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All Journal Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Biology, Medicine, & Natural Product Chemistry MPI (Media Pharmaceutica Indonesiana) JOPS (Journal Of Pharmacy and Science) Jurnal Ilmu Kefarmasian Indonesia JCPS (Journal of Current Pharmaceutical Sciences) Fullerene Journal of Chemistry Cendekia Journal of Pharmacy Jurnal Ilmu Kesehatan Jurnal Pengabdian Kesehatan Jurnal Ilmiah Jophus: Journal of Pharmacy UMUS Jurnal Pengabdian Masyarakat Asia Community Empowerment Jurnal Farmasi dan Sains Indonesia (JFSI) Medical Sains : Jurnal Ilmiah Kefarmasian JAPI: Jurnal Akses Pengabdian Indonesia Prosiding University Research Colloquium Jurnal Bakti Untuk Negeri Kreasi: Jurnal Inovasi dan Pengabdian Kepada Masyaraka Jurnal Pengabdian Masyarakat Bangsa Journal of Pharmacy Science and Technology Batik-Mu : Jurnal Pengabdian Masyarakat Jurnal Ilmiah Kesehatan Benzena Pharmaceutical Scientific Journal Parapemikir Jurnal Ilmiah Farmasi Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Farmasi Galenika
Urmatul Waznah
Program Studi Sarjana Farmasi, Fakultas Ilmu Kesehatan, Universitas Muhammadiyah Pekajangan, Pekalongan
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Journal : Journal of Pharmacy Science and Technology

 1 
Stabilitas Membran Sel Eritrosit Ekstrak, Fraksi Kloroform, Etil Asetat dan Metanol Herba Patah Tulang (Euphorbia Tirucalli L.) Fika, Irma; Wirasti, Wirasti; Pambudi, Dwi Bagus; Waznah, Urmatul
JOURNAL OF PHARMACY SCIENCE AND TECHNOLOGY Volume 5 No. 1: Juli 2024
Publisher : Prodi Farmasi Fakultas Kedokteran Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/pst.v5i1.402

Abstract

Euphorbia tirucalli L. (patah tulang) contains secondary metabolites with potential anti-inflammatory activity. This study aimed to identify its bioactive compounds and evaluate erythrocyte membrane stabilization of the extract and fractions. Extraction was performed by maceration with 96% ethanol, followed by fractionation using chloroform, ethyl acetate, and methanol. Total flavonoid and phenolic contents were measured by UV-Vis spectrophotometry, while erythrocyte membrane stabilization was tested in vitro. Phytochemical screening revealed flavonoids, phenols, saponins, steroids, triterpenoids, and tannins. The phenolic content was 432.1 ± 99.4 mg/g in the extract, 1,057 ± 88.02 mg/g in the chloroform fraction, 254.4 ± 48.84 mg/g in the ethyl acetate fraction, and 643.2 ± 267.3 mg/g in the methanol fraction. The highest flavonoid content was found in the chloroform fraction (4.26 ± 0.12 mg/g), followed by the extract (3.63 ± 0.35 mg/g), ethyl acetate (3.56 ± 0.36 mg/g), and methanol (2.6 ± 0.03 mg/g). Membrane stabilization assays showed the extract provided the strongest protection (95.04%), followed by chloroform (89.51%), ethyl acetate (87.71%), and methanol (87.52%), approaching the positive control diclofenac sodium (90.59%). Kruskal-Wallis and Tukey tests indicated the ethanol extract at 100 μg/mL (p=0.997 >0.001) and chloroform fraction at 500 μg/mL (p=0.023 >0.001) were not significantly different from the control, while ethyl acetate and methanol fractions differed significantly (p<0.001). These results demonstrate that the ethanol extract and chloroform fraction possess the highest anti-inflammatory potential, supported by high phenolic and flavonoid levels and consistent statistical analysis.
Co-Authors A'yun, Qurrata Aan Sofyan Achmad Vandian Achmad Vandian Nur, Achmad Vandian Aflit Nuryulia Praswati Aini, Fadhila Nur Ainin, Shabrina Ainun Muthoharoh, Ainun Aisyah, Riski Dewi Aminuyati Amudya, Farry Mushab Usaidy Anjani, Lestari Dwi Atifah, Husnia Azzahra, Nafisa Aufa A’yun, Qurrata Balqis, Fadia Indah citra_dinda Wardany Cut Chiwe Widya Pramesty Dewi, Alfa Yuliana Dian Ayu Kiswanda Kiswanda Dwi Bagus Pambudi Eko Mugiyanto Eko Mugiyanto Eko Mugiyanto, Eko Fadhilah, Isna Fadillah, Rahma Ayu Fajriyah, Nuniek Niezmah Farry Mushab Usaidy Amudya Fika, Irma Firman Faradisi Fissilmi Kaffah Fitriyani, Iva Fortuna, Putri Asabella husna Santika Rahmasari Imam Prasetyo Indriani, Cahya Ismatul Khusna Istiannah, Istiannah Izzudin, Muhammad Izzudin Lutfi Kaffah, Fissilmi Khusna Santika Rahmasari Khusna, Ismatul Kintoko Kintoko Kintoko Kintoko Kiptiyah, Maryatul Kun Harismah Kurnia Oktaviani, Riska Kusumo, Djati Wulan Laula Lia Khusnul Maulidah Mafruroh, Mafruroh Maharisti, Retno Aulia Maryatul Kiptiyah Maulidah, Lia Khusnul Maulvi, M. Arsyi Metha Anung Anindhita Mufrodah, Nely Muhammad Zidni Rizqon Zidni Muldiyana, Tya Musyahar, Ghoni Naila Iva Amalina Putri Sulaiman Ningrum, Wulan Agustin Nisa Nurkhikmah Nuniek Nizmah Fajriyah Nuniek Nizmah Fajriyah Nuniek Nizmah Fajriyah Nunung Mufida Nunung Mufida Nunus Eka Kartikasari Nurharyanto, Jufri Nurkhasanah Nurkhasanah Nuryulia, Aflit OKTAVIANI, RISKA Oktaviani, Riska Kurnia Pambudi, Dwi Bagus Pragusti, Zilla Restiana Pramesty, Cut Chiwe Widya Prastika, Sisca Windy Pulhehe, Hasni R.Kurniawan Dwi Septiady Rahmasari, husna Santika Rahmatullah, ST. Retno Aulia Maharisti Risfigo, Muhammad Rochmat, M. Idhar Khoirul S Slamet S Slamet, S Silvia Rizkiani Slamet . Slamet, Slamet St. Rahmatullah St. Rahmatullah Sudiani, Sheni Sulaiman, Naila Iva Amalina Putri Supriyanto, Lukman Tri Puspita Yuliana Tri Wijaya Ningsih Ulhaq, M Daffa’ Dhiya’ Ulum, M. Miftakhul Ulya, Inalatul Umarella, Novel Vandian, Achmad Vira Septiya W Wirasti Wahyu Permadi, Yulian Wibowo, Danang Novianto Windha Widyastuti Windha Widyastuti Wirasti Wirasti Wirasti, W Wirasti, Wirasti Wulan Agustin Ningrum Wulandari, Hilda Fitria Yuli Nurullaili Efendi, Yuli Nurullaili Yulian Wahyu Permadi Yusrilia Yusrilia Yusrilia, Yusrilia