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All Journal Majalah Kedokteran Bandung Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Althea Medical Journal Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Jurnal Farmasi Klinik Indonesia Global Medical and Health Communication INDONESIAN JOURNAL OF PHARMACY Jurnal Sistem Kesehatan Journal of Medicine and Health Molecular and Cellular Biomedical Sciences (MCBS) Journal Of Vocational Health Studies Indonesian Journal of Rheumatology Jurnal Pendidikan dan Pelayanan Kebidanan Indonesia (Indonesian Journal of Education and Midwifery Care) Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Jurnal Ilmu Kefarmasian Indonesia Majalah Kedokteran Andalas Medika Kartika : Jurnal Kedokteran dan Kesehatan Health Information : Jurnal Penelitian Jurnal Aisyah : Jurnal Ilmu Kesehatan JK Unila (Jurnal Kedokteran Universitas Lampung) JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Journal of Medicine and Health
Achadiyani
Departemen Anatomi, Fisiologi, Dan Biologi Seluler, Fakultas Kedokteran, Universitas Padjadjaran, Bandung
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Dentistry Economics, Econometrics & Finance Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Cytotoxicity Effect of Aqueous Propolis Extract of Geniotrigona thoracica Sumatrans on Colo-201 Colon Cancer Cell Line and Senescence Colo-201 Colon Cancer Cell Line Induced by Low-dose Doxorubicin Latama, Zahra Nabila; Achadiyani, Achadiyani; Kamilah, Mutiara Mila; Putra, Ramadhani Eka; Kinasih, Ida; Faridah, Lia; Ekawardhani, Savira
Global Medical & Health Communication (GMHC) Vol 12, No 2 (2024)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v12i2.13760

Abstract

Propolis, a resinous compound honeybees produce, demonstrates an extensive spectrum of powerful biological properties. However, the anti-cancer activity of propolis derived from Geniotrigona thoracica Sumatrans has yet to be reported. Thus, we sought to investigate the cytotoxicity of aqueous propolis extracts from Geniotrigona thoracica Sumatrans against Colo-201 colon cancer cell line and senescence Colo-201 colon cancer cell line induced by low-dose doxorubicin. This study was conducted at the Parasitology Laboratory of Human, Safety, and Environment, Universitas Padjadjaran Bandung from January to May 2024. This study assessed cell viability using the WST-1 test. Non-induced Colo-201 cells were treated with an aqueous extract of propolis (AEP) 100 ppm, or 5-fluorouracil (5-FU) 5 mg/ml as the positive control or water as a vehicle on untreated control. Colo-201 senescence was induced by doxorubicin 0.1 µM for three days. Doxorubicin-induced Colo-201 senescence was then treated with AEP 100 ppm, with 5-FU 5 mg/ml as the positive control, or with the combination of AEP 100 ppm and 5-FU 5 mg/ml, or water as a vehicle on untreated control. The data were analyzed using SPSS version 25.0, a one-way ANOVA, and Tukey’s post hoc test. The results showed that AEP has cancer-killing effects on Colo-201 cells and Colo-201 senescent cells induced by low-dose doxorubicin. AEP-treated Colo-201 cells and Colo-201 senescent cells induced by low-dose doxorubicin viability were significantly reduced to 37.15% and 13.72%, respectively, although slightly higher than those of the 5-FU-treated one at this concentration. There was also a decrease in the cancer-killing effect of 5-FU from 88.55% in non-induced Colo-201 cells to 41.5% in the doxorubicin-induced Colo-201 senescence model. In conclusion, aqueous extract of propolis from Geniotrigona thoracica Sumatrans showed cancer-killing-effects both on the Colo-201 colon cancer cell line and senescence Colo-201 colon cancer cell line induced by low-dose doxorubicin.
INTRAVENOUS VITAMIN C (IVC) TREATMENT OUTCOME OF COVID 19 PATIENTS ADMITTED IN HOSPITAL: A SYSTEMATIC REVIEW Pratiwi, Auria Ekanti; Suwarsa, Oki; Achadiyani; Atik, Nur
Journal of Vocational Health Studies Vol. 7 No. 1 (2023): July 2023 | JOURNAL OF VOCATIONAL HEALTH STUDIES
Publisher : Faculty of Vocational Studies, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jvhs.V7.I1.2023.68-76

Abstract

Background: Coronavirus disease 2019 (COVID-19) is still becoming a problem in several countries with the emergence of new variants with the latest variant named Omicron. Studies show that patients with COVID-19 tend to have Acute Respiratory Distress Syndrome (ARDS) because of high pro-inflammatory cytokines and chemokines levels. Since its role as an antiviral agent, anti-cytokine, immunomodulator, antioxidant and has potential effect in maintaining body functions, vitamin C can be used as one of therapy. There is still arguable about giving treatment of COVID-19 patients with Intravenous Vitamin C (IVC). Previous research has not been discussed related to accelerating recovery and decreasing mortality. Purpose: To identify the impact of IVC intervention given to COVID-19 patients admitted in hospital by reviewing clinical outcomes particularly on complexity or mortality. Review: Literature information was sourced from PubMed, ScienceDirect, and Google Scholar databases through keywords to retrieve inclusion criteria published during 2019-2021. Result: We found that IVC influenced inflammatory biomarkers such as CRP, d-dimer, ferritin, and several inflammatory cytokines, mortality, length of stay, oxygenation, organ and immune system function but showed no significant difference between the control group. Conclusion: IVC treatment might be an essential adjuvant therapy in the aggravation of mild, severe, and critical COVID-19 patients, but did not understate complexity or mortality. Hence, further research and evaluation in clinical trials are needed.
The Probiotic Effect towards Aspirin-induced Gastric Ulcer Healing Process as Measured by Mucous Thickness, Reepithelization, Gastric Glands Formation, and Angiogenesis in Animal Model Teresa Lucretia; Achadiyani Achadiyani; Sadeli Masria
Journal of Medicine and Health Vol 1 No 4 (2016)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v1i4.533

Abstract

Gastric Ulcer is a common side effect of Non-Steroid Anti Inflammatory Drugs (NSAIDs) use such as Aspirin. Probiotic has many benefits especially for the alimentary system, but the effect on gastric ulcer have yet to be explored. In this research we aimed to find the probiotic effect on histological structure changes during aspirin induced gastric ulcer healing process in animal model. This was simple random sampling animal experimental laboratory, that divided Wistar Rats into two main groups. Both groups were induced with Aspirin (300mg/Kg BW) per oral, once daily for three consecutive days,and subsequently the test group were given probiotic suspension (cfu >108/gr) per oral, once daily, for 14 days. Each subgroups were sacrified serially at day 0, 3, 7, 14. The gaster were collected and processed for histology examination. Better histological structures were shown in the test group at day 14. MANOVA result showed probiotic's effect in enhancing histological structure changes during gastric ulcer healing process. Better histological structure changes were observed in mucus thickness; reepitelization, gastric glands formation, and angiogenesis process of the test group. As a conclusion, probiotic enhanced mucus thickness, reepitelization, glands remodelling, and angiogenesis in Aspirin induced gastric ulcer healing process in animal model. Key words: probiotic, gastric ulcer, histological structure, aspirin, healing process
Topical Effect of Pinneaple (Ananas comosus) Juice in Combustio Healing Process Measured by Granulation Process, Reepitelialisation and Angiogenesis Cherry Azaria; Achadiyani Achadiyani; Reni Farenia
Journal of Medicine and Health Vol 1 No 5 (2017)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v1i5.539

Abstract

Skin protects the body from various trauma, such as high temperature trauma known ascombustio. Pineapple (Ananas comosus) contains lots of substances such as bromelain,antioxidants, and zinc shown to accelerated healing process in previous experiments. Aim ofthis research was to analize the effect of topical pinneaple juice application in combustiohealing process. The method was true experimental laboratory. Wistar rats’ back skin wereinduced by 100 o C iron plat untill 2 nd degree combustio occured, then divided into two groups(n=20). The treatment group were given topical application of pinneaple juice, then the healingprocess were observed macroscopically and microscopically on day 0, 3, 7, and 14. The resultshowed better wound healing in treatment group on day 14. MANOVA test showed topicalapplication of pinneaple juice accelerated healing process (p=0.001). Treatment group showedbetter histological structure changes, as seen from better granulation tissue formed (p=0.003)and reepithelization (p=0,000), but not from angiogenesis (p=0.733). Conclusion, topicalapplication of pinneaple (Ananas comosus) juice accelerated healing process in 2 nd grade ofcombustio animal model measured by granulation maturation process and reepithelizationprocess, but has no effect on angiogenesis.Keywords : Ananas comosus juice, 2 nd degree combustio, granulation tissue, reepitelisation,angiogenesis.
Assessment of Alpha-Tocopheryl Acetate and Metformin Hydrochloride as Independent Agents on Human Dermal Fibroblast Viability: Findings from MTT Assay Alfarafisa, Nayla Majeda; Khairani, Astrid Feinisa; Achadiyani, Achadiyani; Chou, Yoan; Aulia, Fitri; Firdaus, Muhammad Bintang
Althea Medical Journal Vol 12, No 2 (2025)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v12n2.3954

Abstract

Background: Alpha-tocopheryl acetate (Vitamin E) and metformin hydrochloride have been tested as anti-aging compounds at various concentrations. This study aimed to identify the most effective concentrations of alpha-tocopheryl acetate and metformin hydrochloride in promoting the viability of human dermal fibroblasts (HDFs), a primary cell type in skin aging research.Methods: HDFs were isolated using a mechanical isolation method and cultured under standard conditions. Cells were treated with varying concentrations of alpha-tocopheryl acetate and metformin hydrochloride as independents agents. After 48 hours of incubation, cell viability was measured using the MTT assay.Results: Alpha-tocopheryl acetate had the highest HDF cell viability (107%) at a concentration of 50 μM. Metformin hydrochloride had the maximum HDF cell viability (158%) at 5 μM. However, the viability response varied across different concentrations for both agents, indicating that optimal dosing was essential for maximizing their effectiveness.Conclusions: Alpha-tocopheryl acetate at 50 μM and metformin hydrochloride at 50 μM yield the highest viability of HDFs in vitro. These findings suggest potential roles for both agents in anti-aging skin therapies. Further research is recommended to explore their mechanisms of action and to optimize dosing strategies for clinical applications.
Changes in The Aging Cytoskeleton and How Metformin Plays a Role in Delaying Aging Dini, Dini; Achadiyani, Achadiyani; Khairani, Astrid Feinisa
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 9, No 1 (2024): March 2024
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30604/jika.v9i1.2672

Abstract

The cytoskeleton plays an important role in forming the cell framework and dynamics. The part that plays a role in supporting the spatial and mechanical functions of the cell is located in the cytoskeleton. Therefore, strategies to maintain the integrity and dynamics of the cytoskeleton have potential as therapies for age-related disorders. One thing that can be used to delay aging is metformin. Through AMPK activation, it can influence the cytoskeleton; namely, it can remodel the dynamics of the cytoskeleton by influencing structural changes in the actin cytoskeleton, which in turn will reduce the permeability of the filtration barrier in diabetic conditions and can increase insulin sensitivity, especially in old age, thereby delaying aging. In this review, we review the current understanding of the role played by the cytoskeleton in aging and review the opportunities and challenges for transitioning basic research into intervention development. Methods: Several major electronic databases, including PubMed, Scopus, and Cohcrane were used to select articles between April 2013 and April 2023. From the 8 existing literature, we present the activity of metformin as an aging delay. Cytoskeleton can change with age so it can affect the dynamics and structure of the cell. Metformin shows significant benefits, especially in delaying aging, through activation of the AMPK pathway so that it can increase the activity of mitochondria in producing ATP, which can affect the structure of the cytoskeleton. With this article on changes in the cytoskeleton with aging, it is hoped that insight into future research directions can be achieved.
Co-Authors A.R. -, Dewi, A.R. Ahmad Faried Alfarafisa, Nayla Majeda Alfiah Rahmawati Amelia, Rachel Andrew Citrawan Andri Rezano Anggraini, Dita Maulida Anindita Laksmi Anita Deborah Anwar Ardella Tri Novianti Astrid F. Khairani Astrid Feinisa Khairani Bashari, Muhammad Hasan Cherry Azaria Cherry Azaria, Cherry Chou, Yoan Dany Hilmanto Deni K Sunjaya Dewi, A.R. - Dimas Erlangga Dini, Dini Dita Maulida Anggraini Dolvy Girawan E. -, Nurdiamah, E. Eko Fuji Ariyanto Endang Sutedja Endang Sutedja Endang Sutedja Endry Septiadi Enny Rohmawaty Farid Husin Firdaus, Muhammad Bintang Firman Fuad Wirakusumah Fitri Aulia Gaga Irawan Nugraha Hamsiah binti Halim Hamsiah binti Halim Hardisiswo Soedjana Hartati Purbo Dharmadji, Hartati Purbo Hendra Gunawan Hendrikus Masang Ban Bolly Herry Herman Ida Kinasih Ika Friscila Imelda, Imelda - Indah, Astrina Rosaria Insi Farisa Arya Insi Farisa Arya, Insi Farisa Irma Ruslina Ishak Abdulhak Ivanna Valentina Jansen Budiono Jansen Budiono Julaecha Julaecha Kamilah, Mutiara Mila Kartika Farahdilla Fitri Kurnia Wahyudi Laniyati Hamijoyo, Laniyati Latama, Zahra Nabila Lia Faridah Meita Dhamayanti Michael V.L Tumbol Mohammad Ghozali Monita Sugianto Muhammad Begawan Bestari Muhammad Zafrullah Arifin Nadifa, Safira Nanan Sekarwana Nani Murniati Nikla Sekar Salsabila Nur Atik Nur Ramadani Meliani Syukri Nurdiamah, E. - Oki Suwarsa Pitaloka, Pritha Pratiwi, Auria Ekanti Putri Halleyana Rahman Rachel Amelia Ramadhani Eka Putra Ratumanan, Samuel Permana Reni Farenia Reni Farenia Reni Farenia Rina Puspasari Herdiawan Rizqy Dimas Monica Ronny Lesmana Rovina Ruslami, Rovina Sadeli Masria Sari Puspa Dewi Savira Ekawardhani Sharon Noor Alya Shelly Iskandar Silvana Anggreini Rosa Sudigdo Adi Sudigdo Adi Sudigdo Adi Sunarjati Sudigdo Adi Sunaryati S. Adi Susi Susanah Tenny Putri Teresa Lucretia Teresa Lucretia, Teresa Tjahjodjati Tri Hanggono Achmad Tri Hanggono Achmad Tryando Bhatara Uci Ary Lantika Uni Gamayani Vita Murniati Tarawan Vitriana Vitriana Yuli Kurniawati Yuni Susanti Pratiwi Yuni Susanti Pratiwi Yuni Susanti Pratiwi, Yuni Susanti Yuniarti