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Efek Antiangiogenik Ekstrak Etanol Buah Mahkota Dewa (Phaleria macrocarpa (Scheff.) Boerl.) pada Membran Korio Alantois (CAM) Embrio Ayam Roat Yeti Mustafida; Al Munawir; Rosita Dewi
Pustaka Kesehatan Vol 2 No 1 (2014)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Angiogenesis is the growth of new blood vessels that are used to supply nutrients and oxygen including cancer cells. Phaleria macrocarpa contains tannin, saponin, alkaloid, and flavonoid, known as an antiangiogenesis. This study determined the antiangiogenic effects of ethanolic extract of Phaleria macrocarpa on chorio allantoic membrane of chicken embryos. The antiangiogenesis trials used chorio allantoic membrane of 9 days chicken embryos. There were 5 groups, negative control group [K(-)] and 4 treatment groups (P), each group containing 4 eggs. K(-) group using aquadest and tween 80%; P groups with ethanolic extract of Phaleria macrocarpa at a concentration 10 ug/µL, 40 ug/µL, 80 ug/µL, 160 ug/µL for P1, P2, P3, dan P4 respectively. The number of new blood vessels on chorio allantoic membrane were K(-): (42.5 ± 14.57), P1: (28.25 ± 3.59), P2: (28.5 ± 1.73), P3: (15 ± 4.32), and P4: (6.5 ± 1.73). In conclusion, the ethanolic extract of phaleria macrocarpa has an antiangiogenic effect on chorio allantoic membran by decreasing the number of new blood vessels.Keywords: angiogenesis, Phaleria macrocarpa, ethanolic extract, chorio allantoic membrane
Efek Ekstrak Kulit Mangga Arumanis (Mangifera indica L.) terhadap Paw Licking Time Mencit Putih Jantan yang Diinduksi Formalin (The Effect of Arumanis Mango (Mangifera indica L.) Peel Extract on the Paw Licking Time in White Male Mice Induced by Formalin Rosita Sopwi Nur Lailly; Cicih Komariah; Rosita Dewi
Pustaka Kesehatan Vol 4 No 3 (2016)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Mango is one of the plants which have a lot of benefits in pharmacology. Total phenol in its peel is higher than in its flesh with the main component is mangiferin and quercetin which known have activity to inhibit cyclooxygenase 2 (COX-2) enzyme. The inhibition of COX-2 leads to the decrease of the production of prostaglandin (PgE2) so it can reduce pain which marked by the decrease of paw licking time on mice induced by formalin. Formalin-induced pain is divided into two phase: early phase at 0-5th minutes and late phase at 15-30th minutes. The aim of this research was to know the effect of Arumanis mango peel extract to decrease the paw licking time in white male mice. The research design was true experimental. The result of analyses used One Way Anova shows that there were significant difference in each treatment groups with significance p < 0,05. The LSD analysis on late phase showed no significant difference between the fifth treatment group and the positive control group in LSD test. It can be concluded that arumanis mango peel extract has equal effect with natrium diclofenac in decreasing paw licking time on late phase in dosage 26 mg/g. Keywords: mango peel, paw licking time, flavonoid
Study of Kidney Repair Mechanism of Cassava Leaf Extract on Gentamicin induced Nephrotoxicity Rena Normasari; Rosita Dewi; Sheilla Rachmania
Journal of Agromedicine and Medical Sciences Vol 3 No 1 (2017)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v3i1.4090

Abstract

Drugs consumption like gentamicin caused damage and decreased of kidney function. Cassava leaf contain lots of micronutrients, such as vitamin C, vitamin A and carotenoids, which also as an antioxidant. The results of the study conducted by Almashuri proved that cassava leaf have high levels of carotenoid compounds. The purpose of this study was to determine the effect of cassava leaf extract on the repairment of renal damage in mice in vivo. This research is true experimental using mice (mus musculus) and were grouped into 5 groups. Two control groups (positive and negative) and 3 treatment groups (cassava leaves 150, 300, and 450 mg / day). Gentamicin is given every day for 14 days and then observed on serum levels of creatinine along with histopathological scores of kidneys’ damage. Statistical analysis showed a significant reduction in serum levels of creatinine (P <0.05) and a significant decrease in renal histopathologic score. This study suggests that cassava leaf extract can repair kidney damage as a result gentamicin-induced nephrotoxicity in mice.Keywords: cassava leaf extract, creatinin, kidney histopathology 
Protective Effect of Cassava Leaf Extract on Gentamicin-Induced Hepatotoxity In Mice Rosita Dewi; Rena Normasari
Journal of Agromedicine and Medical Sciences Vol 5 No 3 (2019)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v5i3.13815

Abstract

Abstract Gentamicin usage can cause the damage of liver structure and function. The basic mechanism inducing liver damage from gentamicin is lipid peroxidation in cell membrane and the suppresion of antioxidant defence system in liver. Antioxidant in cassava leaf such as vitamin C, carotene, flavonoid, dan mineral can protect liver from drug toxicity effect. This research aimed to determine hepatoprotective effect of cassava leaf through microscopic observation of liver histopathology slide of mice induced by gentamicin. The research design was post test only control group design. Mice were divided into five groups, normal group, positive control (gentamicin 80 mg/kg b.w.); P1, P2, and P3 (gentamicin 80 mg/kg b.w. and cassava leaf extract 150 mg/kg b.w., 300 mg/kg b.w., 450 mg/kg b.w. respectively, for 14 days). The average score of liver cell damage was determined by microscopic observation of 200 liver cells undergoing parenchymal degeneration, hidrophic degeneration, and necrosis. One Way Anova analysis showed significant difference among the groups (p<0,05) and Post Hoc Tukey HSD test showed that cassava leaf extract at the dose level of 450 mg/kg b.w. resulted significant liver cell characteristic improvement in liver histophatology slide (p<0,05) compared to positive control group. It could be concluded that cassava leaf extract had protective effect on gentamicin-induced hepatotoxicity in mice. Keywords: cassava leaf extract, hepatotoxicity, gentamicin, liver histopathology
EFFECT OF PERIWINKLE (CATHARANTHUS ROSEUS) LEAF EXTRACT ON LIVER HISTOLOGY OF MICE (MUS MUSCULUS L) AFTER ASPARTAME INDUCE Mahriani Mahriani; Rosita Dewi Wulandari; Susantin Fajariyah
BIOLINK (Jurnal Biologi Lingkungan Industri Kesehatan) Vol. 8 No. 2 (2022): February 2022
Publisher : Universitas Medan Area

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31289/biolink.v8i2.5161

Abstract

Aspartame is an artificial sweetener in foods and beverages. Continuous use of aspartame will result in oxidative stress in the liver. So we need antioxidants from outside the body such as periwinkle leaves.This study aims to determine the effect of periwinkle leaves (Catharanthus roseus L) on aspartame-induced liver histology. This study used 24 male mice divided into 4 groups, namely negative control (K-) without treatment; Positive control (K +) treatment of aspartame; D1: treatment of aspartame and periwinkle extract doses of 0.42 mg/kg. D2: aspartame and periwinkle  extract doses of 0.84 mg/kgbb. Administration of aspartame dose of 0.2 mg /kgbb by intraperitoneal  for 14 days followed by gavage administration of periwinkle leaf extract for 12 days. The liver was taken on the 27th day by surgery, then made slide histology with Hematoxylin-Eosin staining. The results show that the administration of Catharanthus roseus leaf extract at a dose of 0.84 mg/kgbw in aspartame-induced mice was effective in reducing hepatocyte damage, namely hydrophilic degeneration and necrosis.
Pengaruh Gaya Kepemimpinan dan Motivasi Kerja terhadap Kinerja Karyawan PT. BPR BKK TASIKMADU (Perseroda) Kantor Cabang Jumantono Kabupaten Karanganyar Rosita Dewi; Winarti Winarti; Damayanti Suhita
Eksekusi : Jurnal Ilmu Hukum dan Administrasi Negara Vol. 2 No. 4 (2024): November : Jurnal Ilmu Hukum dan Administrasi Negara
Publisher : Sekolah Tinggi Ilmu Administrasi (STIA) Yappi Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/eksekusi.v2i4.1513

Abstract

Leadership in an organization is considered a turning point and central in improving employee performance. A leader's approach to directing, motivating, and managing a team can be achieved through leadership style. Moreover, work motivation also becomes a driving factor in enhancing employee performance within an institution or company. PT. BPR BKK TASIKMADU (Perseroda) Jumantono branch has experienced changes in target achievements in each period, which sparked the researcher’s interest in conducting this study. The objective of this research is to determine the influence of leadership style and work motivation variables on employee performance at PT. BPR BKK TASIKMADU (Perseroda) Jumantono branch, Karanganyar Regency. This research uses a quantitative method, utilizing leadership style theory by Kartini Katono, work motivation theory by Abraham Maslow, and employee performance theory by Robbins. The study includes the entire population, which consists of 16 employees of PT. BPR BKK TASIKMADU (Perseroda) Jumantono branch. The data analysis technique used is multiple linear regression. The results show a strong relationship between leadership style and work motivation. Leadership style obtained a t-value of 6.085, while work motivation scored 2.727, indicating that both variables significantly influence employee performance. Leadership style and work motivation simultaneously influence employee performance, with an F-value of 35.143.
Trade-off Anak Adat Status as a High-cost of Political Transaction in Papua Local Elections Dewi, Rosita; Widyatmoko, Bondan
Bestuurskunde: Journal of Governmental Studies Vol 4 No 2 (2024): High Political Costs: Causes and Effects of High Election Costs in Indonesia
Publisher : Ministry of Home Affairs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53013/bestuurskunde.4.2.141-156

Abstract

Currently, the political transaction through trade-off anak adat (customary child) status is wider applied in Papua local election. Benefiting from the direct elections, the elites competed for political power in the regions by mobilizing ethno-religious sentiments and utilizing money-politics. The voters, in return, behave as clients as they seek to gain material benefits from their preferred candidates in exchange for political loyalty. This condition caused the high-cost politics during the local election. Based on this problem, this paper attempts to analyze the hijacking of adat (customs) through trade-off anak adat status as a form of political transaction which impacted to high-cost politics. This study cultivates the theory of political transactions to analyze the political transaction in Papua local election especially in the gubernatorial election 2018 and election of DPRD (Regional Representative Council)’s member in 2019. This form of political transaction has caused the high-cost of local election in Papua, which is not only in the form of money, but also carried the social cultural high-cost impact. Of course, vote buying will make the candidates have to spend a lot of money. The trade-off of anak adat status from other than Papuan through buying and selling mechanism rather than using achievement and acknowledgement from the adat community would harm the Papuans. Moreover, this practice has brought detrimental destruction to the socio-cultural values of Papuan adat community. This study is qualitative research that use political approach to observe the local election processes in Papua. We used the criteria of credibility and confirmability to validate the data in our qualitative research.
Analisis Perilaku Pengguna Sistem Informasi Terpadu Layanan Program Studi (SIPLO) Menggunakan Model Unified Theory Of Acceptance And Use Of Technology (UTAUT) Dewi, Rosita; Widagdo, Putut Pamilih; Setyadi, Hario Jati
Adopsi Teknologi dan Sistem Informasi (ATASI) Vol. 2 No. 2 (2023): Adopsi Teknologi dan Sistem Informasi (ATASI)
Publisher : Mulawarman University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30872/atasi.v2i2.343

Abstract

Suatu penerapan teknologi tentu saja berhubungan dengan penerimaan perilaku pengguna. Penerapan Sistem Informasi Terpadu Layanan Prodi (SIPLO) di Program Studi Sistem Informasi terdapat kendala di dalamnya karena SIPLO merupakan website yang masih tergolong baru. Sehingga dirasa perlu untuk melakukan analisis dengan tujuan guna mengetahui faktor-faktor apa saja yang berpengaruh terhadap perilaku pengguna SIPLO. Responden pada penelitian ini adalah mahasiswa aktif angkatan 2019-2021 yang ada di Program Studi Sistem Informasi. Analisis pengolahan data dibantu dengan menggunakan aplikasi statistik SmartPLS Versi 4.0.8. Hasil penelitian menunjukkan bahwa variabel ekspektasi usaha, ekspektasi kinerja dan kondisi yang memfasilitasi berpengaruh terhadap perilaku pengguna. Variabel moderasi jenis kelamin memengaruhi variabel ekspektasi usaha terhadap perilaku pengguna tetapi moderasi jenis kelamin tidak memengaruhi variabel ekpektasi kinerja terhadap perilaku pengguna SIPLO. Variabel moderasi usia memengaruhi variabel ekspektasi usaha, ekspektasi kinerja, dan kondisi memfasilitasi terhadap perilaku pengguna SIPLO, variabel moderasi pengalaman memengaruhi kondisi memfasilitasi dan variabel ekspektasi usaha terhadap perilaku pengguna SIPLO. Berdasarkan hasil variabel yang digunakan maka dapat meningkatkan perilaku pengguna dalam SIPLO.
Analisis Perilaku Desainer dalam Memanfaatkan Software Figma untuk Mendesain Herniyanti; Hafidin, Muhammad Ananda Faris; Prasetya, Eky; Shabrina; Dewi, Rosita; Kamila, Vina Zahrotun
Adopsi Teknologi dan Sistem Informasi (ATASI) Vol. 1 No. 2 (2022): Adopsi Teknologi dan Sistem Informasi (ATASI)
Publisher : Mulawarman University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30872/atasi.v1i2.374

Abstract

Sebuah pekerjaan dapat dilakukan dalam berbagai macam bentuk. Bahkan terkadang sebuah pekerjaan dapat diperoleh hanya dengan bermodalkan suatu situs atau platform intenet saja. Figma merupakan editor grafis vektor dan alat prototyping dengan berbasis web serta fitur offline tambahan yang diaktifkan oleh aplikasi desktop untuk Mac OS dan Windows. Adapun tujuan dari penelitian ini ialah untuk mengetahui apa saja faktor-faktor penerimaan penggunaan Figma dalam memenuhi kebutuhan pengggunanya dan untuk mengetahui perilaku desainer dalam menggunakan Figma. Berdasarkan hasil penelitian yang dilakukan dapat ditarik kesimpulan dari penelitian ini mengenai pengaruh kinerja individu dalam menggunakan software Figma dalam bidang desain yaitu hasil penelitian ini memberikan bukti empiris terdapat pengaruh pelajar dan pekerja terhadap kinerja individu dalam bidang desain menggunakan software Figma.
Teknologi Informasi dan Komunikasi (TIK) dalam Pembelajaran di Sekolah Dasar Ulfa, Maria; Yudha, Chrisnaji Banindra; Dewi, Rosita; Apriani, Susi; Nurhaliza, Salsabilla
BERBAKTI : Jurnal Pengabdian Kepada Masyarakat Vol 1 No 3 (2024): BERBAKTI: Jurnal Pengabdian Kepada Masyarakat | January 2024
Publisher : Fakultas Keguruan dan Ilmu Pendidikan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30822/berbakti.v1i3.2857

Abstract

Learning in the 21st century must be ICT-based. Professional elementary school teachers in the 21st century are teachers who can facilitate student learning. PGSD Study Program, STKIP Kusuma Negara through MK KKL held a national webinar with the theme Creative and Innovative Elementary School Teachers through ICT Implementation. This webinar was held online via the zoom meeting application and was attended by 287 participants, consisting of elementary school teachers, educational practitioners, and students (STKIP Kusuma Negara and the general public). The aim of this training is to equip elementary school teachers to be creative and innovative through the implementation of ICT. The stages of implementing the national webinar go through three stages, namely planning, implementation and evaluation. The national webinar material is Creative and Innovative Teachers Through Digital-Based Implementation and Innovative I-Teaching Teaching and Digital Tools. Schools are places to facilitate teachers in implementing ICT in the learning process to make learning creative and innovative. However, in reality in the field only students are able to use ICT tools. So that ICT-based learning does not become two-way. As a result, teachers are increasingly distant from ICT. Teachers must be able to implement ICT to create e-teaching and e-learning based learning.
Co-Authors Adi Darma Effendi Afrina, Cut Agus R Rahman Agustina, Ani Aini, Nada Qurrota Ajeng Margareta Sari Al Munawir Alif Mardijana Amilin Amilin Angga Mardro Raharjo, Angga Mardro Apriani, Susi Aprilia, Annisa Nadya Aprilya Pratiwi, Nadilla Awani Irewati Azham Purwandhono Aziz, Ayu Munawaroh Bi’izzyk, Avie Baldana Brahmantya Putra, Denny Christian Cholis Abrori, Cholis Chrisnaji Banindra Yudha Cicih Komariah CPF. Luhulima Damayanti Suhita Dessy Agustina Sari Dewantoro, Dicky Dewi Riniarti Dhiah Anis Salsabila Dina Helianti Dini Agustina Dita Diana Parti Dodo Zaenal Abidin Effiyaldi Eko Subastian Elly Nurus Sakinah, Elly Nurus Erma Sulistyaningsih Erma Sulistyaningsih Gianevan, Nicholas Jirezra Gilang Vigorous Akbar Eka Candy Hafidin, Muhammad Ananda Faris Hakiim, Azafilmi Hasyim Asy’ari Hayati Nufus Herdhata Agusta Herniyanti Indriana Kartini Irawan Fajar Kusuma Irawan, Riyant Julius Kalangi Kamila, Vina Zahrotun Khoirul Fahri Arrijal Laily Rahmawati liza Marlia Luthfiyyah, Nur Atikah M. Ali Shodikin Mahriani Mahriani Maria Ulfa Maulana, Aditha Satria Moch. Agus Krisno Budianto Muhammad Noor Kholid Muhammad Zidan Muhtar Ady Kusuma Nadaa Avria Hanum Nafisa, Tsabita Nindya Audatus Sa’diyah Nindya Shinta Rumastika Nurhaliza, Salsabilla Pelita Sari Pralampita, Pulong Wijang Prasetya, Eky Putut Pamilih Widagdo, Putut Pamilih Rahami, Nahla Ahmad Rahma, Nafisah Hani Asyifah Rena Normasari Rini Riyanti Roat Yeti Mustafida Rosita Sopwi Nur Lailly Sahrir Sillehu Sandy Nur Ikfal Raharjo septa surya wahyudi, septa surya Setyadi, Hario Jati Shabrina Shahifa Audy Rahima Sheila Rachmania Sheilla Rachmania, Sheilla Siti Zaenab Solihin Sidik Sudradjat Sudradjat Sulistyaningsih , Erma Sumadi Susantin Fajariyah Teuku Salfiyadi Tri Nuke Pudjiastuti Widyatmoko, Bondan WINARTI WINARTI Winarti Winarti Yan Sukmawan, Yan Yuli Hermansyah Yuli Hermansyah, Yuli Yunita Armiyanti Zahniar, Zahniar