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Journal : Syntax Idea

Genetic Comparison of H3N2 Influenza Virus in Indonesia with WHO Recommended Strains During the Period 2004 – 2021 Johny Hartawan Sutrisno; Triyana Sari; Sari Mariyati Dewi Nataprawira; Erick Sidarta
Syntax Idea 1338-1355
Publisher : Ridwan Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46799/syntax-idea.v5i10.2557

Abstract

Influenza caused by A/H3N2 virus is one commonly found infections in tropical countries. Vaccination policy against A/H3N2 virus is already established for Northern and Southern hemisphere, however, no specified policy is established for tropical countries such as Indonesia. World Health Organization (WHO) has recommended Indonesia to use vaccine formulation designated for Northern hemisphere. Some studies, however, have shown that there were mismatches between recommended vaccine and circulating strains present in Asian countries, which might have caused regional outbreaks. This study was aimed to compare the genetic makeup of WHO recommended vaccine strain with H3N2 virus circulating in Indonesia. A total of 147 HA and 148 NA complete nucleotide sequences from Indonesian population, as well as 14 HA and 14 NA WHO-recommended nucleotide sequences, were downloaded from GISAID. These sequences were subjected to phylogenetic analysis using MEGA 11. Furthermore, antigenicity of these isolates was analyzed using Kolaskar and Tangonkar Prediction method accessible through IEDB website and Vaxijen 2.0. This study revealed that WHO-recommended vaccine strain for southern hemisphere in 2010 were compatible with Indonesian strains circulating in 2009. Furthermore, there were no recommended vaccine strain that matched strain in circulation between 2010 to 2012 and 2019. Kolaskar and Tongaonkar antigenicity prediction analysis had simulated that several mutations rendered some antigenic epitopes of HA and NA protein to be non-antigenic. These findings highlighted the importance of reliable national surveillance network of influenza to prevent regional epidemic and the development of local influenza vaccine to better accommodate Indonesian population.
Co-Authors Alexander Halim Santoso Alexander Halim Santoso Alfianto Martin Alifia, Tosya Putri Alya Dwiana Alya Dwiana Alya Dwiana Andianto, Ivan Christian Anindya, Najwa Arlends Chris Averina, Friliesa Brian Albert Gaofman Bruce Edbert Bryan Anna Wijaya Chairunnisa Savitri Damar Sajiwo Damar Sajiwo Daniel Goh David Limanan Dean Ascha Wijaya DENY KURNIAWAN Destra, Edwin Dewi, Andriana Kumala Dorna Y.L. Silaban Edbert, Bruce Edwin Destra Enike, Syilvia Cendy Erick Sidharta Fadilah, Diana Farell Christian Gunaidi Fernando Nathaniel Fiona Valencia Setiawan Fladys Jashinta Mashadi Gabriella, Regina Gaofman, Brian Albert Geoffrey Christian Lo Giovani Evangelista Alfonsius Giovani Evangelista Alfonsius Giovanno Sebastian Yogie Goh, Daniel Gracienne Gracienne Gunaidi, Farell Christian Hartono, Vincent Aditya Budi I Made Satya Pramana Jaya Jap, Ayleen Nathalie Johny Hartawan Sutrisno Joshua Kurniawan Khoto, Anthon Eka Prayoga Kosasih, Robert Kristianto, Angeline Florencia Grace Kurniawan, Joshua Laura, Gabrielle Lucius, Steven Hizkia Lumintang, Valentino Gilbert Mashadi, Fladys Jashinta Meilani Kumala Nataprawira, Sari Mariyati Dewi Normala, Ajeng Olivia Charissa Permatasari, Nabila Jingga Peter Ian Limas Pratama, Dena Adistiya Rambe, Novitasari Reynardo, Reynardo Ribka Anggeline Hariesti Sajiwo, Damar Santoso, Alexander Halim Sara Jayanti Sari Mariyati Dewi Nataprawira Sari Mariyati Dewi Nataprawira Sari Mariyati Dewi Nataprawira Sari Mariyati Dewi Nataprawira Sari, Fadhilah Permata Satyanegara, William Gilbert Satyo, Yovian Timothy Savitry, Chairun Nisa Setiawan, Fiona Valencia Shirly Gunawan Sidarta, Erick Sidharta, Erik Silvia W. Lestari Sitorus, Ribka Angeline Hariesti Sugiharto, Hans Sukianto, Louise Audrey Sukmawati Tansil Tan Susilodinata Halim Sutrisno, Johny Hartawan Syarifah, Andini Ghina Teguh, Stanislas Kotska Marvel Mayello Tiara Rahmananda Valentino Gilbert Lumintang Wijaya, Bryan Anna Wijaya, Christian William Gilbert Satyanegara Windiatmoko, Dhio Dwi Yani, Jovan Falian Yohanes Firmansyah Yovian Timothy Satyo