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All Journal HAYATI Journal of Biosciences Jurnal Teknologi Dan Industri Pangan Jurnal Farmasi Udayana Media Komunikasi FPIPS Majalah Kedokteran Bandung Journal of Mathematical and Fundamental Sciences Indonesian Journal of Pharmaceutical Science and Technology JURNAL PENDIDIKAN KEPERAWATAN INDONESIA MPI (Media Pharmaceutica Indonesiana) INDONESIAN JOURNAL OF PHARMACY Acta Pharmaceutica Indonesia Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) JURNAL PENDIDIKAN JASMANI DAN OLAHRAGA Jurnal Keperawatan Padjadjaran JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) JSKK (Jurnal Sains Keolahragaan dan Kesehatan) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal SPORTIF : Jurnal Penelitian Pembelajaran JURNAL FARMASI GALENIKA Jurnal Kesehatan Bakti Tunas Husada Borneo Journal of Pharmacy Kartika : Jurnal Ilmiah Farmasi Journal of Tropical Pharmacy and Chemistry Jurnal Farmasi Galenika
I Ketut Adnyana
Institut Teknologi Bandung
Agriculture, Biological Sciences & Forestry Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences

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Journal : Indonesian Journal of Pharmaceutical Science and Technology

 1 
In Vitro And in Vivo Antidiabetic Activity of Ethanol Extract and Fractions of Hibiscus surattensis L Leaves Yuliet, Yuliet; Sukandar, Elin Yulinah; Adnyana, I Ketut
Indonesian Journal of Pharmaceutical Science and Technology Suppl 1, No. 1 (2018)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (384.099 KB) | DOI: 10.15416/ijpst.v1i1.16120

Abstract

Hisbiscus surattensis L the local name “tamoenju” is utilized by ethnic Sumari (Central Sulawesi) as an antidiabetic herbal, but de nitive studies on ef cacy and safety are lacking. Therefore, this study was aimed to investigate the antidiabetic activity of ethanolic extract of the leaves and fractions using in vitro and in vivo models. Ethanol extract (EE) of the leaves of H. surattensis L was prepared by maceration. The ethanol extract was separated into three fractions by liquid/liquid extractions to yield n-hexane (HF), ethyl acetate (EAF) and water fraction (WF). Firstly, the extract and fractions were tested for its inhibitory activity on α-glucosidase in vitro. The results showed IC50 EE, HF and WF more than 5000 ppm while the IC50 fraction of EAF 3888.34 ppm. Then, oral glucose tolerance test (OGTT) of the extract/fractions were carried out in normal mice. On OGTT, the ethanol extract, EAF, and WF at doses of 150 and 300 mg/kg BW were able to inhibit increasing the level of glucose in the blood. The results showed that the extract and fraction of H. surattensis L leaves in vitro had no effect as α-glucosidase inhibitor but in vivo had the hypoglycemic effect especially on the fraction of ethyl acetate and the water fraction. Key words: α-glucosidase, antidiabetic, Hibiscus suratttensis, glucose tolerance.
In Vitro And in Vivo Antidiabetic Activity of Ethanol Extract and Fractions of Hibiscus surattensis L Leaves Yuliet Yuliet; Elin Yulinah Sukandar; I Ketut Adnyana
Indonesian Journal of Pharmaceutical Science and Technology Suppl 1, No. 1 (2018)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (384.099 KB) | DOI: 10.24198/ijpst.v1i1.16120

Abstract

Hisbiscus surattensis L the local name “tamoenju” is utilized by ethnic Sumari (Central Sulawesi) as an antidiabetic herbal, but de nitive studies on ef cacy and safety are lacking. Therefore, this study was aimed to investigate the antidiabetic activity of ethanolic extract of the leaves and fractions using in vitro and in vivo models. Ethanol extract (EE) of the leaves of H. surattensis L was prepared by maceration. The ethanol extract was separated into three fractions by liquid/liquid extractions to yield n-hexane (HF), ethyl acetate (EAF) and water fraction (WF). Firstly, the extract and fractions were tested for its inhibitory activity on α-glucosidase in vitro. The results showed IC50 EE, HF and WF more than 5000 ppm while the IC50 fraction of EAF 3888.34 ppm. Then, oral glucose tolerance test (OGTT) of the extract/fractions were carried out in normal mice. On OGTT, the ethanol extract, EAF, and WF at doses of 150 and 300 mg/kg BW were able to inhibit increasing the level of glucose in the blood. The results showed that the extract and fraction of H. surattensis L leaves in vitro had no effect as α-glucosidase inhibitor but in vivo had the hypoglycemic effect especially on the fraction of ethyl acetate and the water fraction. Key words: α-glucosidase, antidiabetic, Hibiscus suratttensis, glucose tolerance.
Co-Authors - Liandhajani - Sukrasno . Patonah Afifa, Alia Tri Afifa, Alia Tri Agung Dwi Juniarsyah Agung Dwi Juniarsyah Alia Tri Afifa Ame Suciati Setiawan Andayani, Desak Gede Sri Andreanus A. Soemardji Apriantono, Tommy Armina, Tjokorde Istri Cempaka Kuning Christanti, Yohanna Dadan Resmana Dangin, I Gede Rama Andika Yuda Daryono Hadi Tjahjono Desak Gede Sri Andayani Desak Gede Sri Andayani Dewi Safitri Dewi Safitri DEWI SAFITRI Eka Fitri Susiani Elin Y. Sukandar Elin Yulinah Elin Yulinah Sukandar Elin Yulinah Sukandar Elin Yulinah Sukandar Elin Yulinah Sukandar Elin Yulinah Sukandar Elin Yulinah Sukandar Elin Yulinah Sukandar Elin Yulinah Sukandar Elis Susilawati Elis Susilawati Finna Setiawan Fisheri, Neng Gunawan Pamudji Widodo Gusdinar, Tutus Hannan, Hannan Hasan, Muhamad Fahmi HENI RACHMAWATI Hikmat Permana I Made Agus Gelgel Wirasuta Irda Fidrianny Irianti Bahana Maulida Reyaan Irvani Rakhmawati Iwo, Maria Immaculata Juniarsyah, Agung Dwi Kartasasmita, R. E. Kogilavani Ramasamy Kuning, Cempaka Kusnaedi Kusnaedi Kusnandar Anggadiredja Leni Herliani Afrianti Leonny Yulita Hartiadi Lia Amalia Liandhajani, - Linda Amalia Lisna Anisa Fitriana, Lisna Anisa Maria Immaculata Iwo Mariani, Ria Marlina Indriastuti Mukti Priastomo Nawawi, As’ari Nazhifa Ufamy Neng Fisheri Ni Kadek Warditiani Niken Indriyanti Niken Indriyanti Nisrina Dita Arlinda Nisrina Dita Arlinda, Nisrina Dita Nugrahani, Retta Poety Prawestyi Pratiwi Wikaningtyas Prawestyi, Poety Primal Sudjana Purwanti, Sandra Jati Rahmana Emran Kartasasmita Rahmatullah, Satrio Wibowo Rahmawati, Siti Farah Rakhmawati, Irvani Ramasamy, Kogilavani Ray, Hamidie Ronald Daniel Readi, Septa Reyaan, Irianti Bahana Maulida Rika Hartati Rini Syafriani Rini Syafriani Rizki Mulyawan Rizki Mulyawan Rosmadi, Arief Samsul Bahri Sandi, Dita Ayulia Dwi Sansan Candra Setiawan . Setiawan Setiawan Setiawan, Finna Sigit, Joseph Iskendiarso Slamet Ibrahim Soemardji, Andreanus A. Sukandar, Elin Yulinah Sukandar, Elin Yulinah Sukandar, Elin Yulinah Sukandar, Ukan Sukrasno Sukrasno Sukrasno Sukrasno Sukrasno, Sukrasno Susiani, Eka Fitri Susilawati, Elis Suwendar Suwendar Tommy Apriantono Tutus Gusdinar Kartawinata Ufamy, Nazhifa Ukan Sukandar Ukan Sukandar Wikaningtyas, Pratiwi Wirasutisna, Komar Ruslan Wiyasa, Komang Ngurah Yani Mulyani Yani Mulyani Yedy Purwandi Sukmawan Yohanna Christanti Yuliet Yuliet Yuniarto, Ari Zazuli, Zulfan Zulfan Zazuli