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All Journal Medula Juke Jurnal Medika Hutama JK Unila (Jurnal Kedokteran Universitas Lampung) Nusantara Hasana Journal Jurnal Pengabdian Masyarakat Bidang Sains dan Teknologi Majority JPM (Jurnal Pengabdian Masyarakat) Ruwa Jurai Jurnal Agromedicine Unila: Jurnal Kesehatan dan Agromedicine
Ety Apriliana
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POLYGENIC RISK SCORE SEBAGAI PREDIKTOR DIABETES MELLITUS TIPE 2: SYSTEMATIC RIVIEW Ni Ketut Diah Ayu Pramisswari; Ety Apriliana; Selvi Marcellia; Putu Ristyaning Ayu Sangging
Nusantara Hasana Journal Vol. 5 No. 8 (2026): Nusantara Hasana Journal, January 2026
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i8.1881

Abstract

Type 2 diabetes mellitus (T2DM) is a multifactorial metabolic disease with a significant genetic contribution. Polygenic risk score (PRS) has been developed to integrate the cumulative effects of multiple genetic variants to improve T2DM risk prediction. This Systematic review aimed to evaluate the role of PRS in predicting T2DM incidence, disease progression, and related complications across different populations. This study was conducted in accordance with the PRISMA guidelines, with a literature search performed using the PubMed database and keywords related to PRS and T2DM. Included studies were observational in design and assessed the association between PRS and T2DM incidence or clinical outcomes. Three main studies with case-control, cross-sectional, and cohort designs were analyzed. The results demonstrated that PRS was significantly associated with increased T2DM risk, disease progression, and metabolic complications such as liver fibrosis, including in the context of organ transplantation. Integration of PRS with traditional clinical risk factors improved predictive performance. PRS has the potential to support precision-based T2DM risk stratification, although further cross-population validation is still required.
Co-Authors A. Rialdi Pranada Ade Yonata Agustyas Tjiptaningrum Alexander Dicky Alfan Tammi Ayu Agustira Centya Cheirini Denny Habiburrrohman Dian Isti Angrani Dita Noviyanda Saerulloh Diva Lole Humaira Dwiki WIjaya Rahman Dwita Oktaria Echa Putri Anjani Efrida Warganegara Fiana Deswita Fitria Saftarina Ghina Nisrina Nurfatin Hanna Mutiara Haula Rizqiyah Irma Nur Humaida Lantani Nafisah Heviana Liana Sidharti M. Ricky Ramadhian Mallarangeng, Andi Nafisah Tendri Adjeng Meiwa Rizky Ardhi Blla Putri Merry Indah Sari Meta Gapila Muhamad Jyuldi Prayoga Muhammad Ferdiansyah Putra Muhammad Ricky Ramadhian Muhammad Yusran Mukhlis Imanto Nabila Casogi Adryana Ni Ketut Diah Ayu Pramisswari Novita Carolia Nurul Islamy Oktafany Putu Ristyaning Ayu S Putu Urvasi Ari Utami Rana Mufidah Raydian Rani Himayani Rasmi Zakiah Oktarlina Ratna Dewi Puspita Sari Reffilia Irfa Retno Julianingrum Rika Lisiswanti Rindu Bunga Putri Ringgi Tantra Setiawan Rizki Hanriko Sangging, Putu Ristyaning Ayu Selvi Marcellia Siti Aminah Hasibuan Siti Zahnia Suryadi Islami Susianti Susianti Syafira Alifia Audiani Syazili Mustofa Tri Umiana Soleha Viera Rininda Mauli Dinar Waluyo Rudiyanto Wildan Kautsar Irawan