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All Journal HAYATI Journal of Biosciences Jurnal Teknologi Dan Industri Pangan Jurnal Farmasi Udayana Media Komunikasi FPIPS Majalah Kedokteran Bandung Journal of Mathematical and Fundamental Sciences Indonesian Journal of Pharmaceutical Science and Technology JURNAL PENDIDIKAN KEPERAWATAN INDONESIA MPI (Media Pharmaceutica Indonesiana) INDONESIAN JOURNAL OF PHARMACY Acta Pharmaceutica Indonesia Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) JURNAL PENDIDIKAN JASMANI DAN OLAHRAGA Jurnal Keperawatan Padjadjaran JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Indonesian Journal of Rheumatology JSKK (Jurnal Sains Keolahragaan dan Kesehatan) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Ilmu Kefarmasian Indonesia JURNAL FARMASI GALENIKA Jurnal Kesehatan Bakti Tunas Husada Borneo Journal of Pharmacy Kartika : Jurnal Ilmiah Farmasi Journal of Tropical Pharmacy and Chemistry Jurnal Farmasi Galenika Jurnal Analogi Hukum
I Ketut Adnyana
Institut Teknologi Bandung
Agriculture, Biological Sciences & Forestry Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences

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Journal : INDONESIAN JOURNAL OF PHARMACY

 1 
Antibacterial activity of ethanolic extract and fraction of leaves of singawalang (Petiveria alliaceae) against resistant bacteria Mulyani, Yani; Sukandar, Elin Yulinah; Adnyana, I Ketut
INDONESIAN JOURNAL OF PHARMACY Vol 22 No 4, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (436.342 KB) | DOI: 10.14499/indonesianjpharm0iss0pp293-29

Abstract

One  of the plants  that grow  in Indonesia,  and  still does  not  use widely  is singawalang  (Petiveria  alliaceae)  from  Phytolaceae  family.  Traditional   herbal medicine  preparations  contained  of  Petiveria  alliacea  in  the  Caribbean,  Latin America,  West  Africa  and  other  regions  for  hundreds  years  has  been  used  to treat  pain,  colds,  inflammation,  tumor,  bacterial  and  fungal   infection,hyperlipidemia,  diabetes and  other  diseases.  This  study  aims to determine  the antibacterial  activity  of  singawalang  growth  in  Indonesia  against  resistant bacteria  to  antibiotics.  The  minimum  inhibitory  concentration   (MIC)  and minimum  bactericidal  concentration(MBC)  were  determined  by  microdilution broth method and type of antibacterial action were determined by observing the profile of bacterial growth curve. Ethanol extract of dried leaves showed activity against bacteria i.e. MRSA (Methicillin-Resistant Staphylococcus aureus), MRCNS (Methicillin-Resistant  Coagulase-Negative  Staphylococci),  VRE  (VancomycinResistant  Enterococcus).   Further  studies  conducted  by  reviewing  the  type  of work  by  looking  at the  growth curve  and  the observed changes  in cell walls by scanning  electron  microscopy  (SEM)  at  MRCNS  (Methicillin-Resistant Staphylococcus  coagulase-Negative).  The  results  showed  that  ethanol  extracts and  all  fractions  showed  good  antibacterial  activity  against  resistant  bacteria, are  bacteriostatic  hexane  fraction  until  the  concentration  of  8  MIC  and  change the morphology of the cell wall of MRCNS.Key words:Singawalang, Antibacteria, Broth Microdilution, bacterial growth curve, SEM 
HEPATOPROTECTIVE ACTIVITY OF SAPONIN FRACTION OF OYONG SEED FLESH AND ITS COMBINATION AGAINST CCl4-INDUCED CHRONIC LIVER DAMAGE IN MALE WISTAR RAT Rachmawati, Heni; Y. Hartiadi, R. Leonny; Fidrianny, Irda; Adnyana, I Ketut
Indonesian Journal of Pharmacy Vol 24 No 3, 2013
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (940.23 KB) | DOI: 10.14499/indonesianjpharm0iss0pp177-185

Abstract

Saponin fraction of seed flesh of Oyong (Luffaacutangula [L.]Roxb) has been investigated to have a hepatoprotective activity in rats with fibrotic chronic liver damage. This research was conducted to evaluate whether saponin fraction of Oyongseed flesh has a hepatoprotective activity in CCl4-induced acute liver damage. Hepatoprotective activity was determined by measuring the activity of liver enzymes (SGOT, SGPT, LDH), total nitrite/nitrate level, liver index and liver histology. Saponin fraction of Oyong flesh seeds 10mg/kg BW and meniran extract 400mg/kg BW alone showed hepatoprotective activity. Administration of saponin fraction 10mg/kb BB decreased SGPT and LDH significantly over untreated group. Group given meniran extract at dose of 200mg/kg BW showed decreased on LDH, while at dose of 400mg/kg BW decreased SGPT, SGOT, and LDH significantly. Hystological observation revealed any improvement in liver morphology especially after treated with saponin fraction 10mg/kg BWand meniran extract at dose of 400mg/kg BW. However, all groups treated with combination of saponin and meniran did not show improvement both at biochemical parameter and liver histology. In conclusion, saponin extract with dose of 10mg/kg BW and meniran extract at dose of 400mg/kg BW showed hepatoprotector activity. In contrast, combination of both did not show any hepatoprotective effect and it was suspected that they have antagonist effects.Key words:hepatoprotective, CCl4-induced liver fibrosis, Luffaacutangula, Phyllanthusniruri
Synthesis and gastric ulcer protective activity of chlorinated quercetin Gusdinar, Tutus; Herowati, Rina; Kartasasmita, R. E.; Adnyana, I Ketut
Indonesian Journal of Pharmacy Vol 20 No 4, 2009
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (233.755 KB) | DOI: 10.14499/indonesianjpharm0iss0pp163-169

Abstract

Gastrointestinal toxicity due to non-steroid anti-inflammatory drugs can be inhibited by the compounds that have antioxidant activity. Quercetin is a flavonoid that has antioxidant activity and protection effect against gastric ulcer. Chlorination of quercetin enhanced the antioxidant activity. This study aims to obtain the chlorinated derivative of quercetin and examine the protection effect against acetosal-induced gastric ulcer. Chlorination was done by the addition of chlorine at room temperature. Ulcer induction was carried out on rats by oral administration of acetosal. Incidences of gastric ulcer were determined by macroscopic and microscopic observation. Chlorination of quercetin with chlorine gas produced 6-chloroqueretin as major product. The protection effect against acetosal-induced gastric ulcer of this compound was higher than quercetin.Key words : quercetin, chlorination, gastric ulcer, NSAIDs
Anti-inflammatory activity of dominant compound of mahkota dewa fruit Phaleria macrocarpa Scheff. Boerl Mariani, Ria; Wirasutisna, Komar Ruslan; Nawawi, As’ari; Adnyana, I Ketut
Indonesian Journal of Pharmacy Vol 21 No 2, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (183.241 KB) | DOI: 10.14499/indonesianjpharm0iss0pp129-133

Abstract

The anti-inflammatory effectof dominant compound of mahkota dewa fruit (Phaleria macrocarpaScheff. Boerl), a hydroxyl benzophenon glucoside,to Wistar  female  rats  (using  λ-karagenan  as  inflammatory  inducer)  has  been investigated.   The inflammation was measured by pletismometer.  The test has been used physiology NaCl solution as a control andNaproxen at a dose of 22.5 mg/kg body weight as a standard. Anti-inflammatorytest was showed that the decreased  inflammation  of  the  isolate  at  a  dose  of  22.5  mg/kg  body  has  twice lower than the standard.Key words:  Phaleria  macrocarpa,  anti-inflammatory  activity,  hydroxyl  benzophenon glucoside
Co-Authors - Liandhajani - Sukrasno . Patonah A Nawawi Afifa, Alia Tri Afifa, Alia Tri Agung Dwi Juniarsyah Agung Dwi Juniarsyah Alia Tri Afifa Ame Suciati Setiawan Andayani, Desak Gede Sri Andreanus A. Soemardji Andri Reza Rahmadi Apriantono, Tommy Armina, Tjokorde Istri Cempaka Kuning Christanti, Yohanna Dadan Resmana Dangin, I Gede Rama Andika Yuda Daryono Hadi Tjahjono Desak Gede Sri Andayani Desak Gede Sri Andayani Dewi Safitri Dewi Safitri DEWI SAFITRI Dewi, Sumartini Dwi Hadi Setya Palupi Eka Fitri Susiani Elin Y. Sukandar Elin Yulinah Elin Yulinah Sukandar Elin Yulinah Sukandar Elin Yulinah Sukandar Elin Yulinah Sukandar Elin Yulinah Sukandar Elin Yulinah Sukandar Elin Yulinah Sukandar Elin Yulinah Sukandar Elis Susilawati Elis Susilawati Finna Setiawan Fisheri, Neng Gunawan Pamudji Widodo Gusdinar, Tutus Hannan, Hannan Hasan, Muhamad Fahmi HENI RACHMAWATI Hikmat Permana I Gusti Agung Ayu Kartika I Made Agus Gelgel Wirasuta I NYOMAN SUTAMA Irda Fidrianny Irianti Bahana Maulida Reyaan Irvani Rakhmawati Iwo, Maria Immaculata Juniarsyah, Agung Dwi Kartasasmita, R. E. Kogilavani Ramasamy Kuning, Cempaka Kusnaedi Kusnaedi Kusnandar Anggadiredja Leni Herliani Afrianti Leonny Yulita Hartiadi Lia Amalia Liandhajani, - Linda Amalia Lisna Anisa Fitriana, Lisna Anisa Maria Immaculata Iwo Mariani, Ria Marlina Indriastuti Mukti Priastomo Nawawi, As’ari Nazhifa Ufamy Neng Fisheri Ni Kadek Warditiani Niken Indriyanti Niken Indriyanti Nisrina Dita Arlinda Nisrina Dita Arlinda, Nisrina Dita Nugrahani, Retta Poety Prawestyi Pratiwi Wikaningtyas Prawestyi, Poety Primal Sudjana Purwanti, Sandra Jati Rachmat Gunadi Wachjudi Rahmana Emran Kartasasmita Rahmatullah, Satrio Wibowo Rahmawati, Siti Farah Rakhmawati, Irvani Ramasamy, Kogilavani Ray, Hamidie Ronald Daniel Readi, Septa Reyaan, Irianti Bahana Maulida Rika Hartati Rini Syafriani Rini Syafriani Rizki Mulyawan Rizki Mulyawan Rosmadi, Arief Samsul Bahri Sandi, Dita Ayulia Dwi Sansan Candra Setiawan . Setiawan Setiawan Setiawan, Finna Sigit, Joseph Iskendiarso Slamet Ibrahim Soemardji, Andreanus A. Sukandar, Elin Yulinah Sukandar, Elin Yulinah Sukandar, Elin Yulinah Sukandar, Ukan Sukrasno Sukrasno Sukrasno Sukrasno Sukrasno, Sukrasno Suryani Suryani Susiani, Eka Fitri Susilawati, Elis Suwendar Suwendar Tommy Apriantono Tutus Gusdinar Kartawinata Ufamy, Nazhifa Ukan Sukandar Ukan Sukandar Widiati, Ida Ayu Putu Wikaningtyas, Pratiwi Wirasutisna, Komar Ruslan Wiyasa, Komang Ngurah Yani Mulyani Yani Mulyani Yedy Purwandi Sukmawan Yohanna Christanti Yuliet Yuliet Yuniarto, Ari Zazuli, Zulfan Zulfan Zazuli