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Potensi Senyawa Turunan Xanton dari Kulit Buah Manggis (Garcinia mangostana L.) Sebagai Inhibitor Protein Mycobacterium tuberculosis: Studi In Silico Maftucha, Nissa; Manalu, RosarioTrijuliamus; Amelia, Rika; Cordia, Petra; Bupu, Regina
Pharmaceutical Journal of Indonesia Vol. 7 No. 2 (2022)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.pji.2022.007.02.7

Abstract

Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis infection that attacks the lungs. Tuberculosis is a dangerous disease that can cause death. In overcoming it, a safe and effective treatment is needed so that this disease can be cured. The purpose of this study was to determine the potential activity of the active compounds derived from xanthones contained in the mangosteen rind as an inhibitor of Mycobacterium tuberculosis protein with the comparison compound Isoniazid. The active compounds used in this study were α-mangostin, β-mangostin, γ-mangostin, garsinon, gartanin, and 8-deoxygartanin. This research uses the molecular docking method with Yasara, MarvinSketch, PubChem, PDB, and Plants 1.1 software. The results showed that the Gibss energy produced by each test ligand had a difference value, either lower or higher than the native ligand protein of Mycobacterium tuberculosis. Lipinski screening was done to make it easier to determine a molecule or compound based on its permeability and absorption properties. The results showed that gartanin and 8-deoxygartanin complied with Lipinski's rules. Prediction of pharmacokinetic properties and toxicity was carried out using the pkCSM website and can be concluded that gartanin and 8-deoxygartanin compounds have good pharmacokinetic properties and low toxicity.
Co-Authors A, Mohamad Fajar Abdul Gazir Syarifudin Adella, Reghina Afianto, Rizky Agustin, Nemia Ahmad Haromaini Amalia, Salsabila Anggreny, Yecy Annisa , Dea Annisa Rachmawati Anti, Tika Roro Azriyah, Azriyah B.A.P, Silvy Kanawanti Bupu, Regina Chairunnisa, Nadine Zahra Cordia, Petra Elvira Destiansari Fadia, Rahma Fahira, Diana Fauziah, Nita Arini Febiana, Via Guna, Bayu Cakra Habiburrohman, Muhammad Hafizd, Jefik Hakim, Moch. Abdul Malik Hanifah, Dinah Hasanah, Alfi Nur Hasibuan, Ahmad Rusdi Pasya Heris Hendriana Hia, Angel Christin Hidayana, Rizki Apriva Hilma Harmen Hindiarti, Yudita Ingga Karim, Noer M. Abdul Khan, Muhammad Fardeen Khasanah, Siti Zaidatul Kholipah, Nenden Siti Nur Loranty Folia Simanjuntak Maftucha, Nissa Manalu, RosarioTrijuliamus Manuela, Angellyca Leoni Marni, Erna Megantara, Tubagus Robbi Muh. Hasan Marwiji Muhamad Parhan Mulyo, Lukman Widoyo Muzayyin, Muzayyin Nahda, Najwa Nahda Nenden Siti Nurkholipah, Nenden Siti Nisa, Puspita Chairun Nisak, Siti Khoirun Normalia, Nita Noviyanti, Alinda Nur Aeni, Ani Nuraini, Sukaesih Intan Nurherawati, Irma Nurhidayah, Nita Nursanti Anggriani Nuryani Nuryani Oktaviani, Tabitha Pangaribuan, Hawila Sabta Pratama, Hendi Yoga Purnama S, Mei Linda Ratna Indriawati, Ratna Razek, Abdur Riska, Ifroh Naila Risma Amelia, Risma Rosiman, Rosiman Sa'adiyah, Imas Santi, Indriana Laila Saputri, Romadhiyana Kisno Septiani, Atikah Sihombing, Melati Siregar, Waidan Nur Sofyan, Rhisma Al-Vyanie Sri Fajar Br. Aritonang, Paulina Sulistiawati Suminar, Ratna Sunita Dasman Susanti, Fahmi Susy Amizera Syahira , Adella Devany Syahira, Adella Devany Wardani, Wanda Putriana Wiatiningsih, Neni Nuraeni Wibisono, Ian Ainun Widiyawati Widyawati, Inayah Yani’ Qoriati Yuningsih, Siti Hadiaty Yusnita Fitrianna, Aflich Zahira, Tira Al