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Liprotide-encapsulated vitamin D3 modulates circulated PTH levels and improved bone microstructure Claradhita Ayu Shauma; Faizah Fulyani; Adriyan Pramono; Endang Mahati; Sylvia Rahmi Putri; Reza Achmad Maulana; Gemala Anjani
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 12, No 1 (2023): December
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jgi.12.1.44-52

Abstract

Background: vitamin D (25(OH)D) is a fat-soluble vitamin that is unstable in the gastrointestinal environment and has low bioavailability. A protein-lipid complex (liprotide) can be used as a shell to increase vitamin D stability and bioavailability. Liprotide can also serve as a delivery system for transporting vitamin D to its intended site. Little attention has been paid to utilizing liprotide as a delivery system for vitamin D and evaluating its functional activity.Objective: to investigate the effect of liprotide-encapsulated vitamin D3 on PTH levels and bone microstructure in vitamin D and calcium (VD-Ca) deficient rats.Materials and Methods: an overall of 24 Wistar rats had been divided into four groups, a normal control group (K), a VD-Ca group without treatment (K-), a VD-Ca group with 180 IU/200 gBW/day free vitamin D3 (FVD3), and a VD-Ca group with 180 IU/200 gBW/day liprotide-encapsulated vitamin D3 (LVD3). Before and after 28 days of vitamin D intervention, blood samples were taken and analysed for serum PTH levels. The microstructure of the bone was analyzed using the Scanning Electron Microscope (SEM).Results: the VD-Ca rats supplemented with vitamin D3 (FVD3 and LVD3) had a significant decrease in serum PTH levels (p<0.001) and improved bone microstructure (p<0.05) compared to the (K-) group. The reduction of PTH in the LVD3 group was higher compared to the FVD3 group. The bone microstructure between the FVD3 and LVD3 groups is significantly different, as seen in the Ct.Wi parameter, with the LVD3 group having a higher Ct.Wi than the FVD3 group.Conclusion: liprotide-encapsulated vitamin D3 improves the serum PTH level and bone microstructure in a rat model of vitamin D and calcium deficiency.
PERAN SENYAWA BIOAKTIF RUMPUT LAUT TERHADAP RESPON GLUKOSA DARAH PADA INDIVIDU OBESITAS: LITERATUR REVIEW Anggriany, Nissa; Noer, Etika Ratna; Margawati, Ani; Pramono, Adriyan; Anjani, Gemala
Journal of Nutrition College Vol 13, No 3 (2024): Juli
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jnc.v13i3.42821

Abstract

ABSTRACTObesity is considered as a risk factor for insulin resistance and hyperglycemia. Strategies for glycemic control are necessary in order to prevent obese individuals from developing diabetes mellitus. Over the last few years, research regarding natural products obtained from seaweed has increased since it contains various bioactive compounds; such as, polysaccharides, polyphenols, carotenoids, fucoxanthin and others. These compounds appear to have various biological effects which are beneficial to health; such as, antioxidant, anti-inflammatory, antimicrobial and anti-diabetic activities. In addition, the low energy content of seaweed and various bioactive compounds can prevent diabetes through various mechanisms. This narrative review provides summary of the various bioactive compounds contained in seaweed and provides a summary regarding the mechanisms of seaweed bioactive compounds on blood glucose responses in obese individuals.Keywords: Seaweed; bioactive compounds; blood glucose; obesity                                                                           ABSTRAKObesitas merupakan faktor risiko terjadinya resistensi insulin dan hiperglikemia. Kontrol glikemik sangat penting untuk menjaga individu obesitas agar tidak sampai pada kondisi diabetes mellitus, sehingga diperlukan strategi untuk mengontrol glikemik. Selama beberapa tahun terakhir, penelitian terkait produk alami yang diperoleh dari rumput laut semakin meningkat karena mengandung berbagai senyawa bioaktif seperti polisakarida, polifenol, karotenoid, fukosantin dan lainnya. Senyawa tersebut tampaknya memiliki berbagai efek biologis yang bermanfaat bagi kesehatan seperti aktivitas antioksidan, antiinflamasi, antimikroba, dan antidiabetes. Selain itu, kandungan energi yang rendah pada rumput laut dan berbagai senyawa bioaktif dapat mencegah diabetes melalui berbagai mekanisme. Tinjauan naratif ini merangkum berbagai kandungan senyawa bioaktif rumput laut dan memberikan ringkasan terkait mekanisme senyawa biaktif rumput laut terhadap respon glukosa darah pada individu obesitas.Kata Kunci: Rumput laut; senyawa bioaktif; glukosa darah; obesitas
Sorghum Tempeh on Cholesterol Levels and Histopathology of Aorta in High-Fat Diet-Induced Rat Model Bintang, Francisca Natalia; Lestari, Endang Sri; Afifah, Diana Nur; Muniroh, Muflihatul; Anjani, Gemala; Syauqy, Ahmad; Djamiatun, Kis
Journal of Biomedicine and Translational Research Vol 10, No 2 (2024): August 2024
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v10i2.22689

Abstract

Background: Elevated cholesterol levels are associated with hypercholesterolemia, the primary cause of death and lost productivity, and a significant risk factor for the onset of cardiovascular disease. Sorghum is known for its high bioactive components and phenolic compounds, flavonoids, β-glucans, and dietary fiber, which act as anti-cholesterol properties.Objective: This study aimed to analyze the impact of sorghum tempeh on cholesterol levels and histopathology of aorta in rats fed a high-fat diet.Methods: A total of 24 male 8-weeks-old Sprague Dawley rats were randomly assigned to four groups: standard diet group (SD), high-fat diet control group (FD), rats fed high-fat diet + low dose of sorghum tempeh (T1), and high-fat diet + high dose of sorghum tempeh (T2). Measurements of cholesterol levels were determined using the total cholesterol ELISA method. Histopathology of aorta analysis was carried out after four weeks of intervention of the four treatment groups using Hematoxylin-Eosin staining.Results: The average total cholesterol levels post-intervention in the SD, FD, T1, and T2 were 89.986±2.089, 220.365±3.847, 121.161±4.111, and 97.836±2.504 mg/dL, respectively. The results showed that the total cholesterol level significantly decreased (p<0.05) after giving a formula of sorghum tempeh with doses of 0.75 g and 1.50 g per 200 g body weight of rats for four continuous weeks. Histopathology of the aorta in the FD and T2 groups showed a significant difference compared to the SD group. The result which was closest to the SD group was the T1 group.Conclusion: Sorghum tempeh is a high-fiber and antioxidant source that can control hypercholesterolemia by lowering serum total cholesterol. It is also possible to improve histopathology but not yet able to approach normal conditions. The administration of sorghum tempeh with a low dose is sufficient, and further research is still required to determine the effect of sorghum tempeh on aorta histopathology.
Potensi Susu Fermentasi dalam Mempengaruhi Parameter Furkaniaty, Annisa; Anjani, Gemala; Limijadi, Edward Kurnia Setiawan; Legowo, Anang Mohamad; Syauqy, Ahmad
Journal of Telenursing (JOTING) Vol 6 No 1 (2024): Journal of Telenursing (JOTING)
Publisher : Institut Penelitian Matematika, Komputer, Keperawatan, Pendidikan dan Ekonomi (IPM2KPE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31539/joting.v6i1.8372

Abstract

This study aims to explain the effect of milk on hematological parameters. The method used is a literature review made through a systematic approach, using the PICO method, by searching for articles in the Pubmed, Scopus, and EBSCOhost databases. The research results showed that 425 articles were found, and seven articles met the inclusion criteria; these articles were fermented milk containing lactic acid bacteria, which are probiotics. Fermented milk products such as yogurt, Yakult, kefir, active, fermented goat's milk, and dahi influence hematological parameters. Namely, they can increase hemoglobin, ferritin, and erythrocyte count and reduce MCV. Milk fermentation affects hematological parameters, namely increasing hemoglobin, ferritin, and erythrocyte count and reducing MCV. Keywords: Anemia, Probiotics, Fe Absorption, Fermented Milk, Iron Status
Karakteristik Sensori dan Hedonik pada Pacid Kule Ikan Mas (Cyprinus Carpio) Fermentasi Pramesti, Yuli; Anjani, Gemala; Hunaefi, Dase
Journal of Telenursing (JOTING) Vol 6 No 1 (2024): Journal of Telenursing (JOTING)
Publisher : Institut Penelitian Matematika, Komputer, Keperawatan, Pendidikan dan Ekonomi (IPM2KPE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31539/joting.v6i1.8406

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This research aims to determine the best and most preferred sensory and hedonic characteristics of fermented Pacik kule goldfish (cyprinus carpio) typical of the Alas tribe, Southeast Aceh district. The research method was an experiment using a completely randomized design (CRD) with 3 treatments for the storage time of Pacik kule fish typical of Aceh. With 2 repetitions. Statistical tests for sensory use the Kruskal Wallis test and for hedonic tests use the Fiedman test to see test ranking. The results showed that the sensory characteristics for aroma attributes were different for each sample (p = 0.03 < 0.05). For sensory taste, there are differences in each attribute (p = 0.01 < 0.05). The hedonic test of color, aroma, taste and texture that was most liked by the panelists was found in the F2 fermentation time (12 hour fermentation), with a very like classification and the lowest classification, namely F3 (36 hour fermentation) with a dislike classification. The research conclusion is that the aroma sensory characteristic with the highest intensity is the very aromatic attribute of Pacik kule spices typical of Southeast Aceh, for the taste sensory characteristic with the highest intensity is the characteristic fish taste attribute. The best hedonic test was found in the F2 treatment or fermentation for 12 hours. Keywords: Hedonic, Pacik kule, Sensory
Correlation between Blood Vitamin D Levels and Lipid Profiles in Post-Ischemic Stroke Patients Jaeri, Santoso; Retnaningsih, Retnaningsih; Husni, Amin; Maharani, Nani; Anjani, Gemala
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 24, No 2 (2024): July
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v24i2.22202

Abstract

Dyslipidemia and vitamin D deficiency are the predisposing factors for stroke. It is also established that vitamin D contributes to cholesterol metabolisms. Unfortunately, there is no evidence regarding the correlation between blood vitamin D levels and lipid profiles in patients with post-ischemic stroke. Herewith, the authors determine the correlation between blood vitamin D levels and lipid profiles among patients with post-ischemic stroke. A cross-sectional approach among 40 patients with post-ischemic stroke was obtained consecutively. Demographic characteristics, as well as the history of other diseases and 24 24-hour recall diet, were recorded. Then, the measurement of blood vitamin D levels and lipid profiles, such as total, LDL, HDL cholesterol, and triglyceride levels, were performed. Their correlations were determined using the Spearman correlation test. Among 40 subjects, no significant correlation was revealed between blood vitamin D levels and the serum total, LDL, HDL cholesterol, and triglycerides levels (p=0.898, 0.560, 0.361, and 0.622 respectively, and r=0.021, -0.095, 0.080, and 0.080 respectively). To summarize, there is no significant correlation between blood vitamin D levels and all lipid profiles in patients with post-ischemic stroke.
Potensi dan Mekanisme Kacang Tropis terhadap Sindrom Metabolik: Tinjauan Literatur: The Potential Benefits and Mechanism of Action of Tropical Nuts Against Metabolic Syndrome: A Literature Review Setyawati, Amalia Rani; Anjani, Gemala; Mahati, Endang
Amerta Nutrition Vol. 8 No. 3 (2024): AMERTA NUTRITION (Bilingual Edition)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/amnt.v8i3.2024.480-495

Abstract

Background: Metabolic syndrome is a significant risk factor for both type 2 diabetes mellitus and cardiovascular disease, with a high prevalence in Asia Pacific, particularly in Indonesia. To reduce its prevalence, several studies have recommended the use of tropical nuts, which can be developed as functional foods and complementary treatment. In this context, the bioactivities of tropical nuts can largely be attributed to their rich content of monounsaturated fatty acids, polyunsaturated fatty acids, fiber, minerals, vitamins, phytosterols, and polyphenols. Objectives: This literature review aims to evaluate the potential benefits and mechanism of action of tropical nuts against metabolic syndrome. Methods: The study design was a literature review of several articles from 3 online databases, including PubMed, Google Scholar, and ScienceDirect. Discussions: The results showed that tropical nuts (peanut, sacha inchi, cashew, tropical almond, and Brazil nut) had several biologically active components, such as arginine, fiber, fatty acid, mineral, vitamin, phenolic compounds, resveratrol, and phytosterol. The test samples were reported to have the ability to modulate Nrf2, SOD, MDA, GSH, GPx, and CAT due to their antioxidant activity. In inflammation, tropical nuts had a significant effect on NF-κB, NLRP3, TNF-ɑ, IL-8, IL-1ꞵ, IL-6, and IL-10. The results also showed their ability to enhance lipid synthesis, nitric oxide production, advanced glycation end-product, prostaglandin, SIRT3, homocysteine, protein kinase C, adhesion molecules, platelet aggregation, GLP-1, PYY, AGRP, PPARɑ/ꞵ/δ, GLUT4, and insulin receptor. Conclusions: Tropical nuts had beneficial effects on metabolic syndrome due to their bioactivities, including antioxidants, anti-inflammatory, anti-obesity, antidiabetic, antihypertensive, anti-dyslipidemia, and cardioprotective.
The Effect of Sacha Inchi Tempe on Blood Glucose, HOMA-IR, and TNF-ɑ in Rats with Metabolic Syndrome Setyawati, Amalia Rani; Anjani, Gemala; Mahati, Endang; Afifah, Diana Nur; Syauqy, Ahmad; Astawan, Made; Rahmawati, Irma Sarita
Jurnal Gizi dan Pangan Vol. 19 No. 2 (2024)
Publisher : Food and Nutrition Society of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25182/jgp.2024.19.2.97-106

Abstract

This research aimed to evaluate the impact of sacha inchi tempe (Plukenetia volubilis L.) on Fasting Blood Glucose (FBG), Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), and Tumor Necrosis Factor Alpha (TNF-ɑ) levels. In addition, metabolic syndrome was induced in 36 male Wistar rats aged 2 months at 150–200 g weight by giving a High-Fat High-Fructose diet (HFFD) for 2 weeks. The extract was administered through oral gavage in dose-dependent manner and rats were allocated into 6 groups, namely: 1). Normal control or K0; 2). Negative control or K-; 3). Positive control or K+ with 0.18 mg/200 g BB of simvastatin; 4). Intervention with 0.9 g sacha inchi tempe or P1; 5). Intervention with 1.8 g sacha inchi tempe or P2, and; 6). Intervention with 3.6 g sacha inchi tempe or P3. Meanwhile, normal chow rats were used and served as the control group. After 2 and 5 weeks of induction and intervention, blood was drawn to determine FBG. Blood insulin was examined after 5 week of intervention. Rats were euthanized at the end of the intervention for hepatic TNF-α analysis before calculating HOMA-IR. The result showed that there was a significant difference (p<0.05) in FBG, HOMA-IR and hepatic TNF-α levels after sacha inchi tempe treatment. Rats receiving the highest dose of sacha inchi tempe had the most significant reduction (p<0.05) in FBG, HOMA-IR and hepatic TNF-α, when compared to simvastatin group. Therefore, sacha inchi tempe could attenuate glycemic and inflammation profiles in metabolic syndrome.
The sociodemographic factors on food insecurity among household living in disaster-prone area in Central Java, Indonesia Hastuti, Vivilia Niken; Afifah, Diana Nur; Sugianto, Denny Nugroho; Anjani, Gemala; Noer, Etika Ratna
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 12, No 2 (2024): June
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jgi.12.2.136-142

Abstract

Background: Demak, as a disaster-prone coastal area in Central Java, faces issues such as malnutrition and food insecurity due to the impacts of climate change. As a result of coastal disasters, vulnerable people in coastal areas often experience loss of livelihoods, limited access to nutritious food, and increased risk of malnutrition.Objective: The study aimed to analyze the association between household food security and household demographic factors in Central Java’s coastal areas.Materials and Methods: A cross-sectional study was conducted on 138 households living in the coastal area of Demak by simple random sampling. The socio-demographic characteristics were conducted by interviewing the mother/child caregiver. The degree of household food security (HFS) was obtained using the Household Food Security Survey Module (HFSSM) Questionnaire. Descriptive statistics and Chi-square were used for statistical analysis.Results: Based on HFS status, 49.3% of respondents were food secure, 26.1% were food insecure without hunger, 20.3% were food insecure with moderate hunger, and 4.3% were food insecure with severe hunger. There was significant correlation between father’s educational level, mother’s educational level, and monthly household income per month on the HFS status (p<0.05).Conclusion: Sociodemographic factors associated with household food security status were father's and mother's education and monthly household income (p<0.05). The potential negative impact of household food insecurity on the nutritional status of family members needs to be studied further, especially vulnerable age groups such as toddlers and mothers in the household.
Functional Properties of Protein Hydrolysates from Skipjack Tuna Byproducts Using Response Surface Methodology Prasetyo, Dwi Yanuar Budi; Agustini, Tri Winarni; Anjani, Gemala; Riyadi, Putut Har
Squalen, Buletin Pascapanen dan Bioteknologi Kelautan dan Perikanan Vol 19, No 3 (2024): December 2024
Publisher : :Agency for Marine and Fisheries Research and Human Resources, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15578/squalen.929

Abstract

Protein hydrolysates from skipjack tuna by-products are rich in protein and excellent in functional properties, making them a valuable source of nutrients for humans. This research sought to determine the optimal pH, temperature, and hydrolysis time for producing protein hydrolysates from skipjack tuna byproducts (PHST) using Response Surface Methodology (RSM). A total of 20 g of PHST was prepared from frames and trimmings, samples were hydrolyzed under the following conditions: pH of 6 (P1) and 7 (P2), temperatures of 50°C (S1), 60°C (S2), and 70°C (S3), and hydrolysis times of 90 minutes (T1), 180 minutes (T2), and 270 minutes (T3). The hydrolysis process was terminated by inactivating the enzyme at 80°C for 30 minutes. The filtrate was ready for further analysis in the laboratory. Data and design experiments were analyzed using Box-Behnken Design (BBD) with the Design-Expert (DX) 13® software (Stat-Ease Inc. Minneapolis) to determine the optimum conditions for higher PHST production. A quadratic model was developed to predict the production of PHST. The RSM recommendation was to perform hydrolysis at pH 6.386 and a temperature of 61.190°C for a hydrolysis time of 228.540 minutes to result in a desirability of 0.906 in producing PHST with 85.680% DH, a protein solubility of 51.538%, and a viscosity of 3.587%. The study results showed that PHST can be used as a promising food ingredient and protein source in the food system.
Co-Authors Abyyudha, Dany Adriyan Pramono Agustina, Ayu Widiawati Ahmad Syauqy Ahmad Syauqy Ahmad Syauqy Ahmad Zulfa Juniarto Aleda Florince Oyay Amin Husni Anang M Legowo Anggray Duvita W Anggriany, Nissa Ani Margawati Ariani Ariani Ayu Rahadiyanti Ayu, Azzahra Mutiara Ayustaningwarno , Fitriyono Binar Panunggal Bintang, Francisca Natalia Christanto, Monica Lemuela Claradhita Ayu Shauma Denny Nugroho Sugianto Deny Yudi Fitranti Dewi Marfu'ah Kurniawati Diana Nur Afifah Diana Nur Afifah, Diana Nur Dwi Ratna Sari Edward Kurnia Setiawan Limijadi Edward Kurnia Setiawan Limijadi, Edward Kurnia Setiawan Ekowati Chasanah Endang Mahati Endang Mahati Endang Mahati Endang Sri Lestari Endang Sri Lestari Endang Yuli Purwani, Endang Yuli Enny Probosari Etika Ratna Noer Faizah Fulyani Fatih Az Zahra Fitriyono Ayustaningwarno Fulyani, Faizah Furkaniaty, Annisa Galuh Dwi Astuti Gunawan, Sekar Ayu Putri Hardhono Susanto Hartanti Sandi Wijayanti Hastuti, Vivilia Niken Hunaefi, Dase Indrastati, Nandia Indriyanti, Risa Ivena Claresta Jaeri, Santoso Jalasena, Rizka Akbar Juwita, Riza Iska Kis Djamiatun Kusmiyati Tjahjono Kusmiyati Tjahjono Lili Nor Indah Sari Lubis, Syahrani Aulia MADE ASTAWAN Mambaya, Helvi Desi Maulana, Reza Achmad Miftahul Adnan Millah, Shoffyyatul Mira Dian Naufalina Mohammad Sulchan Mohammad Zen Rahfiludin Muchlis Achsan Udji Sofro Muchlis Achsan. Udji Sufro Mumpuni, Ocka Febrian Muniroh, Muflihatul Nafisah Nani Maharani Nani Maharani Nareswara, Anastu Regita Ninik Rustanti Ninik Rustanti Ninik Rustanti Nur Afifah, Diana Nur Faizah Nurdin, Nurhanifah Muthmainnah Nurmasari Widyastuti Nuryanto Nuryanto Pramesti, Yuli Prasetyo, Dwi Yanuar Budi Pristina Adi Rachmawati Putut Har Riyadi Rachma Purwanti Rafika, Muhana Rahayu, Gita Riski Rahmawati, Irma Sarita Rahmawati, Siti Irma Ratna Ratna Rena Budiyatri Resti, Nina Retnaningsih Retnaningsih Rimadhani Ulfa Rohmatul Ummah S Fatimah Muis Setyawati, Amalia Rani Sherlin Regina Jami Siti Fatimah Muis Siti Fatimah-Muis Siti Fatimah-Muis Sofro, Muchlis AU Sumardi Widodo Sylvia Rahmi Putri Tasya Safira Meliasari Tiffany Nisa Arviyani Tri Winarni Agustini Untari Utama, Affini Nurratri Utami, Wahyu Widyasari Velicia, Velicia Welresna Juliatri Putri Rupiasa Widya, Fiona Christina Zhu, Fan