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All Journal HAYATI Journal of Biosciences Natural Science: Journal of Science and Technology CAKRA KIMIA (Indonesian E-Journal of Applied Chemistry) Jurnal Kimia (Journal of Chemistry) Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) The Journal of Pure and Applied Chemistry Research JPM17: Jurnal Pengabdian Masyarakat Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Majalah Obat Tradisional Pharmascience Jurnal Farmasi Sains dan Komunitas Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Wiyata : Penelitian Sains dan Kesehatan JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) Jurnal Katalisator GERVASI: Jurnal Pengabdian kepada Masyarakat Pharmaceutical Journal of Indonesia International Journal of Agricultural Sciences Jurnal Farmamedika (Pharmamedica Journal) Medika Alkhairaat : Jurnal Penelitian Kedokteran dan Kesehatan Jurnal Kefarmasian AKFARINDO Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang Jurnal Insan Farmasi Indonesia Jurnal Farmasi Journal of Community Practice and Social Welfare (JaCiPS) Indonesian Community Journal JOMPA ABDI: Jurnal Pengabdian Masyarakat Lamahu: Jurnal Pengabdian Masyarakat Terintegrasi Sainsbertek Jurnal Ilmiah Sains & Teknologi Jurnal Permata Indonesia Journal of Global Pharma Technology Borneo Journal of Pharmacy Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas Jurnal Kefarmasian Indonesia Khidmat: Journal Community Service
Rollando, Rollando
Program Studi Farmasi, Fakultas Ilmu Kesehatan, Universitas Ma Chung
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Journal : Pharmascience

 1 
Efek Afrodisiaka dari Ekstrak Batang Bajakah Kalalawit (Uncaria gambir Roxb.) terhadap Tikus Jantan Galur Wistar (Rattus novergicus) Rollando Rollando; Arum Ardanareswari; FX Haryanto Susanto; Eva Monica
Jurnal Pharmascience Vol 9, No 2 (2022): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v9i2.13289

Abstract

Bajakah kalalawit (BK) secara empiris digunakan sebagai obat tradisional untuk meningkatkan daya tahan seksual. Penelitian ini bertujuan untuk menganalisis pengaruh pemberian ekstrak dari batang BK terhadap aktivitas seksual tikus putih (Rattus norvegicus) jantan dengan parameter pendekatan, menunggang, dan kawin. Desain penelitian yaitu rancangan acak lengkap dengan 5 perlakuan dan induksi selama 3 hari. Batang BK dimaserasi dengan etanol 96%. Kontrol negatif diinduksi dengan CMC-Na 0,5% dan kontrol positif diinduksi dengan sildenafil sitrat pada dosis 10 mg/KgBB. P1, P2, dan P3 masing-masing diinduksi ekstrak batang BK pada dosis 150 mg/KgBB, 200 mg/KgBB, dan 250 mg/KgBB/hari. Aktivitas pendekatan, menunggang, dan kawin pada hewan uji yang telah diinduksi diamati menggunakan libidometer. Hasil penelitian menunjukkan bahwa pemberian ekstrak batang BK dapat meningkatkan aktivitas seksual tikus putih jantan pada dosis 150 mg/KgBB/hari jika dibandingkan dengan kelompok kontrol dan kelompok perlakuan yang lain. Kata Kunci: Uncaria gambir Roxb, Tikus Jantan, Afrodisiaka, Libidometer Bajakah kalalawit (BK) is empirically used as a traditional medicine to increase sexual endurance. This study aimed to analyze the effect of administration of BK stem extract on the sexual activity of white male rats (Rattus norvegicus) with the parameters of introduction, climbing, and coitus. The research design was a Completely Randomized Design with five treatments and three days of induction. BK stems were macerated with 96% ethanol. Negative control was induced with 0.5% CMC-Na and positive control was induced with sildenafil citrate at 10 mg/kg BW. P1, P2, and P3 were induced by BK stem extract at dose of 150 mg/kg BW/day, 200 mg/kg BW/day, and 250 mg/kg BW/day, respectively. Introduction, climbing and coitus activities in the induced test of male rats were observed using libidometer. The results showed that the induction of BK stem extract could increase the sexual activity of male rats at dose of 150 mg/kg BW/day compared to the control group and other treatment groups. 
Optimasi Pelarut dalam Proses Ekstraksi Daun Teh-Tehan (Acalypha Siamensis) dengan Menggunakan Metode Simplex Lattice Design (SLD) Rollando Rollando; Muhammad Hilmi Afthoni; Benedictus Karel
Jurnal Pharmascience Vol 10, No 2 (2023): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v10i2.15046

Abstract

Penelitian ini bertujuan untuk mengoptimalkan komposisi pelarut dalam proses ekstraksi daun Acalypha siamensis guna mendapatkan hasil yang maksimal dalam hal rendemen total, kadar flavonoid, dan aktivitas antioksidan. Daun A. siamensis, yang mengandung flavonoid, tanin, saponin, dan alkaloid, dievaluasi untuk aktivitas antibakteri dan antioksidan. Dalam penelitian ini, metanol, aseton, dan akuades digunakan sebagai pelarut. Metode Simplex Lattice Design dengan aplikasi Design Expert 12 Trial Version digunakan untuk menentukan perbandingan komposisi pelarut yang tepat. Hasil penelitian menunjukkan bahwa menggunakan pelarut metanol:aseton:akuades (0:0,5:0,5) menghasilkan rendemen ekstrak terbesar, yaitu 24,97%. Pengukuran kadar flavonoid total menunjukkan bahwa penggunaan pelarut metanol:aseton:akuades (1:0:0) menghasilkan kadar flavonoid total tertinggi, yaitu 453,27 miligram kuersetin ekivalen per gram ekstrak. Selanjutnya, hasil uji aktivitas antioksidan menunjukkan bahwa pelarut metanol:aseton:akuades (0:1:0) menghasilkan aktivitas antioksidan paling tinggi, yaitu 81,22 ppm. Analisis menggunakan Simplex Lattice Design menunjukkan bahwa komposisi pelarut yang optimal dalam proses  ekstraksi daun A. siamensis adalah metanol:aseton:akuades (0:69,28:30,72). Dalam kondisi ini, diperoleh hasil total flavonoid sebesar 296,64 miligram kuersetin ekivalen per gram ekstrak, rendemen sebesar 20,00%, dan aktivitas antioksidan sebesar 91,79 ppm. Kata Kunci: Optimasi, Simplex Lattice Design, Rendemen, Flavonoid Total, Antioksidan The objective of this study was to optimize the solvent composition for the extraction of Acalypha siamensis leaves to achieve maximum yield, flavonoid content, and antioxidant activity. A. siamensis leaves, which contain flavonoids, tannins, saponins, and alkaloids, were evaluated for their antibacterial and antioxidant properties. Methanol, acetone, and water were used as solvents. The Simplex Lattice Design method with Design Expert 12 Trial Version was employed to determine the appropriate solvent ratios. The findings demonstrated that the highest extract yield (24.97%) was obtained using a solvent mixture of methanol:acetone:water (0:0.5:0.5). The measurement of total flavonoid content revealed the highest level (453.27 mg of quercetin equivalents per gram of extract) with a solvent composition of methanol:acetone:water (1:0:0). Moreover, the antioxidant activity test indicated the highest activity (81.22 ppm) when using a solvent composition of methanol:acetone:water (0:1:0). The analysis using Simplex Lattice Design determined the optimal solvent composition for A. siamensis leaf extraction as methanol:acetone:water (0:69.28:30.72), resulting in a total flavonoid content of 296.64 mg of quercetin equivalents per gram of extract, a yield of 20.00%, and an antioxidant activity of 91.79 ppm.
Co-Authors Ade Irene Beactris Saudale Adi Hermansyah, Adi Adi Sofyan Ansori, Muhammad Aini, Nur Sofiatul Alfanaar, Rokiy Arum Ardanareswari Atarodang Beatrico Lyo Ayu Merli Wahyuni Aziz, Nur Bella Vania Sianto Benedictus Karel Bezhinar, Tatyana Burkov, Pavel Chandra, Melisa Dwi Charina Halim Sugiono Chresiani Destianita Yoedistira Chresiani Destianita Yoedistira Chresiani Destianita Yoedistira Christopher Daniel Kurniawan Collins, Ellen Derkho, Marina Dhanang Prawira Nugraha Dhita Rizki Amalia Dion Notario Dion Notario Dodi Iskandar Dodi Iskandar, Dodi E. Monica Eka Anggie Amalia Eka Anggie Amalia Erizcha Debora Embang Erlinawati Santoso Erlinawati Santoso Eva Monica Eva Monica Eva Monica Eva Monica, Eva Fauziya Radani Fibe Yulinda Cesa FX Haryanto Susanto Godeliva Adriani Hendra Gudz, Petr Gytha Novella Ongkowijoyo Herdiansyah, Mochammad Aqilah Hery Purnobasuki Ichsan Ichsan Indriani Nuraini Widya Ismaurasi, Marcelina Fransisca Alecia Kestrilia Rega Prilianti Khairullah, Aswin Rafif Kharisma, Viol Dhea Kotimah, Chusnul Leny Yuliati Maksimiuk, Nikolai Maria Sindy Marsha Anggita Amelia Martanty Aditya, Martanty Masruri Masruri Masruri Masruri Maywan Hariono Mifta Devin Suwandi Monica, Eva Muhammad Hilmi Afthoni Muhammad Setiyawan Munawir Sazali Murtadlo, Ahmad Affan Ali Nashi Widodo Nashi Widodo Natanael Anugerah Tuuk Natan Nugraha, Dhanang Prawira Nurmiati Nurul Azmi Wibawanty P. N. Alfiyandri Paulina Genoveva Moza Pramesti, Agatha Tri Endha Rahadi, Theresa Dhea Lonika Raharja, Albert Rebezov, Maksim Rehmadanta Sitepu Rehmadanta Sitepu Rehmadanta Sitepu Rehmadanta Sitepu Rehmadenta Sitepu Renata Hadi Resha Ramadhania Rino Tam Cahyadi, Rino Tam Ririn Nurdiani Ririn Nurdiani Ruth Febriana Kesuma Sabrina Handayani Tambun Sandra Dewi Tansil Setiawan, Hendry Siswadi Siswadi Sitepu, Rehmadanta Sitepu, Rehmadanta Sophia Yusnita Wahyu Timur Sophia Yusnita Wahyu Timur Sri Hardyastutik Sugiono, Charina Halim Suharyani Amperawati Susana Susana Susanto, F.X Haryanto Susanto, FX. Haryanto Teguh Hari Sucipto, Teguh Hari Trianom Suryandharu W. Swastika Wahyu Timur, Sophia Yusnita Warsito Warsito Warsito Warsito Widyananda, Muhammad Hermawan Windra Swastika Windra Swastika Y. Erning Indrastuti Yandriyani, Devilke Yanuar, Michael Resta Surya Yuni Purwaningdiah Yurida Ekawati Yurida Ekawati Yuyun Yuniati