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All Journal Jurnal Kesehatan Andalas Journal of Agromedicine and Medical Sciences Buletin Ilmiah Nagari Membangun Oto Rhino Laryngologica Indonesiana Majalah Kedokteran Andalas Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Ilmu Kesehatan Indonesia (JIKSI) SENTRI: Jurnal Riset Ilmiah Jurnal Anestesi: Jurnal Ilmu Kesehatan dan Kedokteran Jurnal Otorinolaringologi Kepala dan Leher Indonesia (JOKLI) Jurnal Riset Ilmiah Seroja Husada: Jurnal Kesehatan Masyarakat
Ade Asyari
Bagian Telinga, Hidung, Tenggorok, Kepala, Dan Leher FK Unand/RSUP Dr. M. Djamil Padang
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NILAI AMBANG PROKALSITONIN DAN RISIKO KEMATIAN DINI PADA ABSES LEHER DALAM: PERSPEKTIF KLINIS: procalciton pada abses leher dalam Asyari, Ade; Tri Novriansyah, Wahyu; Novialdi, Novialdi; Dia Rofinda, Zelly; Rasyid, Rosfita; Utami, Refi Amalia
Oto Rhino Laryngologica Indonesiana Vol. 55 No. 2 (2025): VOLUME 55, NO. 2 JULY - DECEMBER 2025
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v55i2.744

Abstract

Background: Procalcitonin (PCT) is widely used as an inflammatory marker in sepsis, but still controversial in deep neck abscesses. Purpose: To evaluate the usefulness of PCT as outcome predictor in deep neck abscess. Method: A prospective observational cohort study was conducted at Dr. M. Djamil Hospital, Padang, Indonesia (March 2022–May 2023). Patients with confirmed deep neck abscess by pus aspiration in the Emergency Department were included. Baseline laboratory and serum PCT tests were performed before surgical drainage. All patients received broad-spectrum antibiotics and standard postoperative care. Assessed outcomes were mortality, septic shock, organ failure, mediastinitis, empyema/ pleural effusion, necrotizing fasciitis, tracheostomy, pharyngocutaneous fistula, Intensive Care Unit >24 hours, and hospital stay. Result: Thirty-five patients met inclusion criteria. Multiple neck space involvement was found in 74.3%, and 93.4% underwent surgery. Mortality occurred in 28.6%, septic shock in 20%, mediastinitis in 14.3%, empyema/pleural effusion in 11.4%, necrotizing fasciitis in 8.6%, tracheostomy in 5.7%, fistula in 8.6%, and ICU stay >24 hours in 20%. Mean hospital stay was 9.03±7.90 days. Mean admission PCT was 0.313±0.677 ng/mL, with 17.1% having elevated PCT>0.5 ng/mL. No significant correlation was found between PCT and overall outcome. However, Receiver Operating Characteristic (ROC) analysis showed PCT≥0.14 ng/mL, predicted <5-day mortality (sensitivity 85.7%, specificity 78.4%), Area Under Curve (AUC) 0.773, p=0.027). Conclusion: Procalcitonin showed potential as an adjunctive marker in deep neck abscess. Although low initial levels are frequent, they do not exclude severe complications, highlighting its role in early risk stratification and clinical decisions.
Delayed Diagnosis of a Tracheobronchial Foreign Body: A Case Report on Peanut Shell Aspiration and Management Challenges Aroli, Hazazi Nur Adli; Asyari, Ade
Jurnal Ilmu Kesehatan Indonesia Vol. 7 No. 1 (2026): Maret 2026
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v7i1.1874

Abstract

Introduction: Delayed diagnosis of tracheobronchial foreign body aspiration often leads to significant complications, including pneumonia and bronchiectasis. Symptoms of foreign body aspirations can mimic other respiratory conditions such as asthma, pneumonia, or viral croup, leading to misdiagnosis. Rigid bronchoscopy remains the gold standard for the removal of tracheobronchial foreign bodies. Objective: To understand the diagnosis and management of a delayed aspiration foreign body in tracheobronchial. Case Report: A 2 years old boy was brought by his parents to outpatient clinic ORL-HNS of Dr. M. Djamil Hospital Padang, with chief complaints difficulty in breathing with cough since a month before admission. The parents do not know exactly what kind of aspiration incident occurred; patient was diagnosed suspected foreign body “Peanut” on bronchus. The patient underwent foreign body extraction using rigid bronchoscope and flexible grasping forcep. Conclusion: Management of delayed foreign body aspiration needs to be done comprehensively, and treated on time, coordination between family, caregivers, specialists and knowledge about symptoms, risks and complications of aspiration foreign bodies should be better understood. Early detection and treatment can significantly reduce the risk of long-term respiratory problems, by using rigid bronchoscope and flexible forceps foreign bodies can be removed properly with minimal complications and good visualization
Intraoperative Vagal Excitation During Rigid Esophagoscopy for an Esophageal Earring in a 4-Month-Old Infant: A Case Report Ilham Daryl Fathurozzi Alamsjah; Ade Asyari; Rio Rusman
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 3 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i3.1533

Abstract

Background: Esophageal foreign body ingestion is a prevalent otorhinolaryngologic emergency in the pediatric population but is epidemiologically rare in infants under six months of age. While rigid esophagoscopy remains the gold standard for extraction, it involves stimulating the highly innervated aerodigestive tract. This case highlights a life-threatening vagal reflex—an underreported complication in infants—during foreign body removal. Case presentation: A 4-month-old female infant presented with a history of accidental earring ingestion three days prior, manifesting as hypersalivation and feeding refusal. Radiographic imaging confirmed a radiopaque foreign body at the T1 vertebral level or thoracic inlet. The patient underwent rigid esophagoscopy under general anesthesia. During the extraction phase, mechanical manipulation of the esophageal mucosa triggered profound vagal excitation, resulting in severe bradycardia and oxygen desaturation. The procedure was immediately paused, and the patient was successfully resuscitated using vagolytic agents and hyperoxygenation by the anesthesiology team. A second attempt was successful without recurrence of the reflex. Post-operative recovery was uneventful. Conclusion: Foreign body ingestion in early infancy requires a high index of suspicion and meticulous perioperative planning. The manipulation of the esophageal inlet can trigger potent vagovagal reflexes, particularly in infants with high vagal tone. This case underscores the necessity of deep anesthetic planes, prophylactic vagolytic preparation, and seamless communication between the surgeon and anesthesiologist to manage hemodynamic instability.
Hubungan Paparan Tungau Debu Rumah dengan Riwayat Rinitis Alergi pada Anak di Salah Satu Panti Asuhan Kecamatan Pauh Kota Padang Rahmat Agusman; Selfi Renita Rusjdi; Ade Asyari; Muhammad Rafif Sulthan Habibi; Ade Nofendra; Eryati Darwin; Eka Nofita
SENTRI: Jurnal Riset Ilmiah Vol. 5 No. 7 (2026): SENTRI : Jurnal Riset Ilmiah, Juli 2026
Publisher : LPPM Institut Pendidikan Nusantara Global

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55681/sentri.v5i7.6933

Abstract

Allergic rhinitis is an inflammation of the nasal mucosa caused by a type I hypersensitivity reaction, which house dust mites (HDM) as one of the inhalant allergens causing allergic rhinitis. Children living in crowded environments, such as orphanages, are at high risk of HDM exposure. This study aimed to determine the relationship between house dust mite exposure and history of allergic rhinitis in children at an orphanage in Pauh District, Padang City.This was an observational analytical study with a cross-sectional approach. It was conducted at an orphanage in Pauh District, Padang City, and in the Parasitology Laboratory of the Faculty of Medicine, Andalas University, from March to August 2025. The sampling technique used was total sampling. Bed dust was collected using a vacuum cleaner, and interviews using the ISAAC questionnaire were conducted. Chi-square test was used to analyze the relationship between the two variables. The results of this study showed that all dust samples (100%) were positive, and the identification revealed that the most common species of house dust mites found was Dermatophagoides sp. (34,%), followed by Acarus sp. (19,14%), Cheyletus sp. (14,89%), Carpoglyphus sp. (10,63%) Glycyphagus sp. (8,51%), Thyrophagus sp. (8,51%), and Blomia tropicalis (4,25%). Most of the house dust mite density is in the low category with the average house dust mite density being 72,85 mites/gram of dust. The prevalence of allergic rhinitis in children based on the ISAAC questionnaire was 18.75%, with the highest prevalence in the 13–18 year age group. This study there was no significant association between house dust mite density and the history of allergic rhinitis. The conclusion of this study is that factors such as genetic predisposition, environmental conditions, and immune sensitization status are likely to contribute to the development of allergic rhinitis.
Pola Bakteri Berdasarkan Hasil Kultur dan Sensitivitas Antibiotik pada Penderita Abses Leher Dalam di Bagian THT-KL RSUP Dr. M. Djamil Padang Periode 2019-2021 Aurelia Agantha Salim; Yuniar Lestari; Ade Asyari; Netti Suharti; Cimi Ilmiawati
Jurnal Otorinolaringologi Kepala dan Leher Indonesia Vol. 2 No. 1 (2023)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jokli.v2i1.37

Abstract

Latar Belakang : Penyakit abses leher dalam merupakan perluasan peradangan dari berbagai sumber infeksi yang membentuk suatu pus di dalam ruang potensial leher dalam. Infeksi pada ruang potensial leher dalam dapat disebabkan oleh bakteri aerob, bakteri anaerob, maupun multibakterial. Terapi antibiotik empiris diberikan sebelum hasil kultur dan uji sensitivitas antibiotik didapatkan. Tatalaksana pemberian antibiotik yang tidak tepat dapat menyebabkan terjadinya resistensi antibiotik. Tujuan : Penelitian ini bertujuan untuk mengetahui pola bakteri berdasarkan hasil kultur dan sensitivitas antibiotik pada penderita abses leher dalam di Bagian THT-KL RSUP Dr. M. Djamil Padang periode 2019-2021. Metode : Jenis penelitian ini adalah deskriptif retrospektif dengan teknik total sampling dan menggunakan data sekunder. Sampel penelitian adalah pasien abses leher dalam yang terdapat hasil kultur dan uji sensitivitas antibiotik di Bagian THT-KL RSUP Dr. M. Djamil Padang periode 2019-2021 dengan total 77 pasien. Hasil : Hasil pada penelitian ini menunjukkan usia terbanyak ialah usia pertengahan (>44-59 tahun) (37,7%), jenis kelamin terbanyak ialah laki-laki (74%), lama perawatan terbanyak ialah < 7 hari (44,2%). Jenis abses leher dalam terbanyak ialah abses submandibula (42,9%), etiologi paling banyak ialah infeksi odontogenik (71,4%), terapi antibiotik empiris yang paling banyak digunakan ialah kombinasi ceftriaxone dan metronidazole (68,8%), hasil kultur terbanyak ialah bakteri Klebsiella pneumonia (18,2%), antibiotik dengan angka sensitif tertinggi ialah antibiotik amikacin (89,7%) dan meropenem (82,4%), dan angka resisten tertinggi ialah antibiotik amoxicillin (100%) dan ampicillin (93,3%). Kesimpulan : pola bakteri berdasarkan hasil kultur ialah Klebsiella pneumoniae dan uji sensitivitas antibiotik didapatkan gentamicin dengan kombinasi metronidazole yang dapat digunakan sebagai antibiotik empiris pada penderita abses leher dalam.
Gambaran Kadar Pepsin pada Saliva Pasien Refluks Laringofaring di RSUP Dr. M. Djamil Padang Mutiara Adinda Rahma; Ade Asyari; Yustini Alioes
Jurnal Otorinolaringologi Kepala dan Leher Indonesia Vol. 2 No. 1 (2023)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jokli.v2i1.38

Abstract

Laryngopharyngeal reflux (RFL) is a condition of tissue inflammation in the upper aerodigestive tract due to the reflux of gastric and duodenal contents, the symptoms such as post-nasal drip, globus sensation, and heartburn which decrease quality of life. RFL was diagnosed subjectively using the Reflux Symptom Index (RSI) and Reflux Finding Score (RFS). The pepsin levels in saliva that were detected by ELISA can be a sensitive and objective diagnostic marker for RFL because pepsin was only produced by chief cells in the stomach. The purpose of this study was to determine the characteristics of RFL patients based on age, sex, features of complaints in RSI, features of anatomic abnormalities in RFS, and salivary pepsin levels. This study was a descriptive observational retrospective design. From September to October 2022, this study was carried out at the Medical Record Department of RSUP Dr. M. Djamil Padang. The Lemeshow formula was used as the minimum number sampling in this study, 22% was the value of the proportion of events. The findings of this study revealed that 20 patients with RFL were tested for pepsin levels in saliva at Dr. RSUP. M. Djamil Padang, with nearly the same total number of RFL patients in each age group. The majority of RFL patients (60.0%) were female, and the most common complaint felt by RFL sufferers was post-nasal drip (90.00%). The most common anatomic abnormality was diffuse laryngeal edema (100%), and the mean pepsin levels in saliva was 15.863 ng/mL. Pepsin was found in all samples. Keywords: laringofaringeal reflux, pepsin, saliva
Analisis Nilai Peak Nasal Inspiratory Flow pada Kejadian Rinitis Alergi Ken Rabbani Faathira; Ade Asyari; Afdal Afdal
Jurnal Otorinolaringologi Kepala dan Leher Indonesia Vol. 2 No. 1 (2023)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jokli.v2i1.44

Abstract

Latar Belakang: Gejala hidung tersumbat sering merupakan gejala yang dominan pada rinitis alergi. Peak Nasal Inspiratory Flow (PNIF) adalah alat yang sangat bermanfaat untuk mengukur sumbatan hidung pada rinitis alergi karena terkait erat dengan tanda-tanda rinitis alergi berdasarkan pemeriksaan klinis dan berkorelasi baik dengan derajat keparahan rinitis alergi dan memiliki kelebihan yang sederhana, murah, nyaman, dan cepat. Penelitian ini bertujuan untuk menganalisis perbedaan nilai PNIF antara orang dengan rinitis alergi dan non-rinitis alergi. Metode: Penelitian ini merupakan penelitian analitik komparatif dengan menggunakan pendekatan cross sectional. Skrining rinitis alergi menggunakan kuesioner Score For Allergic Rhinitis (SFAR) kemudian dilakukan anamnesis, nasoendoskopi, dan pengukuran PNIF di poliklinik THT BKL RSUP Dr. M. Djamil Padang. Populasi adalah seluruh mahasiswa Program Studi Kedokteran Universitas Andalas yang mengidap rinitis alergi dan non-rinitis alergi dengan total sampel sebanyak 36 orang. Teknik pengambilan sampel dilakukan dengan convenience sampling. Hasil: Hasil penelitian didapatkan median nilai PNIF pada kejadian rinitis alergi sebesar 100 (50-120) L/m. Rata-rata nilai PNIF pada kejadian non-rinitis alergi sebesar 130,56 ± 24,36 L/m (Maks = 190 L/m, Min = 90 L/m). Dari hasil uji statistik Mann-Whitney didapatkan analisis beda nilai PNIF pada kejadian rinitis alergi dan non-rinitis alergi dengan nilai p < 0,001. Kesimpulan: Kesimpulannya terdapat perbedaan nilai PNIF yang signifikan antara kejadian rinitis alergi dan non-rinitis alergi.
Peran Reflux Symptom Index dalam diagnostik terapi pasien Laryngopharyngeal Reflux sebelum dan sesudah diberikan Lansoprazole di Poliklinik THT-KL RSUP Dr. M. Djamil Padang.: Indonesia Febrina Monica; Ade Asyari; Saptino Miro; Al Hafiz; Rozi Abdullah; Abdiana Abdiana
Jurnal Otorinolaringologi Kepala dan Leher Indonesia Vol. 3 No. 1 (2024)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jokli.v3i1.58

Abstract

Pendahuluan : Laryngopharyngeal Reflux(LPR) adalah pergerakan retrograde dari isi lambung ke daerah laring, faring, trakea, dan bronkus yang berkontak dengan jaringan pada traktus aerodigestif atas yang dapat menimbulkan jejas. Diagnosis dari LPR dapat ditegakkan dengan tindakan non-invasif yaitu dengan Reflux Symptom Index(RSI) dan Reflux Finding Score(RFS), RSI dapat digunakan dalam membantu dokter untuk menilai tingkat keparahan gejala penderita LPR saat pemeriksaan maupun setelah pengobatan. Metode : Jenis penelitian ini adalah analitik observasional dengan pendekatan studi kohort prospektif melalui observasi pasien yang didiagonosis LPR dari nilai RSI yang didapatkan. Jumlah sampel minimal dari hasil perhitungan uji hipotesis beda rata-rata pada 2 kelompok dependen adalah 18 orang. Hasil : Nilai rata-rata sebelum dan sesudah diberikan terapi PPI 21,50±5,969 dan 15,90±9,008 (me=13,5;min=5;maks=36). Hasil uji Wilcoxon Signed Rank Test didapatkan analisis nilai rata-rata RSI sebelum dan sesudah adalah p=0,002. Kesimpulan : didapatkan perubahan bermakna nilai rata-rata RSI sebelum dan sesudah diberikan PPI pada pasien LPR.Kata kunci: Laryngopharyngeal Reflux, Reflux Symptom Index,Proton Pump Inhibitor
Keterlambatan Diagnosis dan Tatalaksana Benda Asing Koin di Esofagus ARIF FAHMI; Ade Asyari
Jurnal Otorinolaringologi Kepala dan Leher Indonesia Vol. 3 No. 1 (2024)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jokli.v3i1.63

Abstract

Pendahuluan : Tertelan benda asing adalah kejadian yang sering terjadi terutama pada anak-anak. Keterlambatan diagnosis dapat terjadi dikarenakan gejala awal yang tidak khas dan kesalahan diagnosis awal yang dapat mengakibatkan kemungkinan komplikasi seperti inflamasi dan nekrotik mukosa esofagus yang membuat gejala menjadi lebih berat. Esofagoskopi kaku digunakan untuk diagnosis dan penatalaksanaan pada benda asing di esofagus. Laporan Kasus : Dilaporkan satu kasus benda asing di esofagus pada seorang anak perempuan usia 3 tahun yang mengeluhkan batuk setelah makan sejak 1 minggu dan nyeri menelan yang semakin memberat sejak 1 hari sebelum masuk Rumah Sakit. Pasien riwayat tertelan koin 3 minggu sebelum masuk Rumah Sakit. Pasien terlambat didiagnosis dan tatalaksana sehingga mengalami komplikasi berupa inflamasi dan nekrosis di mukosa esofagus. Dilakukan tindakan esofagoskopi kaku pada minggu ke tiga setelah tertelan benda asing. Kesimpulan: Keterlambatan diagnosis dan tatalaksana benda asing koin dapat menyebabkan gejala klinis menjadi berat dan terjadinya inflamasi dan terbentuknya nekrotik pada mukosa esofagus. Penegakan diagnosis dan tatalaksana yang tepat penting untuk mencegah terjadinya gejala klinis yang berat dan komplikasi.
Analysis of bile acid in saliva of patients with laryngopharyngeal reflux and non-laryngopharyngeal reflux Ade Asyari; Refi Amalia Utami; Eti Yerizel; Andani Eka Putra; Firdawati Firdawati
Oto Rhino Laryngologica Indonesiana Vol. 53 No. 2 (2023): VOLUME 53, NO. 2 JULY - DECEMBER 2023
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v53i2.561

Abstract

ABSTRACT — Background: Laryngopharyngeal reflux (LPR) is the backflow of gastric and or duodenal fluid into the larynx, pharynx, trachea, and bronchi. The prevalence of LPR is difficult to determine due to the limited gold standard and the large variety of LPR symptoms. Damage can occur due to the decrease in pH value and also because of exposure to harmful enzymes in reflux, including bile acid. Purpose : This study was conducted to analyze bile acid levels in the saliva of LPR patient and non LPR subject. Methods:  This study is an observational study with a case-control design. The study was conducted in the ORL-HNS Department of Dr. M. Djamil Hospital, Padang, West Sumatra, Indonesia. The total sample size was 44 people. We enrolled 22 healthy subjects as the control group and 22 patients suspected of having LPR. Result: LPR patients are more common in women than in men, with 12 women and 10 men. Bile acid in the LPR group means of is 25.08±7.67µM, meanwhile, in the healthy group, the mean was 18.99±8.26 µM. There is a statistically significant in the incidence of LPR with the bile acids (p = 0.015) based on t- independent test. Conclusion: Our study confirmed that bile acids in saliva play a major role in diagnosing LPR. 
Co-Authors Abdiana Abdiana, Abdiana Aci Mayang Sari Ade Nofendra Adrial Adrial, Adrial Afdal Afdal Al Hafiz Al Hafiz Al Hafiz Al Hafiz Ali Djamhuri Amany, Esmaralda Nurul Amri, Siti Salsabilla Andani Eka Putra Arif Fahmi Arni Amir Aroli, Hazazi Nur Adli Asrining Tyas Aurelia Agantha Salim Bestari J Budiman Bestari Jaka Budiman Bonny Murizky Cimi Ilmiawati, Cimi Deni Amri Dia Rofinda, Zelly Dia Diflayzer, Diflayzer Dolly Irfandy Dwininta Alfathika Effy Huriati Effy Huriyati Efrida Efrida Eka Nofita Elniza Morina Elniza Morina Embun Dini Erly Indrama Erwi Saswita Eryati Darwin Esmaralda Nurul Amany Esmaralda Nurul Amany Eti Yerizal Eti Yerizel Fachzi Fitri Fasya, Haidar Haikal Febrina Monica Fika Tri Anggraini Fikri Akbar Firdawati Firdawati Gestina Aliska Hafni Bachtiar Hafni Bachtiar Hafni Bachtiar Hafni Bachtiar Hafni Bachtiar Harun Harnavi Hendra Permana Ilham Daryl Fathurozzi Alamsjah Ilmiawati, Ilmiawati Jacky Munilson Jacky Munilson Julianda, Wahyu Ken Rabbani Faathira Khairil Faiz Amir Lestari, Rahmi Masnadi, Nice Rachmawati Mizwar, Mizwar Muhammad Rafif Sulthan Habibi Mutiara Adinda Rahma Nadhirah binti Sa'an Nasman Puar Naura Aqila Netti Suharti Netti Suharti Nirza Warto Novialdi . Nur Azizah Nur Azizah Octavia, Tri Aryanti Putri Rizki Fitriani Rachmawati, Elvie Zulka Kautzia Rahmadona Rahmadona Rahmat Agusman Refi Amalia Utami Rimelda Aquinas Rio Rusman Rita Risandi Rosfita Rasyid Rossy Rosalinda Rozi Abdullah Saptino Miro Sariwati, Siska Selfi Renita Rusjdi Septiany, Dwi Tika Sri Rahma Liza Sukri Rahman Sutas, Bima Ferdana Tri Novriansyah, Wahyu Tuti Handayani Tuti Handayani Utami, Refi Amalia Wahyu Julianda Wahyu Julianda Yan Edward Yolazenia Yolazenia Yuniar Lestari Yustini Alioes