the development of standardized herbal medicines.
UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN TERONG HIJAU (SOLANUM MELONGENA) DALAM KEBOCORAN DNA DAN PROTEIN BAKTERI Barutu, Liza Anisa Shevia; Nasution, Haris Munandar; Rahayu, Yayuk Putri; Pulungan, Ainil Fithri
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 9 No. 2 (2025): AGUSTUS 2025
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v9i2.45009

Abstract

Penyakit menular merupakan masalah kesehatan yang sering disebabkan oleh berbagai spesies bakteri. Escherichia coli mewakili patogen umum. Enzim metabolisme yang terdapat pada daun terong hijau (Solanum melongena) memiliki sifat antibakteri. Tujuan dari penelitian ini adalah untuk mengevaluasi intensitas aktivitas bakteri dan kebocoran DNA dan protein bakteri. Penelitian ini bersifat eksperimental, dengan dilakukan uji karakterisasi simplisia dan daun terong hijau di ekstraksi dengan metode maserasi. Analisis kimia terhadap serbuk dan ekstrak dilakukan, kemudian diuji aktivitas antibakterinya dengan cara difusi pada kertas pada suhu 37oC selama 24 jam. Kebocoran DNA dan protein bakteri diverifikasi dengan spektrofotometri UV-visibel. Daun terong hijau mengandung alkaloid, flavonoid, glikosida, tanin, saponin dan steroid, menurut hasil percobaan. Berdasarkan konsentrasi 2,5, 5, 7,5 dan 10%, hasil uji aktivitas antibakteri daya hambat ekstrak daun terong hijau adalah 6,7, 7,7, 8,1 dan 9,9 mm. Konsentrasi DNA dan protein 10% pada kelompok perlakuan sedikit lebih tinggi dibandingkan pada kelompok kontrol positif, dengan nilai serapan pada 260 nm (DNA) dan 280 nm (protein).
Analisis Kadar Parasetamol dan Kafein Dalam Sediaan Tablet Menggunakan Metode Spektrofotometri Derivatif Zero Crossing Rosaldi, Hikmah; Pulungan, Ainil Fithri; Ridwanto, Ridwanto
Jambura Journal of Chemistry Vol 7, No 2 (2025): August
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/jambchem.v7i2.24392

Abstract

The development of drugs in the form of combination tablets at this time has increased a lot; combining drugs in a tablet preparation can provide an increasing reaction and ability. This makes combining drugs such as Paracetamol and caffeine an effective combination in the pharmaceutical field. Paracetamol is an antipyretic analgesic drug that can be combined with caffeine which can be used in therapy with a combination of these drugs. The objective of this research was to ascertain the concentration of a combination of paracetamol and caffeine in a tablet formulation by employing a zero cross-derivative spectrophotometric method. In this study, solvent optimization was carried out with 17 categories of solvent selection, and acetate: methanol (30:70) was selected using the zero cross-derivative methods with a dA / d plot utilizing the maximum wavelength of paracetamol 258 nm and caffeine 288 nm, because there was an actual wavelength shift in this analysis. To validate the determination of the level of the zero cross-derivative method using the second absorption in the ace solvent (30:70 acetate: methanol). Spectrophotometric analysis of zero crossing derivatives of a mixture of paracetamol and caffeine found that paracetamol levels in tablet A were 95.24 8.47%, in tablet B of 92.86 0%, and in tablet C of 96.5 0%, while the caffeine content was 104.89 0%, 102.09 0%, and 91.6 0%. According to USP 30 NF 25 (2007), it can be concluded that the test results of the composition of paracetamol and caffeine in tablets meet the requirements.
Analisis kadar parasetamol dan kafein dalam sediaan tablet menggunakan metode spektrofotometri derivatif zero crossing Pulungan, Ainil Fithri; Rosaldi, Hikmah; Rani , Zulmai
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 3 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i3.489

Abstract

The development of drugs in the form of combination tablets at this time has increased a lot; combining drugs in a tablet preparation can provide an increasing reaction and ability. This makes combining drugs such as Paracetamol and caffeine an effective combination in the pharmaceutical field. Paracetamol is an antipyretic analgesic drug that can be combined with caffeine which can be used in therapy with a combination of these drugs. The objective of this research was to ascertain the concentration of a combination of paracetamol and caffeine in a tablet formulation by employing a zero cross-derivative spectrophotometric method. In this study, solvent optimization was carried out with 17 categories of solvent selection, and acetate: methanol (30:70) was selected using the zero cross-derivative methods with a dA / d plot utilizing the maximum wavelength of paracetamol 258 nm and caffeine 288 nm, because there was an actual wavelength shift in this analysis. To validate the determination of the level of the zero cross-derivative method using the second absorption in the ace solvent (30:70 acetate: methanol). Spectrophotometric analysis of zero crossing derivatives of a mixture of paracetamol and caffeine found that paracetamol levels in tablet A were 95.24 8.47%, in tablet B of 92.86 0%, and in tablet C of 96.5 0%, while the caffeine content was 104.89 0%, 102.09 0%, and 91.6 0%. According to USP 30 NF 25 (2007), it can be concluded that the test results of the composition of paracetamol and caffeine in tablets meet the requirements.
Uji toksisitas menggunakan metode BSLT dan uji antibakteri Staphylococcus aureus dan Escherichia coli ekstrak dan fraksi daun karamunting (Rhodomyrtus tomentosa (Aiton) Hassk.) Sagala , Vipi Zetiara; Ridwanto, Ridwanto; Daulay , Anny Sartika; Pulungan , Ainil Fithri
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.823

Abstract

Karamunting leaves are a Myrtaceae family plant used as an antioxidant, antimicrobial, antiviral, anticancer, and antibacterial. This research aimed to determine secondary metabolite compounds, toxicity effects, and antibacterial activity in extracts and fractions of karamunting (Rhodomyrtus tomentosa (Aiton) Hassk.) leaves. This research includes characteristics, phytochemical screening, a BSLT (Brine Shrimp Lethality Test) method toxicity test, and an antibacterial test using the paper disc method. Toxicity tests were carried out with concentrations of (100, 200, 300, 400, 500, 600, 700, 800, 900, 1000) µg/mL, and antibacterial tests against staphylococcus aureus and Escherichia coli were carried out with concentrations of 10, 20 and 30%. The ethanol extract and ethyl acetate fraction results contain alkaloids, flavonoids, triterpenoids or steroids, tannins, and saponins. And the n-hexane fraction contains triterpenoids or steroids. Toxicity test of ethanol extract, n-hexane fraction, and ethyl acetate of karamunting leaves (Rhodomyrtus tomentosa (Aiton) Hassk.) has a toxic effect on Artemia Salina Leach. In the ethanol extract, an LC50 value of 92.593 µg/mL was obtained, followed by the n-hexane fraction with an LC50 value of 153.3829 µg/mL. Then, the ethyl acetate fraction LC50 value was 75.9328 µg/mL. LC50 value. Based on the results obtained from the ethanol extract, the n-hexane and ethyl acetate fractions of caramunting leaves (Rhodomyrtus tomentosa (Aiton) Hassk.) were classified in the toxic category, and the antibacterial test of the ethanol extract, the n-hexane and ethyl acetate fractions of caramunting leaves (Rhodomyrtus tomentosa (Aiton) Hassk.) has antibacterial activity against Staphylococcus aureus and Escherichia coli bacteria. The most potent inhibitory power was found in the ethyl acetate fraction with a concentration of 30% against staphylococcus aureus 16.1 mm and Escherichia coli 17.1 mm in the strong category.
Co-Authors Akbar, Windi Hari Amelia Amelia Amelia, Listri Ananda , Nadia Andi Syahputra, Ricky Anny Sartika Daulay Anny Sartika Daulay Apriyana, Nana Aryunda, Divia Auza , Maharani Azhar, Gustika Bambang Hermanto Barutu, Liza Anisa Shevia Daulay , Anny Sartika Debi Dinha Octora Sitepu Devi Mariana Sinaga Dikki Miswanda Dinda Sari Utami Embun Fajri, Fajrilda Aqilah Fitria Gabena Indrayani Dalimunthe Harahap, Sumiyarni Harahap, Syafrin Ananda Haris Munandar Nasution Hasibuan, Yanuar Rizki Humairah, Dwina Angelina Lubis, Aulia Chairani Lubis, Minda Sari Maghfirah , Dini Malahayati Malahayati Mambang, D Elysa Putri Mardhatillah, Wulan Mayani, Nurhikma Muhammad Amin Nasution Munthe, Ariska Nafisah, Zawahir Nasri Nasri, Nasri Nia Novranda Pertiwi Nurmala, Syandoval Triska Ananda Oktavia, Zela Panjaitan, Mawaddah Mairina Pitaloka, Syifa Amilia Rahayu , Yayuk Putri Rahma Dona, Rahma Rambe, Robiatun Ridwanto Ridwanto Ridwanto Rohmah, Roihanah Rosaldi, Hikmah Sagala , Vipi Zetiara Santasa, Zhazha Sari, Gusti Nawang Siagian , Anggi Yani Sirait, Warhamni Anatasya Sri Wahyuni Sunita, Della Supiyani, Supiyani Tamara Army Vera Estefania Kaban Wijiyaningsih, Dinda Yayuk Putri Rahayu Yunda Lestari, Yunda Yuniarti , Rafita Yuniarti, Rafita Ziza Putri Aisyia Fauzi Zulmai Rani