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All Journal HAYATI Journal of Biosciences Natural Science: Journal of Science and Technology CAKRA KIMIA (Indonesian E-Journal of Applied Chemistry) Jurnal Kimia (Journal of Chemistry) Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) The Journal of Pure and Applied Chemistry Research JPM17: Jurnal Pengabdian Masyarakat Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Majalah Obat Tradisional Pharmascience Jurnal Farmasi Sains dan Komunitas Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Wiyata : Penelitian Sains dan Kesehatan JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) Jurnal Katalisator GERVASI: Jurnal Pengabdian kepada Masyarakat Pharmaceutical Journal of Indonesia International Journal of Agricultural Sciences Jurnal Farmamedika (Pharmamedica Journal) Medika Alkhairaat : Jurnal Penelitian Kedokteran dan Kesehatan Jurnal Kefarmasian AKFARINDO Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang Jurnal Insan Farmasi Indonesia Jurnal Farmasi Journal of Community Practice and Social Welfare (JaCiPS) Indonesian Community Journal JOMPA ABDI: Jurnal Pengabdian Masyarakat Lamahu: Jurnal Pengabdian Masyarakat Terintegrasi Sainsbertek Jurnal Ilmiah Sains & Teknologi Jurnal Permata Indonesia Journal of Global Pharma Technology Borneo Journal of Pharmacy Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas Jurnal Kefarmasian Indonesia Khidmat: Journal Community Service
Rollando, Rollando
Program Studi Farmasi, Fakultas Ilmu Kesehatan, Universitas Ma Chung
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Journal : Jurnal Katalisator

 1 
APLIKASI METODE BIOAUTOGRAFI DALAM PENELUSURAN DAYA ANTIBAKTERI EKSTRAK PEGAGAN (Centella asiatica (L.)) Rehmadanta Sitepu; Ririn Nurdiani; Rollando Rollando
Jurnal Katalisator Vol 5, No 1 (2020): KATALISATOR
Publisher : LLDIKTI Wilayah X

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22216/jk.v5i1.5176

Abstract

Pegagan (Centella asiatica (L.) Urban) is a traditional herbal plant that spread as it grows and in bloom througout the year. Pegagan is believed to be able to cure various type of diseases because it contains bioactive component that’s good for human body. Pegagan’s bioactive component that has anti-bacterial properties are saponin, flavonoid, and tanin. This study was conducted with the purpose to determine the existence of antibacterial activity in ethanol extract of pegagan leaves by applying it in Disc Diffusion Test  method against Escherichia coli and Staphylococcus aureus bacteria. Etanol extract was obtained by using maserasi method with 70% ethanol, separation of the active compound group which one of them is flavonoid using phytochemical screening, and the result was that the pegagan positively contains flavonoid, it was proven by the existence of a red marker on the tube. The result of active compund using methanol eluent: chloroform: glacial acetic acid produces 1 spot point on (Rf 0,5-0,7) on TLC. This spot was used in antibacterial screening by bioatugraphy method and the activity was detected qualitatively. Antibacterial activity was proved by Disc Diffusion Test which the results were ethanol extract on pegagan has inhibitory activity to E.coli and S. aureus. This study can be concluded that ethanol extract of Centella asiatica has a MIC value of 3,200 µg / mL both in E. Coli and S. aureus. The diameter of obstacles zone were 0,06±0,05 mm to E.coli and 0,04±0,019 mm to S. aureus.Centella asiatica (L.) Urban (Pegagan) adalah spesies tumbuhan herbal tradisional dengan karakteristik tumbuh merambat dan berbunga di sepanjang tahun. Komponen bioaktif yang dimiliki pegagan dalam beberapa aspek, dapat digunakan dalam pengobatan penyakit. Golongan-golongan senyawa bioaktif pegagan yang memiliki daya antibakteri adalah saponin, flavonoid, dan tanin. Penelitian ini bertujuan untuk mengetahui adanya aktivitas antibakteri ekstrak etanol daun pegagan dengan metode Disc Diffusion Test  pada Escherichia coli maupun Staphylococcus aureus. Ekstrak tanaman Pegagan diperoleh dengan  maserasi dengan etanol 70%, pemisahan golongan senyawa aktif salah satunya flavonoid menggunakan skrining fitokimia, yang secara kualitatif menunjukkan ekstrak tanaman mengandung flavonoid. Hasil Kromatografi Lapis Tipis (KLT) senyawa aktif menggunakan eluen metanol: kloroform: asam asetat glasial menghasilkan 1 titik spot pada Rf 0,5-0,7 digunakan dalam penelusuran pengujian daya antibakteri dengan metode autobiografi dan menunjukkan adanya pembentukan zona bening. Pada uji kuantitatif, ekstrak etanol pegagan memiliki nilai KHM 3.200 µg/mL baik pada Eschericia coli maupun Staphylococcus aureus. Nilai Kadar Bunuh Minimum (KBM) lebih dari 6.400 µg/mL aktivitas daya hambat dengan diameter 0,06±0,05 mm pada E.coli dan 0,04±0,019 mm untuk S. aureus.
Co-Authors Ade Irene Beactris Saudale Adi Hermansyah, Adi Adi Sofyan Ansori, Muhammad Aini, Nur Sofiatul Alfanaar, Rokiy Anastasia Risvina Easter Ajie Pramesti Arum Ardanareswari Atarodang Beatrico Lyo Ayu Merli Wahyuni Aziz, Nur Bella Vania Sianto Benedictus Karel Bezhinar, Tatyana Burkov, Pavel Chandra, Melisa Dwi Charina Halim Sugiono Chresiani Destianita Yoedistira Chresiani Destianita Yoedistira Chresiani Destianita Yoedistira Christopher Daniel Kurniawan Collins, Ellen Derkho, Marina Dhanang Prawira Nugraha Dhita Rizki Amalia Dion Notario Dion Notario Dodi Iskandar Dodi Iskandar, Dodi E. Monica Eka Anggie Amalia Eka Anggie Amalia Erizcha Debora Embang Erlinawati Santoso Erlinawati Santoso Eva Monica Eva Monica Eva Monica Eva Monica, Eva Fauziya Radani Fibe Yulinda Cesa FX Haryanto Susanto Godeliva Adriani Hendra Gudz, Petr Gytha Novella Ongkowijoyo Herdiansyah, Mochammad Aqilah Hery Purnobasuki Ichsan Ichsan Indriani Nuraini Widya Ismaurasi, Marcelina Fransisca Alecia Kestrilia Rega Prilianti Khairullah, Aswin Rafif Kharisma, Viol Dhea Kotimah, Chusnul Lealita Leny Yuliati Maksimiuk, Nikolai Maria Sindy Marsha Anggita Amelia Martanty Aditya, Martanty Masruri Masruri Masruri Masruri Maywan Hariono Mifta Devin Suwandi Monica, Eva Muhammad Hilmi Afthoni Muhammad Setiyawan Munawir Sazali Murtadlo, Ahmad Affan Ali Nashi Widodo Nashi Widodo Natanael Anugerah Tuuk Natan Nugraha, Dhanang Prawira Nurmiati Nurul Azmi Wibawanty P. N. Alfiyandri Paulina Genoveva Moza Pramesti, Agatha Tri Endha Rahadi, Theresa Dhea Lonika Raharja, Albert Rebezov, Maksim Rehmadanta Sitepu Rehmadanta Sitepu Rehmadanta Sitepu Rehmadanta Sitepu Rehmadenta Sitepu Renata Hadi Resha Ramadhania Rino Tam Cahyadi, Rino Tam Ririn Nurdiani Ririn Nurdiani Ruth Febriana Kesuma Sabrina Handayani Tambun Sandra Dewi Tansil Setiawan, Hendry Siswadi Siswadi Sitepu, Rehmadanta Sitepu, Rehmadanta Sophia Yusnita Wahyu Timur Sophia Yusnita Wahyu Timur Sri Hardyastutik Sugiono, Charina Halim Suharyani Amperawati Susana Susana Susanto, FX. Haryanto Teguh Hari Sucipto, Teguh Hari Trianom Suryandharu W. Swastika Wahyu Timur, Sophia Yusnita Warsito Warsito Warsito Warsito Widyananda, Muhammad Hermawan Windra Swastika Windra Swastika Y. Erning Indrastuti Yandriyani, Devilke Yanuar, Michael Resta Surya Yuni Purwaningdiah Yurida Ekawati Yurida Ekawati Yuyun Yuniati