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All Journal HAYATI Journal of Biosciences Jurnal Agronomi Indonesia (Indonesian Journal of Agronomy) Jurnal Gizi dan Pangan Jurnal Teknologi Dan Industri Pangan Jurnal Pengolahan Hasil Perikanan Indonesia VALENSI Jurnal Veteriner JURNAL KIMIA SAINS DAN APLIKASI BIOTROPIA - The Southeast Asian Journal of Tropical Biology Current Biochemistry Indonesian Journal of Pharmaceutical Science and Technology Agrokreatif Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Media Gizi Indonesia (MGI) Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Aplikasi Teknologi Pangan QARDHUL HASAN: MEDIA PENGABDIAN KEPADA MASYARAKAT Jambura Journal of Chemistry Jurnal Entomologi Indonesia Journal of Telenursing (JOTING) JSMARTech : Journal of Smart Bioprospecting and Technology Indonesian Journal of Applied Research (IJAR) Wood Research Journal : Journal of Indonesian Wood Research Society Wood Research Journal : Journal of Indonesian Wood Research Society Jurnal Pusat Inovasi Masyarakat Jurnal Sylva Lestari JURNAL AGROINDUSTRI HALAL Jurnal Sosial dan Sains Jurnal Ilmiah Multidisiplin Nusantara Jurnal Veteriner dan Biomedis Journal of Fisheries & Marine Halal Studies and Society Buitenzorg: Journal of Tropical Science
DIMAS ANDRIANTO
Departemen Biokimia, Fakultas Matematika Dan Ilmu Pengetahuan Alam, Institut Pertanian Bogor, Bogor 16680
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Red Betel Leaf Bioactive Compounds as ERα Receptor Inhibitors In Silico and MCF-7 Cell Anticancer In Vitro Ayu Tri Nursyarah; Mega Safithri; Dimas Andrianto
HAYATI Journal of Biosciences Vol. 30 No. 5 (2023): September 2023
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.30.5.789-796

Abstract

Cancer is one of the leading causes of death in the world. Excess endogenous estrogen is a risk factor for breast cancer. Red betel leaf herbal plants have been used as an alternative cervical and colon cancer treatment. This study aimed to obtain the active compounds that play a role in ERα receptor inhibitors in silico and to determine the anti-breast cancer cytotoxic activity of the extract and fraction of red betel leaf against MCF-7 cells. We use in silico research method using the YASARA Structure software with anti-breast cancer receptors, namely 3ERT, and in vitro using the MTT test on the anti-breast cancer cytotoxic activity of MCF-7 cells. There are 38 compounds that were obtained from the research. The results of the in silico test showed that the bioactive compound that played a role in inhibiting the ERα was 2-(4-Hydro xyphenyl)-2-phenyl-N(3,3-diphenylpropyl)-acetamide (44578655), a compound from water fraction, with an inhibition constant of 2.82 × 10-8 µM and Gibbs free energy of –10.2880 Kcal/mol. In vitro results showed that the best cell growth inhibition value was obtained from the n-hexane fraction at a concentration of 500 ppm of 73.42%. The conclusions of this study indicate that the bioactive compound of red betel leaf is water fraction is the best fraction inhibition. However, the hexane fraction proved to have cytotoxic activity against breast cancer MCF-7 cells.
Formulasi dan evaluasi krim antijerawat berbahan limbah cangkang kerang bulu (Anadara antiquata Linn.): Formulation and evaluation of anti acne cream from shellfish shells (Anadara antiquata Linn.) Syaefudin Syaefudin; Vina Oktovianti; Dimas Andrianto
Jurnal Pengolahan Hasil Perikanan Indonesia Vol 26 No 2 (2023): Jurnal Pengolahan Hasil Perikanan Indonesia 26(2)
Publisher : Department of Aquatic Product Technology IPB University in collaboration with Masyarakat Pengolahan Hasil Perikanan Indonesia (MPHPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17844/jphpi.v26i2.44109

Abstract

Cangkang kerang bulu mengandung kitosan yang berpotensi sebagai antibakteri sehingga dapat dijadikan sebagai bahan krim antijerawat. Penelitian ini bertujuan menentukan karakteristik fisikokimia (pH, penyebaran warna dan butiran, emulsi, serta daya sebar) produk krim berbahan dasar kitosan dari limbah cangkang kerang bulu serta mengevaluasi bioaktivitas (aktivitas antioksidan dan antibakteri) formula krim antijerawat dengan variasi konsentrasi kitosan 5% (F1), 10% (F2), dan 15% (F3) (b/v). Kitosan yang dihasilkan dari ekstraksi kitosan cangkang kerang bulu memiliki kadar air, rendemen, serta derajat deasetilasi berturut-turut sebesar 3,49%, 47,63%, dan 97,49%. Uji fisikokimia menunjukkan bahwa ketiga formula krim antijerawat memiliki pH 5, tipe penyebaran warna dan butiran homogen, tipe emulsi O/W, dan daya sebar yang menurun seiring meningkatnya konsentrasi kitosan. F3 memiliki aktivitas antioksidan tertinggi dan F1 memiliki kemampuan penghambatan bakteri tertinggi. Formula terpilih, yakni F1, menunjukkan hasil organoleptik (warna, tekstur, bau, daya serap, dan kemudahan untuk dibersihkan) yang cukup disukai panelis.
Keamanan krim anti jerawat berbasis kitosan cangkang kerang bulu : Safety in anti-acne cream based on chitosan from antique ark shells Ukhradiya Magharaniq Safira Purwanto; Dara Anggun Vachyra; Dimas Andrianto
Jurnal Pengolahan Hasil Perikanan Indonesia Vol 26 No 2 (2023): Jurnal Pengolahan Hasil Perikanan Indonesia 26(2)
Publisher : Department of Aquatic Product Technology IPB University in collaboration with Masyarakat Pengolahan Hasil Perikanan Indonesia (MPHPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17844/jphpi.v26i2.44125

Abstract

Chitosan is a chitin derivative, which is known to have antimicrobial properties. These properties make chitosan have a potential as a cosmetics ingredient. This study aimed to determine the safety of anti-acne cream with the addition of chitosan from shells of antique ark shells (Anadara antiquata Linn.) from heavy metal and microbial contamination. Heavy metal content was tested with Atomic Absorption Spectrophotometry (AAS). Microbial contamination of the cream base and 5% chitosan cream was determined by measuring the total plate count (TPC) and yeast mold number (YMN) using the pour cup method. The levels of lead and mercury in shells met the standards with values ​​of 1.78 mg/kg and <0.004 mg/kg, respectively. The TPC values ​​for cream base and 5% cream also met the standards with successive values ​​of 8.3x102 cfu/mL and 7.2x104 cfu/mL, while the YMN values ​​did not meet the standards with consecutive values ​​of 2.2x104 cfu/mL and 1.4x104 cfu/mL. Cream with the addition of 5% chitosan showed lower TPC and YMN values ​​compared to cream base (control). Cream preparations with the addition of chitosan do not meet BPOM Indonesia's safety standards for YMN values.
Aktivitas Antibakteri Senyawa Aktif Esktrak Jintan Hitam (Nigella sativa) Terhadap Bakteri MRSA secara In Silico Dea Khalissa Anidya; Rini Madyastuti Purwono; Dimas Andrianto; Nina Tri Kusumawati
Jurnal Veteriner dan Biomedis Vol. 1 No. 2 (2023): September
Publisher : Sekolah Kedokteran Hewan dan Biomedis

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jvetbiomed.1.2.92-102.

Abstract

Semakin tinggi penggunaan antibiotik akan meningkatkan risiko terjadinya resistensi bakteri. S. aureus merupakan bakteri penyebab mastitis tertinggi yaitu mencapai 67% diantara bakteri patogen penyebab mastitis lainnya. Akibat tingginya penggunaan antibiotik, terbentuklah strain S. aureus yang resisten yaitu MRSA. Bahan alami seperti jintan hitam bisa menjadi alternatif pengobatan penyakit menular bakteri. Penelitian ini bertujuan untuk menguji sifat an-tibakteri ekstrak jintan hitam terhadap bakteri MRSA (ID:3VSL) secara in silico dan mengetahui zat aktif mana yang mempunyai potensi antibakteri terbaik. Berdasarkan hasil LC-MS dari 89 zat aktif yang teridentifikasi, 9 diantaranya mempunyai potensi antibakteri yang cukup baik dibandingkan sefotaksim setelah dilakukan prediksi bioavailabilitas dan toksisitas lipinski. Hasil analisis penelitian menunjukkan 3 zat aktif yang terdiri dari prolylleucine, (2-(1,3-ben-zodioxol-5-yl)-4,5,6,7-tetramethyl-1H-benzimidazole, dan Bis(4-ethylbenzylidene)) Sorbitol merupakan ligan produk alami dengan aktivitas antibakteri terbaik serta menjadi kandidat bahan aktif alternatif pengganti antibiotik.
Total Phenolics, Flavonoids, and Antioxidant Activities of Indonesian Apis Dorsata Honey Due to Heating Akhmad Endang Zainal Hasan; Dimas Andrianto; Mega Safithri; Ilham Gilang Cahya Ahmada
Indonesian Journal of Applied Research (IJAR) Vol. 4 No. 2 (2023): Indonesian Journal of Applied Research (IJAR)
Publisher : Universitas Djuanda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30997/ijar.v4i2.265

Abstract

Honey is rich in phenolic and flavonoid compounds that have the potential as antioxidants. The heating treatment of honey is also known to affect the honey compound. This study aimed to determine the best Indonesian A. dorsata honey from various locations based on the level of total phenolics compounds, flavonoids, and antioxidant capacity due to variations in heating temperature. The procedures carried out in this study included: heating the sample with variations (room temperature, 65 oC, and 121 oC), measuring total phenolic content using the Folin-Ciocalteau method, measuring total flavonoid content using the AlCl3 colorimetric method, and testing antioxidant activity using the DPPH method. Each honey's total phenolic, flavonoid, and antioxidant activity are affected by its origin. The impact of heating at 65 oC and 121 oC resulted in various changes between honey samples (p<0.05). The best A. dorsata honey overall was found in Flores honey after heating at 121 oC heating treatment with total phenolic content of 4.96 mgGAE/mL, total flavonoids of 1.173 mg QE/mL, and IC50 5.76 g/L.
Clusterization of Red Betel Leaves (Piper Crocatum) from Various Regions in Indonesia Based on Secondary Metabolite Fingerprint Analysis and Cytotoxicity Values Eka Wahyu Purnama; Mega Safithri; Dimas Andrianto
Indonesian Journal of Applied Research (IJAR) Vol. 4 No. 2 (2023): Indonesian Journal of Applied Research (IJAR)
Publisher : Universitas Djuanda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30997/ijar.v4i2.293

Abstract

The quality of the ethanol extract of red betel leaves as a medicinal plant is determined by secondary metabolites, which are influenced by geographical conditions and the plant growing environment. This study aims to classify red betel from various regions in Indonesia based on secondary metabolite fingerprint analysis and cytotoxicity values. Observation of the diversity of secondary metabolites of the ethanol extract of red betel leaves from seven different regions (Banda Aceh, Bandung, Bogor, Malang, Samarinda, Kendari, Jayapura) was carried out using a metabolomics approach using liquid chromatography-mass spectroscopy (LC-MS/MS) and determining cytotoxicity value using the Brine Shrimp Lethality Test (BSLT) method. Secondary metabolite fingerprinting analysis using cluster analysis with dendrogram yielded 12 compounds with 3 sample groups based on their region of origin, namely group 1 (Banda Aceh, Samarinda, Jayapura); group 2 (Bandung, Kendari, Malang); group 3 (Bogor). Group 1 samples identified eight compounds that had the highest relative abundance values. Group 2 samples identified 3 compounds that have the highest relative abundance values. Group 3 samples had 1 compound with the highest relative abundance value. Each compound has a different retention time. The cytotoxicity value (LC50) of the ethanol extract of betel leaves was obtained from the Banda Aceh and Malang areas (2.64 µg/mL). The conclusions of this study based on the results of secondary metabolite fingerprinting analysis and cytotoxicity values ​​identified 12 compounds with three clusters of secondary metabolite diversity based on their region of origin, namely group 1 (Banda Aceh, Jayapura, Samarinda); group 2 (Bandung et al.); group 3 (Bogor).
The potential of Myricitrin, a Flavonoid Compound in Eugenia polyantha from Indonesia, as an Antiviral Drug for SARS-Cov-2 through the Molecular Docking Analysis Syamsul Falah; Laksmi Ambarsari; Dimas Andrianto; Rini Kurniasih; Sanro Tachibana
Jurnal Kimia Sains dan Aplikasi Vol 26, No 5 (2023): Volume 26 Issue 5 Year 2023
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.26.5.166-177

Abstract

A Flavonoid glycoside compound, isolated and identified from E. polyantha as myricitrin, was analyzed as a ligand for its molecular binding activity against SARS-CoV-2 protein (receptor binding domain on Spike/RBD, main protease/nsp5, EndoRNAse, RNA-dependent-RNA-polymerase/RdRp), and its receptor, ACE2, and computationally assessed via molecular docking method. This study aims to determine the potential of myricitrin in E. polyantha from Indonesia as an antiviral drug for SARS-CoV-2 through molecular docking and molecular dynamic simulation analysis. The results showed that the myricitrin had the strongest binding affinity energy towards the three important SARS-CoV-2 proteins, namely endoRNAse, main protease (3CLpro), and RdRp with ∆G values of −9.60 kcal/mol, −8.40 kcal/mol, and −8.30 kcal/mol, respectively. These values are stronger than the comparator ligands of favipiravir (−5.60 kcal/mol), atazanavir (−7.20 kcal/mol), and remdesivir (−7.70 kcal/mol). This indicated that the compound has the potential as an inhibitor against 3CLpro, endoRNAse, and RdRp of SARS-CoV-2 proteins. This result was supported by the prediction made according to the Molprobity and PASS Online web servers, which showed that myricitrin has high bioactivity potential as an enzyme inhibitor (with a score of 0.38) and antiviral (with a score of 0.704).
Antibacterial Ingredients That Cause Diarrhea Can Be Made from Black, Green, and White Tea Extract (Camellia sinensis L.) Dadan Rohdiana; Akhmad Endang Zainal Hasan; Dimas Andrianto; Dadan Rohdiana; Heddy Julistiono; Muhamad Alvin Adriyan
Indonesian Journal of Applied Research (IJAR) Vol. 4 No. 3 (2023): Indonesian Journal of Applied Research (IJAR)
Publisher : Universitas Djuanda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30997/ijar.v4i3.353

Abstract

One cause of diarrhea is a bacterial infection. Tea (Camellia sinensis) is a steeping drink that has the efficacy of treating diarrhea. This looks at goals to decide the effect of formulations of three tea extracts that act as antibacterial causes of diarrhea and decide the most appropriate maceration temperature. Extraction was carried out with water solvents at temperatures 70oC, 100oC, and 121oC. The disc method conducted an antibacterial test against E. coli and S. aureus. The most optimal temperature for producing the highest inhibitory zone is the temperature of 100oC. Tea extract temperatures of 100oC are used for antibacterial testing. BSLT test showed the LC50 value of 1800 µg/mL. Tests on E. coli bacteria showed the highest results in a single white tea extract with a diameter of 9.750 mm, and tests on S. aureus showed the highest results in the three tea extract formula with a diameter of 9.65 mm. The inhibitory area evaluation of the system changed into finished using the simplex-centroid design method. It showed a non-huge linear model in the antibacterial test in opposition to E. coli and S. aureus.
Antioxidant Activity and Inhibition of Α-Glucosidase from Yellow Root Extract (Fatuoa Pilosa Gaudich) In Vitro Tukan, Maria Magdalena Nona Motu; Falah, Samsul; Andrianto, Dimas; Najmah, Najmah
Jambura Journal of Chemistry Vol 5, No 2 (2023): August
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34312/jambchem.v5i2.20503

Abstract

Yellow root (Fatoua pilosa Gaudich) is a type of plant which is found on lowland mostly in Japan, China and usually grow in the dry bushes. Traditionally, the yellow root (Fatuoa pilosa Gaudich) is used to treat the disease of diabetes mellitus and as antiinflamation. One of the causes of diabetes disease is oxidative stress. Oxidative stress can be reduced by using antioxidants. This research aims to explore antioxidant activity and inhibition of α-glucosidase enzyme from yellow root extract (Fatoua pilosa Gaudich.). Quantitative determination of total phenolic by using folin-ciocalteu method declared as gallic acid equivalents (GAE) per gram of extract, levels of total flavonoids with AlCl3 method declared as Quercetin equivalen (QE), and antioxidant activity in fertilization with the DPPH (2, 2-diphenyl-1- picrylhydrazyl) stated in the IC50 (concentration inhibition). The Results showed that the highest levels of total flavonoids was in extract ethanol 96% 199.44 g QE/g extract, while the total phenolic levels highest in 70% ethanol extracts 211.54 mg GAE/g extract. The highest IC50 obtained from antioxidant test of yellow root extrat was 70% ethanol extract 14.62 μg/mL and the most active fraction that can inhibit α-glucosidase enzyme was of ethyl acetate fraction with IC50 values 680.54 μg/mL.
A Narrative Review of Known Plants which Have Potential Benefits as Natural Galactagogues in Indonesia Winata, Grace Marlina; Hardinsyah Hardinsyah; Sri Anna Marliyati; Rimbawan Rimbawan; Dimas Andrianto
Media Gizi Indonesia Vol. 19 No. 1 (2024): MEDIA GIZI INDONESIA (NATIONAL NUTRITION JOURNAL)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mgi.v19i1.57-72

Abstract

Human milk is the gold standard for infant nutrition during the first six months of life. According to Indonesia Demographic and Health Survey in 2017, about 45% of mothers in Indonesia provided pre-lacteal feeding within three days postpartum. Low or no milk production and perceived insufficient milk for the infants need were common reasons for pre-lacteal feeding. Galactagogues are believed to help augment human milk production. Therefore, galactagogue consumption is highly recommended, especially natural galactagogue, to help overcome low milk production problem. Most natural galactagogues are used as a local tradition only. Scientific studies regarding the phytochemical compounds and the mechanisms involved are still very limited. This narrative review aimed to describe selected research articles reporting the potency of torbangun, katuk, kelor, and papaya leaves as known plants acting as natural galactagogues in Indonesia. A total of 22 original research articles from Indonesia written in Indonesian or English over a 20 years period were included in this review. Studies were selected if selected natural galactagogues were evaluated at least for the proposed mechanism of action and effects. The data have shown strong evidence about the positive effect of torbangun, katuk, kelor, and papaya leaves as natural galactagogues on increasing human milk production. The five leaves contain different phytoestrogens that have an estrogen effect to stimulate prolactin production and increase milk production. 
Co-Authors Abdjad Asih Nawangsih Abdul Aziz Abdurrahman Zaky Achyar, Catellia Auliany Agus Setiyono Ahmad Faqih Aisyah Sahara Akhmad Endang Zainal Hasan Al Malik, Ahmad Fauzan Aldri Frinaldi Alexandra, Angelya Cintania Amrista Fanzani Kananga Anja Meryandini Antonius Padua Ratu Apipah Aprianti Arya Arendra Assa’addah, Habibah Aulya, Silvy Ayu Tri Nursyarah Azizah, Annisa Nur Wahida Bella Fatima Dora Zaelani Dadan Rohdiana Daeli, Gavriel Allenfar Danty Oktiana Prastiwi Dara Anggun Vachyra Dasman Lanin Dea Khalissa Anidya Destiandani, Khansa Dewi Eriyanti Dewi Kurniasih Dewi Purnamasari Djarot Sasongko Hami Seno Dwicesaria, Maheswari Alfira Eka Wahyu Purnama Elgiani Yassifa Yulia Nur Insari Emidar Khusnu Eny Ida Riyanti Eriyanti, Dewi Etik Mardliyati, Etik Eva Harlina Fahmi Hafid Faisal Rahman Falah, Samsul Febrina, Adella Fina Febrianti Firdaus, Dzikri Anfasa Firdaus, Muhamad Fajar Firmansyah, Muhammad Ade Fitrilia, Tiana Galuh Adhiyaksa Ashari Ghifari, Muhammad Nabil Gholam, Gusnia Meilin Gina Oktaviani Sabrina Hanifati, Qisthina Hardinsyah Hasanah, Ikromatul Hasim - HASIM DANURI Hasim Hasim Hazim, Naufal Wildan Heddy Julistiono Heddy Julistiono Hudayanti, Martini Husnawati, . I MADE ARTIKA Ike Agustiani Ilham Gilang Cahya Ahmada Iman, Ramadhan Nur Imelia Dewi Inawati Inawati Iqrima Basri Irfan Abdul Aziz Irsal, Riyan Alifbi Putera Istikorini, Yunik Jaka Aryantara Kuntala Kusnaedi, Anggi LAKSMI AMBARSARI Latifah Kosim Darusman Latifah, Aminahtun Lestari, Ella Deffi Lukman, Zulfiqar Madyastuti, Rini Marfiana, Arila Safa Maria Bintang Mega Safithri Mhd. Ridha Muhamad Alvin Adriyan Muhammad Farhan Muhammad Irfansyah Pradika Muhammad Zulkifli Mutholaah Mutmainnah Agustiawan Umar Nabilatusyifa, Alivianisa Nabilla, Rahmah Najmah, Najmah Nayanda, Najwa Putri Nina Tri Kusumawati Noor Farikhah Haneda Noviyan Darmawan Nurliani Bermawie Nusyarah, Ayu Tri Olive Wisepti Pratama Prasetyo, Dwiandra Hadi Purwanto, Ukhradiya Magharaniq Safira Putri, Oyi Candra Santoso Putri, Salsabila Yasmin Budi Qolbiyah, Syifa Ainul Qomariah Hasanah Qurrotu Ayni R. Haryo Bimo Setiarto, R. Haryo Bimo Raden Roro Fine Ayu Putri Rafiqi, Akbar Rahmah, Sabrina Firdayani Raisyadikara, Fadila Rara Annisaur Rosyidah Rembrandt Rimbawan Rimbawan Rini Kurniasih, Rini Riska Susila Putri Rosyidah, Rara Annisaur Sanro Tachibana Sari, Sintia Permata Sigiro, Ria Heni Silvy Aulya Sitanggang, Rianta Faustina Siti Maesunah Gilang Maya Slamet Hamzah Sobari, M Hilmy Rifq Sri Anna Marliyati Sri Mariati Sri Wahyuni Suci Hermita Sulistiyani Sulistiyani Sulistiyani SULISTIYANI SULISTIYANI Syaefudin Syaefudin Syaefudin Syamsul Falah Syarthibi, Ahmad Syifa Khaerani Tukan, Maria Magdalena Nona Motu Ukhradiya Magharaniq Safira Purwanto Ulfah Juniarti Siregar Vina Oktovianti Walidayyin, Sekar Wangi Waras Nurcholis Wilujeng, Retno Winata, Grace Marlina Yudono, Nur Annisa Windi Yupi Yulianita Arifin Yusriya, Rifqi Zaelani, Bella Fatima Dora Zulfikar Muchammad