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All Journal Inspiratif Pendidikan Jurnal Bisnis, Manajemen, dan Informatika Al-Ibrah : Jurnal Pendidikan dan Keilmuan Islam Jurnal Pengabdian UntukMu NegeRI Jurnal Penelitian Pendidikan IPA (JPPIPA) Pendas : Jurnah Ilmiah Pendidikan Dasar Al-Mashrafiyah : Jurnal Ekonomi, Keuangan, dan Perbankan Syariah Majalah Ekonomi International Journal of Elementary Education Al-Asalmiya Nursing: Journal of Nursing Sciences Jurnal PPKn International Journal Of Science, Technology & Management (IJSTM) Entrepreneur : Jurnal Bisnis Manajemen dan Kewirausahaan International Journal of Community Service Jurnal Gastronomi Indonesia Jurnal Pengabdian Inovasi dan Teknologi Kepada Masyarakat International Journal of Islamic Business and Management Review Tarjih: Agribusiness Development Journal Jurnal Riset Kedokteran JURNAL INOVASI DAN PENGABDIAN MASYARAKAT INDONESIA Bandung Conference Series : Medical Science Jurnal Bastra (Bahasa dan Sastra) Kharisma: Jurnal Administrasi dan Manajemen Pendidikan Center of Economic Students Journal (CSEJ) Nusantara: Journal Of Law Studies "JAMASTIKA" Jurnal Mahasiswa Teknik Informatika Income Journal: Accounting, Management and Economic Research Jurnal Paramaedutama Adpebi International Journal of Multidisciplinary Sciences Teumulong: Journal of Community Service Jurnal Dedikasi Masyarakat Andragogi Jurnal Pendidikan dan Pembelajaran IECON: International Economics and Business Conference Multidisciplinary Indonesian Center Journal Jurnal Riset Multidisiplin Edukasi Jurnal Lempu International Journal of Language and Culture Masterpiece Journal Society Service Insight As-Sulthan Journal of Education
Ismawati
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Journal : Jurnal Penelitian Pendidikan IPA (JPPIPA)

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The Potential Of Fungi And Bacteria As α-Glucosidase Inhibitors For The Future Treatment Of Type 2 Diabetes Fachrial, Edy; Ismawati; Jati, Afif P; Nugroho, Titania T; Saryono
Jurnal Penelitian Pendidikan IPA Vol 11 No 1 (2025): January
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i1.9457

Abstract

Diabetes, a disorder of hemostasis of carbohydrate and lipid metabolism, is one of today's leading killers. The most prevalent form of diabetes is type 2 diabetes mellitus (T2DM). Rapid hydrolysis of starch by pancreatic α-amylase and α-glucosidase, followed by intestinal absorption of glucose, causes a sudden increase in blood glucose. Available therapies for T2DM are oral insulin secretagogues, sulfonylureas, repaglinide, nateglinide, biguanides, thiazolidinediones, α-glucosidase, inhibitors and insulin. However, several hypoglycemic agents have limitations, such as side effects and increased diabetes complications. α-glucosidase inhibitors are structurally similar to natural oligosaccharides with a higher affinity for α-glucosidases, and they produce a reversible inhibition of membrane-bound intestinal α-glucoside hydrolase enzymes. This causes delayed carbohydrate absorption and digestion and results in a reduction in postprandial hyperglycemia. Natural α-glucosidase inhibitor drugs from natural sources can be used as a therapeutic approach to treat postprandial hyperglycemia for their assumed lower side effect and more affordable price than synthetic drugs. In this article, the author summarizes the potential of α-glucosidase inhibitors from microorganisms, namely fungi and bacteria, along with several active compounds with better activity than commercial α-glucosidase inhibitors.
Co-Authors Adila, Dian Roza Adinda Aisyah Afifah Ramadhani Agnita Utami Agus Maolana Hidayat Ahmad Tamami Ahnaf Yemina Putri Akram Adi Poetra Amin, Muhammad Akbar Andika Saputra Annisa Zulyanti Annisa, Ayati Anugrah Anwar Abidin, Acmad Arfah, Salmawati Arifai, Samsul Ariqa Rahma Abdullah Armelia Khairunnisa Asmila Dewi Astuti, Intan Attachira br Ritonga Avishena, Hima Ayu Rezki Sulfiana Azizeh, Nur Bakar, Muhammad Abu Budiandriani, Budiandriani Cika Lailatus Sholihah Clarisa Alfatihah Erman Dambe, Jumriani Desak Putu Parmiti Desna Edy Fachrial Effendi, Fallgivando Enggarjati, Frisca Adinda Fadillah, Nurul Adin Fadillah, Siti Nur Farahdziba, Alshela Sonya Farhan, Derigani Farhan, Ilham Farras Nur Muhamad Fitria, Zahira Aulida Haryadi, Wahyu Heni Muflihah Herman , Nurmelianda Hikrawati I Gde Wawan Sudatha Imam Syukur Saraha Indryani Irfani Dhia Rafif Isda Iskandar Jati, Afif P K, Amiruddin Kappa, M. Silmi Kurniawansyah Lusi Yusrenti M. Yusuf K Mahir Pradana Marcelin Octavia Marwah Dwi Cahyani Masin, Muhlis Mhd Wahyudi Azmi Mifta Zahira Mira Dyani Dewi Misra Windayani Muh Rasul Kahar Muh. Hanif Muh. Khaidir Ramadhan MUHAJIR Munawir K NANI HANIFAH Nazla Hafizah Ningsih, Dera Rahma Nisa, Vivi Fadira Choirun Nugraha, Muhammad Alfin Nurdin Natan Nurdin Salama Nurhaedah Nurhaedah Nurjannah Odha, RaodahtulJannah Paula Ramona Pelu, M Faisal A R Pipit Ari Aznel Putri, Dhita Indriana Putri, Namira Putri, Nurhalisa Qryoga Irsyad Reyen Rahmat Tisnawan Raisa Amaris Raissa Maharani Putik Kusuma Ramadhani, Alifiah Rifti Ramlawati Ranie Rahma Niza Ratna Dewi Indi Astuti Rima Vien Permata Hartanto Risya Ladiva Bridha Rofiqah Almunawwarah Rohmadiyah, Bulan Roslita, Riau Rosman, Romzie Saiful Muchlis, Saiful Salsabila Nurul Wildani Hasibuan Sanurdi Sara Puspita Saryono Selvi Ariani Sera Faren Setianingsih, Dhian Pastiana Shadiq, Aqil Silvia Maharani SRI RAHAYU Sri Wahyuni Sudirman Suganda Tanuwidjaja Sulfianti Sulistyowati Supriadi Suud Sarim Karimullah Syafruddin Timotius Agung Soripada Titania Tjandrawati Nugroho Tobing, Vella Yovinna Triana Rejekiningsih dkk Trimulato Tyas Mayangputri Hadiana Ubaidillah, Moch Ulfi Kartika Oktaviana Umar, St. Hafsah Usep Abdullah WAHYUNI Wardati Raudah Widayanto, Mutinda Teguh Woro Priatini Yuliana Yuliana Yuni Sukandani Zaehol Fatah Zamroni, M Afif Zulaifah ⁠Ahmad Izzaturrahim