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All Journal Agrikultura Alchemy : Journal of Chemistry Al-Tahrir: Jurnal Pemikiran Islam EDUCATIO : Journal of Education Sketsa Bisnis Studi Arab AGROMIX Edubiotik : Jurnal Pendidikan, Biologi dan Terapan Jurnal al-Murabbi Journal Multicultural of Islamic Education JURNAL MEDIA PENDIDIKAN AGAMA ISLAM Proceedings of Annual Conference for Muslim Scholars Journal of Social Political Sciences (JSPS) Jurnal Mu'allim Soeropati: Journal of Community Service Al-Ittishol : Jurnal Komunikasi dan Penyiaran Islam Borneo Journal of Biology Education (BJBE) At-Tajdid: Jurnal Ilmu Tarbiyah Bukhori: Kajian Ekonomi dan Keuangan Islam Assyfa Learning Journal Assyfa Journal of Islamic Studies Engagement: Jurnal Pengabdian Kepada Masyarakat IERA, Islamic Education and Research Academy Tarbawi : Jurnal Studi Pendidikan Islami Edubiotik : Jurnal Pendidikan, Biologi dan Terapan Tarbawi : Jurnal Studi Pendidikan Islami BISMA: Bimbingan Swadaya Masyarakat Humanist Journal Al-Qiyadah
Amang Fathurrohman
STAI Salahuddin Pasuruan, Indonesia
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Energy Engineering Environmental Science Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Social Sciences Other

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Journal : Alchemy : Journal of Chemistry

 1 
Bioinformatics Approach: Evaluating the Antiviral Potential of Flavonoid Compounds from Phyllanthus urinaria against Foot-and-Mouth Disease in Livestock Animals Nugroho, Endik Deni; Sururi, Ahmad Misbakhus; Ardiansyah, Reza; Rahayu, Dwi Anggorowati; Ainiyah, Roisatul; Fathurrohman, Amang; Ahwan, Zainul; Dayat, Muhammad; Wibisono, Mulyono; Aji, Fatit Rahmar; Kasiman, Kasiman
ALCHEMY:Journal of Chemistry Vol 12, No 1 (2024): ALCHEMY: JOURNAL OF CHEMISTRY
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/al.v12i1.23575

Abstract

Foot-and-mouth disease is a severe problem that must be faced in the livestock sector. This disease has a negative impact on various aspects, especially the economy. One way to develop herbal medicinal compounds is through local Indonesian wild plants, meniran (Phyllanthus urinaria). This research aims to determine the potential of the wild plant P. urinaria as an antiviral agent for FMD using an in silico approach using molecular docking. The compounds used as ligands are flavonoid compounds in P. urinaria, namely, routine, quercetin 7-methyl ether, quercetin 3-O-β-D-glucoside, quercetin, rhamnocitrin, astragalin, and kaempferol. This study used the control drug ribavirin as a comparison. The research stage began with the preparation of the RdRp protein from the FMD virus with Discovery Studio, ligand preparation with the Lipinski druglikeness test and minimization using OpenBabel, followed by docking and visualization. The research results found that the six flavonoid compounds in P. urinaria have potential as antiviral FMD by inhibiting RdRp, with the most potent compound being quercetin (-7.9 kcal/mol). Further research is needed, including in vitro and in vivo testing, to provide confidence in the potential of this wild plant as an antiviral for FMD.
Co-Authors Abd. Aziz Abror, Daimul Ahwan, Zainul Ahwan, Zainul Ainiyah, Roisatul Aji, Fafit Rahmat Aji, Fafit Rahmat Aji, Fatit Rahmar Alfian Adi Saputra Alfian Adi Saputra Saputra Any Urwatul Wusko Apriwiyanto, Syukur Sugeng Ari Khusumadewi Ayu, Yamita Azizah, Imroatul Bahiyyah, Khoridatul Barid Nizarudin Wajdi, Muh Bustomi, Abu Amar Cahya Mar’a Saliha Sumantri Choirudin, Choirudin Dayat, M Dayat, Muhammad Diyono Yusuf Dwi Anggorowati Rahayu Dwi Anggorowati Rahayu Dwi Anggorowati Rahayu Endang Tyasmaning Tyasmaning Endik Deni Nugroho Endik Deni Nugroho Endik Deni Nugroho Endik Deni Nugroho Fadliatul Mukhayyaroh Fafit Rahmat Aji Fafit Rahmat Aji Fafit Rahmat Aji Fafit Rahmat Aji Fafit Rahmat Aji Fajarudin, Ahmad Aris Fatmah K Fauziyah Rahmawati Hasan, Ziyaana Hendratama, Handik Hijrin Fitroni Hufron Husna, Maleek Ida Rochmawati, Ida Imam Syafi’i Irfan, Moh Jauhari, Moh. Irmawan Kasiman Kasiman Kasiman Kasiman Kasiman Kasiman, Kasiman Kasiman, Kasiman Khoirul Anam KHOIRUL ANAM Kinanti Sutama, Daning Lely Ana Ferawati Ekaningsih Lukman Hakim Lukman Hakim M Dayat M. Daimul Abror M. Rifqi Nur Habibi M. Rifqi Nur Habibi M. Rikza Chamami M. Wildan Adnan Makhfud Syawaludin Matrani Mayang Sari Mochamad Hasyim Mohammad Yusuf Wijaya Muhammad Barid Nizaruddin Wajid Muhammad Dayat Muhammad Dayat Muhammad Holimi Muhammad Muhlis Muhammad Nur Hadi Muhammad Wardianto Muhammad Yusuf Mukarromah, Neng Mulyono Wibisono Mulyono Wibisono Mulyono Wibisono Mulyono Wibisono Mulyono Wibisono Mulyono Wobisono Muniroh, Alimul Muyidin Ning Mukaromah Nur Khosiah Nur'aini, Afifah Diyah NURIL HIDAYATI Pamungkas, Muhamad Imam Pasaribu, Aswin Priatmojo Suryo Kuncoro Qulub, Syifaul Reza Ardiansyah Rohmat rohmat Roib Santoso Roisatul Ainiyah Sa'adillah S.A.P. , Rangga Satria Hadingra, Mahendra Sodiq Sodiq Sofiyulloh Suadi Suadi Sukamto . Sururi, Ahmad Misbakhus Syafi'i, Ahmad Syafi’i, Imam Syaiful Mustofa SYAIFUL RIZAL, HASAN Syukur Sugeng Apriwiyanto Syukur Sugeng Apriwiyanto Trio Ageng Prayitno, Trio Ageng Triyandana, Arga Ubaidillah Uddin, Md. Akther Ulya, Fahimatul Umar, Muallief Wajdi, Muh Barid Nizarudin Wardianto, Muhammad Wibisono, Mulyono Wibisono, Mulyono Wildan Adnan Wobisono, Mulyono Yuni Lestari Yuni Masrifatin, Yuni Yusuf Yusuf Yusuf, Diyono Zuhri, Zainullah