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Journal : Majalah Farmaseutik

Analyzing the Potential of Herbal Plant Research for Alzheimer's Disease in Diabetes: A Bibliometric Approach Marzuki, Ahmad; Rahmayani, Almira; Khafi, Muhammad; Hertiani, Triana; Murwanti, Retno
Majalah Farmaseutik Vol 20, No 3 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v20i3.97209

Abstract

Alzheimer’s disease is a progressive neurologic dementia disorder and the fifth leading cause of death among elderly individuals. Its pathogenesis is closely linked to diabetes-induced brain insulin resistance, which accelerates beta-amyloid accumulation, exacerbating disease severity. This condition significantly impacts quality of life and healthcare costs, necessitating effective treatment strategies. Medicinal plants offer a promising avenue, with bibliometric analysis identifying trending active compounds for potential development as therapies for diabetic Alzheimer’s. This study analyzed 200 articles from the Scopus database, employing Scopus and VOSviewer 1.6.20 to visualize bibliometric trends by publication, country/territory, subject area, and keyword co-occurrence. Results indicate a recent decline in research activity, with China leading in publications across pharmacology, medicine, and biochemistry. Notably, flavonoids like “quercetin,” “kaempferol,” and “gallic acid” emerged as prominent topics.Keywords: Alzheimer’s diabetes, Bibliometrics, Herbal medicine, Extracts
Validasi Metode Analisa Penetapan Kadar Glukosa dengan Metode Dubois secara Spektrofotometri Rahmayani, Almira; Marzuki, Ahmad; Ritmaleni, Ritmaleni; Sri Tunjung, Woro Anindito
Majalah Farmaseutik Vol 20, No 4 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v20i4.97119

Abstract

Penetapan kadar glukosa dalam sampel biologis dan makanan sangat penting di berbagai bidanhg khususnya farmasi dan makanan. Ketidakseimbangan kadar glukosa dalam darah dapat menjadi indikator berbagai kondisi kesehatan seperti diabetes mellitus. Penelitian ini bertujuan untuk memvalidasi penetapan kadar glukosa dengan metode Dubois dengan spektrofotometri. Metode ini melibatkan reaksi antara glukosa dengan fenol dan asam sulfat pekat, menghasilkan senyawa berwarna kuning yang dapat terbaca pada panjang gelombang visibel ± 490 nm. Proses validasi mencakup uji spesifisitas, linearitas, LOD-LOQ, akurasi, dan presisi sesuai pedoman ICH Q2(R1). Hasil validasi menunjukkan spesifisitas pada l 488 nm dengan nilai R = 0,999, LOD serta LOQ pada 13,36 ppm dan 44,53 ppm, % perolehan kembali 101,11% dan RSD 1,73%. Berdasarkan parameter validasi yang telah diuji, maka prosedur penetapan kadar glukosa dengan instrumen spektrofotometri telah memenuhi kriteria dan dinyatakan telah valid.
Formulation and Stability Test of HPMC and Carbomer 940 based-Gel Formulation Containing Plantago major L. hydroalcoholic extract Khafi, Muhammad; Hertiani, Triana; Murwanti, Retno; Bayu Irawan, Muhamad; Marzuki, Ahmad; Dwi Salim, Rozin
Majalah Farmaseutik Vol 21, No 2 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v21i2.95893

Abstract

The P. major plant has long been utilized in traditional herbal medicine and is widely accessible in Indonesia and globally. Extensive research has demonstrated its efficacy in wound healing through both clinical and preclinical studies. Gel formulations are recognized for establishing a conducive moist environment essential for wound healing, thus rendering them suitable for topical wound treatment. This study assesses the stability of HPMC gel base, carbomer 940, and their combination as carriers for the ethanol extract of P. major leaves. Stability testing involved a freeze-thaw cycle test at temperatures of 4°C and 40°C for three cycles. The findings indicate no significant alteration in the organoleptic properties and pH of the gel formulations before and after stability testing. However, t-test analysis reveals a noteworthy decrease in viscosity for carbomer and its combination, albeit not for HPMC alone. In conclusion, HPMC exhibits superior stability as a gel base compared to Carbomer 940 and their combination.
Co-Authors A.A. Ketut Agung Cahyawan W Achmad Yusuf Afifah, Sofiatul Ahmad Norhadi, Ahmad Akhmad Nazar Haris, Akhmad Nazar Ali Mohtarom Ali Mohtarom Amalia, Rosyida Angin, Toras Barita Bayo Aprillia, Sofia Sasa Bella ARDIANA, NUNIK Bangun Sartono Bayu Irawan, Muhamad Budi, Eko Prasetyo Butar-Butar, Marianju Cari, Cari Dongoran, Rahmat Afandi Dwi Salim, Rozin DWI SURYANTO Elindra, Rahmatika Fah, Lay Yoon Fikri, Muhammad Shokhiful Fitriani Fitriani Harahap, Sinar Depi Hasibuan, Kevin Sahrony Hidayat, Khanafi Mukmin Himatul Amalia Ilhami ., Ilhami Isnaini Maha Putri Istiqomah, Farihatul Khafi, Muhammad Kholil, Umar Kirom, Askhabul Kurniawan, Dedi Ari Kusuma, Andri Lailatus Syarifah Lawal, Uthman Shehu lubis, ilham sahdi Lubis, Roslian M. Jamhuri M. Mukhid Mashuri Mariana Mariana Mohtarom, Ali Mubarok, Achmat Mubarok, Ardi Maulana Muhammad Syahril Harahap Muhsin Muhsin Muhtarom, H. Ali Muhtarom, H.Ali Nainggolan, Purnama Sari Nasir, Moch. Nasution, Dwi Putria Ndraha, Bagus Hasudungan Ni'mah, Maria Khoirotun Nugroho, Anggit Nun, Luluk Ilma' Pardede, Monika Pasaribu, Joni Winra pengelola, Mar’atus pengelola, pengelola Pertiwi, Peni Prof. Cari Pulungan, Sakinah R. Sapto Hendri Boedi Soesatyo Rahayu, Nafa Kassiri Lutfia Rahmayani, Almira Retno Murwanti Ritmaleni, Ritmaleni Rohani Rohani Rokhimah, Siti Ainur romadhona, Nikmatur Rosadi, Narita Amni Sabri Sabri Safitri, Adek Safitri, Anita Safitri, Reviva Saifulah Sandi, Deka Maita Sari, Erlina Seri Asmaidah, Seri Sholiha, Mar’atus Sidik Sutiasno, Sidik Simamora, Rona Uli Simanjuntak, Supenro Simanullang, Syahtija Sinta, Feni Raz Siregar, Eva Yanti Siti Julaikha Subekti, Trisno Tajuddin Pogo Tholib, Hasan Haikal Triana Hertiani Woro Anindito Sri Tunjung Yunianto, Bagus Yusuf, Achmad Yusuf, Wiwin Fachrudin Zakkiyah, Kuny