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Musyirna Rahmah Nst
Sekolah Tinggi Ilmu Farmasi Riau
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FORMULASI DAN UJI AKTIVITAS TABIR SURYA SEDIAAN KRIM EKSTRAK ETANOL DAUN MARPUYAN (Rhodamnia cinerea Jack): FORMULATION AND SUNSCREEN ACTIVITY OF CREAM CONTAINING MARPUYAN LEAVES (Rhodamnia cinerea Jack) EXTRACT ETHANOL Musyirna Rahmah Nst; Deni Anggraini; Gressy Novita; Mustika Furi; Ihsan Ihtiarudin
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 2 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i2.778

Abstract

Sinar matahari memiliki manfaat bagi kesehatan. Sering terpapar sinar matahari menyebabkan kulit kemerahan, peradangan, dan menyebabkan terjadinya kanker kulit. Salah satu cara untuk melindungi kulit dari sinar matahari yaitu dengan menggunakan tabir surya. Daun marpuyan (Rhodamnia cinerea Jack) mempunyai kandungan flavonoid total dan fenolik total yang tinggi serta memiliki aktivitas antioksidan yang sangat kuat sehingga dapat digunakan sebagai bahan aktif alami krim tabir surya. Tujuan penelitian ini adalah memformulasi dan mengevaluasi krim tabir surya ekstrak etanol daun marpuyan (Rhodamnia cinerea Jack) serta mengetahui nilai persen transmisi eritema (%Te), persen transmisi pigmentasi (%Tp), dan nilai Sun Protection Factor (SPF). Dibuat empat formula dengan variasi konsentrasi ekstrak etanol daun marpuyan dalam krim yaitu, F0 (0%), F1 (0,1% b/b), F2 (0,5% b/b), dan F3 (1% b/b). Hasil menunjukkan nilai SPF F0, F1, F2, dan F3 berturut-turut 1,05; 4,68 (proteksi sedang); 4,74 (proteksi sedang); dan 9,36 (proteksi maksimal). Nilai SPF antar formula berbeda signifikan yang mana konsentrasi ekstrak berbanding lurus dengan nilai SPF. Kata kunci : Tabir surya, daun marpuyan, formulasi, Sun Protection Factor (SPF)
Aktivitas Antijamur Ekstrak Etanol Kulit Buah Ananas comosus (L) Merr. terhadap Trichophyton mentagrophytes dan Malassezia furfur Melzi Octaviani; Delvian Fikrani; Emma Susanti
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 12 No. 2 (2020): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (346.762 KB) | DOI: 10.35617/jfionline.v12i2.35

Abstract

Kulit buah nanas merupakan bagian dari buah nanas (Ananas comosus (L) Merr.) yang biasanya tidak dimanfaatkan. Hasil skrining fitokimia dari ekstrak etanol kulit nanas menunjukkan adanya kandungan flavonoid, alkaloid, fenolik, steroid dan saponin yang dapat menghambat pertumbuhan mikroorganisme. Tujuan penelitian ini adalah untuk mengetahui aktivitas antijamur ekstrak etanol kulit nanas terhadap jamur Trichophyton mentagrophytes dan Malassezia furfur. Penelitian dilakukan dengan metode difusi cakram dengan variasi konsentrasi ekstrak etanol kulit nanas yaitu 25%; 12,5%; 6,25%; 3,125% dan 1,5625% b/v dan kontrol positif yang digunakan adalah nistatin dan kontrol negatif DMSO. Diameter zona hambat yang terbentuk pada uji aktivitas antijamur ekstrak etanol kulit nanas terhadap jamur Trichophyton mentagrophytes dan Malassezia furfur pada konsentrasi 25% adalah 22,73 mm dan 24,90 mm. Hal ini menunjukkan bahwa ekstrak etanol kulit nanas memiliki aktivitas antijamur terhadap jamur Trichophyton mentagrophytes dan Malassezia furfur.
UJI AKTIVITAS ANTIBAKTERI EKSTRAK DAN FRAKSI DARI AKAR DAN BATANG TUMBUHAN SEKUNYIT (Fibraurea tinctoria Lour) Rahayu Utami; Dwi Winarsih; Armon Fernando; Haiyul Fadhli; Mustika Furi; Emma Susanti
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 12 No. 2 (2020): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (530.712 KB) | DOI: 10.35617/jfionline.v12i2.50

Abstract

Sekunyit (Fibraurea tinctoria Lour) is plant species that has been using widely as traditional medicine such as a cure for diarrhea. This study was conducted to determine the antibacterial activity of extract and fractions of its root and stem against bacteria that cause diarrhea. The sample of root and stem were macerated with ethanol and then followed by ultrasonication process for 30 minutes. Fractionation process was performed by acid-base method using three different solvents which were n-hexane, chloroform and n-butanol. The extract and fractions were tested for its antibacterial activity using agar diffusion method at tested concentrations of 30; 15; 7.5; 3.75 and 1.88%. The result showed that the ethanol extract, n-hexane, chloroform A and chloroform B fractions of the root and stem provided antibacterial activity against all tested bacteria with weak to medium activity. Whereas the n-butanol fraction did not give any activity, either to Escherichia coli, Salmonella typhi, Staphylococcus aureus as well as Vibrio cholerae.
FORMULASI DAN UJI AKTIVITAS TABIR SURYA SEDIAAN KRIM EKSTRAK ETANOL DAUN MARPUYAN (Rhodamnia cinerea Jack): FORMULATION AND SUNSCREEN ACTIVITY OF CREAM CONTAINING MARPUYAN LEAVES (Rhodamnia cinerea Jack) EXTRACT ETHANOL Musyirna Rahmah Nst; Deni Anggraini; Gressy Novita; Mustika Furi; Ihsan Ihtiarudin
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 2 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i2.778

Abstract

Sinar matahari memiliki manfaat bagi kesehatan. Sering terpapar sinar matahari menyebabkan kulit kemerahan, peradangan, dan menyebabkan terjadinya kanker kulit. Salah satu cara untuk melindungi kulit dari sinar matahari yaitu dengan menggunakan tabir surya. Daun marpuyan (Rhodamnia cinerea Jack) mempunyai kandungan flavonoid total dan fenolik total yang tinggi serta memiliki aktivitas antioksidan yang sangat kuat sehingga dapat digunakan sebagai bahan aktif alami krim tabir surya. Tujuan penelitian ini adalah memformulasi dan mengevaluasi krim tabir surya ekstrak etanol daun marpuyan (Rhodamnia cinerea Jack) serta mengetahui nilai persen transmisi eritema (%Te), persen transmisi pigmentasi (%Tp), dan nilai Sun Protection Factor (SPF). Dibuat empat formula dengan variasi konsentrasi ekstrak etanol daun marpuyan dalam krim yaitu, F0 (0%), F1 (0,1% b/b), F2 (0,5% b/b), dan F3 (1% b/b). Hasil menunjukkan nilai SPF F0, F1, F2, dan F3 berturut-turut 1,05; 4,68 (proteksi sedang); 4,74 (proteksi sedang); dan 9,36 (proteksi maksimal). Nilai SPF antar formula berbeda signifikan yang mana konsentrasi ekstrak berbanding lurus dengan nilai SPF. Kata kunci : Tabir surya, daun marpuyan, formulasi, Sun Protection Factor (SPF)
Aktivitas Antibakteri dan Antijamur Fraksi Etil Asetat Kulit Buah Jeruk Manis (Citrus sinensis (L.) Osbeck) Octaviani, Melzi; Masnun, Lidiatil; Nasution, Musyirna Rahmah; Susanti, Emma; Utami, Rahayu; Furi, Mustika
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 15 No 2 (2023): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v15i2.140

Abstract

The sweet orange (Citrus sinensis (L.) Osbeck) is a popular fruit. The part of the sweet orange that is consumed is only the fruit flesh, while the orange peel is only thrown away and not utilized. The sweet orange peel contains several secondary metabolites, namely alkaloids, flavonoids, tannins, phenols, saponins, and steroids, which have antimicrobial properties. This study aims to determine the effect of the concentration of the ethyl acetate fraction of sweet orange peel on antibacterial and antifungal activity in Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Salmonella typhi, and Candida albicans fungi using the disc diffusion method. The ethyl acetate fraction was prepared in several concentration series, namely 50%, 25%, 12.5%, 6.25%, 3.125%, and 1.5625% w/v. The results obtained showed that all concentrations of the ethyl acetate fraction series showed activity in inhibiting the growth of Salmonella typhi bacteria. Series concentrations of 3.125% to 50% have activity in inhibiting the growth of Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, and Candida albicans fungi. The results of the data analysis using statistical one-way ANOVA showed that the antibacterial and antifungal activities between the concentration series were significantly different (p<0.05) from the negative control.
Aktivitas Antibakteri dan Antijamur Fraksi Etil Asetat Kulit Buah Jeruk Manis (Citrus sinensis (L.) Osbeck) Octaviani, Melzi; Masnun, Lidiatil; Nasution, Musyirna Rahmah; Susanti, Emma; Utami, Rahayu; Furi, Mustika
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 15 No 2 (2023): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v15i2.140

Abstract

The sweet orange (Citrus sinensis (L.) Osbeck) is a popular fruit. The part of the sweet orange that is consumed is only the fruit flesh, while the orange peel is only thrown away and not utilized. The sweet orange peel contains several secondary metabolites, namely alkaloids, flavonoids, tannins, phenols, saponins, and steroids, which have antimicrobial properties. This study aims to determine the effect of the concentration of the ethyl acetate fraction of sweet orange peel on antibacterial and antifungal activity in Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Salmonella typhi, and Candida albicans fungi using the disc diffusion method. The ethyl acetate fraction was prepared in several concentration series, namely 50%, 25%, 12.5%, 6.25%, 3.125%, and 1.5625% w/v. The results obtained showed that all concentrations of the ethyl acetate fraction series showed activity in inhibiting the growth of Salmonella typhi bacteria. Series concentrations of 3.125% to 50% have activity in inhibiting the growth of Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, and Candida albicans fungi. The results of the data analysis using statistical one-way ANOVA showed that the antibacterial and antifungal activities between the concentration series were significantly different (p<0.05) from the negative control.
Ciplukan (Physalis angulata L.): Review Tanaman Liar yang Berpotensi Sebagai Tanaman Obat Fadhli, Haiyul; Ruska, Shinta Liana; Furi, Mustika; Suhery, Wira Noviana; Susanti, Emma; Nasution, Musyirna Rahmah
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 15 No 2 (2023): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v15i2.144

Abstract

Ciplukan (Physalis angulata L.) has been widely used as a traditional medicine in several countries and regions in Indonesia, such as to increase blood flow and relieve body aches, asthma, diabetes, chickenpox, cough medicine, fever, diarrhea, hypertension, and back pain. This article reviews the potential of ciplukan to overcome various health problems. The preparation of this review article uses references from research articles related to the results of phytochemical screening, the isolation of secondary metabolites, and biological activity tests (pharmacology) of Physalis angulata plants reported in the last 10 (ten) years. This plant contains many secondary metabolite compounds isolated from its roots, leaves, stems, and fruits, such as physalin, withanolide, and flavonoid glycoside compounds. Several studies have reported that this plant has biological and pharmacological activities such as antioxidants, toxicity, anticancer, anti-inflammatory, antidiabetic, antidiarrheal, antibacterial, antifibrotic, and anti-hypercholesterolemia.
Ciplukan (Physalis angulata L.): Review Tanaman Liar yang Berpotensi Sebagai Tanaman Obat Fadhli, Haiyul; Ruska, Shinta Liana; Furi, Mustika; Suhery, Wira Noviana; Susanti, Emma; Nasution, Musyirna Rahmah
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 15 No 2 (2023): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v15i2.144

Abstract

Ciplukan (Physalis angulata L.) has been widely used as a traditional medicine in several countries and regions in Indonesia, such as to increase blood flow and relieve body aches, asthma, diabetes, chickenpox, cough medicine, fever, diarrhea, hypertension, and back pain. This article reviews the potential of ciplukan to overcome various health problems. The preparation of this review article uses references from research articles related to the results of phytochemical screening, the isolation of secondary metabolites, and biological activity tests (pharmacology) of Physalis angulata plants reported in the last 10 (ten) years. This plant contains many secondary metabolite compounds isolated from its roots, leaves, stems, and fruits, such as physalin, withanolide, and flavonoid glycoside compounds. Several studies have reported that this plant has biological and pharmacological activities such as antioxidants, toxicity, anticancer, anti-inflammatory, antidiabetic, antidiarrheal, antibacterial, antifibrotic, and anti-hypercholesterolemia.
Formulasi Losion Minyak Sereh Wangi (Citronella Oil) Sebagai Anti Kutu Kepala (Pediculisid) Agistia, Nesa; Hafizah, Afrah; Susanti, Emma; ., Nofriyanti
Jurnal Penelitian Dan Pengkajian Ilmiah Eksakta Vol 3 No 1 (2024): Jurnal Hasi Penelitian Dan Pengkajian Ilmiah Eksakta - JPPIE
Publisher : LPPM Universitas Dharma Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47233/jppie.v3i1.1269

Abstract

Fleas (Pediculus humanus capitis) is one of the little parasites that live by sucking blood from a human head. While sucking blood, the flea secretes a secretion that irritate the skin tissues it causes a massive itch. Fleas can be treated by chemical drugs like 1 % permethrin, but it did have side effect of itching, rusting, swelling in the skin and massive burning sensation. Citronella oil (Cymbopogon nardus) have a chemical content which are insecticidal among them is citronellal which can be used as a natural pediculosid. This research aims to formulate lotion preparations that are stable and effective as anti-fleas and increase the time of death of fleas compared to permethrin. The concentrations of citronella oil used for F1, F2 and F3 were 5%; 7.5%; and 10%. The three formulas were evaluated including organoleptic examination, homogeneity, pH, emulsion type, dispersibility, viscosity, skin irritation, cycling test, and anti-lice activity test. Data analysis used the Kruskal Wallis statistical test. Based on the results of the evaluation of the preparations, it was found that the organoleptic examination of the preparation of lotions FI, FII, FIII had a consistency of thick to liquid form, white to pale yellow, had a distinctive smell of citronella oil, FI test pH = 7.31-6.51, FII = 7 03-6,38 and FIII = 6,98-6,35, FI spread ability test = 6,15-7,75 cm, FII = 6,55-8,25 cm and FIII = 8,55-10,05 cm, emulsion type test FI, FII, FIII have emulsion type M / A, FI viscosity test = 2956-3107 cPs, FII = 2360-2677 cPs, FIII = 764-980 cPs, homogeneity test on FI, FII, FIII homogeneous, freeze and thaw test on FI, FII is stable while FIII is unstable, skin irritation test on FI, FII, FIII is not irritation, FI anti-flea activity test = 122-167 seconds, FII = 117-128 seconds, FIII = 69-90 seconds.
Antimicrobial of Ethanolic Extract from Marpuyan Stem Bark (Rhodamnia cinerea Jack) Nasution, Musyirna Rahmah; Cahyani, Ardhia Regita; Aqilla, Alya; Fitri, Valentina; Triani, Leni
Acta Chimica Asiana Vol. 7 No. 1 (2024)
Publisher : The Indonesian Chemical Society, Chapter Nusa Tenggara and The University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/aca.v7i1.193

Abstract

The Bark of Marpuyan Tree (Rhodamnia cinerea Jack) is a plant that has been empirically used by communities in Indonesia for the treatment of infectious diseases caused by bacteria and fungi. The bark of Marpuyan contains flavonoids, phenolics, and saponins. This study aimed to evaluate the antibacterial and antifungal activities of the ethanol extract of the bark of Marpuyan using the disc diffusion method at various extract concentrations, namely 30%, 25%, 15%, 10%, and 5%. The results of the antibacterial activity test against Gram-positive bacteria (Staphylococcus aureus, Staphylococcus epidermidis, and Bacillus subtilis) showed inhibitory zones with respective diameters of 11.67±0.21 mm, 12.29±0.43 mm, and 12.78±0.14 mm. These results indicate weak antibacterial activity. In the antibacterial activity test against Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa, and Salmonella typhi), inhibitory zones were found with respective diameters of 13.05±0.05 mm, 12.58±1.78 mm, and 10.98±0.21 mm. These results also indicate weak antibacterial activity. However, in the antifungal activity test, no activity was found against Candida albicans and Malassezia furfur. Nevertheless, the ethanol extract of Marpuyan bark showed moderate antifungal activity against Trichophyton mentagrophytes, with an inhibitory zone diameter of 15.44±2.02 mm.
Co-Authors -, Hasmalina ., Nofriyanti Abdi Wira Septama Abdifi, Reza Abrar Hafudz Qalbi Adinda Rusyamsi Afandi, Rifath Afnita, Fakhiratunnisa Afrida Yeti Agfa Febriyananda agistia, nesa Agistia, Nesa Agustini, Tiara Tri Akmal Djamaan Al Fadhilah, Shafira Alfian ) Alfitra Raisya alfitrah ramadhan Alimia Woelandri Amanda Putri Pratiwi Amnan, Wekis Raya Andarini Diharmi Andriani, Sindy Anggraini, Annisa Fitri Anita Lukman Anita Lukman Annisa Annisa Annisa Riski Permata Sari Antasya, Vaylia Aqilla, Alya Arfan Zasliadi Armon Fernando Arundita, Silvy Aulya, Nurliza Ayuni, Putri Azhari, Weriska Restu Azkia Wanudya Rahmadhani A’dilah, Nur Bella Ardhiyati Benni Iskandar Cahyani, Ardhia Regita Cindy Ayu Lestari Cindy Novia R Dasni Syafril Dasni Syafril Della Vasmawati Delvian Fikrani Deni Anggraini Denisya amanda Denisya Anggraini Depa Gloria Kristin Pardede Dessy Novita Sari Desvica Fitriyani Putri Dheanita Liana Dita Bina Julianti Habeahan Diwa, Resi Oktamara Dwi Andreyas Dwi Winarsih Elsa Etavianti Elsa Safitri Elvi Nurjannah Emrizal Enda Mora Enda Mora Etavianti, Elsa Fadiyah Yueflen Fahri, Elifia Cahyani Fahriza, Mela Febrian, Dyan Felycia Wardi Ferdy Firmansyah Fharisti Kirana Fina Aryani, Fina Firman Nugroho Fitri, Ramadini Fitri, Valentina Furi, Mustika Ginta Rio Maranti Gressy Novita Gustina &#039; Hafizah, Afrah Haiyul Fadhli Hanifa, Dhea Hanifa, Elvi Hasmalina - Hasmalina Nasution Hexsha Rizki Amelia Husnawati Ihksani, Nurul Ihsan Ikhtiaruddin Ihsan Ikhtiarudin Intan Putri Utami Jannah, Ninuk Rodhiatul Kamalrullah ) Kiranti Azlin Kolista Sisilawati Kolista Sisilawati Ladiona, Maria Yella Lamun Bathara Larasati Arsad Lilik Septiana Manik, Dhea Putri Bertuah Br Maria Yella Ladiona Marli, Nofrita Martina Br Manullang Masnun, Lidiatil Mayrade, Salma Yudhistira Mega Fatimah Rosana Meiriza Djohari, Meiriza Melati, Putri Melzi Octaviani Mery Sukmiwati Milianty, Jesy Mira Febriana Musyirna Rahma Nst musyirna Rahmah Muthmainnah, Nurillah Nabilah, Clara Nabilla, Vivi Gita Nanang Nasution, Tio Afandi Neni Frimayanti Ningrum, Tilar Eka Widia Ningsih, Yozi Fiedya Nofriyanti - Novianti, Yetri Nur Rahmadani Fitri Nuraina, Nuraina Nurhapipah, Nurhapipah Octavia, Richa Pardede, Depa Gloria Kristin Peng-Wei, Ching Pratiwi, Erniza Putri Binti Jakfar Putri Lestari, Putri Putri Putri, Putri R. Rizatita Fitriani Rabiatul Adawiyah Rahayu Utami Rahayu Utami Rahayu Utami Rahayu Utami Utami Rahma Dona Rahman, Sumiati Raja Adli Husein Raja adli husin Rajeb Fadillah ramadhan, alfitrah Ramadhani, Ayu Indah Ramadhani, Elsha Fadhika Dwi Ramanda safitri Ratna Sari Dewi Reza Abdifi Rizda Fitriani Robiatun Rambe Roli Oktaviana Ronapadua Sahara Ruska, Shinta Liana S.Farm., M.Farm., Apt, Sondang Khairani Safitri, Ramanda Safli, Fazza Aulia Sahara, Ronapadua Sakinah, Norma Salsabila alhamdania Balqis Salsabila Zahirah Ananda Saryono Saryono Selvi Aulia Wibowo Septi Muharni Serlin Partika Sari Silalahi, Rizka Fitri Silvera Devi Silvy Arundita Simanjuntak, Asnika Putri Siti Nurhaliza Sri Hardianti Sudarsi, Yulisma Suhelmi - Suhelmi - Sumiati Rahman Susi lestari - Syahbandi, Ilham Syamira Syaputri, Rezy Tambunan, Beatrix Evalin Titania T Nugroho Tri Budhi Murdiati Tri Budhi Murdiati Tria Halianti Triani, Leni Ulfa, Rodia Vaylia Antasya Wardi, Felycia Wei-Ching Peng Winda Sri Wahyuni Wira Noviana, Wira Noviana Wulan Desmar Utari Wulan, Nimas Yuharmen - Yuli Haryani Yulisma Sudarsi Yunelva, Rinda Zulmai Rani