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All Journal Jurnal Kesehatan Andalas INDONESIAN JOURNAL OF PHARMACY Universa Medicina Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan Buletin Ilmiah Nagari Membangun Majalah Kedokteran Andalas Bioscientia Medicina : Journal of Biomedicine and Translational Research Sumatera Medical Journal Indonesian Journal of Health Sciences Research and Development (IJHSRD) Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Ilmu Kesehatan Indonesia (JIKSI) JKKI : Jurnal Kedokteran dan Kesehatan Indonesia SENTRI: Jurnal Riset Ilmiah The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Consilium Sanitatis: Journal of Health Science and Policy
Dwitya Elvira, Dwitya
Fakultas Kedokteran Universitas Andalas
Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary Other

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Journal : INDONESIAN JOURNAL OF PHARMACY

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The Effect of Thionamide to TRH, TSH, IL-4, T-REG, and Anti-TPO in Graves’ Disease Eva Decroli; Dwitya Elvira; Dinda Aprilia
Indonesian Journal of Pharmacy Vol 30 No 2, 2019
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (774.604 KB) | DOI: 10.14499/indonesianjpharm30iss2pp122-127

Abstract

The most common cause of hyperthyroidism is Graves' disease. TRH and TSH are hormonal factors that modulate and control thyroid function in Graves' disease. In the immunological aspect, Graves' disease is played by the role of T-reg, IL-4, and anti-TPO. Graves' disease treatment goal is to inhibit thyroid hormone secretion by administering thionamide. The evaluation of this treatment is its hormonal and immunological aspects. To describe the effect of thionamide on serum TRH, TSH, IL-4, T-reg, and anti-TPO levels in Graves' disease. This study is a clinical trial study in 25 study participants. All study participants were given thionamide, namely PTU 300mg for three months and blood samples were taken for laboratory tests. Serum TRH, TSH, IL-4, T-reg FOXP3, and anti-TPO levels were examined by ELISA. The mean levels at the beginning and after three months of therapy are: serum TRH 92.589pg/mL and 115.944pg/mL; serum TSH 0.041mU/L and 0.223mU/L; serum IL-4 19.759pg/mL and 23.040pg/mL; T-reg FOXP3 gene polymorphism 0.621ng/mL and 0.518 ng/mL; serum anti-TPO 2697.539pg/mL and 2604.710pg/mL. Increased levels of serum TRH and TSH levels were statistically significant. The change in serum IL-4, T-reg FOXP3 gene polymorphism, and anti-TPO levels were not statistically significant. The administration of thionamide in Graves' disease for three months will significantly decrease Wayne index and serum FT4 levels, increase serum TRH and TSH levels.
Co-Authors Abdiana Addina, Azka Adrial Adrial Afriwardi Afriwardi Ahmad, Armen Akmal M. Hanif Akmal, Elfi Fauzana Alexander Kam Alexander Kam Almurdi Almurdi Amirah Zatil Izzah Aprilia, Dinda Arina Widya Murni Arnelis . Arridho, Rijalun Azia Putri Al Jamil Bestari J. Budiman Citra Manela Deddy Saputra Delfin, Muhamad Dian Pertiwi Dinda Aprilia Dolly Irfandy Efrida Efrida Efrida Elvia Fataya Eva Decroli Fadrian, Fadrian Faheri, Eifel Firdawati Fortuna, Fory Gestina Aliska Gustia Anugrahwati Gustin, Hanna Hendriati, Hendriati Herinda, Dwi Putri Herman, Deddy Ilmiawati, Ilmiawati Jannah, Lidya Raudhatul Julizar Kurniawan, Eka Linosefa Linosefa Malinda Meinapuri masri, Raveinal Muhamad Delfin Muhammad Iqbal Andreas Mustafa Noer Mustafa Noer Nadia, Rizka Netti Suharti Netti Suharti, Netti Noverika Windasari Paishal Mizan Poedjijo, Yanuar Saputra Poedjijo, Yanuar Surya Saputra Putra, Andani E. Rahayuningsih, Sri Puji Rahmadina, Rahmadina Rahmadina, Rahmadina Ramadanti, Zilhadia Mona Raveinal Raveinal Raveinal RAVEINAL RAVEINAL Raveinal Raveinal Rido Wandrivel Rikarni Rikarni Rini Gusya Liza, Rini Gusya Rismawati Yaswir Rizka Nadia Rizqy Auliya Lubis Rose Dinda Martini Roza Kurniati Roza Kurniati Roza Kurniati Roza Mulyana RR. Ella Evrita Hestiandari Rudy Afriant Russilawati, Russilawati Saptino Miro Saptino Miro, Saptino Saputra Poedjijo, Yanuar Surya Siti Nurhajjah Steven, Rios Suci Maulida Syandrez Prima Putra Triananda, Claudia Ulti, Zifa Amanda Viotra, Deka WAHYUDI Wahyudi . Yoga, Vesri Yuliarni Syafrita Yulistini, Yulistini zahra salsabila Zelly Dia Rofinda