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Analisis Penerapan Metode ATC/DDD dan DU90% Dalam Penggunaan Antibiotik Pada Pasien Rawat Inap Rumah Sakit Stella Maris Makassar Arsyad, Rival Al-fazri; Pakaya, Mahdalena Sy.; Paneo, Mohamad Aprianto; Rasdianah, Nur; Madania, Madania
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Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/jrpi.v3i1.36531

Abstract

The antimicrobial resistance (AMR) crisis poses a serious threat to global health, making the rational use of antibiotics a priority within Antimicrobial Stewardship (AMS) programs. This study aims to evaluate the patterns and quantity of antibiotic use among inpatient populations at Stella Maris Hospital Makassar using the Anatomical Therapeutic Chemical (ATC) classification, Defined Daily Dose (DDD), and Drug Utilization (DU) 90% methods. This research employed a retrospective descriptive observational design using medical record data of patients who received antibiotic therapy from October to December 2024. The analysis was conducted by calculating DDD per 100 patient-days and identifying antibiotics contributing to 90% of total use. The results showed eight types of antibiotics were utilized. The three antibiotics with the highest DDD/100 patient-days were Cefuroxime (13.43), Ceftriaxone (11.8), and Cefotiam (10), which, together with Moxifloxacin, were included in the DU 90% segment. The predominance of second-generation cephalosporins—particularly among diagnoses such as unspecified fever, bronchiectasis, typhoid, and bronchitis—indicates a tendency toward broad-spectrum empirical therapy in chronic pulmonary conditions such as COPD and bronchiectasis. In conclusion, antibiotic use at Stella Maris Hospital Makassar is dominated by the cephalosporin class, highlighting the need for ongoing evaluation and strengthened implementation of AMS programs to optimize antibiotic therapy, improve treatment effectiveness, and reduce the risk of increasing antimicrobial resistance at the hospital level.
Inovasi Kue Cup Brudel Fungsional : Formulasi Jahe, Kunyit, dan Ubi Ungu Sebagai Pangan Sehat Untuk Kesehatan Jantung dan Tulang Paneo, Mohamad Aprianto; Thomas, Nurain; Polamolo, Cristian; Lihawa, Karmila; Raji, Andre; Latif, Multiani S; Pomalango, Zulkifli B
Jurnal Pengabdian Masyarakat Farmasi : Pharmacare Society Vol 5, No 1 (2026)
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/phar.soc.v5i1.34986

Abstract

Program pengabdian ini bertujuan untuk mengembangkan inovasi produk pangan fungsional melalui pembuatan kue cup brudel berbahan dasar kunyit, jahe, dan ubi ungu yang mendukung kesehatan jantung dan tulang. Tujuan utama dari pengabdian ini adalah untuk meningkatkan aspek produksi dan pemasaran digital pada UMKM Rumah Brudel li Ummu Azzam, serta memperkenalkan bahan fungsional yang bermanfaat bagi kesehatan konsumen. Program ini dilaksanakan dengan pendekatan partisipatif yang melibatkan pelatihan dalam proses produksi, pengelolaan bahan baku sehat, pembuatan SOP produksi, serta penerapan strategi pemasaran digital melalui platform media sosial. Selain itu, dilakukan uji coba pasar dengan melibatkan kelompok dewasa dan lansia untuk mengumpulkan feedback mengenai rasa dan manfaat produk. Hasil pengabdian menunjukkan peningkatan signifikan dalam aspek produksi, dengan 82% responden melaporkan peningkatan dalam kemampuan mengolah bahan fungsional dan efisiensi produksi. Di sisi pemasaran, 82% responden mengungkapkan peningkatan kemampuan dalam membuat konten promosi dan menggunakan platform digital secara lebih efektif. Produk ini juga mendapatkan penerimaan positif dari konsumen terkait cita rasa dan manfaat kesehatan, dengan jangkauan pemasaran yang lebih luas berkat strategi pemasaran digital yang diterapkan. Program ini berhasil meningkatkan kapasitas produksi dan memperkuat pemasaran digital UMKM Rumah Brudel li Ummu Azzam. Inovasi produk kue cup brudel fungsional tidak hanya meningkatkan kualitas produk tetapi juga memperluas pasar, memberikan dampak positif terhadap kesehatan masyarakat, serta meningkatkan daya saing UMKM di pasar lokal dan digital.
Analysis of the Frequency of Antihypertensive Drug Use at the Outpatient and Inpatient Pharmacy Rauf, Shalwa Azahrah; Tuloli, Teti Sutriyati; Paneo, Mohamad Aprianto; Abdulkadir, Widy Susanti; Makkulawu, Andi
Jambura Nursing Journal Vol 8, No 1: January 2026
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jnj.v8i1.34812

Abstract

The use of antihypertensive drugs at Faisal Islamic Hospital, Makassar, wasanalyzed in this study, considering the high prevalence of hypertension in Makassar, which reached 290,247 cases in 2020. Hypertension is a serious condition that requires appropriate management; thus, evaluating patterns of drug use in healthcare facilities is highly important. Specifically, this study focused on identifying the types, calculating the quantities, and analyzing the frequency of antihypertensive drug prescriptions at both outpatient and inpatient pharmacies during the period from February to April. The study employed a quantitative approach with a descriptive observational design and a retrospective case series method. Data were obtained from drug utilization reports and subsequently analyzed. To examine differences in the frequency of drug use across months, the Friedman test was applied using the SPSS statistical software. The findings revealed that 18 types of antihypertensive drugs were available at the hospital. Among them amlodipine 10 mg was the most frequently used, accounting for 27.54% of total prescriptions. Statistical analysis using the Friedman test yielded a significance value (Asymp. Sig) of 0.008. Since this value was lower than 0.05, it indicated a statistically significant difference in the frequency of antihypertensive drug use across different months. In conclusion, although amlodipine 10 mg was the predominant choice, significant variations were observed in the pattern of antihypersensitive drug use at Faisal Islamic Hospital, Makassar, during the study period.
Penggunaan Insulin dan Tren Berdasarkan Jenis Kelamin pada Pasien Diabetes Melitus Tipe 2 Rawat Jalan di RS Islam Faisal: Insulin Use and Gender Based Trends in Type 2 Diabetes Mellitus Outpatients at Faisal Islamic Hospital Tuloli, Teti Sutriyati; Paneo, Mohamad Aprianto; Palowa, Mohamad Tahir; Abdulkadir, Widi Susanti; Makkulawu, Andi
Jurnal Kesehatan Bakti Tunas Husada: Jurnal Ilmu-ilmu Keperawatan, Analis Kesehatan dan Farmasi Vol 26 No 1 (2026)
Publisher : LPPM Universitas Bakti Tunas Husada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36465/jkbth.v26i1.1809

Abstract

Penelitian ini bertujuan untuk mengevaluasi pola penggunaan insulin pada pasien diabetes melitus tipe 2 rawat jalan di Rumah Sakit Islam Faisal Makassar selama periode Februari hingga April 2025. Metode yang digunakan adalah desain observasional deskriptif dengan pendekatan kuantitatif dan metode retrospektif, dengan data yang diperoleh dari laporan penggunaan insulin di DEPO rawat inap dan rawat jalan selama tiga bulan. Hasil penelitian menunjukkan bahwa penggunaan insulin Sansulin Rapid pada bulan Februari tercatat 43,75% pada laki-laki dan 56,25% pada perempuan, dengan peningkatan pada bulan Maret dan April (80% pada perempuan dan 20% pada laki-laki). Penggunaan Sansulin Log-G pada Februari adalah 35,29% untuk laki-laki dan 64,71% untuk perempuan, dengan persentase yang lebih seimbang pada bulan Maret dan April (42,85% laki-laki dan 57,15% perempuan). Uji one-sample t-test menunjukkan perbedaan signifikan antar bulan (p < 0,001), mengindikasikan adanya variasi penggunaan insulin yang signifikan. Kesimpulannya, penggunaan insulin di RS Islam Faisal Makassar didominasi oleh pasien perempuan, dengan jenis insulin yang lebih sering digunakan adalah Sansulin Log-G. Penggunaan insulin tertinggi terjadi pada bulan Februari, menurun pada Maret, dan sedikit meningkat pada April, menunjukkan pola yang rasional dan adaptif dalam terapi insulin, meskipun diperlukan evaluasi lanjutan terhadap efektivitas terapi untuk mencapai kontrol glikemik yang optimal.
Biopotential of Gorontalo Hulu’u Fish (Giuris margaritacea) Albumin in a Novel Spray Gel Formulation for the Treatment of BurnWounds: In Vivo Evaluation in Rats Paneo, Mohamad Aprianto; Djuwarno, Endah Nurrohwinta; Habibie, Sitty Ainsyah; Thomas, Nurain; Latif, Multiani S.; Munafri, Nur Alifia Karina; Anasiru, Rayhan Firman
Science and Technology Indonesia Vol. 11 No. 2 (2026): April
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2026.11.2.389-404

Abstract

This study aimed to evaluate the efficacy of different concentrations of Hulu’u fish albumin-based spray gels in promoting wound healing in burn injuries in male white rats. The formulations included 10%, 15%, and 20% concentrations of Hulu’u fish albumin, which were compared to a commercial snakehead fish albumin gel (positive control) and a spray gel base without albumin (negative control). Wound diameter reduction was assessed over seven days. The results indicated a clear dose response relationship, with the 20% Hulu’u fish albumin formulation (F3) achieving the most significant reduction in wound diameter, averaging 1.57 mm (range: 1.5–1.6 mm), representing a 91.8% improvement compared to the negative control group, which showed an average reduction of 19.13 mm (range: 18.1–19.7 mm). The Positive Control (snakehead fish albumin gel) demonstrated a moderate reduction with an average of 6.97 mm (range: 6.6–7.6 mm). The 10% Hulu’u fish albumin (F1) and 15% Hulu’u fish albumin (F2) formulations showed moderate improvements, with average reductions of 4.73 mm (range: 4.4–5.1 mm) and 4.5 mm (range: 4.7–3.9 mm), respectively. These findings suggest that higher concentrations of Hulu’u fish albumin, particularly the 20% formulation, offer superior wound healing properties, outperforming both the negative control and the commercial snakehead fish albumin gel. The study highlights the potential of Hulu’u fish albumin as a novel bioactive compound for burn wound treatment and warrants further investigation for clinical applications.
Community Understanding of Household Emergency Medicines for Flood Preparedness in Lekobalo Urban Village, Gorontalo City, Indonesia Andi Makkulawu; Teti Sutriyati Tuloli; Mohamad Aprianto Paneo; Multiani S Latif; Larastiyas Pulukadang
Indonesian Journal of Pharmaceutical Education Vol 6, No 1 (2026): January–April 2026
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v6i1.34884

Abstract

Flood events in Gorontalo City repeatedly generate acute health risks and disrupt access to routine healthcare, making household-level preparedness particularly the availability and appropriate use of emergency medicines an essential component of disaster risk reduction. This study assessed community understanding of household emergency medicines for flood preparedness in Lekobalo Urban Village, Gorontalo City, Indonesia, using a cross-sectional design. A total of 95 residents were recruited by purposive sampling and completed a 24-item questionnaire covering four domains: knowledge of emergency medicines, medication procurement behaviour, medication use, and information sources; the instrument demonstrated excellent internal consistency (Cronbach’s alpha = 0.958). Overall, community understanding was predominantly moderate (55.8%), followed by low (27.4%) and high (16.8%) categories, indicating that preparedness knowledge and practical medication readiness remain suboptimal in a substantial proportion of households. Descriptive comparisons suggested variability across sociodemographic characteristics, implying that targeted health education and community-based pharmaceutical counselling may be required to strengthen household readiness before, during, and after flood events. These findings support the integration of structured risk communication on essential emergency medicines into local disaster preparedness programmes, aligned with primary healthcare and community pharmacy engagement. 
Evaluation of Physical Stability of Carbopol Gel Containing Curcumin under Temperature Variations Najwa Athifah Tsamarah Umar; Mohamad Aprianto Paneo; Nurain Thomas; Fika Nuzul Ramadhani; Lisa Efriani Puluhulawa
Jurnal Farmasi Teknologi Sediaan dan Kosmetika Vol. 3 No. 2 (2026): Volume 3 Nomor 2 Tahun 2026
Publisher : Jurnal Literasi Mandiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70075/jftsk.v3i2.307

Abstract

Inflammation is a biological response to tissue damage characterized by swelling, redness, pain, and increased local temperature. Curcumin is known to possess anti-inflammatory activity by inhibiting inflammatory mediators such as tumor necrosis factor-alpha (TNF-α). This study aimed to develop a Carbopol-based curcumin gel formulation and evaluate its physical characteristics and stability under various temperature conditions. This research employed a laboratory experimental method including gel base optimization, formulation of curcumin gel with concentration variations (1%, 2%, and 3%), physical evaluation, and stability testing using a temperature stress test at low and high temperatures. The results showed that Carbopol 0.5% was the optimal gel base. All formulations met the required physical characteristics, including homogeneity, pH, viscosity, spreadability, and adhesiveness. Stability testing indicated that the formulations were organoleptically stable and relatively stable chemically, although viscosity decreased at higher temperatures. Therefore, Carbopol-based curcumin gel has potential as a stable and effective topical preparation.
Isolation and Characterization of Endophytic Fungi Producing L-Asparaginase Enzyme from Kencur Plant (Kaempferia galanga L.) Riyanti Djafar; Mahdalena Sy. Pakaya; A.Mu’thi Andy Suryadi; Mohamad Aprianto Paneo; Wiwit Zuriati Uno
International Journal of Health, Economics, and Social Sciences (IJHESS) (Special Issue) - International Journal of Health, Economics, and Social Sciences (IJHESS) April 202
Publisher : Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/ijhess.v8i2.10927

Abstract

L-Asparaginase is an enzyme that catalyzes the hydrolysis of L-asparagine into L-aspartate and ammonia. This enzysne has important benefits in the medical field, particularly as a biological agent is the therapy of acute lymphoblastic leukemia, due to its ability to inhibit the growth of asparagine-dependent cancer cells. This study aims to isolate and characterize endophytic fungi derived from the rhizome of the aromatic ginger (Kaempferia galanga L.) plant, and to test the ability of these isolates to produce the L-asparaginase enzyme. The research method used is an experimental method conducted in a pharmaceutical microbiology laboratory Endophytic fungi were isolated using surface sterilization techniques and culturing on PDA media. Enzyme production was performed using the submerged fermentation method, while enzyme purification used the ammonium sulfate fractionation method with concentration ranges of 0-20%, 20-40%, 40-60%, 60-80%, and 80-100%. The L-asparaginase enzyme activity test was conducted using the Nesslerization method, with Asparagus as an inducer. The results showed that several endophytic fungal isolates were capable of producing L-asparaginase, as evidenced by a brownish color in the Nessler test. The purified fractions showed varying enzyme activity at each level of ammonium sulfate saturation. Thus,endophytic fungi from the aromatic ginger rhizome have potential as an alternative source for producing the L-asparaginase enzyme, which can be further developed in the fields of pharmacy and biotechnology
Penggunaan Insulin dan Tren Berdasarkan Jenis Kelamin pada Pasien Diabetes Melitus Tipe 2 Rawat Jalan di RS Islam Faisal: Insulin Use and Gender Based Trends in Type 2 Diabetes Mellitus Outpatients at Faisal Islamic Hospital Teti Sutriyati Tuloli; Mohamad Aprianto Paneo; Mohamad Tahir Palowa; Widi Susanti Abdulkadir; Andi Makkulawu
Jurnal Kesehatan Bakti Tunas Husada: Jurnal Ilmu-ilmu Keperawatan, Analis Kesehatan dan Farmasi Vol 26 No 1 (2026)
Publisher : LPPM Universitas Bakti Tunas Husada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36465/jkbth.v26i1.1809

Abstract

Penelitian ini bertujuan untuk mengevaluasi pola penggunaan insulin pada pasien diabetes melitus tipe 2 rawat jalan di Rumah Sakit Islam Faisal Makassar selama periode Februari hingga April 2025. Metode yang digunakan adalah desain observasional deskriptif dengan pendekatan kuantitatif dan metode retrospektif, dengan data yang diperoleh dari laporan penggunaan insulin di DEPO rawat inap dan rawat jalan selama tiga bulan. Hasil penelitian menunjukkan bahwa penggunaan insulin Sansulin Rapid pada bulan Februari tercatat 43,75% pada laki-laki dan 56,25% pada perempuan, dengan peningkatan pada bulan Maret dan April (80% pada perempuan dan 20% pada laki-laki). Penggunaan Sansulin Log-G pada Februari adalah 35,29% untuk laki-laki dan 64,71% untuk perempuan, dengan persentase yang lebih seimbang pada bulan Maret dan April (42,85% laki-laki dan 57,15% perempuan). Uji one-sample t-test menunjukkan perbedaan signifikan antar bulan (p < 0,001), mengindikasikan adanya variasi penggunaan insulin yang signifikan. Kesimpulannya, penggunaan insulin di RS Islam Faisal Makassar didominasi oleh pasien perempuan, dengan jenis insulin yang lebih sering digunakan adalah Sansulin Log-G. Penggunaan insulin tertinggi terjadi pada bulan Februari, menurun pada Maret, dan sedikit meningkat pada April, menunjukkan pola yang rasional dan adaptif dalam terapi insulin, meskipun diperlukan evaluasi lanjutan terhadap efektivitas terapi untuk mencapai kontrol glikemik yang optimal.
Quality Risk Management In The Pharmaceutical Industry: A Literature Review Aditya Naufal Maulana; Hari Restu Putra Martam Murad; Dyah Mashita Nur Hanan Rahim; Mohamad Aprianto Paneo; Multiani S. Latif
International Journal of Health Engineering and Technology Vol. 5 No. 2 (2026): Vol 5. No. 2 JULY 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v5i2.891

Abstract

Quality Risk Management (QRM) is increasingly recognized as a critical framework for ensuring pharmaceutical product quality, safety, and regulatory compliance throughout the product lifecycle. This literature review aimed to examine the implementation of QRM in the pharmaceutical industry, with a particular focus on its role in preventing deviations and quality failures. A total of 25 scientific articles published between 2020 and 2026 were systematically collected and analysed from databases including Google Scholar, ScienceDirect, PubMed, and ResearchGate using predefined inclusion and exclusion criteria. The results indicate that QRM tools — particularly Failure Mode and Effect Analysis (FMEA), Corrective and Preventive Action (CAPA), Quality by Design (QbD), and risk matrices — are widely applied across manufacturing, supply chain, warehousing, packaging, and distribution processes. FMEA was identified as the most prevalent risk assessment method, while integrated CAPA systems have demonstrably shifted quality management from a reactive to a proactive paradigm. Challenges including subjectivity in risk scoring, limited training, and suboptimal integration with quality management systems remain prevalent. This review concludes that comprehensive QRM implementation significantly reduces the frequency of deviations, strengthens GMP compliance, and enhances patient safety in the pharmaceutical industry.
Co-Authors A.Mu’thi Andy Suryadi Abdulkadir, Widi Susanti Aditya Naufal Maulana Aisyah Agustina Mokoginta Alfa B Handayani Anasiru, Rayhan Firman Andi Makkulawu Andi Makkulawu Andy Suryadi, A. Mu'thi Anggai, Rifka Anggraini Angreni Ayuhastuti ANWAR IBRAHIM, ANWAR Ariani H. Hutuba Arsyad, Rival Al-fazri Ayu Maloho, Sity Nur Rahayu Maloho Balikan, Virginia Banne, Pratiwi Zesika baruadi., siti_yustika. Basri, Rakhmadana Fitraeni Cristian Polamolo Djayadi Azis Djayadi Azis Dolih Gozali Dr. Apt. Hamsidar Hasan S.Si.,M.Si Dyah Mashita Nur Hanan Rahim Endah N. Djuwarno Endah Nurrohwinta Djuwarno Faradila Ratu Cindana Fauziah Rahmola Fika Nuzul Ramadhani Fira Irianti Umar Hari Restu Putra Martam Murad Hiola, Faramita Irmayanti Irmayanti, Irmayanti Isha Isa Ishak Isa Ishak, Siti Magfira Jumantrin, Nur Fitriah Kadaria Toana Kahar, Oktaviani Karmila Lihawa La Ode Aman Larastiyas Pulukadang LATIF, MULTIANI S Latif, Multiani S. Lihawa, Karmila Lisa Efriani Puluhulawa Lutfia Nurfadila Arifin Madania, Madania Mahdalena Sy Pakaya Mahdalena Sy. Pakaya Makkulawu, Andi Manno, Mohamad Reski Manno, Mohammad Reski Moh. Rivai Nakoe Mohamad Adam Mustapa Mohamad Tahir Palowa Moo, Faradila Ratu Cindana Muhammad Taupik Multiani S Latif Mumtazah, Naharil Munafri, Nur Alifia Karina Nabila Husnunnisa Ismail Najwa Athifah Tsamarah Umar Nani, Indriyati Nasrun Pakaya Nikmasari Pakaya Nur Ain Thomas Nur Rasdianah Nurain Abdullah Nurkamiden, Firman Nurkamiden, Sri Devi Maharani Olii, Zihan Maura Putri Palowa, Mohamad Tahir Papeo, Dizky Ramadani Putri Pido, Nur Huda Pratiwi Abdullah Puluhulawa, Lisa Efriani Radjak, Fahmi As Raji, Andre Rani Orelia A. Unga Rasdiana, Nur Rauf, Shalwa Azahrah Rismayani, Nur Riyanti Djafar Robert Tungadi Sabrina, Putri Sabrina, Putri Febbiyanti Serly Daud Siti Ruqaiyah Lakoro Sitty Ainsyah Habibie Solang, Wicawati Van Suleman, Putri Rawe Suryadi, A Mu'thi Andy Suryadi, A. Mu'thi Andy Suryadi, A. Mu’thi Andy Suyadi, A. Mu’thi Andy Taofik Rusdiana Teti Sutriyati Tuloli Teti Tuloli Thamrin, Rahmulia Timo, Nur Kharisma Ekaputri Widi Susanti Abdulkadir Widy Susanti Abdulkadir Widy Susanti Abdulkadir Wiwit Zuriati Uno Wiwit Zuriati Uno Zulkifli B Pomalango