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Effect of hyperbaric oxygen treatment on liver hepatocyte damage in oral candidiasis immunosuppressed rats Pargaputri, Agni Febrina; Andriani, Dwi; Hartono, Mardiyanto Riski; Widowati, Kharinna
Odonto : Dental Journal Vol 9, No 2 (2022): December 2022
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.9.2.319-326

Abstract

Background: Liver is an organ that performs a role in metabolism and detoxification of chemical substances. The use of immunosuppressive drugs excessively not only become predisposing factor for oral candidiasis, but also can cause damage and affect liver’s function. Hyperbaric oxygen treatment was known to preserve hepatocytes and prevent liver damage. This study was aimed to investigate the effect of hyperbaric oxygen treatment on liver hepatocyte damage in oral candidiasis immunosuppressed rats.Method: We divided fifteen Wistar rats randomly into three groups: G1 (healthy rats), G2 (immunosuppressed rats with oral candidiasis), and G3 (immunosuppressed rats with oral candidiasis given hyperbaric oxygen). The immunosuppressed condition was made by giving dexamethasone and tetracycline orally for 14 days. Induction of Candida albicans 0.1 cc was conducted on the fourth day. Hyperbaric oxygen treatment was given for five days continuously. The histopathological changes in the liver were measured by counting the amount of normal hepatocytes, pycnotic, karyolysis, karyorrhexis, and score of necrosis area using light microscope with 400x magnification.Result: The amount of pycnotic, karyolysis, and karyorrhexis hepatocytes increased in G2 and decreased significantly in G3, likewise the score of necrosis area. The statistical test using oneway Anova and LSD test showed significant differences (p<0,05) in pycnotic, karyolysis, and karyorrhexis hepatocytes between G1, G2, and G3.Conclusion: The hyperbaric oxygen treatment effect on liver hepatocyte damage in oral candidiasis immunosuppressed rats.
EFEKTIVITAS EDUKASI KESEHATAN GIGI DENGAN METODE TRAIN THE TRAINERS DALAM MENINGKATKAN PENGETAHUAN GURU DAN WALI MURID SD YAPITA SURABAYA: EFFECTIVENESS OF DENTAL HEALTH EDUCATION USING THE TRAIN THE TRAINERS METHOD IN IMPROVING THE KNOWLEDGE OF TEACHERS AND PARENTS OF YAPITA ELEMENTARY SCHOOL SURABAYA Andriani, Dwi; Twi Agnita Cevanti; Nora Lelyana; Aprilia; Dianty Saptaswari; Bambang Sucahyo; Dwi Setianingtyas; Nafiah; Henu Sumekar; Arya Brahmanta; Shintya Rizki Ayu Agitha; Sularsih; Yufita Fitriani; Vivin Ariestania; Arifzan Razak
Jurnal Pengabdian Masyarakat Pesisir VOLUME 4 NOMOR 1
Publisher : Universitas Hang Tuah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/jpmp.v4i1.137

Abstract

Dental and oral problems in Indonesian children are caused by low knowledge, comprehension, and behavior that ignores dental and oral health maintenance, resulting in tooth and mouth damage. This activity is in partnership with SD Yapita which is a school supported by the Faculty of Dentistry, Hang Tuah University. The aim is to prepare parents and teachers of Yapita Elementary School students to become ambassadors for oral and dental hygiene so that they can become mentors for their children or students. This method is carried out online and offline from classes 1 to 6 using a simple random sampling technique. The results were statistically analyzed using the Paired T-test. The average pre-test score from the teacher was 60 and the parents were 56, while the post-test result from the teacher was 84 and the parents was 85. The results of the data analysis were normally distributed (p>0.05) followed by the Paired correlation test T-test. The results show a relationship between the pre and post-test of teachers and parents. This shows that this educational activity can increase the knowledge of teachers and parents so that they can become ambassadors of oral and dental hygiene to their children or students.