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All Journal HAYATI Journal of Biosciences ILMU KELAUTAN: Indonesian Journal of Marine Sciences Jurnal Ilmu Kedokteran (Journal of Medical Science) BIOTROPIA - The Southeast Asian Journal of Tropical Biology Perspektif : Review Penelitian Tanaman Industri Indonesian Journal of Pharmaceutical Science and Technology Indonesian Journal of Biotechnology Elkawnie Majalah Obat Tradisional Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan Acta Pharmaceutica Indonesia JSFK (Jurnal Sains Farmasi & Klinis) JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurnal Farmasi Indonesia Perspektif, Review Penelitian Tanaman Industri Current Research on Biosciences and Biotechnology Nusantara Hasana Journal Archives Pharmacia Proceeding of Mulawarman Pharmaceuticals Conferences Journal of Applied Agricultural Science and Technology Jurnal Farmasi Sains dan Praktis Jurnal Natural Riset Informasi Kesehatan AGRIC Jurnal Pengabdian Masyarakat Kesehatan (JURABDIKES) Borneo Journal of Pharmacy Kartika : Jurnal Ilmiah Farmasi Journal of Tropical Pharmacy and Chemistry Greensusmater Agroscript: Journal of Applied Agricultural Sciences
Elfahmi Elfahmi, Elfahmi
School of Pharmacy, Bandung Institute of Technology
Agriculture, Biological Sciences & Forestry Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary

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Journal : HAYATI Journal of Biosciences

 1 
The Inhibition of 15-Lipoxygenase by Blechnum orientale Leaves and its Glycoside-flavonoid Isolates: In Vitro and In Silico Studies Rissyelly Rissyelly; Syaikhul Aziz; Frangky Sangande; Agung Wibawa Mahatva Yodha; Krisyanti Budipramana; Elfahmi Elfahmi; Sukrasno Sukrasno
HAYATI Journal of Biosciences Vol. 29 No. 3 (2022): May 2022
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.29.3.353-359

Abstract

Fern is one of the groups of primitive plants rich in secondary metabolites that are commonly used to treat various diseases, including antioxidant, anti-hyaluronidase, anti-inflammation, and respiratory disease but less investigated. Flavonoid is one of the secondary metabolites abundantly present in ferns. This study aims to isolate major compounds found in Blechnum orientale act as 15-lipoxygenase (15-LOX) inhibitors. Inhibition of lipoxygenase decrease the production of leukotriene that induces bronchoconstriction in asthma. Isoquercitrin (Quercetin-3-O-β-glucopyranoside) and trifolin (kaempferol-3-O-β-D-galactoside) have been successfully isolated from Blechnum orientale. Further in silico study was performed to explain the binding mode between flavonoid pyranoside or galactoside and flavonoid aglycone in the 15-LOX cavity and their amino acid residues interaction. Isoquercitrin binds with Ile663, Ile400, Leu408, Leu597, Ala404, and Arg403 in the 15-LOX cavity as a lipoxygenase inhibitor. Trifolin binds the same amino acids as isoquercetin with addition His366, Gln596, and Phe175. Both isoquercitrin and trifolin act as competitive inhibitors against lipoxygenase enzymes.
Effect of Media Variation on the Induction and Phytochemical Profile of Callus in Two Varieties of Cat's Whiskers (Orthosiphon aristatus Blume Miq) Fahrauk Faramayuda; Akhirul Kahfi Syam; Totik Sri Mariani; Elfahmi; Sukrasno
HAYATI Journal of Biosciences Vol. 30 No. 1 (2023): January 2023
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.30.1.159-170

Abstract

The levels of rosmarinic acid and sinensetin in purple and white-purple varieties of Orthosiphon aristatus, cat's whiskers, can be increased using modified in vitro culture. This work focused on callus induction of the purple and white-purple variety of cat's whiskers grown on Gamborg (B5) and CHU (N6) with the addition of growth regulators 2,4-dichlorophenoxyacetis acid. Our observation suggested that the callus could grow within three weeks and produce rosmarinic acid and sinensetin. The level of sinensetin from various extraction methods is relatively low; in contrast, the rosmarinic acid from purple callus was detected at about 5% w/w, while the white-purple variety was around 2% w/w. The results of this study also provided new information on the basic media other than MS that can grow cat's whiskers callus while producing active compounds.
Co-Authors Adella Shindy Pratiwi Adji Mustiaji Agus Chahyadi Agus Chahyadi Agus Chahyadi Agus Supriadi Aisyah, Siti Zanuba Akbar Dana Akhirul Kahfi Syam Ana Indrayati Andi Rifki Rosandy Andre Ditya Maulana Lubis Andreanus A Soemardji Anggardiredja, Kusnandar Anita K Ari Sr Windyaswari Ari Sri Widyaswari Ari Sri Windyaswari Ari Sri Windyaswari, Ari Sri Ariranur Haniffadli ARTRI Astrid Indalifiany Ayu, Inna Puspa Bashari, Muhammad Hasan Beginer Subhan Budipramana, Krisyanti Choirul Huda Dana, Akbar DEBBIE SOEFIE RETNONINGRUM Desyane, Heipy Ketrin Dondy Arafat Edikresnha, Dhewa FAHRAUK FARAMAYUDA Fahrauk Faramayuda Fahrauk Faramayuda, Fahrauk Fany Mutia Cahyani Fatimah Arofiati Noor Frangky Sangande Ghozaly, Muchammad Reza Hapidin, Dian Ahmad Heipy Ketrin Desyane Jaka Permana Jenny Tri Yuspita Sari Khairunisa Harizqi Nurul Husna Khairunnisa Sy Khairurrijal khairurrijal Komar Ruslan Komar Ruslan Wirasutisna Komar Ruslan Wirasutisna Komar Ruslan Wirasutisna Kusnandar Anggardiredja Laode M.R. Al Muqarrabun Laode M.R. Al Muqarrabun Lusi Putri Dwita Luthfianti, Halida Rahmi Manalu, Meilina Marsinta Maria Immaculata Iwo Maria Immaculata Iwo Maria Immaculata Iwo MARLIA SINGGIH WIBOWO Marlia Singgih Wibowo Marlin Megalestin Raunsai Meilina Marsinta Manalu Melani, Putri Dwi Morawati, Soufni Muamar Abdillah Nabila K Nafisah, Nuraini Nebuchadnezzar Akbar NEVIATY PUTRI ZAMANI Ni Kadek Dita Cahyani, Ni Kadek Dita Niken Tunjung Murti Pratiwi Novriyandi Hanif Nurinanda Prisky Qomaladewi Nurul Nadiah Binti Abdul Rahman Oktiyas Muzaky Luthfi Pratiwi Ramadhani Feriza Rachmat Mauludin Ramelan, Riska Sigit RENALDI OKTAVIANUS Retno Wahyuningrum Retno Wahyuningrum Ridzka Magfirah Rika Amran Rika Hartati Riska Sigit Ramelan Rissyelly Rissyelly Rozida Khalid Sahidin Sahidin Salsabila, Syefira Sani, Lalu M. Iqbal Santoso, Winny Sartika Yuniarti Sawitri, Asti Shinta Maulida Rosandhy Sigid Pamungkas Wicaksono Silvy Julian Soemardji AA Sony Suhandono SONY SUHANDONO Sony Suhandono Soraya Riyanti Soraya Riyanti Sufyan Zainul Arifin Sukrasno Sukrasno Sukrasno Sukrasno Sukrasno Sukrasno Sukrasno Sukrasno Sukrasno Sulistiarini, Riski Sultan Salahudin Jamal Sumirtapura, Yeyet Cahyati Syafrizayanti, Syafrizayanti Syaikhul Aziz Tan MI Tati Kristanti TATI KRISTIANTI Tina Rostinawati Totik Sri Mariani Totik Sri Mariani Totik Sri Mariani Totik Sri Mariani Waresindo, William Xaveriano Weni Widy Astuti Winny Santoso Wirasutisna, Komar Ruslan Wirasutisna, Komar Ruslan Wiwin Herdwiani Yasa, Yanti Fitri Yeni Karlina Yodha, Agung Wibawa Mahatva Yolazenia Yolazenia Yosie Andriani Yuspita Sari, Jenny Tri Zaini Alfahmi