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Pengaruh Tanaman Lidah Mertua (Sansevieria Sp) Sebagai Biofilter terhadap Gambaran Histopatologi Trakea Pada Tikus Putih Jantan (Rattus Novergicus) Galur Sprague Dawley yang Diberi Paparan Asap Rokok Nabil Abdurrahman; Rizki Hanriko; Rodiani
MAJORITY Vol 10 No 2 (2021): MAJORITY
Publisher : Majority

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Abstract

Smoking is a lifestyle that is currently one of the causes of health problems. Every year the number of smokers has increased. Airway irritation by cigarette smoke and other toxic substances will cause an airway inflammatory reaction. Various ways to avoid cigarette smoke bad effect have been tried, one of them is by placing the tongue-in-law (Sansevieria sp) in the room that can absorb air pollution, especially cigarette smoke. The purpose of this study was to determine the effect of tongue-in-law (Sansevieria sp) as a biofilter on tracheal cell damage in Sprague Dawley rats. The method used in this study is a randomized controlled design with a Post Test Only Control Group Desig. This research was conducted by using randomly selected samples and divided into 3 treatment groups with each group consisting of 6 white rats. In group 1 was negative control, rats were given food and drink as usual and were not exposed to cigarette smoke. In group 2 was a positive control, rats were exposed to cigarette smoke as much as 2 cigarettes per day. In group 3 is a treatment group with rats exposed to cigarette smoke and placed the tongue-in-law plant in the cage as a biofilter for 14 days. In this study was found that there were significant difference in the positive control group (who were exposed to cigarette smoke every day as much as 2 cigarettes for 14 days without the biofilter of the tongue-in-law plant) and the treatment group (with Sanseviera sp). So that it can be concluded that there was an effect of the tongue-in-law (Sansevieria sp) as a biofilter on tracheal cell damage in Sprague Dawley rats.
Pola Bakteri Ulkus Diabetikum Pada Penderita Diabetes Melitus di RSUD Dr. H. Abdul Moeloek Haula Rizqiyah; Tri Umiana Soleha; Rizki Hanriko; Ety Apriliana
MAJORITY Vol 9 No 2 (2020): MAJORITY
Publisher : Majority

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Abstract

Diabetes mellitus is a term for heterogeneous of metabolism disturbances for which the main finding is chronic hyperglycaemia. In diabetes mellitus, elevated glycaemic levels increases the risk of microvascular and macrovascular complications. These increase risk of further complications such as peripheral neuropathy which can cause foot ulcerations. Diabetic extremity ulcers develop in approximately 15% of people with diabetes and are a leading cause of hospitalization and amputation among such patient. Diabetic foot ulcer infection followed by amputation contribute dramatically not only to the morbidity among persons with diabetes, but are also associated with severe clinical depression and increased mortality rates. The aim of the study was to determine the bacterial profile of diabetic foot ulcer in RSUD Dr. H. Abdul Moeloek. This study was a descriptive study using a cross sectional study. Sampling was conducted at RSUD Dr. H. Abdul Moeloek and examined in Microbiology-Parasitology Laboratorium in Medicine Faculty of Lampung University. The diabetic foot ulcer swab was taken to identified the bacteria. Bacteria were isolated on nutrient agar, blood agar, Mc Conkey agar, and identified using Gram staining and biochemical test. In the 21 diabetic foot patients, 16 were males (76.2%) and 5 were females (23.8%) and grade-II Wagner’s ulcers were predominant, which is deep ulcer without bony involvement or abscess. In the diabetic foot ulcers cases, 85.7% cases had monomicrobial infections while 14.3% cases had mixed bacterial infection. Gram-positive bacteria accounted for 62.5%. Staphylococcus aureus was the most frequent microorganism yielded (58%). Gram-negative rods accounted for 37.5%. Escherichia coli was the most predominant gram-negative organism (17%). Staphylococcus aureus, Staphylococcus epidermidis, Citrobacter freundii, Escherichia coli, and Proteus mirabilis were found in diabetic foot infections in the present study.
Hubungan Pengetahuan Gizi Ibu Hamil terhadap Peningkatan Berat Badan Selama Kehamilan di Puskesmas Bandar Lampung Tasya Khalis Ilmiani; Dian Isti Angraini; Rizki Hanriko
MAJORITY Vol 9 No 1 (2020): MAJORITY
Publisher : Majority

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Abstract

Adequacy of nutrition for pregnant women is very important because it can contribute to both the mother and the baby. Pregnant women with poor nutritional status can cause a risk of fetal development, disability in infants, low birth weight, and death before birth. Nutrition in pregnant women is influenced by the mother's nutritional knowledge during pregnancy. This study aims to determine the relationship between nutritional knowledge in pregnant women and weight gain during pregnancy. The design of study was cross sectional analytic using primary data obtained from the questionnaires and secondary data obtained from the KIA / KMS book that include maternal weight. Sampling was examined at Puskesmas Bandar Lampung which is Kedaton, Way Kandis, Satellite, Sukaraja, Sukabumi, and Simpur Puskesmas in 2018. The total sample is 130 pregnant womans with purposive sampling technique. The data analysis using Chi Square with α = 0.05 and CI = 95%. The results of the research showed that there is a relationship between nutritional knowledge in pregnant women and weight gain during pregnancy in Bandar Lampung Primary Health Center with a value of p = 0.003. From the results of this study it can be concluded that nutritional knowledge in pregnant women influences the weight gain during pregnancy.
Black Garlic (Allium sativum) Sebagai Terapi Adjuvan Potensial pada Kerusakan Hepar yang Diinduksi Minyak Jelantah Putu Devie Sri Astari; Rizki Hanriko
MAJORITY Vol 9 No 1 (2020): MAJORITY
Publisher : Majority

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Abstract

People from the lower middle class have consume used cooking oil patterns to save costs but can cause liver damage. Used cooking oil contains free radicals which cause liver damage. Black garlic can be a liver protective because it contains high antioxidant substances that can capture free radicals and prevent oxidative reactions. Flavonoids have a role to capture free radicals to stabilize fat peroxy radicals. Flavonoids have the ability to modulate cell signaling pathways that can regulate various cell processes, for example in growth, proliferation, and apoptosis. Black garlic has hepatoprotective potential to block the effect of tert-Butyl Hydroperoxide (t-BHP) oxidant on cell death, lipid peroxidation, oxidative stress, and inflammation in rat hepatocytes and can be an excellent natural candidate in the development of adjuvant therapies and healthy food for liver protection from damage due to the consumption of used cooking oil.
PENGARUH PEMBERIAN TEH HITAM (Camellia sinensis) TERHADAP GAMBARAN HISTOPATOLOGI ARTERI KORONARIA TIKUS PUTIH GALUR WISTAR YANG DIINDUKSI MINYAK JELANTAH Yovani Rehuel Br Sitepu; Rizki Hanriko; Ari Wahyuni
MAJORITY Vol 12 No 1 (2023): MAJORITY
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Abstract

Used cooking oil contains free radicals and free fatty acids which can cause damage to the coronary artery. Black tea contains flavonoids and theaflavins are antioxidants that can prevent coronary artery damage. This study aims to determine the effect of giving black tea (Camellia sinensis) on the coronary artery histopathology of Wistar white rats induced by used cooking oil. This study used a Post-test Control Group Design pattern using 25 rats which were divided into 5 groups with 28 days of treatment. The group K- was given 2 ml distilled water. The group K+ was given used cooking oil 1,5 ml/day. The group P1 was given used cooking oil of 1,5 ml/day and black tea 15 mg/day. The group P2 was given used cooking oil of 1,5 ml/day and black tea 30 mg/day. The group P3 was given used cooking oil 1.5 ml/day and black tea 45 mg/day. Observations were made using a microscope by looking at the circumference of the lumen diameter. The results of the mean coronary artery lumen diameter of the rats at K-=116,21±13,17 μm; K+=69,25±7,74 μm; P1=90,72±9,58 μm; P2=102,89±17,69 μm; and P3=125,06±9,67μm. This study used the one-way ANOVA parametric test (p<0,05) and continued with the post-hoc LSD test (p<0,05). There is an effect of giving black tea (Camellia sinensis) on the coronary artery histopathology of Wistar white rats induced by used cooking oil.
Karakteristik Penderita Adenokarsinoma Paru Di RSUD Dr. H. Abdul Moeloek Lampung Periode Tahun 2014-2019 Trixie Almira; Rizki Hanriko; Ari Wahyuni; Retno Ariza Soeprihatini
MAJORITY Vol 12 No 1 (2023): MAJORITY
Publisher : Majority

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Abstract

Adenonacarcinoma of the lung is the largest type of lung carcinoma. Risk factors of lung adenocarcinoma are include age, gender and smoking history. Lung adenocarcinoma therapy generally consists of chemotherapy and developed targeted therapy, such as targeting genes that activate proliferation such as Epidermal Growth Factor Receptor (EGFR). The research is a descriptive and observational analytic study with a cross sectional approach. The number of samples obtained was 82 samples obtained using the Total Random Sampling technique. Analyze descriptive statistical test results showed that most patients with lung adenocarcinoma were found in the 40-60 years age group (61.0%), the most sex was found in men (64.6%), had a history of smoking (54.9%), some large were diagnosed at stage IV (80.5%), there was no EGFR gene mutation (54.9%), and had survival rate > 1 year diagnosed (62.2%). The results showed a relationship between gender (p value = 0.040), smoking history (p value = 0.002), survival rate (0.012) with EGFR gene mutations. Meanwhile, there was no significant corelation between sex (p value = 0.448) and the EGFR gene mutation. Lung adenocarcinoma is most commonly found in males in the adolescent age group of 40-60 years with a history of smoking, stage IV, no EGFR gene mutation and survival rate >1 year and there is an association between sex, smoking history, survival rate with EGFR gene mutations in patients lung adenocarcinoma.
Co-Authors - Muhartono - Muhartono Ade Yonata Ahmad Syah Putra Alif Fernanda Putra Anggraeni Janar Wulan, Anggraeni Janar Anggun Elidiya Annisa Shafira Pramono ari wahyuni Ari Wahyuni Baehaqi Bella Pratiwi Anzani Betta Kurniawan, Betta Dewi Nur Fiana Dian Isti Angraini Dian Isti Angraini Diana Mayasari Dwi Indria Anggraini Dyah Wulan Sumekar Rengganis Wardani Eca Cania Ety Apriliana Ety Apriliana Exsa Hadibrata Fadly, Ahmad Aulia Fatahillah, Fatahillah Fauziani, Andra Nabila Fauziyyah Nuur Al azizah Fidha Ramayani Gede Ardi Saputra Hadibrata, Exsa Hamidi, Syahrul Hanarisha Putri Azkia Hanna Mutiara Haryani Dwita Haula Rizqiyah Helsa Apty Tamara Hendra Tarigan Sibero Hendri Busman Indri Windarti Intanri Kurniati Jhons Fatriyadi Suwandi Johns Fatriyadi Suwandi Khairun Nisa KHAIRUNNISA SALSABILA Liana Sidharti Lukman Pura M. Ricky Ramadhian M. Ridho Ulya M. Yusran Meriska Cesia Putri Mohamad Reihansyah Deswindra Muhammad Iz Zuddin Adha Muhartono Muhartono Muhartono Muhartono Muhartono Muhartono Muhartono Muhartono Mukhlis Imanto, Mukhlis Nabil Abdurrahman Nailul Azizah Naufal Rasyid Aswan Naufal Rasyid Aswan Neza Ukhalima Hafia Sudrajat Nisa Karima Nora Ramkita Nurul Islamy Okki Muhammad Fajar Muthahhari Oktadoni Saputra, Oktadoni Oktafany, Oktafany Pairulsyah Pairulsyah Panca Bayu Prabowo, Arif Yudho Putu Devie Sri Astari Rahmayani, Fidha Ramadhan Triyandi Rani Himayani Ratna Dewi PS Ratna Dewi Puspita Sari Retno Ariza Soeprihatini Rinaldy, Dino Risal Wintoko Risal Wintoko Riska Wulandari Riyan Wahyudo Rodiani Rodiani, Rodiani Roro Rukmi Windi Perdani, Roro Rukmi Rudiyanto, Waluyo Septiani, Linda Sezia Marina Siti Raqiya Rasyid Sri Janahtul Hayati Suharmanto Suharyani Sulinawati Sulinawati Suryadi Islami Susianti Susianti Susianti Susianti, Susianti Syahrul Hamidi Nasution Tarrinni Inastyarikusuma Tasya Khalis Ilmiani Tri Umiana Soleha Tri Umiana Soleha Trixie Almira Uliana Nur Melin Veny Anisya Waluyo Rudiyanto Widya Pebryanti Manurung Wulan, Anggraini Janar Yovani Rehuel Br Sitepu