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All Journal The Journal of Pure and Applied Chemistry Research Jurnal Pendidikan Matematika RAFA Biota JIP: Jurnal Ilmiah PGMI Kuttab: Jurnal Ilmu Pendidikan Islam Jurnal Tadris Matematika JMIE (Journal of Madrasah Ibtidaiyah Education) PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat ALKIMIA : Jurnal Ilmu Kimia dan Terapan Jurnal Caksana: Pendidikan Anak Usia Dini Al-Khidmat : Jurnal Ilmiah Pengabdian Kepada Masyarakat Jurnal Inovasi Pendidikan dan Sains Journal of Multidisciplinary Applied Natural Science Jurnal Pengabdian Multidisiplin Berkala Ilmiah Pendidikan Wisanggeni : Jurnal Pengabdian Masyarakat Journal Research in Islamic Education International Journal of Community Engagement Payungi Bulletin of Early Childhood Bioactivities Engagement: Jurnal Pengabdian Kepada Masyarakat Jurnal Tadris Matematika Journal of Biotropical Research and Nature Technology
Amrulloh, Hanif
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Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Economics, Econometrics & Finance Education Energy Environmental Science Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Public Health Social Sciences Other

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Journal : Journal of Multidisciplinary Applied Natural Science

 1 
Antioxidant and Antibacterial Activities of Magnesium Oxide Nanoparticles Prepared using Aqueous Extract of Moringa Oleifera Bark as Green Agents Hanif Amrulloh; Awalul Fatiqin; Wasinton Simanjuntak; Hapin Afriyani; Annissa Annissa
Journal of Multidisciplinary Applied Natural Science Vol. 1 No. 1 (2021): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.v1i1.9

Abstract

In this research, magnesium oxide nanoparticles (MgONPs) was prepared from MgCl2 solution using aqueous extract of Moringa oleifera (M. oleifera) bark as green agent. Preparation procedure involved mixing of MgCl2.6H2O solution and the aqueous extract of M. oleifera bark, followed by drop wise addition of NaOH solution. The formation of MgONPs in this study was confirmed using UV-Vis absorption. The spherical crystal structure of MgONPs was confirmed by XRD analysis. The average particle size of the synthesized MgONPs was found between 60—100 nm  using  SEM and TEM images and PSA results. The MgONPs synthesized showed good antioxidant activity, as well as antibacterial activity against S. aureus, E. faecalis, E. coli, and S. dysenteriae bacteria.
Investigation of the Anti-diabetic and Anti-lipid Peroxidative Properties of Gallic Acid in Diabetic Rats Mitra Arman; Mostafa Alinaghizadeh; Mahmoud Kordi; Saeid Tamadoni Jahromi; Hanif Amrulloh; Hamed Kioumarsi
Journal of Multidisciplinary Applied Natural Science Vol. 5 No. 1 (2025): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.226

Abstract

Diabetes mellitus is a chronic non-communicable disease that occurs due to insulin deficiency or reduced function in the body. Therefore, the scientific investigation of herbal plants and their effectiveness is essential. It has been shown that gallic acid has hypoglycemic properties. In this study, the anti-diabetic and anti-lipid peroxidation properties of gallic acid were investigated. For this purpose, Streptozotocin was injected intraperitoneally into male rats at a dose of 60 mg/kg to induce type I diabetes. Seven days after Streptozotocin injection, blood samples were taken and rats with serum glucose levels higher than 250 mg/dL were considered diabetic. The rats were divided into 4 groups. Two groups of diabetic rats received either water or gallic acid at a dose of 40 mg/kg, and two groups of normal rats received either water or gallic acid at 40 mg/kg dose. The treatment period for all groups was 8 weeks. After the end of the period, blood samples were taken from the rats under fasting conditions. The collected blood samples were analyzed for serum biochemical factors (glucose, cholesterol, triglycerides, High-density lipoprotein, and creatinine) using spectrophotometry with the respective kits, and the level of lipid peroxidation in red blood cells was measured. The administration of gallic acid at a dose of 40 mg/kg (8 weeks) significantly reduced serum levels of glucose, triglycerides, cholesterol, alanine aminotransferase, aspartate aminotransferase, very low-density lipoprotein, low-density lipoprotein, and creatinine, while significantly increasing serum levels of high-density lipoprotein. Additionally, the level of Malondialdehyde in red blood cells was decreased in the diabetic group receiving gallic acid compared to the diabetic control group, and in normal rats receiving gallic acid at a dose of 40 mg/kg (8 weeks), it had no significant effect on serum factors and had no toxicity.
Evaluation of Xanthone and Cinnamoylbenzene as Anticancer Agents for Breast Cancer Cell Lines through In Vitro and In Silico Assays Yehezkiel Steven Kurniawan; Hanif Amrulloh; Ervan Yudha; Nela Fatmasari; Faris Hermawan; Anggit Fitria; Harno Dwi Pranowo; Eti Nurwening Sholikhah; Jumina Jumina
Journal of Multidisciplinary Applied Natural Science Vol. 5 No. 1 (2025): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.231

Abstract

Breast cancer is a severe global disease for women as the number of deaths increases annually. Therefore, attempts to find new anticancer agents are critical and inevitable. In this work, we report the investigation on the anticancer activity of xanthone and cinnamoylbenzene compounds against two breast cancer cell lines, i.e., T47D and MCF-7, through experimental in vitro and theoretical in silico assays. Xanthone and cinnamoylbenzene exhibit anticancer activity with a half-maximal inhibitory concentration (IC50) of 136.7–194.3 and 235.8–262.4 µg/mL against T47D and MCF-7 cancer cells, respectively. Cinnamoylbenzene generates less cytotoxicity to normal Vero cells with a selectivity index of 1.095–2.102. The molecular docking studies agree with the experimental data in which cinnamoylbenzene is more active against T47D with an IC50 of 136.7 µg/mL due to Topoisomerase II inhibition through π-π stacked interactions with Adenine12 and Guanine13 nitrogen bases. Meanwhile, xanthone is more active against MCF-7 with an IC50 of 235.8 µg/mL due to EGFR inhibition through van der Waals interaction and hydrogen bond with Glutamic acid767 and Methionine769 amino acid residues, respectively. Additionally, the pharmacokinetic parameters of xanthone and cinnamoylbenzene are predicted through absorption, distribution, metabolism, excretion, and toxicity (ADMET) analysis, and they show better suitability than doxorubicin as the commercial anticancer drug.
Co-Authors Abrori, M. Sayyidul Afifah, Nida Rafa Afriyani, Hapin Agus Setiawan Ahmad Zarnuji Ahmad Zarnuji Ahmad Zarnuji Ahmad Zarnuji, Ahmad Ali Khakpour Aliya Nabila Sari Aluko, Olukemi Anggit Fitria Ani Mardiantari Annissa, Annissa Anwar, Muhammad Saidun Ari Rohmawati Arif Cahyo Imawan Askari Bozayeh, Fatemeh Aziz, Ikhwan Azizah, Isnaini Nur Bahareh Rafiei Banon Ferdiana Choirudin, Choirudin Dedi . Dedi Setiawan Dedi Setiawan Dedi Setiawan Desta Sari Dian Herasari, Dian Dwi Setia Ningsih Eka Fitria Ningsih Eka Prasetiawati, Eka Ervan Yudha Eti Nurwening Sholikhah Fadilah, Lutfi Faranida, Qori Hikmah Faris Hermawan Fatiqin, Awalul Fauzan . Fauziah, Hani Matul Febriani, Anisa Bela Finny Ligery Golbanoo Azizpoor Habib Shulton Asnawi Hadis Ahmadnia Hamed Kioumarsi Hamed Kioumarsi Hapin Afriyani Haris Santoso Harno Dwi Pranowo Hayani, Aida Hernisawati, Hernisawati Indriani, Marcella Isnaini Nur Azizah Isnaini Nur Azizah Isnaini Nur Azizah Jaenullah Jaenullah Jaenullah Jarnuzi, Ahmad Jumina Jumina Khulus, Al Afidatul Kiki Abelia Kioumarsi, Hamed Krisfian Tata Aneka Priyangga Langit Cahya Adi Lestari, Restu Lutviana, Ani M. Sayyidul Abrori Mahmoud Kordi Marzieh Alidoust Pahmedani Masrurotul Mahmudah Masrurotul Mahmudah, Masrurotul Mega Suaedah Prastika Mispani Mispani Mitra Arman Mohammadreza Mahdavian, Seyed Mostafa Alinaghizadeh Muafifah, Sri Muhammad Nur Amin Muhammad Yusuf Negar Ahmadi Shadmehri Nela Fatmasari Nobakht Haghighi, Shahab NUR AINI Nur Alfi Khotamin nur khotimah Nur Laili Nur Laili Nurul Aisyah Nurul Aisyah Nurul Khotimah Okta Nur Azizah Ramadani, Arip Ridho Nahrowi Rikha Bramawanto Rizki Asrarul Mufidah Rizky Hidayatullah Rudy T M Situmeang Saeid Tamadoni Jahromi Sarsozo, Makario Seyed Reza Fani Shariman Yahaya, Zary Situmeang, Rudy T M Sophia Lasma Sagala Sri Wahyuni Suhono Suhono, Suhono Tantiana Indriani Theledi, Karim Umi Habibah Wahyudi Wahyudi Wasinton Simanjuntak Wasinton Simanjuntak Wasinton Simanjutak Yehezkiel Steven Kurniawan Yulinarsih, Yulinarsih Zeynab Kazemkhah Hasankiadeh