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Journal : Juke

Efek Protektif Madu Terhadap Ginjal Tikus Putih Yang Diinduksi Etanol - Muhartono; Rizki Hanriko; Haryani Dwita
JUKE Unila Vol 2, No 1 (2012)
Publisher : Fakultas Kedokteran Universitas Lampung

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Abstract

Honey  already used as natural food sources since long time ago.  Honey has been shown contained active chemical compounds that are antioxidants, yet there is still only a few experimental studies about the protective effect of honey against ethanol-induced renal damage. This study aims to prove the protective effect of honey against renal damage and determine the relationship of increasing doses of honey against renal damage in male rat (Rattus norvegicus). Research subjects were used 25 Sprageu dawley strain male rat.  Rat weredivided into 5 groups that was negative control were given only distilled, positif control (only given ethanol 0,01 ml/gBW/day), treatment group I (given honey 0,0018 ml/gBW/day dan ethanol 0,01 ml/gBW/day), treatment group II (given honey 0,0054 ml/gBW/day dan ethanol 0,01 ml/gBW/day), treatment group III (given honey 0,0162 ml/gBW/day dan ethanol 0,01 ml/gBW/day) for 14 days. Based on result of the Kruskal wallis test performed on this data p<0,05, which mean there were protective effect of giving the honey treatment to renal damage male rat.  Mann whitney test result p <0,05, which  means that there were significant differences proximal tubulus on rat almost found between each groups except positif control group with treatment group I and treatment group II with treatment group III. Honey shown to have protective effects against ethanol-induced renal damage of Sprageu dawley strain male rat. Increasing doses of honey can increase the protective effects against the renal damage of Sprageu dawley strain male rat at certain dose, on dose 0,0018 ml/gBW/day and 0,0054 ml/gBW/day
Co-Authors - Muhartono - Muhartono Ade Yonata Ahmad Syah Putra Alif Fernanda Putra Anggraeni Janar Wulan, Anggraeni Janar Anggun Elidiya Annisa Shafira Pramono ari wahyuni Ari Wahyuni Baehaqi Bella Pratiwi Anzani Betta Kurniawan, Betta Dewi Nur Fiana Dian Isti Angraini Dian Isti Angraini Diana Mayasari Dwi Indria Anggraini Dyah Wulan Sumekar Rengganis Wardani Eca Cania Ety Apriliana Ety Apriliana Exsa Hadibrata Fadly, Ahmad Aulia Fatahillah, Fatahillah Fauziani, Andra Nabila Fauziyyah Nuur Al azizah Fidha Ramayani Gede Ardi Saputra Hadibrata, Exsa Hamidi, Syahrul Hanarisha Putri Azkia Hanna Mutiara Haryani Dwita Haula Rizqiyah Helsa Apty Tamara Hendra Tarigan Sibero Hendri Busman Indri Windarti Intanri Kurniati Jhons Fatriyadi Suwandi Johns Fatriyadi Suwandi Khairun Nisa KHAIRUNNISA SALSABILA Liana Sidharti Lukman Pura M. Ricky Ramadhian M. Ridho Ulya M. Yusran Meriska Cesia Putri Mohamad Reihansyah Deswindra Muhammad Iz Zuddin Adha Muhartono Muhartono Muhartono Muhartono Muhartono Muhartono Muhartono Muhartono Mukhlis Imanto, Mukhlis Nabil Abdurrahman Nailul Azizah Naufal Rasyid Aswan Naufal Rasyid Aswan Neza Ukhalima Hafia Sudrajat Nisa Karima Nora Ramkita Nurul Islamy Okki Muhammad Fajar Muthahhari Oktadoni Saputra, Oktadoni Oktafany, Oktafany Pairulsyah Pairulsyah Panca Bayu Prabowo, Arif Yudho Putu Devie Sri Astari Rahmayani, Fidha Ramadhan Triyandi Rani Himayani Ratna Dewi PS Ratna Dewi Puspita Sari Retno Ariza Soeprihatini Rinaldy, Dino Risal Wintoko Risal Wintoko Riska Wulandari Riyan Wahyudo Rodiani Rodiani, Rodiani Roro Rukmi Windi Perdani, Roro Rukmi Rudiyanto, Waluyo Septiani, Linda Sezia Marina Siti Raqiya Rasyid Sri Janahtul Hayati Suharmanto Suharyani Sulinawati Sulinawati Suryadi Islami Susianti Susianti Susianti Susianti, Susianti Syahrul Hamidi Nasution Tarrinni Inastyarikusuma Tasya Khalis Ilmiani Tri Umiana Soleha Tri Umiana Soleha Trixie Almira Uliana Nur Melin Veny Anisya Waluyo Rudiyanto Widya Pebryanti Manurung Wulan, Anggraini Janar Yovani Rehuel Br Sitepu