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All Journal The Journal of Pure and Applied Chemistry Research Jurnal Pendidikan Matematika RAFA Biota JIP: Jurnal Ilmiah PGMI Pendas : Jurnah Ilmiah Pendidikan Dasar Kuttab: Jurnal Ilmu Pendidikan Islam Jurnal Tadris Matematika JMIE (Journal of Madrasah Ibtidaiyah Education) PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat ALKIMIA : Jurnal Ilmu Kimia dan Terapan Jurnal Caksana: Pendidikan Anak Usia Dini Al-Khidmat : Jurnal Ilmiah Pengabdian Kepada Masyarakat Jurnal Inovasi Pendidikan dan Sains Indonesian Journal of Primary Science Education (IJPSE) Jurnal Simki Pedagogia TEACHING : Jurnal Inovasi Keguruan dan Ilmu Pendidikan Journal of Multidisciplinary Applied Natural Science Jurnal Pengabdian Multidisiplin Berkala Ilmiah Pendidikan Wisanggeni : Jurnal Pengabdian Masyarakat Journal Research in Islamic Education International Journal of Community Engagement Payungi Bulletin of Early Childhood Bioactivities Engagement: Jurnal Pengabdian Kepada Masyarakat Jurnal Tadris Matematika Indonesian Journal of Learning and Instructional Innovation
Amrulloh, Hanif
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Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Education Energy Environmental Science Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Public Health Social Sciences Other

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Journal : bioactivities

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The Journey of Natural Products: From Isolation Stage to Drug’s Approval in Clinical Trials Yehezkiel Steven Kurniawan; Tantiana Indriani; Hanif Amrulloh; Langit Cahya Adi; Arif Cahyo Imawan; Krisfian Tata Aneka Priyangga; Ervan Yudha
Bioactivities Vol. 1 No. 2 (2023): Bioactivities
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/bioactivities.2963-654X.190

Abstract

Nature serves as an excellent inspiration for researchers in the fields of chemistry and medicine. Terrestrial or marine organisms produce billions of natural products with unique chemical and physical properties. Some of them have been used in traditional therapy for specific diseases since ancient times. Although their exact chemical structures have yet to be elucidated clearly in that time, investigations in medicinal chemistry have been well documented. Furthermore, utilizing natural products in drug design and development offers advantages such as high biocompatibility, low toxicity, fewer side effects, wide bioactivities, and large structure diversity. Nowadays, rational drug research using computer-aided drug design is well established to cut the long way of drug discovery and overcome the resistance cases and the increment in the number of active patients. This review will highlight some natural products to comprehensively understand their journey from unknown natural products, isolation, purification, characterization, in silico evaluation, bioactivity screening assay, drug modifications, in vitro investigation, in vivo examination, and clinical trial.
Antibacterial Effect of Juglans regia, Citrus sinensis, Vicia faba, and Urtica urens Extracts under In vitro Conditions Ali Khakpour; Negar Ahmadi Shadmehri; Hanif Amrulloh; Hamed Kioumarsi
Bioactivities Vol. 1 No. 2 (2023): Bioactivities
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/bioactivities.2963-654X.195

Abstract

Various agricultural products are known to have anti-microbial, anti-cancer, and anti-inflammatory effects. As we can mention, Walnut (Juglans regia) husk, orange (Citrus sinensis) peel, Broad bean (Vicia faba) peel, and Nettle (Urtica urens) are proven to have antimicrobial and anticancer actions. Also, plant diseases such a Pectobacterium carotovorum, Ralstonia solanacearum, Dickeya chrysanthemi, and Pseudomonoas syringae are known to cause annual damage to plant products. Therefore, in the current study, the researchers evaluated their antibacterial activity on the mentioned bacteria under in vitro conditions. Extracts of J. regia husk, C. sinensis peel, V. faba outer peel and U. urens were prepared by maceration method and their anti-bacterial activity on P. carotovorum, D. chrysanthemi, P. syringae, R. solancearum was evaluated using blank disk and well diffusion to obtain minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values. J. regia (husk) and V. faba (outer peel) extracts revealed an anti-bacterial effect on all 4 studied bacteria, while C. sinensis (peel) only inhibited the growth of P. syringae and U. urens only had this effect on P. syringae and R. Solancearum. The inhibition zones varied from 8 to 14 mm, while almost all MIC and MBC rates were 6.25 and 12.5 mg/mL, respectively. Based on the antimicrobial results, the extracts that showed suitable antibacterial effects on certain bacteria can be further studied to be used as natural pesticides.
Co-Authors Abrori, M. Sayyidul Afifah, Nida Rafa Afriyani, Hapin Agus Setiawan Ahmad Zarnuji Ahmad Zarnuji Ahmad Zarnuji Ahmad Zarnuji, Ahmad Aini, Intan Nur Ali Khakpour Aliya Nabila Sari Aluko, Olukemi Anggit Fitria Ani Mardiantari Annissa, Annissa Anwar, Muhammad Saidun Ari Rohmawati Arif Cahyo Imawan Askari Bozayeh, Fatemeh Aziz, Ikhwan Azizah, Isnaini Nur Bahareh Rafiei Banon Ferdiana Choirudin, Choirudin Choirunnisa, Silvi Dedi . Dedi Setiawan Dedi Setiawan Dedi Setiawan Desta Sari Dian Herasari, Dian Dwi Setia Ningsih Eka Fitria Ningsih Eka Prasetiawati, Eka Ervan Yudha Eti Nurwening Sholikhah Fadilah, Lutfi Faranida, Qori Hikmah Faris Hermawan Fatiqin, Awalul Fauzan . Fauziah, Aisyah Yuliana Fauziah, Hani Matul Febriani, Anisa Bela Finny Ligery Golbanoo Azizpoor Habib Shulton Asnawi Hadis Ahmadnia Hamed Kioumarsi Hamed Kioumarsi Hapin Afriyani Haris Santoso Harno Dwi Pranowo Hayani, Aida Hernisawati, Hernisawati Indriani, Marcella Isnaini Nur Azizah Isnaini Nur Azizah Isnaini Nur Azizah Jaenullah Jaenullah Jaenullah Jarnuzi, Ahmad Jumina Jumina Khulus, Al Afidatul Kiki Abelia Kioumarsi, Hamed Krisfian Tata Aneka Priyangga Kurniawan, Yehezkiel Steven Langit Cahya Adi Lestari, Restu Lutfi Fadilah Lutviana, Ani M. Sayyidul Abrori Mahmoud Kordi Marzieh Alidoust Pahmedani Masrurotul Mahmudah Masrurotul Mahmudah, Masrurotul Mega Suaedah Prastika Mispani Mispani Mitra Arman Mohammadreza Mahdavian, Seyed Mostafa Alinaghizadeh Muafifah, Sri Muhammad Nur Amin Muhammad Yusuf Negar Ahmadi Shadmehri Nela Fatmasari Ningsih, Dwi Setia Nobakht Haghighi, Shahab NUR AINI Nur Alfi Khotamin nur khotimah Nur Laili Nur Laili Nurul Aisyah Nurul Aisyah Nurul Khotimah Okta Nur Azizah Ramadani, Arip Restu Lestari Ridho Nahrowi Rikha Bramawanto Rizki Asrarul Mufidah Rizky Hidayatullah Rudy T M Situmeang Saeid Tamadoni Jahromi Sarsozo, Makario Seyed Reza Fani Shariman Yahaya, Zary Situmeang, Rudy T M Sophia Lasma Sagala Sri Wahyuni Suhono Suhono, Suhono Tantiana Indriani Theledi, Karim Umi Habibah Wahyudi Wahyudi Wasinton Simanjuntak Wasinton Simanjuntak Wasinton Simanjutak Yulinarsih, Yulinarsih Zeynab Kazemkhah Hasankiadeh