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Flavonoid Concentration and Tyrosinase Inhibition Activity of Ethanol Extract of Piper crocatum (Piper crocatum var. Ruiz & Pav) from Various Regions in Indonesia and Their Correlations Irsal, Riyan Alifbi Putera; Safithri, Mega; Andrianto, Dimas; Mardliyati, Etik
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 9, No. 1, May 2023
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v9i1.31426

Abstract

Hyperpigmentation is a condition of darkening of the skin which is generally caused by an increase in melanin production. Melanin is produced in melanocytes by the enzyme tyrosinase. Piper crocatum contains flavonoid compounds that are known from previous research to inhibit tyrosinase. The goals of this study were to determine the tyrosinase inhibitory activity and total flavonoid content of seven accessions, as well as look at the Pearson’s correlation and clustering PCA (principal component analysis). The method used was water content analysis, extraction yield measurement, total flavonoids analysis, and in vitro tyrosinase inhibition. Based on the results, P. crocatum from Kendari had the best yield and total flavonoid content of 24.07% and 5.10 mg QE g-1, while P. crocatum from Bogor had the lowest water content with a value of 6.21% and the best in tyrosinase inhibition of 13.77. The correlation between total flavonoid content and percent inhibition showed a very weak correlation. The results of clustering formed four clusters of seven accessions based on total flavonoids and percent inhibition. The cluster was divided into Malang (506mDPL) and Jayapura (287mDPL), Banda Aceh (0.80mDPL) and Bandung (670mDPL), Samarinda (8mDPL) and Bogor (190-350m DPL), and Kendari (14mDPL). In conclusion, the correlation between total flavonoid levels and percent inhibition is very weak and regional diversity had a significant effect on total flavonoids and total inhibition.
Amino Acids Isolation from α-keratin of Javanese Goat (Capra hircus) Hair and Garut Sheep (Ovis aries) Hair Waste Using Acid Hydrolysis Method as BCAA Supplement Firdaus, Dzikri Anfasa; Andrianto, Dimas; Darmawan, Noviyan
Jurnal Kimia Valensi Jurnal Kimia VALENSI, Volume 10, No. 1, May 2024
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v10i1.38146

Abstract

Javanese goat and Garut sheep hair contain α-keratin, a protein that can be broken by hydrolysis to produce simpler amino acids. Feather waste generates millions of tons of α-keratin biomass originating from animal slaughterhouses, thereby raising health concerns. The utilization of acid hydrolysis is considered to be more cost-effective compared to enzymatic hydrolysis, and it provides a broader range of amino acid cleavage sites compared to enzymes, which exhibit specific cleavage. This study aimed to isolate amino acids from Javanese goat and Garut sheep hair through acid hydrolysis. The methods included hair sample preparation, acid hydrolysis used 6 M HCL at 110°C, reflux isolation, amino acid separation based on isoelectric pH 4.9 –5.4, functional groups analysis using FTIR, and analysis of amino acid content by HPLC methods. The results showed that the yield produced after isolation on Javanese goat hair samples was 0.92% and Garut sheep hair 0.32%, respectively. The FTIR spectrum showed amino acid functional groups in both samples, including carboxyl (COOH), amine (C-N primer), (C-S disulfide), and amide I (-CONH2). Successful breakdown of α-keratin proteins into simpler amino acids was achieved for Javanese goat and Garut sheep hair. Amino acid analysis of Javanese goat hair isolates revealed the presence of aspartic acid, threonine, serine, glutamate, proline, glycine, alanine, valine, methionine, isoleucine, leucine, tyrosine, phenylalanine, histidine, lysine, and arginine amino acids, respectively. The highest content was isoleucine at 0.60% w/w. In conclusion, the isolated amino acids from Javanese goat hair can be used as a halal supplement that serves as nutrition in the body.
Pengolahan Sampah Organik Menggunakan Maggot BSF sebagai Pakan Ikan Alternatif pada Desa Lesmana, Banyumas Yusriya, Rifqi; Daeli, Gavriel Allenfar; Prasetyo, Dwiandra Hadi; Firmansyah, Muhammad Ade; Nayanda, Najwa Putri; Qolbiyah, Syifa Ainul; Putri, Salsabila Yasmin Budi; Assa’addah, Habibah; Andrianto, Dimas
Jurnal Pusat Inovasi Masyarakat Vol. 6 No. 2 (2024): Oktober 2024
Publisher : Direktorat Pengembangan Masyarakat Agromaritim, Institut Pertanian Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jpim.6.2.221-230

Abstract

Organic waste has become a significant problem in Lesmana Village, Ajibarang District, Banyumas Regency, West Java Province, Indonesia. The treatment of organic wastes needs to be done by various means, one of them using black soldier fly (Hermetia illucens) maggots. The training in maggot farming aimed to explore maggot potency as a decomposing agent in organic waste treatment, and analyzed the factors affecting the process, including environment, type of waste, and operational scale. The establishment of maggot farming has the potencial to be developed as an alternative fish pellet with high protein content. The community service methods involved eight persons from a community self-help group (Kelompok Swadaya Masyarakat), namely Berkah Runtah in Lesmana Village, who participated in the education seminar on 2nd July and continuous maggot farm training in July 2024. Besides the training, a seminar about using maggot as fish pellets was also held on 15th July to increase community knowledge about maggot use as a fish pellet. The farming cage size was 1.5 m x 1 m x 0.5 m, which was also an output of this activity. In conclusion, education and implementation of organic waste treatment using maggots in Lesmana Village showed great potency in establishing sustainable organic waste treatment as well as empowerment of society.
Masyarakat Sehat, Pangan Sehat: Penguatan Gizi dengan Implementasi Rumah Produksi Sari Kedelai Sebagai Solusi Terpadu Masyarakat Desa Safithri, Mega; Andrianto, Dimas; Fitrilia, Tiana; Rosyidah, Rara Annisaur; Purwanto, Ukhradiya Magharaniq Safira; Kurniasih, Rini; Hudayanti, Martini; Destiandani, Khansa; Raisyadikara, Fadila
Qardhul Hasan: Media Pengabdian kepada Masyarakat Vol. 10 No. 3 (2024): DESEMBER
Publisher : Universitas Djuanda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30997/qh.v10i3.15546

Abstract

Kesehatan masyarakat di pedesaan Indonesia seringkali terhambat oleh pola konsumsi pangan yang tidak seimbang, dengan ketergantungan tinggi pada karbohidrat dan asupan protein nabati yang kurang optimal. Salah satu solusi potensial adalah peningkatan konsumsi sari kedelai, yang kaya akan protein, vitamin, dan mineral. Sari kedelai dapat membantu memperbaiki gizi dan mengurangi risiko penyakit degeneratif. Desa Sukamaju di Kecamatan Cigudeg, Kabupaten Bogor, memiliki potensi untuk mengembangkan produksi sari kedelai, tetapi pemanfaatannya belum maksimal. Program ini bertujuan untuk meningkatkan gizi masyarakat dan memberdayakan ekonomi lokal melalui pendirian rumah produksi sari kedelai. Kegiatan melibatkan kader Posyandu dan PKK melalui sosialisasi dan pelatihan. Metode yang digunakan meliputi pengumpulan data melalui kuisioner pre-test dan post-test untuk menilai pengetahuan sebelum dan setelah pelatihan. Hasil pelatihan menunjukkan peningkatan pemahaman masyarakat tentang sari kedelai, meskipun awalnya pengetahuan mereka terbatas. Program ini berhasil meningkatkan minat dan pengetahuan mengenai sari kedelai, serta berpotensi untuk menjadi model bagi desa lain. Kesimpulannya, program ini memberikan manfaat ganda dengan meningkatkan gizi masyarakat dan mendukung ekonomi lokal, meskipun masih ada tantangan dalam mendorong produksi dan konsumsi sari kedelai secara mandiri.
Potensi Beberapa Ikan Sungai Batanghari Sebagai Suplemen Zink bagi Anak dengan Infeksi Saluran Pernapasan Akut (ISPA) Kurniasih, Dewi; Latifah, Aminahtun; Syarthibi, Ahmad; Andrianto, Dimas; Hafid, Fahmi
Journal of Telenursing (JOTING) Vol 6 No 2 (2024): Journal of Telenursing (JOTING)
Publisher : Institut Penelitian Matematika, Komputer, Keperawatan, Pendidikan dan Ekonomi (IPM2KPE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31539/joting.v6i2.12911

Abstract

This study aims to analyze the zinc content in several types of fish from the Batanghari River as an alternative zinc supplement for children with ISPA. The method used is descriptive analytical to analyzing the results of the zinc level examination and comparing zinc levels in different types of specimens. The results of the research showed that the average zinc content in gabus fish, patin, and lambak was 0.7867 mg/100 gr. The result showed that there is a difference the average zinc content in gabus fish, patin, and lambak (p<0,05) . Keywords: Zinc supplementation; River fish; Acute Respiratory Infection.
In Vitro Study of Piper Crocatum Ruiz & Pav Potency as HMG-CoA Reductase and Malondialdehyde Formation Inhibitor Zaelani, Bella Fatima Dora; Safithri, Mega; Andrianto, Dimas
Indonesian Journal of Applied Research (IJAR) Vol. 5 No. 3 (2024): Indonesian Journal of Applied Research (IJAR)
Publisher : Universitas Djuanda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30997/ijar.v5i3.504

Abstract

Coronary heart disease is a serious health problem and it is known to be lethal. The disease can be triggered by the accumulation of cholesterol plaques in the walls of blood vessels This cholesterol formation is assisted by methylglutaril-CoA reductase (HMG-CoA reductase) enzyme. Red betel contains active compounds that have the potential to act as HMG-CoA reductase inhibitor. This study aimed to predict the potential of ethanol extract compounds, water fraction, ethyl acetate fraction, and red betel n-hexane fraction as HMG-CoA reductase inhibitors by in vitro method. The in vitro method which consisted of extraction by maceration, graded fractionation with n-hexane, ethyl acetate, and water, continued by thiobarbituric acid (TBA) method to see the potential antioxidant activity of the sample. The Result showed that the highest inhibition of HMG-CoA reductase is 94% was found in the concentration 200 ppm ethyl acetate fraction. Also antioxidant activity of red betel showed by the inhibition of malondialdehyde formation had the highest activity in the ethyl acetate fraction than other fractions used.
Aktivitas antioksidan ekstrak sulur buah naga putih (Hylocereus undatus) dengan metode DPPH dan Rancimat Hasim, Hasim; Andrianto, Dimas; Lestari, Ella Deffi; Faridah, Didah Nur
Jurnal Gizi dan Pangan Vol. 12 No. 3 (2017)
Publisher : The Food and Nutrition Society of Indonesia in collaboration with the Department of Community Nutrition, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (408.497 KB) | DOI: 10.25182/jgp.2017.12.3.203-210

Abstract

The objectives of this study were to analyze phytochemical components, to determine total phenol and flavonoid content, and to test the antioxidant activity of dragon fruit vine extract. The results of phytochemical analysis showed acetone and ethyl acetate extracts contain alkaloids, flavonoids and steroids, while methanol extracts contained alkaloids, flavonoids and triterpenoids. Total phenol and flavonoid content determination results showed the highest concentration in acetone extract of 460.01 GAE mg / 100 g sample and 229.27 RUE mg/100 g sample. Extract of dragon fruit vine has a potencial as antioxidant by inhibition of free radical of DPPH with best IC50 value on acetone extract 25.32 mg / L. The results of antioxidant testing in lipid system using rancimat method obtained the highest protection factor on methanol extract of 1.64.
Evaluation of Fatty Acid Profile in Red Tilapia Fed Black Soldier Fly Larvae and Tofu Waste-Based Diets Purwanto, Ukhradiya Magharaniq Safira; Sari, Sintia Permata; Nabilla, Rahmah; Andrianto, Dimas; Safithri, Mega
Jurnal Ilmiah Perikanan dan Kelautan Vol. 17 No. 3 (2025): JURNAL ILMIAH PERIKANAN DAN KELAUTAN
Publisher : Faculty of Fisheries and Marine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jipk.v17i3.74569

Abstract

Graphical Abstract    Highlight Research Feed formulations based on black soldier fly (BSF) larvae and tofu waste meet the quality requirements based on the Indonesian National Standard Feed formulations based on black soldier fly (BSF) larvae and tofu waste improve fish growth performance comparable to commercial feed Feed formulations based on black soldier fly (BSF) larvae and tofu waste did not increase the level of cholesterol content in fish flesh Fish flesh with black soldier fly (BSF) larvae and tofu waste diet have higher total fatty acid content compared to commercial feed     Abstract Despite growing interest in sustainable aquaculture, studies on the combined use of Black Soldier Fly Larvae (BSFL) and tofu waste as alternative protein sources in tilapia diets, particularly their effects on fatty acid profiles, remain limited. This study evaluates the effects of fish feed formulated with BSFL and tofu waste on the growth performance, proximate composition, and fatty acid profile of red tilapia (Oreochromis niloticus). Experimental diets included: commercial feed, dried BSFL, and a combination of BSFL:tofu waste. Fish were reared for eight weeks under controlled conditions. Treatment with BSFL:tofu waste exhibited superior growth performance, with the highest weight gain (102.88%) and length gain (33.75%). Proximate analysis revealed significant variations across treatments, with a combination of BSFL:tofu waste achieving the highest caloric value (110.71 cal/g) and fat content (3.75%) while maintaining protein levels comparable to commercial feed. Fatty acid analysis showed a combination of BSFL:tofu waste enhanced total fatty acid content (77.92%), predominantly polyunsaturated fatty acids (PUFAs), increasing from 37.34% in commercial feed to 47.04%. Essential fatty acids, including DHA and linoleic acid, were elevated in a combination of BSFL:tofu waste, indicating improved nutritional quality. Cholesterol levels remained unaffected among treatments. These findings suggest that combining BSFL and tofu waste can enhance fish feed quality, optimize growth performance, and improve the nutritional value of red tilapia. Future research should explore refining feed formulations to maximize nutrient stability and sustainability for broader aquaculture applications.
Peningkatan Kesehatan Melalui Pengolahan Sumber Daya Herbal Menjadi Minuman Fungsional SIJAKA Safithri, Mega; Andrianto, Dimas; Fitrilia, Tiana; Rosyidah, Rara Annisaur; Purwanto, Ukhradiya Magharaniq Safira; Kurniasih, Rini; Hudayanti, Martini; Achyar, Catellia Auliany; Febrina, Adella; Dwicesaria, Maheswari Alfira; Gholam, Gusnia Meilin; Nusyarah, Ayu Tri
Qardhul Hasan: Media Pengabdian kepada Masyarakat Vol. 11 No. 2 (2025): Qardhul Hasan: Media Pengabdian kepada Masyarakat
Publisher : Universitas Djuanda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30997/qh.v11i2.18127

Abstract

Program pelatihan dan sosialisasi mengenai pemanfaatan SIJAKA (sirih merah, jahe merah, dan kayu manis) sebagai minuman fungsional antidiabetes bertujuan untuk meningkatkan pemahaman dan praktik masyarakat dalam mengelola diabetes secara alami. Desa Sukamaju yang terletak di Kecamatan Cigudeg, Kabupaten Bogor memiliki peluang untuk mengembangkan produksi minuman fungsional berbahan dasar SIJAKA, namun potensi ini belum dimanfaatkan secara optimal. Program ini dirancang untuk meningkatkan taraf kesehatan masyarakat serta mendorong pertumbuhan ekonomi lokal melalui pendirian fasilitas produksi minuman fungsional SIJAKA. Pelaksanaan kegiatan melibatkan kader Posyandu dan PKK melalui kegiatan penyuluhan dan pelatihan. Metode yang digunakan mencakup pengisian kuisioner pre-test dan post-test guna mengevaluasi tingkat pengetahuan peserta sebelum dan sesudah pelatihan. Hasil pelatihan menunjukkan adanya peningkatan pemahaman masyarakat terkait minuman fungsional SIJAKA, meskipun sebelumnya pengetahuan mereka masih terbatas. Pelatihan ini juga mengungkapkan bahwa 79,31% peserta mengenal sirih merah dan jahe merah sebagai herbal potensial, sedangkan 72,41% mengetahui manfaat kayu manis. Hasil ini menunjukkan adanya peningkatan kesadaran akan potensi herbal dalam mengelola diabetes. Selain itu, mayoritas peserta (92,11%) menunjukkan ketertarikan yang tinggi terhadap pelatihan dan ingin lebih memahami manfaat serta cara pembuatan SIJAKA. Program ini terbukti mampu meningkatkan antusiasme dan wawasan masyarakat terhadap SIJAKA, serta memiliki potensi untuk dijadikan sebagai contoh bagi desa-desa lainnya. Secara keseluruhan, program ini memberikan dua manfaat utama, yaitu peningkatan kualitas kesehatan masyarakat dan penguatan ekonomi lokal, meskipun masih terdapat kendala dalam mendorong masyarakat untuk memproduksi dan mengonsumsi SIJAKA secara mandiri.
Molecular Docking of the Bioactive Compound Physalis angulata as an Activator of Superoxide Dismutase 1 Wilujeng, Retno; Harlina, Eva; Purwono, Rini Madyastuti; Andrianto, Dimas
Indonesian Journal of Applied Research (IJAR) Vol. 6 No. 2 (2025): Indonesian Journal of Applied Research (IJAR)
Publisher : Universitas Djuanda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30997/ijar.v6i2.737

Abstract

Physalis angulata was known for its pharmacological potential, including antioxidant activity, yet the specific bioactive compounds responsible for enhancing endogenous antioxidant enzymes, such as superoxide dismutase 1 (SOD 1), remained unclear. This study aimed to identify and evaluate the active compounds of P. angulata as natural SOD 1 activators using an In silico molecular docking approach. Forty-nine ligands derived from the active constituents of P. angulata were screened based on Lipinski’s Rule of Five and ADMET properties. Molecular docking was performed using the SOD 1 protein (PDB ID: 5YTO), and docking validation yielded an RMSD value of 0.005 Å. Among the test ligands, withanolide exhibited the most favorable binding energy (−7.011 kcal/mol) and the lowest inhibition constant (7.0 pM), forming strong interactions with key catalytic residues of the enzyme. These findings indicated that withanolide had promising potential as a natural SOD 1 activator, providing a basis for future antioxidant drug discovery.
Co-Authors Abdjad Asih Nawangsih Abdul Aziz Abdul Razak Abdurrahman Zaky Achyar, Catellia Auliany Agus Setiyono Ahmad Faqih Aisyah Sahara Akhmad Endang Zainal Hasan Al Malik, Ahmad Fauzan Alexandra, Angelya Cintania Ambarsavitri, Rahmadhani Amrista Fanzani Kananga Anja Meryandini Antonius Padua Ratu Apipah Aprianti Arya Arendra Assa’addah, Habibah Aulya, Silvy AYU LESTARI Ayu Tri Nursyarah Bella Fatima Dora Zaelani Dadan Rohdiana Daeli, Gavriel Allenfar Danty Oktiana Prastiwi Dara Anggun Vachyra Dea Khalissa Anidya Destiandani, Khansa Dewi Eriyanti Dewi Kurniasih Dewi Purnamasari Dimas Andrianto Djarot Sasongko Hami Seno Dwicesaria, Maheswari Alfira Eka Wahyu Purnama Elgiani Yassifa Yulia Nur Insari Emidar Khusnu Eni Kamal Eny Ida Riyanti Eriyanti, Dewi Etik Mardliyati, Etik Eva Harlina Fahmi Hafid Faisal Rahman Falah, Samsul Febrina, Adella Fina Febrianti Firdaus, Dzikri Anfasa Firdaus, Muhamad Fajar Firmansyah, Muhammad Ade Fitrilia, Tiana Galuh Adhiyaksa Ashari Ghifari, Muhammad Nabil Gholam, Gusnia Meilin Gina Oktaviani Sabrina Hardinsyah Hasanah, Ikromatul Hasim Hasim - HASIM DANURI Hasim Hasim Hazim, Naufal Wildan Heddy Julistiono Heddy Julistiono Hudayanti, Martini Husnawati, . I MADE ARTIKA Ike Agustiani Ilham Gilang Cahya Ahmada Imelia Dewi Inawati Inawati Irfan Abdul Aziz Irsal, Riyan Alifbi Putera Istikorini, Yunik Jaka Aryantara Kuntala Jihad Waffiqa Rahmah Kusnaedi, Anggi LAKSMI AMBARSARI Latifah Kosim Darusman Latifah, Aminahtun Lestari, Ella Deffi Lukman, Zulfiqar Madyastuti, Rini Marfiana, Arila Safa Maria Bintang Mega Safithri Mhd. Ridha Muhamad Alvin Adriyan Muhammad Farhan Muhammad Irfansyah Pradika Muhammad Zulkifli Mutholaah Mutmainnah Agustiawan Umar Nabilatusyifa, Alivianisa Nabilla, Rahmah Najmah, Najmah Nayanda, Najwa Putri Nina Tri Kusumawati Noor Farikhah Haneda Noviyan Darmawan Nurliani Bermawie Nusyarah, Ayu Tri Olive Wisepti Pratama Prasetyo, Dwiandra Hadi Pratiwi, Anggita Aziz Purwanto, Ukhradiya Magharaniq Safira Putri, Oyi Candra Santoso Putri, Salsabila Yasmin Budi Qolbiyah, Syifa Ainul Qomariah Hasanah Qurrotu Ayni R. Haryo Bimo Setiarto Raden Roro Fine Ayu Putri Rafiqi, Akbar Rahmah, Sabrina Firdayani Rahman, Syabilla Aulia Raisyadikara, Fadila Rara Annisaur Rosyidah Rimbawan Rimbawan Rini Kurniasih, Rini Riska Susila Putri Rizki Amelia Sasqia Putri Rosyidah, Rara Annisaur Sanro Tachibana Sari, Sintia Permata Sigiro, Ria Heni Silvy Aulya Sitanggang, Rianta Faustina Siti Maesunah Gilang Maya Slamet Hamzah Sobari, M Hilmy Rifq Sri Anna Marliyati Sri Mariati Sri Wahyuni Suci Hermita Sulistiyani Sulistiyani Sulistiyani SULISTIYANI SULISTIYANI Syaefudin Syaefudin Syaefudin Syamsul Falah Syarthibi, Ahmad Syifa Khaerani Tukan, Maria Magdalena Nona Motu Ukhradiya Magharaniq Safira Purwanto Ulfah Juniarti Siregar Vina Oktovianti Walidayyin, Sekar Wangi Waras Nurcholis Widya Prarikeslan Wilujeng, Retno Winata, Grace Marlina Yudono, Nur Annisa Windi Yupi Yulianita Arifin Yusriya, Rifqi Zaelani, Bella Fatima Dora Zulfikar Muchammad Zulfikar Muhammad, Zulfikar