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All Journal Majalah Kedokteran Bandung Medula Juke Jurnal Kesehatan JURNAL ILMIAH KESEHATAN SANDI HUSADA Bioscientia Medicina : Journal of Biomedicine and Translational Research JURNAL PENELITIAN PERAWAT PROFESIONAL JK Unila (Jurnal Kedokteran Universitas Lampung) Bioscientia Medicina : Journal of Biomedicine and Translational Research Indonesian Journal of Nursing and Health Sciences (IJNHS) Majority Jurnal Ilmiah Kesehatan Sandi Husada JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia JPM (Jurnal Pengabdian Masyarakat) Ruwa Jurai Jurnal Agromedicine Unila: Jurnal Kesehatan dan Agromedicine
Rizki Hanriko
Universitas Lampung
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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Journal : Medula

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PENGARUH EKSTRAK BAWANG PUTIH (Alium sativum) TERHADAP GAMBARAN HISTOPATOLOGI HEPAR PADA TIKUS PUTIH (Rattus norvegicus) GALUR Sprague- dawley YANG DIINDUKSI STREPTOZOTOCIN Fadly, Ahmad Aulia; Windarti, Indri; Hanriko, Rizki
Medula Vol 14 No 6 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i6.1154

Abstract

Diabetes Mellitus (DM) is a chronic disease characterized by blood sugar levels that exceed normal limits. Chronic DM can cause liver complications in the form of inflammation. Streptozotocin can induce mice to become a DM model and can also directly damage the liver. Garlic (Allium sativum) is a tuber that is often found in Indonesia. The various compounds contained in it have anti-diabetic and antioxidant effects which have the potential to prevent inflammation in the liver. This research was conducted to determine the effect of garlic extract (Allium sativum) on histopathological features in the form of lymphocyte cell infiltration in the portal and lobular tracts of the liver in white rats (Rattus norvegicus) of the Sprague-dawley strain induced by streptozotocin. The method used was a randomized controlled design with a pre-clinical Post-test Only Control Group Design pattern. This study used 24 mice divided into 4 groups with 6 mice in each group. The appearance of lymphocyte cell infiltration will be assessed based on the Omenetti scoring. The mean scores for lymphocyte cell infiltration in the portal tract obtained were KN=0.22, K+=2.10, P1=0.60, and P2=0.56. From the analysis using the One-Way ANOVA test followed by the Post Hoc Benferroni test, the results showed a significant difference in scores between K+ and P1 and P2. Meanwhile, the mean scores for lymphocyte cell infiltration in the lobular area obtained were KN=0.50, K+=1.16, P1=0.50, and P2=0.33. From the analysis using the Kruskal-Wallis test, no significant differences in scores were found between all groups. There was an effect of garlic extract (Allium sativum) on the infiltration of lymphocyte cells in the portal tract and no effect was found on the lobular area of ​​the liver in white rats (Rattus norvegicus) of the Sprague-dawley strain which were induced by streptozotocin.
Peran Shunt Ventrikuloperitoneal dalam Strategi Pengobatan Hidrosefalus Pada Anak : Literature Review Sari, Indah Purnama; Roro Rukmi Windi Perdani; Diana Mayasari; Intanri Kurniati; Fidha Ramayani; Rizki Hanriko; Dewi Nur Fiana
Medula Vol 14 No 10 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i10.1357

Abstract

Hydrocephalus is a condition characterized by the accumulation of cerebrospinal fluid (CSF) within the brain's ventricles, presents a significant challenge in pediatric care. The increased intracranial pressure resulting from this CSF buildup can lead to severe neurological damage if left untreated. Ventricular peritoneal shunt (VP shunt) surgery remains a primary surgical intervention aimed at diverting excess CSF, thereby reducing intracranial pressure and mitigating the risk of irreversible neurological damage. This literature review provides a comprehensive review of the role of VP shunts in the management of pediatric hydrocephalus, encompassing a detailed examination of indications and contraindications for shunt placement, various surgical techniques employed, and the effective management of common post-operative complications such as infection, shunt malfunction (obstruction or overdrainage), and hemorrhage. We meticulously analyze current literature data to assess the effectiveness of VP shunts in improving neurological outcomes, fostering cognitive development, and enhancing the overall quality of life for children affected by hydrocephalus. The analysis will incorporate a review of long-term followup studies to evaluate the durability and efficacy of different shunt types and materials. Case studies and clinical experiences are integrated to provide a nuanced understanding of current clinical practices and to highlight the complexities often encountered in managing this condition. Furthermore, this literature review delves into recent advancements in shunt technology, including the development of programmable valves and less invasive surgical approaches. It also addresses the persistent challenges in optimizing hydrocephalus care, emphasizing the crucial need for a multidisciplinary approach involving neurosurgeons, pediatric neurologists, developmental pediatricians, and other healthcare professionals to ensure holistic and individualized patient care. The ultimate goal is to provide practical, evidence-based guidance for healthcare professionals in the effective and safe management of pediatric hydrocephalus using VP shunts, ultimately improving patient outcomes and quality of life.
Co-Authors - Muhartono - Muhartono Ade Yonata Ahmad Syah Putra Alif Fernanda Putra Anggraeni Janar Wulan, Anggraeni Janar Anggun Elidiya Annisa Shafira Pramono ari wahyuni Ari Wahyuni Baehaqi Bella Pratiwi Anzani Betta Kurniawan, Betta Dewi Nur Fiana Dian Isti Angraini Dian Isti Angraini Diana Mayasari Dwi Indria Anggraini Dyah Wulan Sumekar Rengganis Wardani Eca Cania Ety Apriliana Ety Apriliana Exsa Hadibrata Fadly, Ahmad Aulia Fatahillah, Fatahillah Fauziani, Andra Nabila Fauziyyah Nuur Al azizah Fidha Ramayani Gede Ardi Saputra Hadibrata, Exsa Hamidi, Syahrul Hanarisha Putri Azkia Hanna Mutiara Haryani Dwita Haula Rizqiyah Helsa Apty Tamara Hendra Tarigan Sibero Hendri Busman Indri Windarti Intanri Kurniati Jhons Fatriyadi Suwandi Johns Fatriyadi Suwandi Khairun Nisa KHAIRUNNISA SALSABILA Liana Sidharti Lukman Pura M. Ricky Ramadhian M. Ridho Ulya M. Yusran Meriska Cesia Putri Mohamad Reihansyah Deswindra Muhammad Iz Zuddin Adha Muhartono Muhartono Muhartono Muhartono Muhartono Muhartono Muhartono Muhartono Mukhlis Imanto, Mukhlis Nabil Abdurrahman Nailul Azizah Naufal Rasyid Aswan Naufal Rasyid Aswan Neza Ukhalima Hafia Sudrajat Nisa Karima Nora Ramkita Nurul Islamy Okki Muhammad Fajar Muthahhari Oktadoni Saputra, Oktadoni Oktafany, Oktafany Pairulsyah Pairulsyah Panca Bayu Prabowo, Arif Yudho Putu Devie Sri Astari Rahmayani, Fidha Ramadhan Triyandi Rani Himayani Ratna Dewi PS Ratna Dewi Puspita Sari Retno Ariza Soeprihatini Rinaldy, Dino Risal Wintoko Risal Wintoko Riska Wulandari Riyan Wahyudo Rodiani Rodiani, Rodiani Roro Rukmi Windi Perdani, Roro Rukmi Rudiyanto, Waluyo Septiani, Linda Sezia Marina Siti Raqiya Rasyid Sri Janahtul Hayati Suharmanto Suharyani Sulinawati Sulinawati Suryadi Islami Susianti Susianti Susianti Susianti, Susianti Syahrul Hamidi Nasution Tarrinni Inastyarikusuma Tasya Khalis Ilmiani Tri Umiana Soleha Tri Umiana Soleha Trixie Almira Uliana Nur Melin Veny Anisya Waluyo Rudiyanto Widya Pebryanti Manurung Wulan, Anggraini Janar Yovani Rehuel Br Sitepu