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All Journal Jurnal Akuntansi & Auditing Indonesia Majalah Kedokteran Bandung e-Journal Pustaka Kesehatan Jurnal Sains dan Teknologi Althea Medical Journal Jurnal Sumberdaya Alam dan Lingkungan Journal of Agromedicine and Medical Sciences Jurnal Pendidikan Biologi Indonesia Biology, Medicine, & Natural Product Chemistry MNJ (Malang Neurology Journal) Al-Jabar : Jurnal Pendidikan Matematika Jurnal Penelitian Politik Medical Laboratory Technology Journal BIOLINK (Jurnal Biologi Lingkungan, Industri, Kesehatan) Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Solidaritas Jurnal Respirasi (JR) Medika Kartika : Jurnal Kedokteran dan Kesehatan Bestuurskunde: Journal of Governmental Studies JKKI : Jurnal Kedokteran dan Kesehatan Indonesia DHeJA Adopsi Teknologi dan Sistem Informasi Jurnal Manajemen Teknologi dan Sistem Informasi JURNAL ILMIAH SAINS TEKNOLOGI DAN INFORMASI Eksekusi: Jurnal Ilmu Hukum dan Administrasi Negara Jurnal Farmasi SYIFA BERBAKTI: Jurnal Pengabdian Kepada Masyarakat Saber: Jurnal Teknik Informatika, Sains dan Ilmu Komunikasi Jurnal Pengabdian Masyarakat dan Riset Pendidikan Jurnal Kesehatan dr. Soebandi Ardhi: Jurnal Pengabdian dalam Negri Pelayanan Unggulan: Jurnal Pengabdian Masyarakat Terapan Inflasi : Jurnal Ekonomi, Manajemen dan Perbankan Jurnal Ekonomi, Manajemen, Akuntansi Journal of Indonesian Social Sciences and Humanities
Rosita Dewi
Fakultas Kedokteran Universitas Jember
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Efek Antiangiogenik Ekstrak Etanol Buah Mahkota Dewa (Phaleria macrocarpa (Scheff.) Boerl.) pada Membran Korio Alantois (CAM) Embrio Ayam Roat Yeti Mustafida; Al Munawir; Rosita Dewi
Pustaka Kesehatan Vol 2 No 1 (2014)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Angiogenesis is the growth of new blood vessels that are used to supply nutrients and oxygen including cancer cells. Phaleria macrocarpa contains tannin, saponin, alkaloid, and flavonoid, known as an antiangiogenesis. This study determined the antiangiogenic effects of ethanolic extract of Phaleria macrocarpa on chorio allantoic membrane of chicken embryos. The antiangiogenesis trials used chorio allantoic membrane of 9 days chicken embryos. There were 5 groups, negative control group [K(-)] and 4 treatment groups (P), each group containing 4 eggs. K(-) group using aquadest and tween 80%; P groups with ethanolic extract of Phaleria macrocarpa at a concentration 10 ug/µL, 40 ug/µL, 80 ug/µL, 160 ug/µL for P1, P2, P3, dan P4 respectively. The number of new blood vessels on chorio allantoic membrane were K(-): (42.5 ± 14.57), P1: (28.25 ± 3.59), P2: (28.5 ± 1.73), P3: (15 ± 4.32), and P4: (6.5 ± 1.73). In conclusion, the ethanolic extract of phaleria macrocarpa has an antiangiogenic effect on chorio allantoic membran by decreasing the number of new blood vessels.Keywords: angiogenesis, Phaleria macrocarpa, ethanolic extract, chorio allantoic membrane
Efek Ekstrak Kulit Mangga Arumanis (Mangifera indica L.) terhadap Paw Licking Time Mencit Putih Jantan yang Diinduksi Formalin (The Effect of Arumanis Mango (Mangifera indica L.) Peel Extract on the Paw Licking Time in White Male Mice Induced by Formalin Rosita Sopwi Nur Lailly; Cicih Komariah; Rosita Dewi
Pustaka Kesehatan Vol 4 No 3 (2016)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Mango is one of the plants which have a lot of benefits in pharmacology. Total phenol in its peel is higher than in its flesh with the main component is mangiferin and quercetin which known have activity to inhibit cyclooxygenase 2 (COX-2) enzyme. The inhibition of COX-2 leads to the decrease of the production of prostaglandin (PgE2) so it can reduce pain which marked by the decrease of paw licking time on mice induced by formalin. Formalin-induced pain is divided into two phase: early phase at 0-5th minutes and late phase at 15-30th minutes. The aim of this research was to know the effect of Arumanis mango peel extract to decrease the paw licking time in white male mice. The research design was true experimental. The result of analyses used One Way Anova shows that there were significant difference in each treatment groups with significance p < 0,05. The LSD analysis on late phase showed no significant difference between the fifth treatment group and the positive control group in LSD test. It can be concluded that arumanis mango peel extract has equal effect with natrium diclofenac in decreasing paw licking time on late phase in dosage 26 mg/g. Keywords: mango peel, paw licking time, flavonoid
Study of Kidney Repair Mechanism of Cassava Leaf Extract on Gentamicin induced Nephrotoxicity Rena Normasari; Rosita Dewi; Sheilla Rachmania
Journal of Agromedicine and Medical Sciences Vol 3 No 1 (2017)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v3i1.4090

Abstract

Drugs consumption like gentamicin caused damage and decreased of kidney function. Cassava leaf contain lots of micronutrients, such as vitamin C, vitamin A and carotenoids, which also as an antioxidant. The results of the study conducted by Almashuri proved that cassava leaf have high levels of carotenoid compounds. The purpose of this study was to determine the effect of cassava leaf extract on the repairment of renal damage in mice in vivo. This research is true experimental using mice (mus musculus) and were grouped into 5 groups. Two control groups (positive and negative) and 3 treatment groups (cassava leaves 150, 300, and 450 mg / day). Gentamicin is given every day for 14 days and then observed on serum levels of creatinine along with histopathological scores of kidneys’ damage. Statistical analysis showed a significant reduction in serum levels of creatinine (P <0.05) and a significant decrease in renal histopathologic score. This study suggests that cassava leaf extract can repair kidney damage as a result gentamicin-induced nephrotoxicity in mice.Keywords: cassava leaf extract, creatinin, kidney histopathology 
Protective Effect of Cassava Leaf Extract on Gentamicin-Induced Hepatotoxity In Mice Rosita Dewi; Rena Normasari
Journal of Agromedicine and Medical Sciences Vol 5 No 3 (2019)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v5i3.13815

Abstract

Abstract Gentamicin usage can cause the damage of liver structure and function. The basic mechanism inducing liver damage from gentamicin is lipid peroxidation in cell membrane and the suppresion of antioxidant defence system in liver. Antioxidant in cassava leaf such as vitamin C, carotene, flavonoid, dan mineral can protect liver from drug toxicity effect. This research aimed to determine hepatoprotective effect of cassava leaf through microscopic observation of liver histopathology slide of mice induced by gentamicin. The research design was post test only control group design. Mice were divided into five groups, normal group, positive control (gentamicin 80 mg/kg b.w.); P1, P2, and P3 (gentamicin 80 mg/kg b.w. and cassava leaf extract 150 mg/kg b.w., 300 mg/kg b.w., 450 mg/kg b.w. respectively, for 14 days). The average score of liver cell damage was determined by microscopic observation of 200 liver cells undergoing parenchymal degeneration, hidrophic degeneration, and necrosis. One Way Anova analysis showed significant difference among the groups (p<0,05) and Post Hoc Tukey HSD test showed that cassava leaf extract at the dose level of 450 mg/kg b.w. resulted significant liver cell characteristic improvement in liver histophatology slide (p<0,05) compared to positive control group. It could be concluded that cassava leaf extract had protective effect on gentamicin-induced hepatotoxicity in mice. Keywords: cassava leaf extract, hepatotoxicity, gentamicin, liver histopathology
EFFECT OF PERIWINKLE (CATHARANTHUS ROSEUS) LEAF EXTRACT ON LIVER HISTOLOGY OF MICE (MUS MUSCULUS L) AFTER ASPARTAME INDUCE Mahriani Mahriani; Rosita Dewi Wulandari; Susantin Fajariyah
BIOLINK (Jurnal Biologi Lingkungan Industri Kesehatan) Vol. 8 No. 2 (2022): February 2022
Publisher : Universitas Medan Area

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31289/biolink.v8i2.5161

Abstract

Aspartame is an artificial sweetener in foods and beverages. Continuous use of aspartame will result in oxidative stress in the liver. So we need antioxidants from outside the body such as periwinkle leaves.This study aims to determine the effect of periwinkle leaves (Catharanthus roseus L) on aspartame-induced liver histology. This study used 24 male mice divided into 4 groups, namely negative control (K-) without treatment; Positive control (K +) treatment of aspartame; D1: treatment of aspartame and periwinkle extract doses of 0.42 mg/kg. D2: aspartame and periwinkle  extract doses of 0.84 mg/kgbb. Administration of aspartame dose of 0.2 mg /kgbb by intraperitoneal  for 14 days followed by gavage administration of periwinkle leaf extract for 12 days. The liver was taken on the 27th day by surgery, then made slide histology with Hematoxylin-Eosin staining. The results show that the administration of Catharanthus roseus leaf extract at a dose of 0.84 mg/kgbw in aspartame-induced mice was effective in reducing hepatocyte damage, namely hydrophilic degeneration and necrosis.
Increased of Spleen White Pulp Diameter Post Dbl2β-Pfemp1 Recombinant Protein Injection in Wistar Rats: Pre-Clinical Study for Malaria Vaccine Development Sulistyaningsih, Erma; Sa’diyah, Nindya Audatus; Kusuma, Irawan Fajar; Dewi, Rosita; Rachmania, Sheilla
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 18 No 1 (2024): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jpm.v18i1.7451

Abstract

Malaria is a major infectious disease worldwide, and vaccination is essential for disease control. The Plasmodium falciparum Erythrocyte Membrane Protein-1 (PfEMP1) is a potential malaria vaccine candidate due to its involvement in pathogenesis. Injection of DBL2β-PfEMP1 recombinant protein in animal models induces IgG and CD4+ production and inhibits binding with host endothelial receptors. This study aimed to analyze the spleen immune response by measuring the white pulp diameter. The experimental study used Wistar rats (Rattus norvegicus) that were divided into four groups, a control group and three treatment groups, which were injected with 100, 150, and 200 μg of DBL2β-PfEMP1 protein. Injection was done thrice with three-week intervals (days 0, 21, and 42). On day 56, rats were euthanized, and spleens were prepared for histology examination. The white pulp diameter increased along with increasing the dose of protein. The ANOVA test showed a significant difference between groups (p=0.001). The posthoc Bonferroni test showed a significant difference between the control and the 150 and 200 μg groups and the 100 μg and 200 μg groups. In conclusion, the DBL2β-PfEMP1 recombinant protein injection increased the spleen white pulp diameter in Wistar rats, and the 200 μg dose resulted in the highest increase.
Rancang Bangun Media Pembelajaran Interaktif pada Mata Pelajaran Desain Grafis Fahmi Romisa; Dewi Rosita
JURNAL ILMIAH SAINS TEKNOLOGI DAN INFORMASI Vol. 2 No. 3 (2024): Juli
Publisher : CV. ALIM'SPUBLISHING

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59024/jiti.v2i3.778

Abstract

. Design and Development of Interactive Learning Media in Graphic Design Subjects is a research that aims to develop effective and practical interactive learning media on basic graphic design topics. This research uses the ADDIE development model, which consists of five development stages: analysis, design, development, implementation, and evaluation.At the analysis stage, this research understands the problems found in the use of learning media in graphic design subjects, such as the limited use of print media and the need for more interactive and interesting media. At the design stage, this research develops a learning media design that involves multimedia elements such as text, images, graphics, sound, video, animation and comprehensive simulations. At the development stage, this research develops multimedia-based interactive learning media, which can provide certain forms of interaction that allow users to interact actively with the program. The research results show that the Basic Graphic Design interactive learning media developed is valid from the instructional and display aspects, and is practical and suitable for use for basic graphic design learning. Thus, this research contributes to the development of interactive learning media that is effective and practical in improving the quality of learning in graphic design subjects.
Pengaruh Gaya Kepemimpinan dan Motivasi Kerja terhadap Kinerja Karyawan PT. BPR BKK TASIKMADU (Perseroda) Kantor Cabang Jumantono Kabupaten Karanganyar Rosita Dewi; Winarti Winarti; Damayanti Suhita
Eksekusi : Jurnal Ilmu Hukum dan Administrasi Negara Vol. 2 No. 4 (2024): November : Jurnal Ilmu Hukum dan Administrasi Negara
Publisher : Sekolah Tinggi Ilmu Administrasi (STIA) Yappi Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/eksekusi.v2i4.1513

Abstract

Leadership in an organization is considered a turning point and central in improving employee performance. A leader's approach to directing, motivating, and managing a team can be achieved through leadership style. Moreover, work motivation also becomes a driving factor in enhancing employee performance within an institution or company. PT. BPR BKK TASIKMADU (Perseroda) Jumantono branch has experienced changes in target achievements in each period, which sparked the researcher’s interest in conducting this study. The objective of this research is to determine the influence of leadership style and work motivation variables on employee performance at PT. BPR BKK TASIKMADU (Perseroda) Jumantono branch, Karanganyar Regency. This research uses a quantitative method, utilizing leadership style theory by Kartini Katono, work motivation theory by Abraham Maslow, and employee performance theory by Robbins. The study includes the entire population, which consists of 16 employees of PT. BPR BKK TASIKMADU (Perseroda) Jumantono branch. The data analysis technique used is multiple linear regression. The results show a strong relationship between leadership style and work motivation. Leadership style obtained a t-value of 6.085, while work motivation scored 2.727, indicating that both variables significantly influence employee performance. Leadership style and work motivation simultaneously influence employee performance, with an F-value of 35.143.
Trade-off Anak Adat Status as a High-cost of Political Transaction in Papua Local Elections Dewi, Rosita; Widyatmoko, Bondan
Bestuurskunde: Journal of Governmental Studies Vol 4 No 2 (2024): High Political Costs: Causes and Effects of High Election Costs in Indonesia
Publisher : Ministry of Home Affairs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53013/bestuurskunde.4.2.141-156

Abstract

Currently, the political transaction through trade-off anak adat (customary child) status is wider applied in Papua local election. Benefiting from the direct elections, the elites competed for political power in the regions by mobilizing ethno-religious sentiments and utilizing money-politics. The voters, in return, behave as clients as they seek to gain material benefits from their preferred candidates in exchange for political loyalty. This condition caused the high-cost politics during the local election. Based on this problem, this paper attempts to analyze the hijacking of adat (customs) through trade-off anak adat status as a form of political transaction which impacted to high-cost politics. This study cultivates the theory of political transactions to analyze the political transaction in Papua local election especially in the gubernatorial election 2018 and election of DPRD (Regional Representative Council)’s member in 2019. This form of political transaction has caused the high-cost of local election in Papua, which is not only in the form of money, but also carried the social cultural high-cost impact. Of course, vote buying will make the candidates have to spend a lot of money. The trade-off of anak adat status from other than Papuan through buying and selling mechanism rather than using achievement and acknowledgement from the adat community would harm the Papuans. Moreover, this practice has brought detrimental destruction to the socio-cultural values of Papuan adat community. This study is qualitative research that use political approach to observe the local election processes in Papua. We used the criteria of credibility and confirmability to validate the data in our qualitative research.
Analisis Perilaku Pengguna Sistem Informasi Terpadu Layanan Program Studi (SIPLO) Menggunakan Model Unified Theory Of Acceptance And Use Of Technology (UTAUT) Dewi, Rosita; Widagdo, Putut Pamilih; Setyadi, Hario Jati
Adopsi Teknologi dan Sistem Informasi (ATASI) Vol. 2 No. 2 (2023): Adopsi Teknologi dan Sistem Informasi (ATASI)
Publisher : Mulawarman University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30872/atasi.v2i2.343

Abstract

Suatu penerapan teknologi tentu saja berhubungan dengan penerimaan perilaku pengguna. Penerapan Sistem Informasi Terpadu Layanan Prodi (SIPLO) di Program Studi Sistem Informasi terdapat kendala di dalamnya karena SIPLO merupakan website yang masih tergolong baru. Sehingga dirasa perlu untuk melakukan analisis dengan tujuan guna mengetahui faktor-faktor apa saja yang berpengaruh terhadap perilaku pengguna SIPLO. Responden pada penelitian ini adalah mahasiswa aktif angkatan 2019-2021 yang ada di Program Studi Sistem Informasi. Analisis pengolahan data dibantu dengan menggunakan aplikasi statistik SmartPLS Versi 4.0.8. Hasil penelitian menunjukkan bahwa variabel ekspektasi usaha, ekspektasi kinerja dan kondisi yang memfasilitasi berpengaruh terhadap perilaku pengguna. Variabel moderasi jenis kelamin memengaruhi variabel ekspektasi usaha terhadap perilaku pengguna tetapi moderasi jenis kelamin tidak memengaruhi variabel ekpektasi kinerja terhadap perilaku pengguna SIPLO. Variabel moderasi usia memengaruhi variabel ekspektasi usaha, ekspektasi kinerja, dan kondisi memfasilitasi terhadap perilaku pengguna SIPLO, variabel moderasi pengalaman memengaruhi kondisi memfasilitasi dan variabel ekspektasi usaha terhadap perilaku pengguna SIPLO. Berdasarkan hasil variabel yang digunakan maka dapat meningkatkan perilaku pengguna dalam SIPLO.
Co-Authors Adi Darma Effendi Afrina, Cut Agus R Rahman Agustina, Ani Aini, Nada Qurrota Ajeng Margareta Sari Al Munawir Alif Mardijana Amilin Amilin Andriani, Made Prasanti Angga Mardro Raharjo, Angga Mardro Apriani, Susi Aprilia, Annisa Nadya Aprilya Pratiwi, Nadilla Awani Irewati Azham Purwandhono Aziz, Ayu Munawaroh Bintang, Muhammad Farrel Ravidinata Masoga Bi’izzyk, Avie Baldana Cholis Abrori, Cholis Chrisnaji Banindra Yudha Cicih Komariah CPF. Luhulima Damayanti Suhita Dewantoro, Dicky Dewi Riniarti Dhiah Anis Salsabila Dina Helianti Dini Agustina Dita Diana Parti Dodo Zaenal Abidin Effiyaldi Eko Subastian Elly Nurus Sakinah, Elly Nurus Erfan Efendi Erma Sulistyaningsih Fahmi Romisa Fitriana, Ani Qotuz Zuhro’ Gianevan, Nicholas Jirezra Gilang Vigorous Akbar Eka Candy Hafidin, Muhammad Ananda Faris Hasyim Asy’ari Hayati Nufus Herdhata Agusta Herniyanti Indriana Kartini Irawan Fajar Kusuma Julius Kalangi Kamila, Vina Zahrotun Khoirul Fahri Arrijal Kholifaturrohmah, Sakinatus Sariroh Kholifaturrohmy, Muhammad Rizqi Laily Rahmawati liza Marlia Luthfiyyah, Nur Atikah M. Ali Shodikin Mahriani Mahriani Maria Ulfa Maulana, Aditha Satria Moch. Agus Krisno Budianto Muhammad Noor Kholid Muhammad Zidan Muhtar Ady Kusuma Munawaroh, Ayu Nadaa Avria Hanum Nindya Shinta Rumastika Nurhaliza, Salsabilla Pelita Sari Pralampita, Pulong Wijang Prasetya, Eky Putut Pamilih Widagdo, Putut Pamilih Rahami, Nahla Ahmad Rahma, Nafisah Hani Asyifah Rena Normasari Rini Riyanti Roat Yeti Mustafida Rosita Sopwi Nur Lailly Sanda, Fara Fasah Sandy Nur Ikfal Raharjo Sa’diyah, Nindya Audatus septa surya wahyudi, septa surya Setyadi, Hario Jati Shabrina Shahifa Audy Rahima Sheila Rachmania Sheilla Rachmania, Sheilla Sillehu, Sahrir Siti Zaenab Solihin Sidik Sudradjat Sudradjat Sulistyaningsih , Erma Sumadi Susantin Fajariyah Teuku Salfiyadi Tri Nuke Pudjiastuti Widyatmoko, Bondan WINARTI WINARTI Winarti Winarti Yan Sukmawan, Yan Yuli Hermansyah Yuli Hermansyah, Yuli Yunita Armiyanti Zahniar, Zahniar