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All Journal Jurnal Natur Indonesia Jurnal Perikanan dan Kelautan Jurnal Sains Dasar Jurnal Ilmu Perairan (Aquatic Science) JURNAL PETERNAKAN Jurnal Riset Kimia Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Biology, Medicine, & Natural Product Chemistry Medical Laboratory Technology Journal ALCHEMY Jurnal Penelitian Kimia Jurnal Penelitian Farmasi Indonesia JOPS (Journal Of Pharmacy and Science) JURNAL PHOTON JFL : Jurnal Farmasi Lampung Jurnal Ilmu Kefarmasian Indonesia Jurnal Dunia Farmasi Asian Journal of Aquatic Sciences Acta Chimica Asiana Jurnal Insan Farmasi Indonesia Medical Sains : Jurnal Ilmiah Kefarmasian SITAWA : Jurnal Farmasi Sains dan Obat Tradisional Journal of Artificial Intelligence and Digital Business Jurnal Katalisator Jurnal Farmasi Indonesia Jurnal Pengabdian Masyarakat Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Perikanan dan Kelautan Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Musyirna Rahmah Nst
Sekolah Tinggi Ilmu Farmasi Riau
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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THE ROLE OF THE COMMUNITY IN ENVIRONMENTAL MANAGEMENT IN THE COASTAL AREA OF RUPAT DISTRICT Bathara, Lamun; Nedi, Syahril; Effendi, Irwan; NST, Musyirna Rahmah; Nasution, Tio Afandi; Tanjung, Afrizal
Asian Journal of Aquatic Sciences Vol. 8 No. 3 (2025): December
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31258/ajoas.8.3.364-372

Abstract

Coastal environmental problems in Rupat District cannot be resolved solely through a top-down approach or government intervention. This study was conducted in 2025 with the intention of comprehensively analyzing the role of the community in environmental management in the coastal areas of Rupat District, particularly on Ketapang and Lancah beaches. Through a systematic research approach, this study aims to identify the forms of community roles in coastal environmental management efforts, analyze factors that influence the level of community participation, describe the various challenges faced in implementing community-based environmental management, and formulate strategies for strengthening community roles that can be implemented sustainably. The method used in this study was a survey method with a total of 31 respondents, consisting of fishermen, seaweed farmers, fish traders, community leaders, and people involved in marine tourism activities. The results of the study can be concluded that community-based coastal environmental management has enormous potential but faces complex structural challenges
Optimizing carrot extract serum (Daucus carota L.) for anti-aging: efficacy in moisturizing and pore size reduction using Box-Behnken design method Iskandar, Benni; Antasya, Vaylia; Nasution, Musyirna Rahmah; Peng, Wei-Ching
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 23 No. 2 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1566

Abstract

Carrot extract (Daucus carota L.) contains various bioactive compounds, including vitamins A, B, and C, alkaloids, flavonoids, tannins, anthraquinones, saponins, diterpenes, steroids, beta-carotene, phenols, terpenoids, and minerals, all of which possess antioxidant properties. These compounds are known to help slow down the aging process. The aim of this study was to determine the optimal concentrations of gelling and alkalizing agents, assess their interactions, and evaluate the anti-aging effects of the most effective serum formulation. The formulation was optimized using the Box–Behnken design with two key factors: Carbopol 940 concentration (0.5–1%) and triethanolamine (0.5–1%). The effects on pH, adhesion, and spreadability were evaluated. The best formulation was achieved with 0.837% Carbopol 940 and 0.855% triethanolamine,  showing a pH error of 2.45%, adhesion error of 0.76%, and spreadability error of 1.01%, all within acceptable limits (errors < 10%). After four weeks of stability testing, the formulation remained stable, well-mixed, with a pH of 5.16, an adhesion time of 1.60 seconds, and spreadability of 6.73 cm, with no discomfort. The combination of Carbopol 940 and triethanolamine improved the physical properties, enhancing anti-aging effects compared to the base formula. The optimized serum increased skin moisture by 84.62%, reduced pore size by 64.71%, lightened spots by 62.79%, and reduced wrinkles by 67.50%. This indicates the optimized carrot extract serum is stable, safe, and effective as an anti-aging agent, making it a promising natural skincare product.
Kombucha tea from ambarella fruit as a natural antibacterial agent against Escherichia Coli and Staphylococcus aureus Musyirna Rahmah Nasution; Agfa Febriyananda
Acta Chimica Asiana Vol. 8 No. 2 (2025)
Publisher : The Indonesian Chemical Society, Chapter Nusa Tenggara and The University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/aca.v8i2.257

Abstract

Kombucha tea is a traditional fermented beverage known for its probiotic benefits, produced from sweetened tea fermented with a Symbiotic Culture of Bacteria and Yeast (SCOBY). Recent innovations have focused on enhancing its functional properties using local fruit extracts. However, studies on the incorporation of Spondias dulcis (kedondong), a native fruit of Riau, remain limited. This study aims to formulate kombucha tea enriched with kedondong juice and evaluate its quality and antibacterial activity against Escherichia coli and Staphylococcus aureus. Four formulations were prepared with kedondong juice concentrations of 0% (F1), 10% (F2), 20% (F3), and 30% (F4). Parameters observed included organoleptic properties, pH, alcohol content, microbial growth, and total acidity. Antibacterial activity was tested using the disc diffusion method, and results were statistically analyzed using One-Way ANOVA. F4 on day 7 showed the highest inhibition zones (13.30 mm for E. coli and 14.49 mm for S. aureus), with significant differences between formulations (p < 0.05). This study highlights the potential of kedondong-enriched kombucha tea as a functional probiotic beverage and a natural source of mild antibacterial agents, offering an innovative approach to utilizing local biodiversity in public health.
Optimization of Riau Local Lactic Acid Bacteria Concentration and Evaluation of Cell and Supernatant Antifungal Activity Against Aspergillus parasiticus Musyirna Rahmah Nasution; Nesa Agistia; Dita Bina Julianti Habeahan; Saryono Saryono
Biology, Medicine, & Natural Product Chemistry Vol 15, No 1 (2026)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2026.151.401-409

Abstract

Lactic acid bacteria (LAB) are capable of producing bioactive metabolites that can inhibit the growth of molds, including Aspergillus parasiticus. However, the potential of local LAB strains from Riau as biocontrol agents has not been extensively explored. This study aimed to optimize the concentration of LAB isolated from Riau to obtain the best antifungal activity, evaluate the effectiveness of their supernatants against the growth of A. parasiticus, and assess their potential application in food commodities.The antifungal activity of cell suspensions was tested using the well-diffusion method with varying concentrations (OD). Cell-free supernatants were analyzed through dilution assays to determine the percentage of fungal inhibition. Application testing was conducted on corn kernels as a biocontrol model. The results showed that increasing LAB cell density correlated with a larger inhibition zone against the mold. The two best isolates, S28 and AERH7, at OD 0.8 and 48 hours of incubation, produced inhibition zones of 18.67 mm and 17.58 mm, respectively. The supernatants of both isolates also demonstrated strong activity, with inhibition percentages of 72.17% and 64.39%, confirming the role of LAB metabolites in antifungal activity. Application on corn kernels further showed a visible reduction in mold growth compared to the control.This study concludes that LAB strains from Riau possess significant potential as natural biocontrol agents against A. parasiticus. These findings provide practical benefits for developing microbial-based biopreservation strategies to enhance food safety and quality.
Sintesis, Karakterisasi Struktur, dan Kajian In Silico Potensi 2'-Hidroksicalkon dan Flavonol Tersubstitusi Trimetoksi sebagai Inhibitor Main Protease (MPro) SARS-CoV-2 Ikhtiarudin, Ihsan; Frimayanti, Neni; Nasution, Musyirna Rahmah; Adawiyah, Rabiatul; Mora, Enda; Septama, Abdi Wira
ALCHEMY Jurnal Penelitian Kimia Vol 20, No 1 (2024): March
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.20.1.78445.98-119

Abstract

Pada penelitian ini, 2'-hidroksicalkon (C345) dan flavonol (F345) tersubstitusi trimetoksi telah disintesis menggunakan metode iradiasi microwave dan metode pengadukan. Struktur kedua produk telah dikarakterisasi melalui analisis spektroskopi UV-Vis, FT-IR, 1H NMR, 13C NMR, dan HRMS. Hasil analisis spektroskopi menunjukkan bahwa kedua produk memiliki struktur yang sesuai dengan struktur molekul target yang diharapkan. Selain itu, hasil sintesis juga menunjukkan bahwa metode iradiasi microwave terbukti dapat mempercepat waktu reaksi (dari 1,5-3,0 jam menjadi 3-6 menit) dan meningkatkan rendemen produk murni pada sintesis senyawa C345 (55,31 %) dan F345 (83,65 %). Selanjutnya, hasil docking menunjukkan bahwa kedua senyawa dapat membentuk ikatan hidrogen dengan beberapa residu penting pada sisi aktif dan dapat terikat pada kedua situs katalik MPro SARS-CoV-2 (PDB ID:6M2N), yaitu His41 dan Cys145 melalui interaksi hidrofobik dengan nilai energi bebas pengikatan yang lebih negatif (-8,95 dan -9,02 kcal/mol) dibandingkan dengan baicalein sebagai inhibitor pembanding. Hasil kajian in silico lainnya juga menunjukkan bahwa kedua senyawa memiliki profil farmakokinetik yang baik dan memiliki sifat kemiripan dengan obat berdasarkan aturan Lipinski, Ghose, Veber, Egan, dan Muegge. Selain itu, senyawa F345 juga diprediksi memiliki risiko toksisitas yang lebih kecil dibandingkan dengan baicalein. Synthesis, Structural Characterization, and In Silico Study of the Potential of 2'-Hydroxychalcone and Trimethoxy-Substituted Flavonols as Inhibitors of the Main Protease (MPro) of SARS-CoV-2. In this study, trimethoxy-substituted 2'-hydroxychalcone (C345) and flavonol (F345) were synthesized using microwave irradiation and stirring methods. The structure of the two products were characterized by spectroscopic analyses including UV-Vis, FT-IR, 1H NMR, 13C NMR, and HRMS. The result of spectroscopic analyses showed that the products had structures consistent with the expected target molecules. In addition, the synthesis results showed that the microwave irradiation method was proven to speed up the reaction time (from 1.5-3.0 hours to 3-6 minutes) and increased the yield of pure product in the synthesis of compounds C345 (55.31 %) and F345 (83.65 %). Furthermore, the docking result showed that the two compounds can form hydrogen bonds with several important residues on the active site and also can bind to catalytic dyad of the SARS-CoV-2 MPro (PDB ID:6M2N), namely His41 and Cys145 through hydrophobic interactions with a more negative binding free energy (-8.95 and -9.02 kcal/mol) than baicalein as a reference inhibitor. The result of silico studies also showed that the two compounds exhibited good pharmacokinetic profiles and drug-likeness properties based on Lipinski, Ghose, Veber, Egan, and Muegge rules. In addition, compound F345 was also predicted to has a smaller toxicity risk compared to baicalein.
Co-Authors -, Hasmalina Abdi Wira Septama Abdifi, Reza Afnita, Fakhiratunnisa Afrida Yeti Afrizal Tanjung Agfa Febriyananda agistia, nesa Agustini, Tiara Tri Akmal Djamaan Amnan, Wekis Raya Anggraini, Annisa Fitri Anita Lukman Annisa Riski Permata Sari Antasya, Vaylia Aqilla, Alya Armon Fernando Armon Fernando Arundita, Silvy Aulya, Nurliza Ayuni, Putri Azhari, Weriska Restu Bella Ardhiyati BENNI ISKANDAR Cahyani, Ardhia Regita Dasni Syafril Dasni Syafril Deni Anggraini Dita Bina Julianti Habeahan Diwa, Resi Oktamara Dwi Andreyas Elsa Etavianti Emrizal Enda Mora Etavianti, Elsa Febrian, Dyan Fina Aryani, Fina Firman Nugroho Fitri, Ramadini Fitri, Valentina Furi, Mustika Ginta Rio Maranti Gressy Novita Gustina &#039; Haiyul Fadhli Hanifa, Elvi Hasmalina - Hasmalina Nasution Husnawati Ihsan Ikhtiarudin Intan Putri Utami Irwan Irwan Jannah, Ninuk Rodhiatul Ladiona, Maria Yella Lamun Bathara Manik, Dhea Putri Bertuah Br Maria Yella Ladiona Martina Br Manullang Masnun, Lidiatil Meiriza Djohari, Meiriza Melati, Putri Melzi Octaviani Milianty, Jesy Muthmainnah, Nurillah Nabilah, Clara Nabilla, Vivi Gita Nanang Nasution, Tio Afandi Neni Frimayanti Ningrum, Tilar Eka Widia Ningsih, Yozi Fiedya Nur Rahmadani Fitri Nurhapipah, Nurhapipah Pardede, Depa Gloria Kristin Peng, Wei-Ching Peng-Wei, Ching Putri Lestari, Putri Putri Putri, Putri Rabiatul Adawiyah Rahayu Utami Rahayu Utami Utami Rahma Dona Rahman, Sumiati Rajeb Fadillah ramadhan, alfitrah Ramadhani, Elsha Fadhika Dwi Ratna Sari Dewi Reza Abdifi Ronapadua Musyirna Rahmah Nasution Sahara dan Emma Susanti Ronapadua Sahara Ruska, Shinta Liana S.Farm., M.Farm., Apt, Sondang Khairani Safitri, Ramanda Sahara, Ronapadua Sakinah, Norma Saryono Saryono Septi Muharni Silvera Devi Simanjuntak, Asnika Putri Sri Hardianti Sudarsi, Yulisma Suhelmi - Suhelmi - Sumiati Rahman Syahbandi, Ilham Syahril Nedi Syamira Tri Budhi Murdiati Tri Budhi Murdiati Tria Halianti Triani, Leni Winda Sri Wahyuni Wira Noviana, Wira Noviana Wulan Desmar Utari Yuharmen - Yulisma Sudarsi Yunelva, Rinda