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All Journal Jurnal Ilmu Kedokteran (Journal of Medical Science) Medical Journal of Indonesia Jurnal Kesehatan Andalas JIMKesmas (Jurnal Ilmiah Mahasiswa Kesehatan Masyarakat) The Indonesian Biomedical Journal The Southeast Asian Journal of Midwifery Jurnal Endurance: Kajian Ilmiah Problema Kesehatan Buletin Ilmiah Nagari Membangun Oto Rhino Laryngologica Indonesiana Majalah Kedokteran Andalas Jurnal Ilmu dan Teknologi Kesehatan Health and Medical Journal Contagion: Scientific Periodical Journal of Public Health and Coastal Health Psychosophia: Journal of Psychology, religion, and humanity Community Development Journal: Jurnal Pengabdian Masyarakat Poltekita: Jurnal Pengabdian Masyarakat Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks JOURNAL LA MEDIHEALTICO Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Jurnal Pengabdian Inovasi dan Teknologi Kepada Masyarakat The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Indonesian Journal of Advanced Research (IJAR) Jurnal Riset Ilmiah Seroja Husada: Jurnal Kesehatan Masyarakat Jurnal Sains, Teknologi dan Kesehatan
Arni Amir
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Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Journal : Majalah Kedokteran Andalas

 1 
Gene Polymorphisms Vitamin D Receptor Against Dengue Infection In Children Ahmad Kurniawan Akbar; Nur Indrawaty Lipoeto; Arni Amir; Finny Fitry Yani
Majalah Kedokteran Andalas Vol 45, No 3 (2022): Online July 2022
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v45.i3.p417-422.2022

Abstract

BACKGROUND: Dengue infection is a vector-born disease associated with endemic areas in the tropics and subtropics. Genetic factors that play a role such as mutations and polymorphisms that influence a person's susceptibility to dengue fever. AIM: This study aims to determine gene polymorphisms of vitamin D against dengue infection in children. MATERIAL AND METHODS: This study was an observational study with a cross-sectional design, where the dependent and independent variables were examined at the same time in pediatric patients who were hospitalized with clinical symptoms of dengue infection at Raden Mattaher Hospital Jambi and Baiturrahim Jambi Hospital who met the inclusion criteria with positive anti-dengue IgM. and or positive anti-dengue IgG in children aged less than two years to eighteen years. RESULT: The results showed that the relationship between patients who have polymorphisms in one of the vitamin D receptor genes will experience heavier dengue infection than those who do not have polymorphisms in the vitamin D receptor gene and this difference is statistically significan (p= 0.005). CONCLUSION: This study concluded that there was a relationship between vitamin D receptor gene polymorphisms and the degree of dengue virus infection. Keywords: Dengue infection in children, Vitamin D receptor gene polymorphisms, vitamin D level
Hubungan Kadar 25-Hidroksivitamin D (25(OH)D) Serum pada Ibu Hamil Trimester III dengan Fetal Outcome Delfina, Delfina; Amir, Arni; Ilmiawati, Cimi
Majalah Kedokteran Andalas Vol 46, No 9 (2024): Supplementary Januari 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i9.p1444-1451.2024

Abstract

Tujuan: Penelitian ini bertujuan untuk mengetahui hubungan kadar 25(OH)D serum pada ibu hamil trimester III dengan fetal outcome. Metode: Penelitian ini merupakan penelitian observasional analitik dengan rancangan cohort terhadap 77 ibu hamil trimester III dan bayi baru lahir, penelitian dilakukan di wilayah kerja Puskesmas Andalas. Pengambilan sampel secara purposive sampling. Pengukuran kadar 25(OH)D serum dilakukan dengan metode ELISA secara dupleks. Data fetal outcome (berat badan, panjang badan, lingkar kepala) didapatkan dari buku Kesehatan Ibu dan Anak. Korelasi antar variabel diuji dengan uji korelasi Pearson atau Spearman. Hasil: Kadar 25(OH)D serum ibu hamil trimester III didapatkan nilai median yaitu 21,10 ng/ml dan 32 ibu hamil yang mengalami defisiensi. Kadar 25(OH)D) serum ibu berkorelasi negatif dengan berat badan bayi lahir (uji Pearson; r=-0,239; p=0,036), namun tidak memiliki korelasi yang bermakna secara statistik dengan panjang badan (uji Spearman; r=-0,106; p=0,360) dan lingkar kepala bayi  (uji Spearman; r=-0,031; p=0,788). Kesimpulan: Disimpulkan bahwa sebagian besar ibu hamil mengalami defisiensi 25(OH)D dan hal ini dapat mempengaruhi fetal outcome.
Time and Concentration-dependent Cytotoxicity of Piperine on Hela Cells Oktavia, Sri; Amir, Arni; Wahyuni, Fatma Sri; Hasmiwati, Hasmiwati
Majalah Kedokteran Andalas Vol. 48 No. 3 (2025): MKA July 2025
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v48.i3.p288-293.2025

Abstract

Piperine, the primary alkaloid of Piper nigrum and Piper longum, is believed to have anticancer properties. Although research on cervical cancer is still in its early stages, piperine's anticancer capabilities have been established in numerous types of cancer and have been shown to target pathways involved in the cell cycle and apoptosis. This study aims to determine how piperine administration time and concentration affect the viability of Hela cells. The MTT method was used to conduct this study. The concentration of piperine utilized was 1,000; 500; 250; 125, and 62.5 µg/mL, and it was administered for 24 and 48 hours. The IC50 values, obtained after incubation for 24 and 48 hours, were 711.21 µg/mL and 419.75 µg/mL, respectively. We may conclude that the viability of HeLa cells is influenced by piperine in a time- and concentration-dependent manner (p<0.05).
Hubungan Kadar 25-Hidroksivitamin D (25(OH)D) Serum pada Ibu Hamil Trimester III dengan Fetal Outcome Delfina, Delfina; Amir, Arni; Ilmiawati, Cimi
Majalah Kedokteran Andalas Vol. 48 No. 2 (2025): MKA April 2025
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v48.i2.p173-180.2025

Abstract

Tujuan: Penelitian ini bertujuan untuk mengetahui hubungan kadar 25(OH)D serum pada ibu hamil trimester III dengan fetal outcome. Metode: Penelitian ini merupakan penelitian observasional analitik dengan rancangan cohort terhadap 77 ibu hamil trimester III dan bayi baru lahir, penelitian dilakukan di wilayah kerja Puskesmas Andalas. Pengambilan sampel secara purposive sampling. Pengukuran kadar 25(OH)D serum dilakukan dengan metode ELISA secara dupleks. Data fetal outcome (berat badan, panjang badan, lingkar kepala) didapatkan dari buku Kesehatan Ibu dan Anak. Korelasi antar variabel diuji dengan uji korelasi Pearson atau Spearman. Hasil: Kadar 25(OH)D serum ibu hamil trimester III didapatkan nilai median yaitu 21,10 ng/ml dan 32 ibu hamil yang mengalami defisiensi. Kadar 25(OH)D) serum ibu berkorelasi negatif dengan berat badan bayi lahir (uji Pearson; r=-0,239; p=0,036), namun tidak memiliki korelasi yang bermakna secara statistik dengan panjang badan (uji Spearman; r=-0,106; p=0,360) dan lingkar kepala bayi  (uji Spearman; r=-0,031; p=0,788). Kesimpulan: Disimpulkan bahwa sebagian besar ibu hamil mengalami defisiensi 25(OH)D dan hal ini dapat mempengaruhi fetal outcome.
Co-Authors - Evitayani Ade Asyari Adeline Sacharissa Firdaus Afdal Afriwardi Afriwardi Ahmad Kurniawan Akbar Aisyah Elliyanti Alfina, Nabila Amri, Siti Salsabilla Andani Eka Putra Andi Friadi Aziza, Zulva Basyir, Vaulinne Berliana Irianti, Berliana Berliani, Hasvia Cimi Ilmiawati, Cimi Daan Khambri Darmayanti Siregar Dedi Afandi Defrin, Defrin Defrin, Defrin Delfina, Delfina Delmi Sulastri Desmawati Desmawati Desmawati Desmawati Desmawati Desmiwarti Desmiwarti Dina Khaira Mizana Dolly Irfandy Elizabeth Bahar Ellyza Nasrul Endrinaldi Ermawati Ermawati Erwani, Erwani Eryati Darwin Eti Yerizel Fadil Oenzil Faradila, Selvy Fatma Sri Wahyuni Fika Tri Anggraini Finny Fitry Yani Firdawati, Firdawati Furqan, Muhammad Afif Gumilar, Erry Hadya Gorga Haifa Wahyu Hamidah, Waldatul Hanum, Fathiya Juwita Hasmiwati Hillbertina, Noza Hudilla Rifa Karmia Humaira, Noni Ibrahim Ibrahim Ihsan, Indra Ilhami, Yose Ramda Indah Wahyuni Insani, Aldina Ayunda Irvandy, Dolly Jamsari Jamsari Joserizal Serudji Karmia, Hudilla Rifa Karmila, Hudila Rifa Kumagai, Hajime Lili Irawati Linosefa Linosefa Lisma Evareny Lismanto, Ferry Maharani, Rifty Zhafira Mardiah, Ainal Masrul Mayetti - Mega Ulfah Meilinda Agus, Meilinda Miftah Irramah Miranie Safaringga Mohammad Tegar Indrayana Muchtar, Masrul Muhammad Reza Mutia Lailani Nelson, Nelvianti Netti Suharti Netty Suharti Ningrat, Rusmana Setia Noni Humaira Novirman Jamarun Nur Indrawaty Lipoeto Nurrizma, Delsy Nuzulia Irawati Oea Khairsyaf Oktavia, Sri Pratama, Weno Putra, Bela Putri Sri Lasmini Putri, Mira Eka Rafika Oktova Rahmadian, Rizki Rahmat Nurul Yuda Putra Rahmatina B Herman Rahmi Junaida Randa Novalino Rani Armalita Rika Susanti Rina Rina Roslaili Rasyid Saptino Miro, Saptino Saputri, Mona Sari, Maharani Permata Sari, Nur Purnama Setiawan, Mentari Adinda Seto, Astari Siti Nurhajjah, Siti Suminta RS, Teresia Syahid MP, Miskah Indah Syahputra, Roni Eka Syawqi, Rahmat Tri Astuti Tri Rahayuningsih Ulya Uti Fasrini Utama, Bobby Indra Vaulinne Basyir Vinda Dwi Apriora Yanti, Farah Sevnell Yanwirasti Yanwirasti Yulia Kurniawati Yuniar Lestari Yusrawati - Yusrawati Yusrawati Yusticia Katar, Yusticia